Connective Tissue Research最新文献_第2页

The beneficial and detrimental effects of exercise and unloading on OA progression after anterior cruciate ligament injury. 运动和卸载对前交叉韧带损伤后骨性关节炎进展的有益和有害影响。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-05-23 DOI: 10.1080/03008207.2025.2507858

Yu-Yang Lin, Blaine A Christiansen

{"title":"The beneficial and detrimental effects of exercise and unloading on OA progression after anterior cruciate ligament injury.","authors":"Yu-Yang Lin, Blaine A Christiansen","doi":"10.1080/03008207.2025.2507858","DOIUrl":"10.1080/03008207.2025.2507858","url":null,"abstract":"Injury of the anterior cruciate ligament (ACL) is a common sports injury that can lead to post-traumatic osteoarthritis (PTOA) within 10-20 years. Surgical ACL reconstruction is often performed several weeks or months after injury, and this period between injury and ACL reconstruction may be a critical time for determining the risk of long-term PTOA progression. However, few (if any) studies in human patients have investigated the long-term effects of exercise or unloading between ACL injury and surgery. Early mobilization is often recommended to maintain range of motion and muscle strength, which are beneficial for positive outcomes of ACL reconstruction, but it is unknown what effects early mobilization or unloading have on long-term PTOA progression. In preclinical animal studies, a brief period of joint unloading immediately after ACL injury significantly decreased osteophyte formation and articular cartilage degeneration, while longer-term non-weightbearing caused muscle atrophy and articular cartilage degradation. Similarly, preclinical studies have shown that different intensities of exercise after knee injury can have divergent effects on PTOA development. Low intensity exercise was protective against joint degeneration, while higher intensity exercise accelerated PTOA progression. The beneficial or detrimental effects of exercise and unloading following ACL injury are likely dependent on the timing, duration, and intensity of these biomechanical interventions. This review summarizes the effects of these biomechanical interventions after ACL injury in both humans and animal models, with the goal of informing therapeutic and rehabilitation strategies for slowing or preventing PTOA progression after injury.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"490-496"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of tissue engineering approaches in osteoarthritis. 组织工程技术在骨关节炎中的应用。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-05-31 DOI: 10.1080/03008207.2025.2509135

Liru Wen, Fatemeh Safari, Zhen Li, Martin J Stoddart

{"title":"Application of tissue engineering approaches in osteoarthritis.","authors":"Liru Wen, Fatemeh Safari, Zhen Li, Martin J Stoddart","doi":"10.1080/03008207.2025.2509135","DOIUrl":"10.1080/03008207.2025.2509135","url":null,"abstract":"This review article examines the application of tissue engineering approaches in the treatment of osteoarthritis (OA), a complex joint disease characterized by tissue crosstalk and inflammation. The article covers preclinical testing platforms, including long-term in vitro studies, ex vivo models with osteochondral explants, and in vivo animal studies. It highlights the advantages and limitations of these models in evaluating tissue-engineered constructs for OA repair and focusses on cartilage specific treatments and resurfacing. The review also explores focal damage approaches such as autologous cultured chondrocytes and Autologous Matrix-Induced Chondrogenesis, which have shown improved patient outcomes. Additionally, it discusses natural and synthetic biomaterials used in cartilage repair, emphasizing the need for combining materials to enhance therapeutic efficacy. The importance of long-term studies in large animal models is underscored to develop effective strategies for cartilage repair. This minireview explores various approaches aimed at effectively addressing and repairing cartilage damage, covering preclinical testing platforms, cartilage resurfacing methods, and tissue engineering (TE) clinical trials. It also highlights challenges in developing future cartilage repair therapies.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"473-480"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetics in osteoarthritis: emerging mechanistic and translational landscape. 骨关节炎的表观遗传学：新兴的机制和转化景观。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-07-12 DOI: 10.1080/03008207.2025.2523520

