Communications Chemistry最新文献_第2页

Towards precision medicine using biochemically triggered cleavable conjugation. 使用生化触发可切割偶联的精准医学。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-04-02 DOI: 10.1038/s42004-025-01491-5

Badri Parshad, Smriti Arora, Balram Singh, Yuanwei Pan, Jianbin Tang, Zhigang Hu, Hirak K Patra

{"title":"Towards precision medicine using biochemically triggered cleavable conjugation.","authors":"Badri Parshad, Smriti Arora, Balram Singh, Yuanwei Pan, Jianbin Tang, Zhigang Hu, Hirak K Patra","doi":"10.1038/s42004-025-01491-5","DOIUrl":"10.1038/s42004-025-01491-5","url":null,"abstract":"Personalised and precision medicines are emerging as the future of therapeutic strategies. Biochemically triggered cleavable conjugation is thus crucial and timely due to its potential to response as per the loco-regional environment. It enables targeted release of therapeutic agents in response to specific biochemical signals and thus minimizing off-target effects and improving treatment precision. It holds promise in a range of biomedical applications, including cancer therapy, senolytic therapy, gene therapy, and regenerative medicine. The focus of this review is to offer comprehensive insight into the significance of biochemically cleavable conjugations within intrinsically stimuli-responsive architectures. Pathological conditions and alteration in tissues microenvironment in the body exhibit distinct biochemical settings characterized by change in redox potential, pH level, hypoxia, reactive oxygen species (ROS), and various catalytic protein/enzyme overexpression. Understanding these intrinsic features is crucial for researchers aiming to develop intelligent cleavable bio-engineered systems for biomedicines. By strategically designing cleavable linkage, researchers can leverage the variations in the tumor, infection, inflammation, and senescence microenvironments. Through an extensive examination of relevant literature, we present a comprehensive classification of the intrinsic physicochemical differences found in pathological areas and their applications in drug delivery, prodrug activation, imaging, and theranostics for future personalised medicines. This review will provide comprehensive guidance and critical insights to researchers in both industry and academia who are involved in the design of advanced, functional biochemically cleavable conjugations.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"100"},"PeriodicalIF":5.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids. 由肠道共生体衍生的糖脂激发的靶向自然杀伤T细胞的潜在免疫调节配体的开发。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-04-01 DOI: 10.1038/s42004-025-01497-z

Jesang Lee, Sumin Son, Minha Lee, Seung Bum Park

{"title":"Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids.","authors":"Jesang Lee, Sumin Son, Minha Lee, Seung Bum Park","doi":"10.1038/s42004-025-01497-z","DOIUrl":"10.1038/s42004-025-01497-z","url":null,"abstract":"α-Galactosylceramide (α-GalCer) is a prototypical antigen recognized by natural killer T (NKT) cells, a subset of T cells crucial for immune regulation. Despite its significance, the complex structure-activity relationship of α-GalCer and its analogs remains poorly understood, particularly in defining the structural determinants of NKT cell responses. In this study, we designed and synthesized potential immunomodulatory ligands targeting NKT cells, inspired by glycolipids derived from the gut symbiont Bacteroides fragilis. A series of α-GalCer analogs with terminal iso-branched sphinganine backbones was developed through rational modification of the acyl chain. Our results identified the C3' hydroxyl group as a structural element that impairs glycolipid presentation by CD1d, as evidenced by reduced IL-2 secretion and weak competition with a potent CD1d ligand. Notably, among C3'-deoxy α-GalCer analogs, those containing an α-chloroacetamide group exhibited robust NKT cell activation with Th2 selectivity. Computational docking and mass spectrometry analyses further confirmed the substantial interaction of α-chloroacetamide analogs to CD1d. These findings underscore the potential of leveraging microbiota-derived glycolipid structures to selectively modulate NKT cell functions for therapeutic purposes.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"98"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ab-initio dynamic study of mechanisms for dust-mediated molecular hydrogen formation in space. 空间尘埃介导的分子氢形成机制的从头算动力学研究。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-04-01 DOI: 10.1038/s42004-025-01489-z

