Clinical nutrition最新文献

{"title":"The relationship between hyponatremia and mortality in patients receiving nutrition support","authors":"Nayu Nakamura ,&nbsp;Arisa Inoue-Hamano ,&nbsp;Seiya Inoue ,&nbsp;Yasuhiro Hamada","doi":"10.1016/j.clnu.2025.01.015","DOIUrl":"10.1016/j.clnu.2025.01.015","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Hyponatremia is frequently seen in clinical practice, but most cases are mild and asymptomatic and therefore often go unmanaged. In recent years, it has been reported that the onset or improvement of hyponatremia, even in mild cases, has an impact on mortality and that hyponatremia is directly related to increased mortality. In addition, it has been reported that patients with Nutrition Support Team (NST) are more likely to develop hyponatremia than the general hospitalized population. This study aimed to determine the association between the development and amelioration of hyponatremia and mortality in patients with NST.</div></div><div><h3>Methods</h3><div>A total of 1553 patients who underwent initial NST intervention from April 1, 2013 to March 31, 2017 were included. Hyponatremia was defined as hyponatremia &lt;138 mEq/L and normal serum sodium level was defined as 138–145 mEq/L based on the laboratory reference values of our hospital. Hyponatremia was defined as L and normal sodium as N. Based on sodium levels at the start and end of the intervention, the population was classified into four groups, L–L, N–L, L–N, and N–N (sodium level at the start of intervention – sodium level at the end of intervention), and the 5-year survival rate curve and hazard ratio for death for each group were calculated. Multivariate analysis adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>Analysis revealed that the L–L group with persistent hyponatremia (hazard ratio (HR) = 3.47, vs N–N, p &lt; 0.0001) had the highest risk of death, while the L–N group with improved hyponatremia (HR = 2.19, vs N–N, p &lt; 0.0001) had a significantly lower risk than the L–L group. The risk of death was also increased in the L–N and N–L groups (HR = 1.97, vs. N–N, p &lt;&lt; 0.0001) after even one episode of hyponatremia compared to the N–N group.</div></div><div><h3>Conclusion</h3><div>The results of this study indicate that hyponatremia is associated with poor survival in patients undergoing NST. Future randomized controlled trials are needed to determine whether correction of hyponatremia leads to improved survival in patients undergoing NST to clarify the need for prevention and management of hyponatremia.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 37-44"},"PeriodicalIF":6.6,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma β-hydroxybutyrate concentration, genetic risk, and the incidence of Alzheimer’s disease: A prospective study of 261,933 participants","authors":"Ha-Na Kim ,&nbsp;Ji Hyun Lee ,&nbsp;John Boscardin ,&nbsp;John C. Newman","doi":"10.1016/j.clnu.2025.01.007","DOIUrl":"10.1016/j.clnu.2025.01.007","url":null,"abstract":"<div><h3>Background</h3><div>We investigated whether plasma β-hydroxybutyrate levels, a genetic risk score for Alzheimer’s disease, and their interaction are associated with incident Alzheimer’s disease.</div></div><div><h3>Methods</h3><div>Using data from the UK Biobank—a population-based cohort study of adults aged 40–69 years, we assessed associations between baseline plasma β-hydroxybutyrate level, genetic risk score for Alzheimer’s disease, and incident Alzheimer’s disease. Incident Alzheimer’s disease data were collected through linked data from hospital admissions and death registries.</div></div><div><h3>Results</h3><div>In total, 261,933 adults were included, 1978 of whom developed incident Alzheimer’s disease. Plasma β-hydroxybutyrate concentrations were not independently associated with Alzheimer’s disease incidence after adjusting for covariates, whereas a higher genetic predisposition was linked to increased Alzheimer’s disease incidence. Interactions were observed between plasma β-hydroxybutyrate concentrations and genetic risk for Alzheimer’s disease on Alzheimer’s disease incidence (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Further studies are warranted to elucidate the impact of plasma β-hydroxybutyrate status on Alzheimer’s disease incidence.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 1-9"},"PeriodicalIF":6.6,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Ultra-processed products and risk of liver cancer: A prospective cohort study\"","authors":"Chenyang Huai","doi":"10.1016/j.clnu.2025.01.003","DOIUrl":"10.1016/j.clnu.2025.01.003","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Page 19"},"PeriodicalIF":6.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of erythrocyte membrane fatty acids with blood pressure in children","authors":"Lan Huang ,&nbsp;Shaowen Li ,&nbsp;Qinwen Zhou ,&nbsp;Xiaozhen Ruan ,&nbsp;Yulin Wu ,&nbsp;Qinzhi Wei ,&nbsp;Hairui Xie ,&nbsp;Zheqing Zhang","doi":"10.1016/j.clnu.2024.12.035","DOIUrl":"10.1016/j.clnu.2024.12.035","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>Different fatty acids may vary in their effect on blood pressure. We tested whether fatty acid classes measured in erythrocytes are associated with blood pressure.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 421 children from Guangzhou, China. Erythrocyte membrane fatty acid concentrations were measured by gas chromatography-mass spectrometry. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured with an electronic sphygmomanometer. Abnormal blood pressure (ABP) was defined as an elevated SBP and/or DBP. Analysis of covariance (ANCOVA) and multivariable logistic regression models were performed to explore the associations of fatty acid subgroups with the risk of blood pressure status. The joint effect of fatty acid subgroups was evaluated using Probit Bayesian Kernel Machine Regression (BKMR).