Yaniet T Ghezai, Nada M Farhat, Saleh M S Ibrahim, Muhammad Farooq Rai

{"title":"Epigenetics in osteoarthritis: emerging mechanistic and translational landscape.","authors":"Yaniet T Ghezai, Nada M Farhat, Saleh M S Ibrahim, Muhammad Farooq Rai","doi":"10.1080/03008207.2025.2523520","DOIUrl":"10.1080/03008207.2025.2523520","url":null,"abstract":"Epigenetic mechanisms are implicated in osteoarthritis (OA) as they regulate the expression of several key genes involved in OA disease progression. This mini-review highlights major epigenetic studies in OA from the past 25 years, focusing on mechanistic and therapeutic perspectives. We discuss how DNA methylation, histone modifications, and non-coding RNAs (ncRNAs) impact OA, highlighting preclinical studies targeting epigenetic mechanisms in mouse models. Indeed, existing studies demonstrate that DNA methylation regulates the expression of OA-related genes through DNA methyltransferases, and targeting their activity has shown promise in restoring cartilage homeostasis. EZH2 and DOT1L are key methyltransferases involved in histone methylation with opposing roles in OA: high EZH2 promotes disease progression and is a potential therapeutic target, whereas DOT1L exerts protective effects, partly by suppressing Wnt signaling. Additionally, targeting enzymes that catalyze histone acetylation (PCAF, BRD4) and deacetylation (HDAC1/2) has demonstrated therapeutic potential in preclinical OA models. ncRNAs-including miRNAs, circRNAs, and lncRNAs-regulate gene expression in OA tissues at multiple levels. Several miRNAs (e.g. miR-17, miR-27b-3p) influence cartilage homeostasis and OA pathogenesis, while circRNAs (e.g. circPDE4B) and lncRNAs (e.g. ELDR) have emerged as important disease regulators, offering new therapeutic avenues. Despite significant advancements in OA-related epigenetic mechanisms, clinical translation remains challenging due to the complexity of epigenetic regulation, patient heterogeneity, and limited success of preclinical studies. Importantly, epigenetic alterations are often context-specific, necessitating nuanced interpretation to accurately discern their role in OA. Future research should prioritize identifying specific epigenetic markers linked to clinical outcomes (e.g. structural changes, functional impairment, pain) and developing more selective and potent epigenetic modulators for therapeutic use.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"313-322"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in understanding the role of obesity in osteoarthritis. 了解肥胖在骨关节炎中的作用的进展。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-07-17 DOI: 10.1080/03008207.2025.2533330

Isabella Y Goh, Ujjyani Ghosh, Natalia S Harasymowicz

{"title":"Advancements in understanding the role of obesity in osteoarthritis.","authors":"Isabella Y Goh, Ujjyani Ghosh, Natalia S Harasymowicz","doi":"10.1080/03008207.2025.2533330","DOIUrl":"10.1080/03008207.2025.2533330","url":null,"abstract":"Obesity is a major risk factor for osteoarthritis (OA), yet the precise contribution to the pathogenesis of OA is still not fully known. Although traditionally viewed as a weight-induced joint deterioration, recent studies have highlighted multiple mechanisms through which obesity contributes to OA. This review summarizes the advances in our understanding of the obesity-associated impact on OA and addresses the knowledge gaps within the field. It highlights the newest findings on the role of local and systemic factors produced by adipose tissue (AT). While AT-derived adipokines, such as leptin and resistin, have been shown to promote cartilage degradation by inducing pro-inflammatory cytokines through multiple pathways, others, like adiponectin, exert both pro- and anti-inflammatory effects. Furthermore, this review focuses on recent findings regarding the reorganization of the obesity-associated immune cell landscape during OA progression, highlighting the reduced content of synovial lining macrophages and patrolling monocytes, as well as the increased content of monocyte-derived macrophages, T cells, and myeloid suppressor cells in obese subjects. Additionally, this review explores the emerging link between the gut microbiome and metabolic dysfunction in obesity-related OA and examines the influence of sex differences on the disease. By framing OA as a systemic condition in the context of obesity, this review underscores the need for multifactorial therapeutic approaches and precision medicine strategies to address this growing public health challenge. By presenting current and emerging treatment strategies, this review features the multifaceted approach to managing and researching OA in obese populations, emphasizing the need for innovative preventative measures.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"345-351"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis. 骨关节炎中软骨下骨重塑和相关疼痛的细胞和分子机制。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-08-13 DOI: 10.1080/03008207.2025.2540950

