Toxicology Research最新文献_第5页

Impact of micro-nano plastics in daily life on human health: toxicological evaluation from the perspective of normal tissue cells and organoids. 日常生活中微纳塑料对人体健康的影响：从正常组织细胞和类器官的角度进行毒理学评价。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1093/toxres/tfae205

Jie Wang, Lan-Gui Xie, Xian-Fu Wu, Zong-Ge Zhao, Yong Lu, Hui-Min Sun

{"title":"Impact of micro-nano plastics in daily life on human health: toxicological evaluation from the perspective of normal tissue cells and organoids.","authors":"Jie Wang, Lan-Gui Xie, Xian-Fu Wu, Zong-Ge Zhao, Yong Lu, Hui-Min Sun","doi":"10.1093/toxres/tfae205","DOIUrl":"10.1093/toxres/tfae205","url":null,"abstract":"Plastics are the most frequently used materials in people's daily life, and the primary and secondary microplastics generated from them may harm the health of adults. This paper focuses on the summary of the existence of microplastics in many objects most closely related to people in daily life, the toxicological influences it causes in cultured human normal cells and organoids, and the prospects for future research directions. Micro- and nano-plastics (MNPs) are found in almost all of our everyday products, such as food, drink, and daily necessities, etc. It can enter the digestive tract, respiratory system, and body fluids of the human body, and at lower or equal environment concentrations exhibits obvious cytotoxicity and genotoxicity toward cells and organoids, probably becoming a kind of toxin affecting human health. In addition, due to MNPs can be transferred from the placenta to the embryo, long-term growth-tracking studies of newborns should be done vitally. Besides, due to their wide usability in daily products and the ability to penetrate cytomembranes, the toxicological effects of polyethylene and polypropylene nanoplastic particles equal to or lower than environmental (normal exposure to human body) concentrations are recommended to be studied on human health in the future. Finally, for those individuals who carry MNPs, long-term health evaluation must be performed.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae205"},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting the molecular mechanisms of cardiovascular toxicity induced by per- and polyfluoroalkyl substances: an In Silico network toxicology perspective. 预测全氟烷基和多氟烷基物质引起的心血管毒性的分子机制：一个硅网络毒理学观点。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1093/toxres/tfae206

Fuat Karakuş, Burak Kuzu

{"title":"Predicting the molecular mechanisms of cardiovascular toxicity induced by per- and polyfluoroalkyl substances: an In Silico network toxicology perspective.","authors":"Fuat Karakuş, Burak Kuzu","doi":"10.1093/toxres/tfae206","DOIUrl":"10.1093/toxres/tfae206","url":null,"abstract":"Background: Per- and polyfluoroalkyl substances (PFAS) are human-made chemicals that accumulate in the human body and the environment over time. Humans are primarily exposed to PFAS through drinking water, food, consumer products, and dust. These exposures can have many adverse health effects, including cardiovascular diseases (CVDs) and factors contributing to CVDs. This study identified the molecular mechanisms of CVDs caused by PFAS.Methods: For this purpose, various computational tools, such as the Comparative Toxicogenomic Database, ShinyGO, ChEA3, MIENTURNET, GeneMANIA, STRING, and Cytoscape, were used to conduct in silico analyses.Results: The results showed that 10 genes were common between PFAS and CVDs, and among these common genes, the PPAR signaling pathway, fatty acid metabolic processes, and lipid binding were the most significantly associated gene ontology terms. Among the top 10 transcription factors (TFs) related to these common genes, peroxisome proliferator-activated receptor gamma and androgen receptor were the most prominent. Additionally, hsa-miR-130b-3p, hsa-miR-130a-3p, and hsa-miR-129-5p were featured microRNAs involved in PFAS-induced CVDs. Finally, PPARA and PPARG were identified as core genes involved in PFAS-induced CVDs.Conclusion: These findings may contribute to a better understanding of the molecular mechanisms and reveal new potential targets in PFAS-induced CVDs.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae206"},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach. 二苯甲酮-3对骨关节炎发病机制的影响：网络毒理学方法。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1093/toxres/tfae199

Yongji Li, Geqiang Wang, Peiran Liu, Lin Zhang, Hai Hu, Xiangjun Yang, Hongpeng Liu

