Toxicology Research最新文献_第10页

Rutin mitigates acetic acid-induced ulcerative colitis: novel coloprotective mechanism. 芦丁缓解醋酸诱发的溃疡性结肠炎：新型结肠保护机制

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-07-25 eCollection Date: 2024-08-01 DOI: 10.1093/toxres/tfae108

Iman O Sherif, Nora H Al-Shaalan, Walaa F Awadin

{"title":"Rutin mitigates acetic acid-induced ulcerative colitis: novel coloprotective mechanism.","authors":"Iman O Sherif, Nora H Al-Shaalan, Walaa F Awadin","doi":"10.1093/toxres/tfae108","DOIUrl":"10.1093/toxres/tfae108","url":null,"abstract":"Background: Ulcerative colitis, an inflammatory bowel disease, is characterized by a status of oxidative stress and inflammation. Rutin is a natural flavonoid with many pharmacological activities and its role in acetic acid-induced ulcerative colitis through the high mobility group B1 (HMGB1)/ toll-like receptor-4 (TLR4)/ myeloid differentiation primary response protein 88 (MYD88)/ nuclear factor-kB (NF-kB) signaling pathway needs to be explored.Methods: Four experimental groups were divided into control group, rutin group: treated with 100 mg/kg/day rutin orally for 10 days, acetic acid (AA) group: given intracolonic instillation of AA to induce ulcerative colitis, and acetic acid with rutin treatment (AA/Rutin) group.Results: Acetic acid caused a marked increase in the colon weight/length ratio and induced colonic histopathological changes, leading to a marked rise in the colonic histopathological scores. Acetic acid exhibited a significant rise in LDH and CRP serum levels as well as TOS colonic levels, accompanied by a marked decline in TAS colonic contents compared to the control group. Moreover, AA-induced activation of the HMGB1/TLR4/MYD88/NF-kB signaling pathway. Rutin demonstrated a significant decrease in the colon weight/length ratio, ameliorated the colonic histopathological changes induced by AA, and exhibited a marked decline in the colonic histopathological scores. Rutin showed a significant decrease in serum LDH, and CRP levels as well as colonic TOS contents when compared with the AA group. Rutin suppressed the colonic activation of the HMGB1/TLR4/MYD88/NF-kB signaling pathway.Conclusion: Rutin could be a promising coloprotective agent against AA-induced ulcerative colitis by targeting the HMGB1/TLR4/MYD88/NF-kB signaling pathway.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 4","pages":"tfae108"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141905101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential Association of Bisphenol A exposure and type 1 diabetes mellitus among Dakahlia Governorate's children sample, Egypt. 埃及达卡利亚省儿童样本中双酚 A 暴露与 1 型糖尿病的潜在关联。

IF 2.2 4区医学

Toxicology Research Pub Date : 2024-06-20 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae093

Basma Ahmed Ali El-Degwi, Mahmoud El-Sayed Awad, Wafaa Laimon, Samar A Askar, Doaa Abdel Wahab El-Morsi, Dalia Alsaied Moustafa Ahmed

{"title":"The potential Association of Bisphenol A exposure and type 1 diabetes mellitus among Dakahlia Governorate's children sample, Egypt.","authors":"Basma Ahmed Ali El-Degwi, Mahmoud El-Sayed Awad, Wafaa Laimon, Samar A Askar, Doaa Abdel Wahab El-Morsi, Dalia Alsaied Moustafa Ahmed","doi":"10.1093/toxres/tfae093","DOIUrl":"10.1093/toxres/tfae093","url":null,"abstract":"Background: Bisphenol A (BPA) is an endocrine disrupter affecting glucose homeostasis.Objectives: This study aimed to investigate BPA's relationship with Type 1 Diabetes Mellitus (T1DM) in Dakahlia Governorate's children, in Egypt.Subjects materials and methods: The study had two parts: clinical and experimental. Clinical Study was conducted on 200 children, equally divided into control and T1DM groups. They underwent: demographic data, height, weight, body mass index, glycosylated HbA1C, random blood glucose, and urinary BPA measurements. Experimental Study was conducted on 60 adult albino rats. Rats were randomly divided into three equal groups: control group: received 0.5 mL of pure olive oil, group 1: received 20 mg/kg/day BPA, and group 2: received 100 mg/kg/day BPA orally for 6 weeks. Fasting and two hours postprandial glucose levels were measured at the beginning and end of the study. Histopathological examination and imaging study of the pancreas were done.Results: In clinical study: HbA1C and random blood glucose levels in diabetic children showed a significant increase compared to control. Children in control group showed controlled HbA1C, while the T1DM group showed 86% with poor diabetic control. There was a significant increase in BPA level in the T1DM group compared to the control. Rats that received BPA showed a marked increase in fasting and two hours postprandial glucose levels, histopathological changes in the pancreas with more changes determined in the high dose group, and a significant decrease in the islets of Langerhans diameters with group 2 more affected.Conclusion: So, BPA exposure could be considered a risk factor for T1DM in children.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae093"},"PeriodicalIF":2.2,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11188686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To explore the protective effect of gastrodin on PC12 cells against oxidative stress induced by lead acetate based on network pharmacology. 以网络药理学为基础，探索天麻素对 PC12 细胞的保护作用，使其免受醋酸铅诱导的氧化应激的影响。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-15 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae085

