Comprehensive Physiology最新文献_第8页

Actions of Dendritic Cells in the Kidney during Hypertension. 树突状细胞在高血压患者肾脏中的作用。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c210050

Xiaohan Lu, Steven D Crowley

{"title":"Actions of Dendritic Cells in the Kidney during Hypertension.","authors":"Xiaohan Lu, Steven D Crowley","doi":"10.1002/cphy.c210050","DOIUrl":"https://doi.org/10.1002/cphy.c210050","url":null,"abstract":"The immune response plays a critical role in the pathogenesis of hypertension, and immune cell populations can promote blood pressure elevation via actions in the kidney. Among these cell lineages, dendritic cells (DCs), the most potent antigen-presenting cells, play a central role in regulating immune response during hypertension and kidney disease. DCs have different subtypes, and renal DCs are comprised of the CD103+ CD11b- and CD103- CD11b+ subsets. DCs become mature and express costimulatory molecules on their surface once they encounter antigen. Isolevuglandin-modified proteins function as antigens to activate DCs and trigger them to stimulate T cells. Activated T cells accumulate in the hypertensive kidney, release effector cytokines, promote renal oxidative stress, and promote renal salt and water retention. Individual subsets of activated T cells can secrete tumor necrosis factor-alpha, interleukin-17A, and interferon-gamma, each of which has augmented the elevation of blood pressure in hypertensive models by enhancing renal sodium transport. Fms-like tyrosine kinase 3 ligand-dependent classical DCs are required to sustain the full hypertensive response, but C-X3 -C chemokine receptor 1 positive DCs do not regulate blood pressure. Excess sodium enters the DC through transporters to activate DCs, whereas the ubiquitin editor A20 in dendritic cells constrains blood pressure elevation by limiting T cell activation. By contrast, activation of the salt sensing kinase, serum/glucocorticoid kinase 1 in DCs exacerbates salt-sensitive hypertension. This article discusses recent studies illustrating mechanisms through which DC-T cell interactions modulate levels of pro-hypertensive mediators to regulate blood pressure via actions in the kidney. © 2022 American Physiological Society. Compr Physiol 12:1-15, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 3","pages":"4087-4101"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10197906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure and Function of the Mammalian Neuromuscular Junction. 哺乳动物神经肌肉连接的结构和功能。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c210022

Leah A Davis, Matthew J Fogarty, Alyssa Brown, Gary C Sieck

{"title":"Structure and Function of the Mammalian Neuromuscular Junction.","authors":"Leah A Davis, Matthew J Fogarty, Alyssa Brown, Gary C Sieck","doi":"10.1002/cphy.c210022","DOIUrl":"https://doi.org/10.1002/cphy.c210022","url":null,"abstract":"The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) Schwann cell. As with any synapse, the purpose of the NMJ is to transmit signals from the nervous system to muscle fibers. This neural control of muscle fibers is organized as motor units, which display distinct structural and functional phenotypes including differences in pre- and postsynaptic elements of NMJs. Motor units vary considerably in the frequency of their activation (both motor neuron discharge rate and duration/duty cycle), force generation, and susceptibility to fatigue. For earlier and more frequently recruited motor units, the structure and function of the activated NMJs must have high fidelity to ensure consistent activation and continued contractile response to sustain vital motor behaviors (e.g., breathing and postural balance). Similarly, for higher force less frequent behaviors (e.g., coughing and jumping), the structure and function of recruited NMJs must ensure short-term reliable activation but not activation sustained for a prolonged period in which fatigue may occur. The NMJ is highly plastic, changing structurally and functionally throughout the life span from embryonic development to old age. The NMJ also changes under pathological conditions including acute and chronic disease. Such neuroplasticity often varies across motor unit types. © 2022 American Physiological Society. Compr Physiol 12:1-36, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"3731-3766"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461538/pdf/nihms-1921908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10097811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Structure and Functions of the Vagus Nerve in Mammals. 哺乳动物迷走神经的结构和功能。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c210042

