Transcranial Alternating Current Stimulation Alters Auditory Steady-State Oscillatory Rhythms and Their Cross-Frequency Couplings.

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
S. de la Salle, J. Choueiry, Mark Payumo, Matt Devlin, Chelsea Noel, A. Abozmal, M. Hyde, Renée Baysarowich, B. Duncan, V. Knott
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引用次数: 0

Abstract

Auditory cortical plasticity deficits in schizophrenia are evidenced with electroencephalographic (EEG)-derived biomarkers, including the 40-Hz auditory steady-state response (ASSR). Aiming to understand the underlying oscillatory mechanisms contributing to the 40-Hz ASSR, we examined its response to transcranial alternating current stimulation (tACS) applied bilaterally to the temporal lobe of 23 healthy participants. Although not responding to gamma tACS, the 40-Hz ASSR was modulated by theta tACS (vs sham tACS), with reductions in gamma power and phase locking being accompanied by increases in theta-gamma phase-amplitude cross-frequency coupling. Results reveal that oscillatory changes induced by frequency-tuned tACS may be one approach for targeting and modulating auditory plasticity in normal and diseased brains.
经颅交流电刺激改变听觉稳态振荡节律及其交叉频率耦合。
精神分裂症的听觉皮层可塑性缺陷可以通过脑电图(EEG)衍生的生物标志物来证明,包括40Hz听觉稳态反应(ASSR)。为了了解40 Hz ASSR的潜在振荡机制,我们检测了23名健康参与者对双侧颞叶经颅交流刺激(tACS)的反应。尽管对伽马tACS没有响应,但40Hz ASSR由θtACS调制(与假tACS相比),伽马功率和锁相的降低伴随着θ-伽马相位振幅交叉频率耦合的增加。结果表明,调频tACS诱导的振荡变化可能是靶向和调节正常和患病大脑听觉可塑性的一种方法。
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来源期刊
Clinical EEG and Neuroscience
Clinical EEG and Neuroscience 医学-临床神经学
CiteScore
5.20
自引率
5.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Clinical EEG and Neuroscience conveys clinically relevant research and development in electroencephalography and neuroscience. Original articles on any aspect of clinical neurophysiology or related work in allied fields are invited for publication.
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