Si-Wen Pan, Yu Zou, Tian-Jiao Xu, Chun-Hui Ma, Xiao-Ming Li, Chun-Lei Yu

{"title":"To explore the protective effect of gastrodin on PC12 cells against oxidative stress induced by lead acetate based on network pharmacology.","authors":"Si-Wen Pan, Yu Zou, Tian-Jiao Xu, Chun-Hui Ma, Xiao-Ming Li, Chun-Lei Yu","doi":"10.1093/toxres/tfae085","DOIUrl":"10.1093/toxres/tfae085","url":null,"abstract":"Objective: Screening and predicting potential targets for gastrodin antioxidant stress based on network pharmacology methods, and exploring the effect of gastrodin on lead acetate induced oxidative stress in PC12 cells through cell experiments.Methods: Through the Pharmaper database Predict the target of action of gastrodin. Through OMIM and GeneCards to collect oxidative stress targets from database, and intersect with drug targets to obtain drug disease intersection targets; Construct a PPI network diagram using the STRING database. Perform GO enrichment analysis and KEGG pathway enrichment analysis on intersection targets through the DAVID platform. Lead acetate (PbAc) exposure was used to establish a lead poisoning cell model, and intracellular ROS levels, ALB, AKT1, and Caspase-3 levels were measured.Results: A total of 288 targets of gastrodin action, 638 targets related to oxidative stress, and 62 drug disease intersection targets were obtained, among which core targets such as ALB, AKT1, CASP3 may be closely related to oxidative stress. KEGG pathway analysis showed that gastrodin antioxidant stress mainly involved in lipid, cancer pathway and other signaling pathways. The results of the cell experiment showed that 50 μM is the optimal effective concentration for PbAc induced ROS production in PC12 cells. Gastrodin significantly increased the ROS content of PC12 cells treated with PbAc, Upregulation of ALB expression and downregulation of AKT1 and CASP3 expression.Conclusions: Gastrodin may alleviate PbAc-induced ROS in PC12 cells, indicating potential protective effects against oxidative stress. Further studies are needed to confirm these findings and explore the underlying mechanisms.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae085"},"PeriodicalIF":2.1,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11179722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The possible therapeutic role of intravenous lipid emulsion in acute aluminium phosphide poisoning: a randomized controlled clinical trial. 静脉注射脂质乳剂对急性磷化铝中毒的可能治疗作用：随机对照临床试验。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-13 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae090

Hafsa Salah Gheat, Manar M Fayed, Fatma M Elgazzar, Eman I Draz, Rabab S El-Kelany

{"title":"The possible therapeutic role of intravenous lipid emulsion in acute aluminium phosphide poisoning: a randomized controlled clinical trial.","authors":"Hafsa Salah Gheat, Manar M Fayed, Fatma M Elgazzar, Eman I Draz, Rabab S El-Kelany","doi":"10.1093/toxres/tfae090","DOIUrl":"10.1093/toxres/tfae090","url":null,"abstract":"Introduction: Aluminum phosphide (ALP) is a highly toxic rodenticide and the mortality rates caused by it have been demonstrated up to 70-100% in various studies. Unfortunately, there is no specific antidote to manage its toxic effects. This study aimed to assess the biochemical and clinical efficacy and safety of intravenous lipid emulsion as an adjuvant therapy in acute aluminum phosphide poisoning.Patients and methods: Sixty-four cases with acute ALP poisoning were stratified according to severity by the Poison Severity Score into severe and moderate groups (32 patients each). Patients were then randomly allocated into either receiving intravenous lipid emulsion in addition to the conventional treatment or receiving the conventional treatment only by using block randomization.Results: Treatment by ILE resulted in a significant improvement in the survival time, the mean arterial blood pressure, arterial blood gases, and a significant reduction in serum lactate levels. The need for intubation and mechanical ventilation was insignificantly lower in the intervention groups compared to control groups. However, the reduction in mortality rate in the patients of intervention groups compared with control groups was found to be non-significant. Intravenous lipid emulsion use in acute ALP poisoning significantly prolonged the survival time, improved the metabolic acidosis, decreased the serum lactate levels and increased the mean arterial blood pressure and hospital stay in the intervention groups. And insignificantly decreased the mortality rate, need of intubation and mechanical ventilation, and the total dose of vasopressors.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae090"},"PeriodicalIF":2.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11170490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Pb, Cu and Zn on development and Wnt/β-catenin signaling pathway genes expression of Ctenopharyngodon idella. 铅、铜和锌对鳕鱼发育和 Wnt/β-catenin 信号通路基因表达的影响