Yuzhen Guo, David R McKenzie

{"title":"Ab-initio dynamic study of mechanisms for dust-mediated molecular hydrogen formation in space.","authors":"Yuzhen Guo, David R McKenzie","doi":"10.1038/s42004-025-01489-z","DOIUrl":"10.1038/s42004-025-01489-z","url":null,"abstract":"The reason for the abundance of molecular hydrogen (H2) in space remains unresolved. Here we study collision dynamics under spacelike conditions to test H2 formation mechanisms where carbonaceous dust grains may have a catalytic role. Density functional theory molecular dynamics simulates atomic hydrogen capture and H2 formation on the surface of buckminsterfullerene as a carbonaceous cosmic dust model. Maximally localized Wannier functions are applied to examine the electronic bonding during transition states. The fullerene surface is shown to be effective at warm (50K) and low (10K) temperatures in achieving atomic H chemisorption, potentially explaining the observed broad temperature range for efficient H2 formation. We revise the Eley-Rideal mechanism and propose that both it and the Langmuir-Hinshelwood mechanism, induced by thermal hopping, contribute to bursts of H2 formation during energetic events. Additionally, we show how fullerene maintains the abundance of H2 in space by selectively preventing H2 molecules from capture.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"97"},"PeriodicalIF":5.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of stack pressure on coulometric titration time analysis. 堆压对库仑滴定时间分析的影响。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-04-01 DOI: 10.1038/s42004-025-01496-0

Jaka Sivavec, Kostiantyn V Kravchyk, Maksym V Kovalenko

引用次数: 0

Author Correction: Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction. 作者更正：半乳糖凝集素-8 n端结构域的纳米摩尔抑制剂通过非规范阳离子-π相互作用结合。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-04-01 DOI: 10.1038/s42004-025-01498-y

Edvin Purić, Mujtaba Hassan, Fredrik Sjövall, Tihomir Tomašič, Mojca Pevec, Jurij Lah, Jaume Adrover Forteza, Anders Sundin, Hakon Leffler, Ulf J Nilsson, Derek T Logan, Marko Anderluh

引用次数: 0

Electrochemically grown porous platinum for electrocatalysis and optical applications. 用于电催化和光学应用的电化学生长多孔铂。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-03-29 DOI: 10.1038/s42004-025-01476-4

Sarmiza-Elena Stanca, Marco Diegel, Jan Dellith, Gabriel Zieger, Uwe Hübner, Andreas Ihring, Heidemarie Krüger

引用次数: 0

Electrochemical heteroarylation and amidation of alkanes using activated glassy carbon electrodes without mediators. 使用无介质的活性玻璃碳电极进行烷烃的电化学杂芳基化和酰胺化反应。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-03-29 DOI: 10.1038/s42004-025-01494-2

Loris Laze, Jose C Gonzalez-Gomez, Irene Bosque

引用次数: 0

Mechanical interlocking of metal organic cages. 机械联锁金属有机笼。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-03-27 DOI: 10.1038/s42004-025-01493-3

Javier Martí-Rujas

{"title":"Mechanical interlocking of metal organic cages.","authors":"Javier Martí-Rujas","doi":"10.1038/s42004-025-01493-3","DOIUrl":"10.1038/s42004-025-01493-3","url":null,"abstract":"[2]-Catenanes formed from three-dimensional (3D) metal organic cages (MOCs) self-assembled from transition metals and organic ligands, hereafter called interlocked MOCs, constitute a relatively new class of mechanically interlocked materials (MIMs) that is receiving considerable research attention. This interest is mainly due to their esthetic synthetic aspects and mechanical properties, but also due to their potential applications in nanotechnological areas, including magnetic materials, guest selectivity, allosteric binding, or thermoresponsive behavior in elastomeric materials. In this article, a perspective on the research on interlocked MOCs (i.e., [2]-catenanes), covering from the first examples of interlocked MOCs to the latest research in this area is presented. The emphasis is in the synthetic methods used for their preparation and the structure‒function correlation aspects. The combination of experimental techniques in the solution state (i.e., NMR, ESI-MAS, etc.) and solid-state X-ray structural data, in combination with theoretical calculations have been very important to getting a rationalization of the experimental results. The described [2]-catenanes are formed from mechanically bonded hollow cages, therefore they can be exploited in host-guest chemistry applications typical from MOCs, with enhanced physical properties ranging from the mechanical bonds like enhanced cage's strength and dynamic behavior, which are needed for developing new smart functional materials.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"92"},"PeriodicalIF":5.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A software tool and strategy for peptidoglycomics, the high-resolution analysis of bacterial peptidoglycans via LC-MS/MS. 肽糖组学的软件工具和策略，通过LC-MS/MS对细菌肽聚糖进行高分辨率分析。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-03-26 DOI: 10.1038/s42004-025-01490-6