{"title":"The impact of Benzophenone-3 on osteoarthritis pathogenesis: a network toxicology approach.","authors":"Yongji Li, Geqiang Wang, Peiran Liu, Lin Zhang, Hai Hu, Xiangjun Yang, Hongpeng Liu","doi":"10.1093/toxres/tfae199","DOIUrl":"10.1093/toxres/tfae199","url":null,"abstract":"Background: Arthritis is a degenerative joint disease influenced by various environmental factors, including exposure to Benzophenone-3 (BP3), a common UV filter. This study aims to elucidate the toxicological impact of BP3 on arthritis pathogenesis using network toxicology approaches.Method: We integrated data from the Comparative Toxicogenomics Database (CTD) and Gene Expression Omnibus (GEO) to identify differentially expressed BP3-related toxicological targets in osteoarthritis (OA). Enrichment analyses were conducted to determine the implicated biological processes, cellular components, and molecular functions. Further, the involvement of the PI3K-Akt signaling pathway was investigated, along with correlations with immune cell infiltration and immune-related pathways. Molecular docking analysis was performed to examine BP3 interactions with key PI3K-Akt pathway proteins.Results: A total of 74 differentially expressed BP3-related targets were identified. Enrichment analysis revealed significant pathways, including PI3K-Akt, MAPK, and HIF-1 signaling. The PI3K-Akt pathway showed notable dysregulation in OA, with reduced activity and differential expression of key genes such as ANGPT1, ITGA4, and PIK3R1. Correlation analysis indicated significant associations between PI3K-Akt pathway activity and various immune cell types and immune pathways. Molecular docking highlighted strong interactions between BP3 and proteins like AREG, suggesting potential disruptions in signaling processes.Conclusions: BP3 exposure significantly alters the expression of toxicological targets and disrupts the PI3KAkt signaling pathway, contributing to OA pathogenesis. These findings provide insights into the molecular mechanisms of BP3-induced OA and identify potential therapeutic targets for mitigating its effects.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae199"},"PeriodicalIF":2.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoliposomal system for augmented antibacterial and antiproliferative efficacy of Melissa officinalis L. extract. 纳米脂质体系统增强梅丽莎提取物的抗菌和抗增殖作用。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-12-01 DOI: 10.1093/toxres/tfae198

Nagihan Nizam, Gokce Taner, Munevver Muge Cagal

{"title":"Nanoliposomal system for augmented antibacterial and antiproliferative efficacy of Melissa officinalis L. extract.","authors":"Nagihan Nizam, Gokce Taner, Munevver Muge Cagal","doi":"10.1093/toxres/tfae198","DOIUrl":"10.1093/toxres/tfae198","url":null,"abstract":"Objective: This study focused on the nanoliposomal encapsulation of bioactive compounds extracted from Melissa officinalis L. (ME) using ethanol as a strategy to improve the antibacterial activity, anticytotoxic, and antiproliferative properties.Methods: Nanoliposomes loaded with ME (MEL) were characterized for total phenolic content, particle size, polydispersity, and encapsulation efficiency. The minimum inhibitory concentration (MIC) values for MEL and ME were determined to evaluate antibacterial activity. To examine the toxicity profiles of ME and MEL, tests were conducted on the A549 and BEAS-2B cell lines using the MTT assay. Furthermore, an in vitro sctrach assay was conducted to evaluate the antiproliferative effects of ME and MEL on A549 cells.Results: Nanoliposomes presented entrapment efficiency higher than 80%, nanometric particle size, and narrow polydispersity. The MIC values for MEL and ME were observed as 93.75 μg/μL against E. coli. MIC values for MEL and ME were achieved as 4.68 μg/μL and 9.375 μg/mL against S. aureus, respectively. The IC50 values for ME were determined to be 1.13 mg/mL and 0.806 mg/mL, while the IC50 values for MEL were found to be 3.5 mg/mL and 0.868 mg/mL on A549 and BEAS-2B cell lines, respectively. Additionally, The MEL showed an antiproliferative effect against A549 cells at 500 μg/mL concentration.Conclusion: All experimental findings unequivocally demonstrate that the novel nanoliposomal system has effectively augmented the antibacterial activities and antiproliferative effects of ME. The initial findings indicate that nanoliposomes could effectively serve as carriers for ME in pharmaceutical applications.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae198"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of cytotoxic Signaling pathways in H1299 cells exposed to alternative Bisphenols: BPA, BPF, and BPS. 暴露于替代双酚的 H1299 细胞中细胞毒性信号通路的比较研究：BPA、BPF 和 BPS。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-12-01 DOI: 10.1093/toxres/tfae200

Ji-Young Kim, Geun-Seup Shin, Mi-Jin An, Hyun-Min Lee, Ah-Ra Jo, Yuna Park, Jinho Kim, Yujeong Hwangbo, Chul-Hong Kim, Jung-Woong Kim