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-13 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae092

A M Tlenshieva, T M Shalakhmetova, M Witeska

{"title":"Effect of Pb, Cu and Zn on development and Wnt/β-catenin signaling pathway genes expression of Ctenopharyngodon idella.","authors":"A M Tlenshieva, T M Shalakhmetova, M Witeska","doi":"10.1093/toxres/tfae092","DOIUrl":"10.1093/toxres/tfae092","url":null,"abstract":"Pollution of the aquatic environment with heavy metals is a serious environmental problem, since they accumulate in aquatic organisms and can affect their development and worsen their condition. According to the scheme of Fig. 1 zinc (Zn), copper (Cu) or lead (Pb) were studied when exposed to concentrations of: Zn (0.01; 0.1; 1 mg/L), Cu (0.001; 0.01; 0.1 mg/L), Pb (0.006; 0.06; 0.6 mg/L) for 144 h after fertilization (hpf) on the grass carp (Ctenopharyngodon idella), one of the important commercial fish species of Kazakhstan, the activity of superoxide dismutase (SOD) and the expression of genes of the Wnt/β-catenin signaling pathway involved in development. All metals significantly reduced survival, hatching rate, and changed biometric parameters and heart rate of cupid larvae. In addition, these metals (mainly Pb and Cu) inhibited superoxide dismutase (SOD) activity and mRNA transcription of genes encoding genes of the Wnt/β-catenin signaling pathway. These results showed that Pb, Cu and Zn not only affect the survival and development of fish at an early stage of life, but also cause oxidative stress and prevent fish detoxification.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae092"},"PeriodicalIF":2.1,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11170660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity. 关于芦根种子（Withania somnifera）对阿莫西林毒性的改善作用的各种研究。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-12 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae091

Mohamed M M Elnasharty, Azhar M Elwan, Mohamed E Elhadidy, Mona A Mohamed, Abeer H Abd El-Rahim, Naglaa A Hafiz, Omaima M Abd-El-Moneim, Kamilia B Abd El-Aziz, Aboelfetoh M Abdalla, Ibrahim M Farag

{"title":"Various investigations of ameliorative role of Ashwagandha seeds (Withania somnifera) against amoxicillin toxicity.","authors":"Mohamed M M Elnasharty, Azhar M Elwan, Mohamed E Elhadidy, Mona A Mohamed, Abeer H Abd El-Rahim, Naglaa A Hafiz, Omaima M Abd-El-Moneim, Kamilia B Abd El-Aziz, Aboelfetoh M Abdalla, Ibrahim M Farag","doi":"10.1093/toxres/tfae091","DOIUrl":"10.1093/toxres/tfae091","url":null,"abstract":"Several studies showed the adverse effects of amoxicillin on various body organs. So, this research has been designed to evaluate the modulatory role of Ashwagandha seed extract (ASE) against amoxicillin (AM) toxicity. Rats treated with AM (90 mg/kg), protected by ASE doses (100, 200 and 300 mg/kg), and treated by ASE at the same three doses. At the end of the experimental period, DNA comet assay, cytogenetic examinations, sperm-shape analysis, evaluation of the malondialdehyde (MDA) percentages, histopathological examinations, and biophysical tests (modulus, relaxation time, permittivity, entropy, and internal energy change of brain) were documented. The results confirmed that AM treatment induced significant elevation of DNA damage, cytogenetic aberrations, and MDA content in brain, liver, and testis tissues and sperm-shape anomalies. ASE treatment significantly minimized the genetic changes, sperm-shape anomalies, and MDA generation. These enhancements were more pronounced by protective ASE and increased by increasing the dose level. In histopathological examinations, AM treatment caused neurotoxicity in brain tissue. ASE treatment, partially, minimized these damages and the positive effects of therapeutic ASE were more noticeable. Biophysical parameters showed that therapeutic ASE was better for relaxation time, permittivity, and free energy change. Protective and therapeutic ASE were able to recover entropy and internal energy changes in variant degrees.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae091"},"PeriodicalIF":2.1,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in bioscavenger mediated detoxification of organophosphorus poisoning. 生物清道夫介导的有机磷中毒解毒技术的进展。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-10 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae089

