精神分裂症患者听觉错配负性和P3a反应的时间和频谱特性

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Nancy B Lundin, Leah P Burroughs, Paul D Kieffaber, Jaime J Morales, Brian F O'Donnell, William P Hetrick
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引用次数: 1

摘要

失配负性(MMN)事件相关电位(ERP)指标相对自动检测感觉刺激的变化,并且在精神分裂症个体中通常减弱。然而,不同频率的脑电图(EEG)活动对精神分裂症患者MMN和后期P3a注意定向反应的贡献知之甚少,这是本研究的重点。有精神分裂症谱系障碍的参与者(n = 85)和没有精神疾病的对照组参与者(n = 74)完成了一项被动听觉古怪任务,其中包含10%的50毫秒“异常”音调和90%的100毫秒“标准”音调。采用空间主成分分析(PCA)、小波时频分析、MMN和P3a erp对脑电数据进行分析。考虑到参与者的年龄和性别,与对照组相比,精神分裂症组的MMN振幅较小,偏离-负标准theta较低,但α事件相关谱摄动(ERSP)较低。更大的MMN和P3a振幅而非潜伏期与更大的θ和α时频活动相关。多元线性回归分析显示,对照组受试者的MMN波幅值越大,试验间相干性越强,P3a波幅值越大,试验间相干性越强,而精神分裂症谱系障碍受试者的动态神经过程耦合程度越低。研究结果有助于澄清基于频率的时域(即ERP)反应的贡献,并表明在精神分裂症中检测感觉刺激变化的神经动力学中存在潜在的干扰。总的来说,这些发现增加了越来越多的证据,证明精神疾病与θ波段广泛的神经功能障碍有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal and Spectral Properties of the Auditory Mismatch Negativity and P3a Responses in Schizophrenia.

The mismatch negativity (MMN) event-related potential (ERP) indexes relatively automatic detection of changes in sensory stimuli and is typically attenuated in individuals with schizophrenia. However, contributions of different frequencies of electroencephalographic (EEG) activity to the MMN and the later P3a attentional orienting response in schizophrenia are poorly understood and were the focus of the present study. Participants with a schizophrenia-spectrum disorder (n = 85) and non-psychiatric control participants (n = 74) completed a passive auditory oddball task containing 10% 50 ms "deviant" tones and 90% 100 ms "standard" tones. EEG data were analyzed using spatial principal component analysis (PCA) applied to wavelet-based time-frequency analysis and MMN and P3a ERPs. The schizophrenia group compared to the control group had smaller MMN amplitudes and lower deviant-minus-standard theta but not alpha event-related spectral perturbation (ERSP) after accounting for participant age and sex. Larger MMN and P3a amplitudes but not latencies were correlated with greater theta and alpha time-frequency activity. Multiple linear regression analyses revealed that control participants showed robust relationships between larger MMN amplitudes and greater deviant-minus-standard theta inter-trial coherence (ITC) and between larger P3a amplitudes and greater deviant-minus-standard theta ERSP, whereas these dynamic neural processes were less tightly coupled in participants with a schizophrenia-spectrum disorder. Study results help clarify frequency-based contributions of time-domain (ie, ERP) responses and indicate a potential disturbance in the neural dynamics of detecting change in sensory stimuli in schizophrenia. Overall, findings add to the growing body of evidence that psychotic illness is associated with widespread neural dysfunction in the theta frequency band.

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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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