{"title":"Comparative study of cytotoxic Signaling pathways in H1299 cells exposed to alternative Bisphenols: BPA, BPF, and BPS.","authors":"Ji-Young Kim, Geun-Seup Shin, Mi-Jin An, Hyun-Min Lee, Ah-Ra Jo, Yuna Park, Jinho Kim, Yujeong Hwangbo, Chul-Hong Kim, Jung-Woong Kim","doi":"10.1093/toxres/tfae200","DOIUrl":"10.1093/toxres/tfae200","url":null,"abstract":"Background: Bisphenols are prevalent in food, plastics, consumer goods, and industrial products. Bisphenol A (BPA) and its substitutes, bisphenol F (BPF) and bisphenol S (BPS), are known to act as estrogen mimics, leading to reproductive disorders, disruptions in fat metabolism, and abnormalities in brain development.Objectives: Despite numerous studies exploring the adverse effects of bisphenols both in vitro and in vivo, the molecular mechanisms by which these compounds affect lung cells remain poorly understood. This study aims to compare the effects of BPA, BPF, and BPS on the physiological behavior of human nonsmall cell lung cancer (NSCLC) cells.Materials and methods: Human non-small cell lung cancer (NSCLC) H1299 cells were treated with various concentration of BPA, BPF and BPS during different exposure time. Cellular physiology for viability and cell cycle was assessed by the staining with apoptotic cell makers such as active Caspase-3 and cyclins antibodies. Toxicological effect was quantitatively counted by using flow-cytometry analysis.Results: Our findings indicate that BPA induces apoptosis by increasing active Caspase-3 levels in H1299 cells, whereas BPF and BPS do not promote late apoptosis. Additionally, BPA was found to upregulate cyclin B1, causing cell cycle arrest at the G0/G1 phase and leading to apoptotic cell death through Caspase-3 activation. Conclusion: These results demonstrate that BPA, BPF, and BPS differentially impact cell viability, cell cycle progression, and cell death in human NSCLC cells.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae200"},"PeriodicalIF":2.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of vitamin D₃ in mitigating sodium arsenite-induced neurotoxicity in male rats. 维生素D3在减轻亚砷酸钠诱导的雄性大鼠神经毒性中的作用。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-11-27 eCollection Date: 2024-12-01 DOI: 10.1093/toxres/tfae203

Heba Mohamed Abdou, Alaa Mohamed Saad, Heba-Tallah Abd Elrahim Abd Elkader, Amina E Essawy

{"title":"Role of vitamin D3 in mitigating sodium arsenite-induced neurotoxicity in male rats.","authors":"Heba Mohamed Abdou, Alaa Mohamed Saad, Heba-Tallah Abd Elrahim Abd Elkader, Amina E Essawy","doi":"10.1093/toxres/tfae203","DOIUrl":"10.1093/toxres/tfae203","url":null,"abstract":"Arsenic is associated with various neurological disorders, notably affecting memory and cognitive functions. The current study examined the protective effects of vitamin D3 (Vit. D3) in countering oxidative stress, neuroinflammation and apoptosis induced by sodium arsenite (SA) in the cerebral cortex of rats. Male Wistar rats were subjected to a daily oral administration of sodium arsenite (NaAsO2, SA) at a dosage of 5 mg/kg, along with 500 IU/kg of Vit. D3, and a combination of both substances for four weeks. The results indicated that Vit. D3 effectively mitigated the SA-induced increase in oxidative stress markers, thiobarbituric acid reactive substances (TBARS) and nitric oxide (NO), the decrease in antioxidants (reduced glutathione; GSH, superoxide dismutase; SOD, catalase; CAT, and glutathione peroxidase; GPx), as well as the increase in pro-inflammatory markers including, tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and amyloid-beta (Aβ)1-42. Furthermore, Vit. D3 reversed the alterations in the neurochemicals acetylcholinesterase (AchE), monoamine oxidase (MAO), dopamine (DA), and acetylcholine (Ach) and ameliorated the histopathological changes in the cerebral cortex. Moreover, immunohistochemical analyses revealed that Vit. D3 reduced the SA-induced overexpression of cerebral cysteine aspartate-specific protease-3 (caspase-3) and glial fibrillary acidic protein (GFAP) in the cerebral cortex of male rats. Consequently, the co-administration of Vit. D3 can protect the cerebral cortex against SA-induced neurotoxicity, primarily through its antioxidant, anti-inflammatory, anti-apoptotic, and anti-astrogliosis effects.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 6","pages":"tfae203"},"PeriodicalIF":2.2,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142749453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential protective role of chlorogenic acid against cyclophosphamide-induced reproductive damage in male mice. 绿原酸对环磷酰胺诱导的雄性小鼠生殖损伤的潜在保护作用