Hexi Li, Cong Lu, Zhenmin Liu, Fengshun Xiang, Bo Liu, Hongjuan Wang, Jie Chang, Li Pan, Youwei Chen, Jingfei Chen

{"title":"Advancements in bioscavenger mediated detoxification of organophosphorus poisoning.","authors":"Hexi Li, Cong Lu, Zhenmin Liu, Fengshun Xiang, Bo Liu, Hongjuan Wang, Jie Chang, Li Pan, Youwei Chen, Jingfei Chen","doi":"10.1093/toxres/tfae089","DOIUrl":"10.1093/toxres/tfae089","url":null,"abstract":"Background: Organophosphorus compounds, widely used in agriculture and industry, pose a serious threat to human health due to their acute neurotoxicity. Although traditional interventions for organophosphate poisoning are effective, they often come with significant side effects.Objective: This paper aims to evaluate the potential of enzymes within biological organisms as organophosphorus bioclearing agents. It analyses the technical challenges in current enzyme research, such as substrate specificity, stereoselectivity, and immunogenicity, while exploring recent advancements in the field.Methods: A comprehensive review of literature related to detoxifying enzymes or proteins was conducted. Existing studies on organophosphorus bioclearing agents were summarised, elucidating the biological detoxification mechanisms, with a particular focus on advancements in protein engineering and novel delivery methods.Results: Current bioclearing agents can be categorised into stoichiometric and catalytic bioclearing agents, both of which have shown some success in preventing organophosphate poisoning. Technological advancements have significantly improved various properties of bioclearing agents, yet challenges remain, particularly in substrate specificity, stereoselectivity, and immunogenicity. Future research will focus on expanding the substrate spectrum, enhancing catalytic efficiency, prolonging in vivo half-life, and developing convenient administration methods.Conclusion: With the progression of clinical trials, bioclearing agents are expected to become widely used as a new generation of therapeutic organophosphate detoxifiers.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae089"},"PeriodicalIF":2.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141304921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurotoxic snakebite envenomation treated with Philippine cobra antivenom in the eastern Visayas: a descriptive study between 2016 and 2020. 米沙鄢群岛东部使用菲律宾眼镜蛇抗蛇毒血清治疗的神经毒性蛇咬伤：2016 年至 2020 年期间的描述性研究。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-10 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae088

Jonathan Paghubasan, Patrick Joseph Tiglao, Yoshihiro Aoki, Mariedel A Tan, Mardie S Sarsalijo, Grace Joy B Aquino, Mercy Grace Beronilla-Uraga, Lourdes C Agosto

{"title":"Neurotoxic snakebite envenomation treated with Philippine cobra antivenom in the eastern Visayas: a descriptive study between 2016 and 2020.","authors":"Jonathan Paghubasan, Patrick Joseph Tiglao, Yoshihiro Aoki, Mariedel A Tan, Mardie S Sarsalijo, Grace Joy B Aquino, Mercy Grace Beronilla-Uraga, Lourdes C Agosto","doi":"10.1093/toxres/tfae088","DOIUrl":"10.1093/toxres/tfae088","url":null,"abstract":"Introduction: There is a significant shortage of observational studies on neurotoxic snakebite envenomation in the Philippines. This lack of data, especially concerning treatment using Purified Cobra Antivenom (PCAV), has prompted the initiation of this foundational study.Methods: The target population included snakebite patients admitted to the Eastern Visayas Medical Center and treated with PCAV between 2016 and 2020. A retrospective chart review was conducted for data collection. The investigation analyzed the hospital stay and patient features of individuals who were administered either lower or higher doses of PCAV.Results: Eighty-two patients were identified during the study. Of these, 27 (33%) were under 20 years of age and 50 (61%) were male. Most patients, totalling 75 (92%) were hailed from rural areas. Of the 82 patients, 59 (72%) received one or two ampoules of PCAV during the course. However, patients who received more than two ampoules had a longer median hospital stay than those who received less than three ampoules [96 h (interquartile range, IQR 66-122) vs. 125 h (IQR 96-218), P = 0.038]. The study reported five in-hospital mortalities (6.1%).Conclusions: The individuals who needed a high dosage of PCAV tended to have more extended hospital stays, yet over 70% of the patient population required a lower dosage. To gain a clearer understanding of the burden of neurotoxic snakebites and determine the optimal PCAV dosage based on disease severity in the area, a more comprehensive, prospective study is recommended.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae088"},"PeriodicalIF":2.1,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11163182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141304922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corylin alleviated sepsis-associated cardiac dysfunction via attenuating inflammation through downregulation of microRNA-214-5p. 苍术素通过下调 microRNA-214-5p 减轻炎症，从而缓解脓毒症相关的心功能不全。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-07 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae081