Matteo M Ottaviani, Vaughan G Macefield

{"title":"Structure and Functions of the Vagus Nerve in Mammals.","authors":"Matteo M Ottaviani, Vaughan G Macefield","doi":"10.1002/cphy.c210042","DOIUrl":"https://doi.org/10.1002/cphy.c210042","url":null,"abstract":"We review the structure and function of the vagus nerve, drawing on information obtained in humans and experimental animals. The vagus nerve is the largest and longest cranial nerve, supplying structures in the neck, thorax, and abdomen. It is also the only cranial nerve in which the vast majority of its innervation territory resides outside the head. While belonging to the parasympathetic division of the autonomic nervous system, the nerve is primarily sensory-it is dominated by sensory axons. We discuss the macroscopic and microscopic features of the nerve, including a detailed description of its extensive territory. Histochemical and genetic profiles of afferent and efferent axons are also detailed, as are the central nuclei involved in the processing of sensory information conveyed by the vagus nerve and the generation of motor (including parasympathetic) outflow via the vagus nerve. We provide a comprehensive review of the physiological roles of vagal sensory and motor neurons in control of the cardiovascular, respiratory, and gastrointestinal systems, and finish with a discussion on the interactions between the vagus nerve and the immune system. © 2022 American Physiological Society. Compr Physiol 12: 1-49, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"3989-4037"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10216414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Does Patient-Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives. 患者应用睾酮替代疗法会导致血压升高吗?昼夜医学展望。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c220014

Michael H Smolensky, Ramon C Hermida, Linda Sackett-Lundeen, Ramon G Hermida-Ayala, Yong-Jian Geng

{"title":"Does Patient-Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives.","authors":"Michael H Smolensky, Ramon C Hermida, Linda Sackett-Lundeen, Ramon G Hermida-Ayala, Yong-Jian Geng","doi":"10.1002/cphy.c220014","DOIUrl":"https://doi.org/10.1002/cphy.c220014","url":null,"abstract":"We reviewed medication package inserts, US Food and Drug Administration (FDA) reports, and journal publications concerning the 10 nonbiosimilar patient-applied (PA) testosterone (T) replacement therapies (TRTs) for intraday serum T patterning and blood pressure (BP) effects. Blood T concentration is circadian rhythmic in young adult eugonadal males, being highest around awakening and lowest before bedtime. T level and 24 h variation are blunted in primary and secondary hypogonadism. Utilized as recommended, most PA-TRTs achieve nonphysiologic T 24 h patterning. Only Androderm® , an evening PA transdermal patch, closely replicates the normal T circadian rhythmicity. Accurate determination of risk for BP elevation and hypertension (HTN) by PA-TRTs is difficult due to limitations of office BP measurements (OBPM) and suboptimal methods and endpoints of ambulatory BP monitoring (ABPM). OBPM is subject to \"White Coat\" pressor effect resulting in unrepresentative BP values plus masked normotension and masked HTN, causing misclassification of approximately 45% of trial participants, both before and during treatment. Change in guideline-recommended diagnostic thresholds over time causes misclassification of an additional approximately 15% of participants. ABPM is improperly incorporated into TRT safety trials. It is done for 24 h rather than preferred 48 h; BP is oversampled during wakefulness, biasing derived 24 h mean values; 24 h mean systolic and diastolic BP (SBP, DBP) are inappropriate primary outcomes, because of not being best predictors of risk for major acute cardiovascular events (MACE); \"daytime\" and \"nighttime\" BP means referenced to clock time are reported rather than biologically relevant wake-time and sleep-time BP means; most importantly, asleep SBP mean and dipping, strongest predictors of MACE, are disregarded. © 2022 American Physiological Society. Compr Physiol 12: 1-20, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"4165-4184"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10197911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging in Pulmonary Vascular Disease-Understanding Right Ventricle-Pulmonary Artery Coupling. 肺血管疾病的影像学——了解右心室-肺动脉耦合。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c210017

Katsiaryna Tsarova, Ashley E Morgan, Lana Melendres-Groves, Majd M Ibrahim, Christy L Ma, Irene Z Pan, Nathan D Hatton, Emily M Beck, Meganne N Ferrel, Craig H Selzman, Dominique Ingram, Ayedh K Alamri, Mark B Ratcliffe, Brent D Wilson, John J Ryan

