运动对2型糖尿病的预防和治疗。

IF 4.2 2区医学 Q1 PHYSIOLOGY

Comprehensive Physiology Pub Date : 2023-02-23 DOI:10.1002/cphy.c220009

John P Kirwan, Elizabeth C Heintz, Candida J Rebello, Christopher L Axelrod

{"title":"运动对2型糖尿病的预防和治疗。","authors":"John P Kirwan, Elizabeth C Heintz, Candida J Rebello, Christopher L Axelrod","doi":"10.1002/cphy.c220009","DOIUrl":null,"url":null,"abstract":"Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control. © 2023 American Physiological Society. Compr Physiol 13:1-27, 2023.","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"13 1","pages":"4559-4585"},"PeriodicalIF":4.2000,"publicationDate":"2023-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":"{\"title\":\"Exercise in the Prevention and Treatment of Type 2 Diabetes.\",\"authors\":\"John P Kirwan, Elizabeth C Heintz, Candida J Rebello, Christopher L Axelrod\",\"doi\":\"10.1002/cphy.c220009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control. © 2023 American Physiological Society. Compr Physiol 13:1-27, 2023.\",\"PeriodicalId\":10573,\"journal\":{\"name\":\"Comprehensive Physiology\",\"volume\":\"13 1\",\"pages\":\"4559-4585\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2023-02-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"3\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comprehensive Physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/cphy.c220009\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220009","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}

引用次数: 3

摘要

2型糖尿病是一种全身性、多因素疾病，是全球发病率和死亡率的主要原因。尽管可用的药物和治疗方法越来越多，但由于在一般人群中已建立的安全性、有效性和耐受性，运动仍然是一线预防和干预策略。本文综述了2型糖尿病的易感危险因素、预防、病理生理和治疗。我们强调关键的细胞和分子适应过程，这些过程为我们对如何、何时以及何种类型的运动可以改善血糖控制提供了深入的了解。©2023美国生理学会。物理学报(自然科学版)，2023(3):1145 - 1145。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Exercise in the Prevention and Treatment of Type 2 Diabetes.

Type 2 diabetes is a systemic, multifactorial disease that is a leading cause of morbidity and mortality globally. Despite a rise in the number of available medications and treatments available for management, exercise remains a first-line prevention and intervention strategy due to established safety, efficacy, and tolerability in the general population. Herein we review the predisposing risk factors for, prevention, pathophysiology, and treatment of type 2 diabetes. We emphasize key cellular and molecular adaptive processes that provide insight into our evolving understanding of how, when, and what types of exercise may improve glycemic control. © 2023 American Physiological Society. Compr Physiol 13:1-27, 2023.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Comprehensive Physiology PHYSIOLOGY-

CiteScore

10.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.