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-10-28 eCollection Date: 2024-10-01 DOI: 10.1093/toxres/tfae176

Hong-Xing Zheng, You-Mei Xu, Shu-Cong Fan, Shan-Shan Qi, Fan-Fan Jia, Wei Wu, Chen Chen

{"title":"Potential protective role of chlorogenic acid against cyclophosphamide-induced reproductive damage in male mice.","authors":"Hong-Xing Zheng, You-Mei Xu, Shu-Cong Fan, Shan-Shan Qi, Fan-Fan Jia, Wei Wu, Chen Chen","doi":"10.1093/toxres/tfae176","DOIUrl":"10.1093/toxres/tfae176","url":null,"abstract":"Background: Cyclophosphamide (CP) is an anticancer drug; however, clinical utilization of CP is limited, resulting from its considerable toxicities. This research was performed to explore the protective effects of Chlorogenic acid (CGA) on reproductive damage induced by CP in mice.Methods: Blood samples were collected for analysis of hormone content subsequently; semen samples were evaluated for quality, and testis samples were used for histopathological evaluation and analysis of oxidative stress biomarkers, protein and gene expression levels of steroid regulatory factors, and steroid synthase.Results: The results noted that CGA increased serum testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) activity; increased SOD, GPx, and GSH oxidative stress levels in testis tissue; and decreased MDA content in testis tissue. Testicular cells in the CGA treatment group gradually returned to normal morphology, and CYP11A1 and CYP17A1 levels increased after CGA treatment. The mRNA levels of CYP11A1, CYP17A1, StAR, 3β-HSD, and 17β-HSD were significantly raised in the CGA dose group. In the test dose range, CGA can improve sperm quality, quantitative abnormality, and serum T synthesis disorder caused by CP. This mechanism may be correlated with the inhibition of oxidative stress and antioxidation levels.Conclusions: Therefore, CGA has a protective impact on testicular injuries arising from CP in mice.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 5","pages":"tfae176"},"PeriodicalIF":2.2,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cliff-edge of toxicological concern: highlighting the potential issues of an over-reliance on "less-than-lifetime" thresholds. 毒理学关注的悬崖边缘：强调过度依赖 "少于终身 "阈值的潜在问题。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-10-27 eCollection Date: 2024-10-01 DOI: 10.1093/toxres/tfae178

Christopher J Waine, Peter Watts, James Hopkins

{"title":"The cliff-edge of toxicological concern: highlighting the potential issues of an over-reliance on \"less-than-lifetime\" thresholds.","authors":"Christopher J Waine, Peter Watts, James Hopkins","doi":"10.1093/toxres/tfae178","DOIUrl":"https://doi.org/10.1093/toxres/tfae178","url":null,"abstract":"The Threshold of Toxicological Concern (TTC) is a very well-established concept in applied toxicology, and has become a key tool for the pragmatic human health risk assessment of data-poor chemicals. Within the pharmaceutical sector, regulatory guidance on genotoxins defaults to a TTC of 1.5 μg/day equating to a maximum lifetime cancer risk of 1 in 100,000. Higher doses for drug products where exposures are intermittent or otherwise \"less-than-lifetime\" (LTL) are also considered tolerable. This also allows substance-specific lifetime Acceptable Intakes (AIs) for known genotoxic carcinogens to be scaled up for shorter durations. The default TTCs for assessing LTL exposures build in conservatism such that there is deviation from strict linearity. However, close to the boundaries between LTL categories there can be such a difference in the default tolerable intakes that a health risk assessment can yield conflicting results. We have presented a theoretical case study based on our recent work that illustrates this apparent \"cliff-edge.\" The total acceptable cumulative dose over a 56-day treatment is - in absolute terms - one third of that allowed over 28 days, despite the maximum cancer risk of the longer exposure being an order of magnitude higher. Our analysis suggests the need for careful consideration of what might represent tolerable exposures in the region of the category limits, rather than simply adopting the hardline default. Where a potential patient exposure is found to be above a default value, there is real value in refining the cancer risk estimates using the Lifetime Cumulative Dose approach.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 5","pages":"tfae178"},"PeriodicalIF":2.2,"publicationDate":"2024-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Immunotoxicity biomarkers, essential elements and vitamin D levels on the severity levels of COVID-19 disease in Turkey. 免疫毒性生物标志物、必需元素和维生素 D 水平对土耳其 COVID-19 疾病严重程度的影响。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-10-20 eCollection Date: 2024-10-01 DOI: 10.1093/toxres/tfae177