Lance A Murphy, Carla R Scanzello

{"title":"Cellular and molecular mechanisms underlying subchondral bone remodeling and associated pain in osteoarthritis.","authors":"Lance A Murphy, Carla R Scanzello","doi":"10.1080/03008207.2025.2540950","DOIUrl":"10.1080/03008207.2025.2540950","url":null,"abstract":"Osteoarthritis (OA) is the most common musculoskeletal-related disease affecting over 27 million US adults, and no disease-modifying agents are currently available. Signs of bone remodeling are a major hallmark of OA, and include subchondral sclerosis (seen on x-ray), subchondral bone marrow lesions (seen on MRI), and osteophytosis. Recent work suggests subchondral bone remodeling is likely a driver of pain in OA. In this review, we seek to provide an overview on what is known about the cellular and molecular mechanisms that play a role in osteoarthritic subchondral bone remodeling and associated pain. Searching for \"subchondral bone remodeling\" \"pain\" and \"osteoarthritis,\" we reviewed publications from 2015 onward. We found new details of how osteoblasts, osteoclasts, and osteocytes communicate in both autocrine and paracrine manners in OA, allowing identification of potential candidates that play a role in the aberrant bone remodeling seen in OA. Furthermore, there is new knowledge regarding mechanisms of how bone cells communicate with nociceptive neurons, providing potential candidates to target for treatment of OA pain. Recent clinical trials targeting OA-associated bone remodeling have been published with some encouraging results. In the future, more work is necessary to understand the inciting events that lead to the pathogenic cell behaviors, and unravel the complex cellular communication detailed in this review. In addition, efforts to understand the discordant results from recent trials of existing agents targeting bone remodeling and to develop novel bone-targeted agents for OA are needed.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"435-441"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial changes in osteoarthritis: symptom or disease driver? 骨关节炎的滑膜改变：症状还是疾病驱动因素？

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-09-04 DOI: 10.1080/03008207.2025.2553080

Liane M Miller, Elizabeth R Bernstein, Carla R Scanzello, Robert L Mauck

{"title":"Synovial changes in osteoarthritis: symptom or disease driver?","authors":"Liane M Miller, Elizabeth R Bernstein, Carla R Scanzello, Robert L Mauck","doi":"10.1080/03008207.2025.2553080","DOIUrl":"10.1080/03008207.2025.2553080","url":null,"abstract":"Osteoarthritis (OA), long regarded as simply a disease of articular cartilage degeneration, has increasingly been recognized as a complex disorder involving multiple joint tissues, including the synovium. This review explores the emerging evidence that synovial changes seen in OA are not merely secondary to cartilage breakdown but may actively drive OA progression. We detail the physiological role of the synovium in joint homeostasis and highlight pathological remodeling processes, such as synovial hyperplasia, immune cell infiltration, and fibroblast activation, that contribute to joint degeneration. Mechanistic insights implicate fibroblast-like synoviocytes and synovial macrophages in initiating and perpetuating inflammatory and catabolic cascades that alter synovial fluid composition, impair cartilage integrity, and exacerbate disease symptoms. Clinical and preclinical data increasingly link synovitis and synovial damage to structural disease progression and pain, underscoring their prognostic and therapeutic significance. Despite promising targets, effective disease-modifying therapies remain elusive due to the molecular complexity and clinical heterogeneity of the disease and limitations in early diagnostic evaluations. To overcome this, innovative research methods, improved diagnostic tools, and interdisciplinary collaboration will be critical. Collectively, this work advocates for a paradigm shift that the synovium is a central player in OA pathogenesis and a viable target for therapeutic intervention.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"442-449"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial joint organ homeostasis: mechanisms and biological considerations. 滑膜关节器官稳态：机制和生物学考虑。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-06-17 DOI: 10.1080/03008207.2025.2512940