{"title":"Imaging in Pulmonary Vascular Disease-Understanding Right Ventricle-Pulmonary Artery Coupling.","authors":"Katsiaryna Tsarova, Ashley E Morgan, Lana Melendres-Groves, Majd M Ibrahim, Christy L Ma, Irene Z Pan, Nathan D Hatton, Emily M Beck, Meganne N Ferrel, Craig H Selzman, Dominique Ingram, Ayedh K Alamri, Mark B Ratcliffe, Brent D Wilson, John J Ryan","doi":"10.1002/cphy.c210017","DOIUrl":"https://doi.org/10.1002/cphy.c210017","url":null,"abstract":"The right ventricle (RV) and pulmonary arterial (PA) tree are inextricably linked, continually transferring energy back and forth in a process known as RV-PA coupling. Healthy organisms maintain this relationship in optimal balance by modulating RV contractility, pulmonary vascular resistance, and compliance to sustain RV-PA coupling through life's many physiologic challenges. Early in states of adaptation to cardiovascular disease-for example, in diastolic heart failure-RV-PA coupling is maintained via a multitude of cellular and mechanical transformations. However, with disease progression, these compensatory mechanisms fail and become maladaptive, leading to the often-fatal state of \"uncoupling.\" Noninvasive imaging modalities, including echocardiography, magnetic resonance imaging, and computed tomography, allow us deeper insight into the state of coupling for an individual patient, providing for prognostication and potential intervention before uncoupling occurs. In this review, we discuss the physiologic foundations of RV-PA coupling, elaborate on the imaging techniques to qualify and quantify it, and correlate these fundamental principles with clinical scenarios in health and disease. © 2022 American Physiological Society. Compr Physiol 12: 1-26, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"3705-3730"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10216412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Aging and Heart Failure with Preserved Ejection Fraction. 老化和心力衰竭与保留射血分数。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-08-11 DOI: 10.1002/cphy.c210035

Kathryn F Larson, Awais Malik, Frank V Brozovich

{"title":"Aging and Heart Failure with Preserved Ejection Fraction.","authors":"Kathryn F Larson, Awais Malik, Frank V Brozovich","doi":"10.1002/cphy.c210035","DOIUrl":"https://doi.org/10.1002/cphy.c210035","url":null,"abstract":"Heart failure is a clinical syndrome characterized by the inability of the cardiovascular system to provide adequate cardiac output at normal filling pressures. This results in a clinical syndrome characterized by dyspnea, edema, and decreased exertional tolerance. Heart failure with preserved ejection fraction (HFpEF) is an increasingly common disease, and the incidence of HFpEF increases with age. There are a variety of factors which contribute to the development of HFpEF, including the presence of hypertension, diabetes, obesity, and other pro-inflammatory states. These comorbid conditions result in changes at the biochemical and cell signaling level which ultimately lead to a disease with a great deal of phenotypic heterogeneity. In general, the physiologic dysfunction of HFpEF is characterized by vascular stiffness, increased cardiac filling pressures, pulmonary hypertension, and impaired volume management. The normal and abnormal processes associated with aging serve as an accelerant in this process, resulting in the hypothesis that HFpEF represents a form of presbycardia. In this article, we aim to review the processes importance of aging in the development of HFpEF by examining the disease and its causes from the biochemical to physiologic level. © 2022 American Physiological Society. Compr Physiol 12: 1-10, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"3813-3822"},"PeriodicalIF":5.8,"publicationDate":"2022-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10216411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chronobiology of Exercise: Evaluating the Best Time to Exercise for Greater Cardiovascular and Metabolic Benefits. 运动的时间生物学:评估运动的最佳时间，以获得更大的心血管和代谢益处。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-06-29 DOI: 10.1002/cphy.c210036

Leandro C Brito, Thais C Marin, Luan Azevêdo, Julia M Rosa-Silva, Steven A Shea, Saurabh S Thosar

{"title":"Chronobiology of Exercise: Evaluating the Best Time to Exercise for Greater Cardiovascular and Metabolic Benefits.","authors":"Leandro C Brito, Thais C Marin, Luan Azevêdo, Julia M Rosa-Silva, Steven A Shea, Saurabh S Thosar","doi":"10.1002/cphy.c210036","DOIUrl":"https://doi.org/10.1002/cphy.c210036","url":null,"abstract":"Physiological function fluctuates across 24 h due to ongoing daily patterns of behaviors and environmental changes, including the sleep/wake, rest/activity, light/dark, and daily temperature cycles. The internal circadian system prepares the body for these anticipated behavioral and environmental changes, helping to orchestrate optimal cardiovascular and metabolic responses to these daily changes. In addition, circadian disruption, caused principally by exposure to artificial light at night (e.g., as occurs with night-shift work), increases the risk for both cardiovascular and metabolic morbidity and mortality. Regular exercise is a countermeasure against cardiovascular and metabolic risk, and recent findings suggest that the cardiovascular benefits on blood pressure and autonomic control are greater with evening exercise compared to morning exercise. Moreover, exercise can also reset the timing of the circadian system, which raises the possibility that appropriate timing of exercise could be used to counteract circadian disruption. This article introduces the overall functional relevance of the human circadian system and presents the evidence surrounding the concepts that the time of day that exercise is performed can modulate the cardiovascular and metabolic benefits. Further work is needed to establish exercise as a tool to appropriately reset the circadian system following circadian misalignment to preserve cardiovascular and metabolic health. © 2022 American Physiological Society. Compr Physiol 12:3621-3639, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 3","pages":"3621-3639"},"PeriodicalIF":5.8,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10214902/pdf/nihms-1897868.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Aging and Susceptibility to Pulmonary Disease. 衰老与肺部疾病易感性