Chunyan Li, Daorong Hou, Yanhong Huang, Yifan Liu, Yong Li, Cheng Wang

{"title":"Corylin alleviated sepsis-associated cardiac dysfunction via attenuating inflammation through downregulation of microRNA-214-5p.","authors":"Chunyan Li, Daorong Hou, Yanhong Huang, Yifan Liu, Yong Li, Cheng Wang","doi":"10.1093/toxres/tfae081","DOIUrl":"10.1093/toxres/tfae081","url":null,"abstract":"Background: Corylin, a natural flavonoid, is isolated from the fruit of Psoralea corylifolia L. Nevertheless, the effect of corylin on sepsis-associated cardiac dysfunction is still unclear. The purpose of this study is to determine the role and mechanism of corylin in sepsis related cardiac dysfunction.Methods: Experiments were carried out on mice with lipopolysaccharide (LPS) or sepsis induced by cecal ligation and puncture (CLP) or myocardial cell sepsis induced by LPS.Results: Administration of corylin improved cardiac dysfunction induced by LPS or CLP in mice. Corylin inhibited the increases of interleukin-1 (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α in the heart of mice with LPS or CLP. LPS elevated the levels of IL-1β, IL-6 and TNF-α in cardiomyocytes, which were inhibited by corylin treatment. Corylin attenuated the increases of microRNA (miRNA)-214-5p in the heart of mice with LPS, CLP, LPS-treated NRCMs, H9c2 and AC16 cells. Administration of miRNA-214-5p agomiR reversed the improving effects of corylin on the damaged cardiac function and the increases of IL-1β, IL-6 and TNF-α in mice treated with LPS.Conclusion: These outcomes indicated that corylin improved sepsis-associated cardiac dysfunction by inhibiting inflammation. And corylin inhibited inflammation of sepsis by decreasing miRNA-214-5p. Downregulation of miRNA-214-5p improved sepsis-associated cardiac dysfunction and inhibited inflammatory factors.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae081"},"PeriodicalIF":2.1,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11161260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network analysis of toxic endpoints of fungicides in zebrafish. 斑马鱼中杀菌剂毒性终点的网络分析。

IF 2.1 4区医学

Toxicology Research Pub Date : 2024-06-05 eCollection Date: 2024-06-01 DOI: 10.1093/toxres/tfae087

Rajesh Pamanji, Prathiviraj Ragothaman, Srikanth Koigoora, Gisha Sivan, Joseph Selvin

{"title":"Network analysis of toxic endpoints of fungicides in zebrafish.","authors":"Rajesh Pamanji, Prathiviraj Ragothaman, Srikanth Koigoora, Gisha Sivan, Joseph Selvin","doi":"10.1093/toxres/tfae087","DOIUrl":"10.1093/toxres/tfae087","url":null,"abstract":"Zebrafish being the best animal model to study, every attempt has been made to decipher the toxic mechanism of every fungicide of usage and interest. It is important to understand the multiple targets of a toxicant to estimate the toxic potential in its totality. A total of 22 fungicides of different classes like amisulbrom, azoxystrobin, carbendazim, carboxin, chlorothalonil, difenoconazole, etridiazole, flusilazole, fluxapyroxad, hexaconazole, kresoxim methyl, mancozeb, myclobutanil, prochloraz, propiconazole, propineb, pyraclostrobin, tebuconazole, thiophanate-methyl, thiram, trifloxystrobin and ziram were reviewed and analyzed for their multiple explored targets in zebrafish. Toxic end points in zebrafish are highly informative when it comes to network analysis. They provide a window into the molecular and cellular pathways that are affected by a certain toxin. This can then be used to gain insights into the underlying mechanisms of toxicity and to draw conclusions on the potential of a particular compound to induce toxicity. This knowledge can then be used to inform decisions about drug development, environmental regulation, and other areas of research. In addition, the use of zebrafish toxic end points can also be used to better understand the effects of environmental pollutants on ecosystems. By understanding the pathways affected by a given toxin, researchers can determine how pollutants may interact with the environment and how this could lead to health or environmental impacts.","PeriodicalId":105,"journal":{"name":"Toxicology Research","volume":"13 3","pages":"tfae087"},"PeriodicalIF":2.1,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0