Garth Blackler, Hanyu Jiang, C Thomas Appleton

{"title":"Synovial joint organ homeostasis: mechanisms and biological considerations.","authors":"Garth Blackler, Hanyu Jiang, C Thomas Appleton","doi":"10.1080/03008207.2025.2512940","DOIUrl":"10.1080/03008207.2025.2512940","url":null,"abstract":"Synovial joints are complex multi-tissue organs that permit movement. A well-functioning synovial joint relies on complex interconnected homeostatic mechanisms to maintain joint organ function in response to biomechanical and metabolic demands. These homeostatic mechanisms include, but are not limited to, appropriate mechanobiological responses to load, nutrient delivery from its vasculature, lubrication, proprioception and pain, immunosurveillance, and maintenance of the extracellular matrix (ECM) composition. In osteoarthritis (OA), joint homeostasis is chronically deranged leading to failure of the synovial joint organ and impairment or loss of function. Maintaining synovial joint organ homeostasis is therefore critical to joint function and relies on complex interconnected physiological process at the joint level. As OA prevalence continues to rise, deepening our understanding of the integrated systems that sustain joint homeostasis may identify fruitful avenues for therapeutic intervention. However, key knowledge gaps will need to be addressed including, characterizing vessel function in joint diseases, understanding the role of novel proteases in ECM catabolism, and determining the role of non-macrophage synovial immune cells in joint immunosurveillance. We believe that future research will find greater success if these homeostatic mechanisms are viewed as a single integrated system that considers the crosstalk between mechanical, vascular, immune, and biochemical factors. Therefore, in this review, we explore the interconnected mechanisms that support joint homeostasis and how dysregulation can lead to failure of the synovial joint organ.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"331-338"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Just a breath away: considerations for oxygen imbalances in osteoarthritis. 稍等片刻：对骨关节炎中氧失衡的考虑。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-07-16 DOI: 10.1080/03008207.2025.2530013

Annemarie Lang, Christophe Merceron, Jay M Patel

{"title":"Just a breath away: considerations for oxygen imbalances in osteoarthritis.","authors":"Annemarie Lang, Christophe Merceron, Jay M Patel","doi":"10.1080/03008207.2025.2530013","DOIUrl":"10.1080/03008207.2025.2530013","url":null,"abstract":"Oxygen availability plays a critical role in maintaining cartilage homeostasis and influencing the progression of osteoarthritis (OA). Articular cartilage is an avascular tissue that depends on a tightly regulated hypoxic microenvironment, with oxygen gradients shaped by diffusion from synovial fluid, cartilage thickness, and mechanical loading. Both degenerative OA, which develops gradually with age, and post-traumatic osteoarthritis (PTOA), which follows joint injury and progresses more rapidly, may involve disruption of this oxygen balance. Such dysregulation, whether through reduced or elevated oxygen tension, can impair chondrocyte metabolism, increase reactive oxygen species (ROS) production, and alter hypoxia-inducible factor 1-alpha (HIF-1α) signaling, ultimately contributing to cartilage degeneration. This mini-review explores the complex oxygen dynamics in cartilage and their potential role in OA. We highlight current knowledge gaps in oxygen level assessment and mechanistic understanding, and discuss emerging therapeutic and biomaterial-based strategies, including oxygen-sensing nanoparticles, ROS-responsive scaffolds, and oxygen-generating materials, that aim to modulate the joint oxygen environment. These approaches underscore the need for temporally controlled oxygen-related pathway modulation to support cartilage repair. Advancing our understanding of oxygen regulation in joint tissues may offer new opportunities for more effective, stage-specific OA therapies.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"421-427"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The utility of animal models in understanding osteoarthritis (OA) pathogenesis - an update on the impact of genetically modified mice. 动物模型在理解骨关节炎（OA）发病机制中的应用——转基因小鼠影响的最新进展。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-07-15 DOI: 10.1080/03008207.2025.2523517