Jülide Secerlı, Serdar Çetinkaya, İlknur Sıla Leblebici, Latif Alperen Özdemir, Çiğdem Yücel, Eda Karaismailoğlu, Umut Kara, Aydan Özcan, Nesrin Öcal, Yakup Arslan, Serkan Şenkal, Onur Erdem, Merve Güdül Bacanlı

{"title":"Effects of Immunotoxicity biomarkers, essential elements and vitamin D levels on the severity levels of COVID-19 disease in Turkey.","authors":"Jülide Secerlı, Serdar Çetinkaya, İlknur Sıla Leblebici, Latif Alperen Özdemir, Çiğdem Yücel, Eda Karaismailoğlu, Umut Kara, Aydan Özcan, Nesrin Öcal, Yakup Arslan, Serkan Şenkal, Onur Erdem, Merve Güdül Bacanlı","doi":"10.1093/toxres/tfae177","DOIUrl":"https://doi.org/10.1093/toxres/tfae177","url":null,"abstract":"Many mechanisms are thought to play a role in the pathogenesis of the COVID-19 pandemic, which started in 2019 and affected the whole world. It has been claimed that a deficiency in the immune system can significantly affect the severity of COVID-19 disease. It is important that the levels of essential elements and vitamin D are at certain levels for the healthy functioning of the immune system. Therefore, in this study, it was aimed to evaluate immunotoxicity biomarkers (tumor necrosis factor-alpha (TNF-α), interleukin (IL)-10, interferon (IFN)-γ, monocyte chemotactic protein-1 (MCP-1)), vitamin D, and essential element levels in COVID-19 patients in Turkey. According to the results of the study, it was found that the magnesium (Mg), zinc (Zn), and selenium (Se) levels decreased as the severity of the disease worsened, while the iron (Fe), and copper (Cu) levels were similar to the mild group and the control group, and the levels decreased as the disease worsened. It has also been found that vitamin D levels decrease as the severity of the disease worsens. Compared to the control group, TNF-α, MCP-1, and IFN-γ levels were found to decrease as the severity of the disease worsened. Also, it was observed that there was a significant relationship between essential metal levels and disease progression in most of the patient groups.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 5","pages":"tfae177"},"PeriodicalIF":2.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11491277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of bio-inorganic metal nanoparticles by low-cost lychee extract for wastewater remediation: a mini-review. 利用低成本荔枝提取物制造生物无机金属纳米颗粒用于废水修复：微型综述。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-10-19 eCollection Date: 2024-10-01 DOI: 10.1093/toxres/tfae170

Khalida Naseem, Sana Asghar, Kiky Corneliasari Sembiring, Mohammad Ehtisham Khan, Asima Hameed, Shazma Massey, Warda Hassan, Aneela Anwar, Haneef Khan, Faluk Shair

{"title":"Fabrication of bio-inorganic metal nanoparticles by low-cost lychee extract for wastewater remediation: a mini-review.","authors":"Khalida Naseem, Sana Asghar, Kiky Corneliasari Sembiring, Mohammad Ehtisham Khan, Asima Hameed, Shazma Massey, Warda Hassan, Aneela Anwar, Haneef Khan, Faluk Shair","doi":"10.1093/toxres/tfae170","DOIUrl":"10.1093/toxres/tfae170","url":null,"abstract":"Introduction: This review article gives an overview of the biogenic synthesis of metal nanoparticles (mNPs) while using Litchi chinensis extract as a reducing and stabilizing agent. The subtropical fruit tree i.e lychee contains phytochemicals such as flavonoids, terpenoids, and polyphenolic compounds which act as reducing agents and convert the metal ions into metal atoms that coagulate to form mNPs.Methodology: Different methodologies adopted for the synthesis of lychee extract and its use in the fabrication of mNPs under different reaction conditions such as solvent, extract amount, temperature, and pH of the medium have also been discussed critically in detail.Techniques: Different techniques such as FTIR, UV-visible, XRD, SEM, EDX, and TEM adopted for the analysis of biogenic synthesis of mNPs have also been discussed in detail. Applications of mNPs: Applications of these prepared mNPs in various fields due to their antimicrobial, antiinflammatory, anticancer, and catalytic activities have also been described in detail.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 5","pages":"tfae170"},"PeriodicalIF":2.2,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0