Marcel G Alamán-Zárate, Brooks J Rady, Raphael Ledermann, Neil Shephard, Caroline A Evans, Mark J Dickman, Robert D Turner, Aline Rifflet, Ankur V Patel, Ivo Gomperts Boneca, Philip S Poole, Marshall Bern, Stéphane Mesnage

{"title":"A software tool and strategy for peptidoglycomics, the high-resolution analysis of bacterial peptidoglycans via LC-MS/MS.","authors":"Marcel G Alamán-Zárate, Brooks J Rady, Raphael Ledermann, Neil Shephard, Caroline A Evans, Mark J Dickman, Robert D Turner, Aline Rifflet, Ankur V Patel, Ivo Gomperts Boneca, Philip S Poole, Marshall Bern, Stéphane Mesnage","doi":"10.1038/s42004-025-01490-6","DOIUrl":"10.1038/s42004-025-01490-6","url":null,"abstract":"Peptidoglycan is an essential component of the bacterial cell envelope-a mesh-like macromolecule that protects the bacterium from osmotic stress and its internal turgor pressure. The composition and architecture of peptidoglycan is heterogeneous and changes as bacteria grow, divide, and respond to their environment. Though peptidoglycan has long been studied via LC-MS/MS, the analysis of this data remains challenging as peptidoglycan's unusual composition and branching can't be handled by proteomics software. Here we describe user-friendly open-source tools and a web interface for building peptidoglycan databases, performing MS searches, and predicting the MS/MS fragmentation of muropeptides. We then use Rhizobium leguminosarum to describe a step-by-step strategy for the high-resolution analysis of peptidoglycan. The unprecedented detail of R. leguminosarum's peptidoglycan composition (>250 muropeptides) reveals even the subtlest remodelling between growth conditions. These new and easier to use tools enable more systematic analyses of peptidoglycan dynamics.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"91"},"PeriodicalIF":5.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A HoLDI mass spectrometry platform for airborne nanoplastic detection. 用于空气中纳米塑料检测的HoLDI质谱分析平台。

IF 5.9 2区化学

Communications Chemistry Pub Date : 2025-03-25 DOI: 10.1038/s42004-025-01483-5

Zi Wang, Nadim K Saadé, Robert J Panetta, Parisa A Ariya

{"title":"A HoLDI mass spectrometry platform for airborne nanoplastic detection.","authors":"Zi Wang, Nadim K Saadé, Robert J Panetta, Parisa A Ariya","doi":"10.1038/s42004-025-01483-5","DOIUrl":"10.1038/s42004-025-01483-5","url":null,"abstract":"There are no established protocols for nanoplastic detection within complex environmental matrices. Mass spectrometry (MS) analysis of environmental nanoplastics is impeded by methodological constraints. We present a versatile platform evolved from matrix-assisted laser desorption/ionization (MALDI) MS for airborne nano/microplastic research. The 3D-printed hollow-laser desorption/ionization (HoLDI) target enables efficient, high-throughput analysis of aerosols collected on simple substrates without pre/post-treatments. HoLDI-MS determines the chemical composition and relative quantity of real-world airborne nano/microplastics, while used with conventional portable samplers and particle analyzers. Polyethylene, polyethylene glycol, and polydimethylsiloxanes are detected in an indoor environment, with a higher amount in the micro-sized range. Polycyclic aromatic hydrocarbons present in an outdoor setting, with a higher quantity in the nano-sized range. Morphological and elemental data provide additional evidence for observed contaminants and support multidisciplinary research interests. HoLDI holds promise as a standardized analytical framework for any air or water samples, facilitating research harmonization worldwide.","PeriodicalId":10529,"journal":{"name":"Communications Chemistry","volume":"8 1","pages":"90"},"PeriodicalIF":5.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0