Carina L Blaker, Cindy C Shu, Jamie Soul, Sanaa Zaki, Christopher B Little

{"title":"The utility of animal models in understanding osteoarthritis (OA) pathogenesis - an update on the impact of genetically modified mice.","authors":"Carina L Blaker, Cindy C Shu, Jamie Soul, Sanaa Zaki, Christopher B Little","doi":"10.1080/03008207.2025.2523517","DOIUrl":"10.1080/03008207.2025.2523517","url":null,"abstract":"Osteoarthritis (OA) is one of the most common health conditions worldwide leading to immense individual and societal burden. Current treatments for OA are inadequate with no approved structural disease modifying therapies, and existing options for chronic pain only moderately successful long-term. Improving this bleak picture requires a better understanding of OA molecular pathophysiology, how this differs between individuals and over time. Critical in this goal are animal models. There have been four key advancements in this field that have dramatically improved OA pathophysiology discovery research: (1) initial studies showing mouse OA-risk is modified by the same factors as humans-age, sex/sex-hormones, diet and genetics (1952-65); (2) first studies of naturally-occurring OA in mice with spontaneous (1972-81) and induced (1993) genetic mutations (GMs); (3) developing reproducible inducible models with good structural and symptomatic fidelity to human OA (1990-2005); and (4) using inducible and spontaneous OA-models in GM-mice to show disease and symptom modification and define molecular causality (1999-present). These milestones revolutionized OA pathophysiology research, such that there are now >500 unique genes/gene-products identified as having significant effects on OA (beneficial or detrimental). Studies in different mouse OA-models have underpinned the concept of OA-phenotypes, and more particularly endotypes and theratypes, with ~35% of tested molecular targets having different effects on post-traumatic (pt)OA versus spontaneous/age-associated-OA. Deciphering and translating the enormous and growing data from animal-models into effective therapeutics for people remains challenging. This will require better identification and stratification of patients with different OA pheno/endotypes, and improved collaboration between clinical and pre-clinical researchers.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"399-406"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of gene therapy in osteoarthritis. 基因治疗在骨关节炎中的应用。

IF 2.1 4区医学

Connective Tissue Research Pub Date : 2025-09-01 Epub Date: 2025-07-27 DOI: 10.1080/03008207.2025.2533332

You Li, Biao Li, Andras Nagy, Christopher Kim

{"title":"Application of gene therapy in osteoarthritis.","authors":"You Li, Biao Li, Andras Nagy, Christopher Kim","doi":"10.1080/03008207.2025.2533332","DOIUrl":"10.1080/03008207.2025.2533332","url":null,"abstract":"Osteoarthritis (OA) is a leading cause of pain and disability globally,characterized by progressive cartilage degeneration, subchondralbone remodeling, and synovial inflammation. Current treatmentsprimarily offer symptomatic relief without addressing the underlyingdisease mechanisms or halting progression. Gene therapy hasemerged as a promising strategy to target the molecular drivers ofOA by modulating key pathways involved in inflammation, tissuedegeneration, and pain. This review summarizes recent advancesin OA gene therapy, including anti-inflammatory approachestargeting IL-1β and IL-10, as well as regenerative strategiesleveraging TGF-β1 and FGF-18. Preclinical and early clinicalstudies have shown encouraging results in both symptom reliefand cartilage preservation. However, significant challengesremain, including vector safety, immune responses, and thecomplex, heterogeneous nature of OA that complicates treatmentresponse. The integration of precision medicine with improved genedelivery platforms and combinatorial therapeutic strategies holdsstrong potential to overcome these limitations. Collectively, theseinnovations may accelerate the development of disease-modifyingosteoarthritis drugs (DMOADs) and provide long-term, effectivetherapeutic options for patients.","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":" ","pages":"450-457"},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0