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-06-29 DOI: 10.1002/cphy.c210026

Julia Budde, Gwen Skloot

{"title":"Aging and Susceptibility to Pulmonary Disease.","authors":"Julia Budde, Gwen Skloot","doi":"10.1002/cphy.c210026","DOIUrl":"https://doi.org/10.1002/cphy.c210026","url":null,"abstract":"The lungs are continually subjected to noxious and inert substances, are immunologically active, and are in a constant state of damage and repair. This makes the pulmonary system particularly vulnerable to diseases of aging. Aging can be understood as random molecular damage that is unrepaired and accumulates over time, resulting in cellular defects and tissue dysfunction. The breakdown of cellular mechanisms, including stem cell exhaustion, genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, altered intercellular communication, and changes in the extracellular matrix is thought to advance the aging process itself. Chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and cancers illustrate a pathologic breakdown in these mechanisms beyond normal aging. The immune system becomes less effective with advancing age. There is a low-level state of chronic inflammation termed inflammaging which is thought to be driven by immunosenescence, the changes in the innate and adaptive immune systems with advancing age that lead to dysregulation and decreased effectiveness of the immune system. These processes of aging lead to expected changes in the form and function of the respiratory system, most notably a loss of lung elasticity, decrease in respiratory muscle strength, increase in ventilation-perfusion mismatching, and stiffening of the vasculature. The astute clinician is aware of these expected findings and does not often attribute dyspnea to aging alone. Maintaining a low threshold to investigate for comorbid disease and understanding how pulmonary disease presents differently in the elderly than in younger adults can improve clinical outcomes. © 2022 American Physiological Society. Compr Physiol 12:3509-3522, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 3","pages":"3509-3522"},"PeriodicalIF":5.8,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Interactions between the Autonomic Nervous System and the Immune System after Stroke. 中风后自主神经系统与免疫系统的相互作用。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-06-29 DOI: 10.1002/cphy.c210047

Li Zhu, Leo Huang, Anh Le, Tom J Wang, Jiewen Zhang, Xuemei Chen, Junmin Wang, Jian Wang, Chao Jiang

{"title":"Interactions between the Autonomic Nervous System and the Immune System after Stroke.","authors":"Li Zhu, Leo Huang, Anh Le, Tom J Wang, Jiewen Zhang, Xuemei Chen, Junmin Wang, Jian Wang, Chao Jiang","doi":"10.1002/cphy.c210047","DOIUrl":"https://doi.org/10.1002/cphy.c210047","url":null,"abstract":"Acute stroke is one of the leading causes of morbidity and mortality worldwide. Stroke-induced immune-inflammatory response occurs in the perilesion areas and the periphery. Although stroke-induced immunosuppression may alleviate brain injury, it hinders brain repair as the immune-inflammatory response plays a bidirectional role after acute stroke. Furthermore, suppression of the systemic immune-inflammatory response increases the risk of life-threatening systemic bacterial infections after acute stroke. Therefore, it is essential to explore the mechanisms that underlie the stroke-induced immune-inflammatory response. Autonomic nervous system (ANS) activation is critical for regulating the local and systemic immune-inflammatory responses and may influence the prognosis of acute stroke. We review the changes in the sympathetic and parasympathetic nervous systems and their influence on the immune-inflammatory response after stroke. Importantly, this article summarizes the mechanisms on how ANS regulates the immune-inflammatory response through neurotransmitters and their receptors in immunocytes and immune organs after stroke. To facilitate translational research, we also discuss the promising therapeutic approaches modulating the activation of the ANS or the immune-inflammatory response to promote neurologic recovery after stroke. © 2022 American Physiological Society. Compr Physiol 12:3665-3704, 2022.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 3","pages":"3665-3704"},"PeriodicalIF":5.8,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Artificial Intelligence-Enabled ECG: Physiologic and Pathophysiologic Insights and Implications. 人工智能支持的心电图:生理和病理生理的见解和意义。

IF 5.8 2区医学

Comprehensive Physiology Pub Date : 2022-06-29 DOI: 10.1002/cphy.c210001

Anthony H Kashou, Demilade A Adedinsewo, Konstantinos C Siontis, Peter A Noseworthy

引用次数: 0