</div></div><div><h3>Results</h3><div>ANCOVA analysis showed that children in the higher quartiles of odd-chain saturated fatty acids (OSFAs) had significantly lower levels of both SBP (P-trend = 0.020) and DBP (P-trend = 0.008). In contrast, DBP increased significantly across quartiles of monounsaturated fatty acids (MUFAs). In adjusted models of logistic regression analysis, the higher quartiles of MUFAs concentrations were associated with a higher risk of ABP (P-trend = 0.001). BKMR analysis showed that the risk of ABP increased significantly with increasing total MUFAs mixture levels. Similar associations were observed between MUFAs and DBP. Conversely, OSFAs concentrations were negatively correlated with both SBP and DBP. Additionally, children with higher levels of mixture of n-3 polyunsaturated fatty acids (n-3 PUFAs) exhibited lower SBP.</div></div><div><h3>Conclusions</h3><div>Fatty acid subclasses may differ in their relationship with abnormal blood pressure in children. MUFAs exhibit a positive association with blood pressure, whereas OSFAs and n-3 PUFAs demonstrate an inverse association with blood pressure.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 30-36"},"PeriodicalIF":6.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition therapy for critically ill patients - Five key problems","authors":"K. Georg Kreymann,&nbsp;Geraldine de Heer","doi":"10.1016/j.clnu.2025.01.004","DOIUrl":"10.1016/j.clnu.2025.01.004","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>A pragmatic trial and its secondary analyses have demonstrated that nutritional care not only reduces complications but also significantly improves survival in medical patients at risk of malnutrition. In contrast, for critically ill patients comparable evidence is scarce. Consequently, many propositions for refining the research agenda and study design in the field of critical care nutrition have already been made. The aim of this paper is to elucidate further critical problems in nutritional care.</div></div><div><h3>Methods</h3><div>Critical appraisal of the literature from the past 70 years.</div></div><div><h3>Results</h3><div>We identified five key problems: 1. The immunologic background of catabolism 2. The energy goal during the acute phase 3. The quantification of endogenous substrate production 4. The incorporation of clinical and biological data into the study design, and 5. The energy goal and cardiopulmonary exercise testing during the recovery phase.</div></div><div><h3>Conclusions</h3><div>The solution of these problems should supplement the propositions made by other authors and is essential to improving nutrition during and after critical care.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"46 ","pages":"Pages 45-51"},"PeriodicalIF":6.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor–“High-density lipoprotein cholesterol level and risk of muscle strength decline and sarcopenia in older adults”","authors":"Qiang Sun,&nbsp;Zhiqiang Zhang","doi":"10.1016/j.clnu.2024.12.007","DOIUrl":"10.1016/j.clnu.2024.12.007","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Pages 127-128"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply- Letter to Editor- ‘A multicenter randomized controlled trial comparing three-times-a-day intermittent enteral postural feeding to continuous enteral feeding among mechanically ventilated patients in intensive care’","authors":"Rakshit Panwar","doi":"10.1016/j.clnu.2024.11.036","DOIUrl":"10.1016/j.clnu.2024.11.036","url":null,"abstract":"","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Page 165"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality and quantity of carbohydrates, faecal short-chain fatty acids and gastrointestinal symptoms – results from a randomised, controlled trial (CARBFUNC)","authors":"Caroline Jensen ,&nbsp;Cathrine Horn Sommersten ,&nbsp;Johnny Laupsa-Borge ,&nbsp;Inghild Storås ,&nbsp;Jørgen Valeur ,&nbsp;Gunnar Mellgren ,&nbsp;Jutta Dierkes ,&nbsp;Simon N. Dankel ,&nbsp;Gülen Arslan Lied","doi":"10.1016/j.clnu.2024.11.041","DOIUrl":"10.1016/j.clnu.2024.11.041","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background &amp; aims&lt;/h3&gt;&lt;div&gt;Diet is a key determinant of gastrointestinal (GI) health, in part in association with microbiota-derived short-chain fatty acids (SCFAs). However, we need more knowledge of the relative impact of dietary carbohydrate amount and quality on GI symptoms, GI-associated quality of life (QoL) and faecal SCFAs.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;193 males and females with obesity were randomly allocated to follow one of three isocaloric, iso-proteinic dietary patterns (2000 kcal/day for females, 2500 kcal/day for males): a higher-carbohydrate lower-fat diet with refined carbohydrate sources (acellular diet, A-HCLF, comparator arm), a higher-carbohydrate lower-fat diet with minimally refined carbohydrate sources (intact cellular structures, cellular diet, C-HCLF), or a low-carbohydrate high-fat diet (LCHF), all low in added sugars. Secondary outcomes of this randomised controlled trial (CARBFUNC) were assessed, i.e., changes in abdominal symptoms (irritable bowel syndrome severity scoring system (IBS-SSS)), reflux symptoms (gastro-oesophageal reflux disease questionnaire (GerdQ)), GI-related QoL (Short-Form Nepean Dyspepsia Index (SF-NDI)) and fatigue (Fatigue Impact Scale), and faecal SCFAs concentrations after following the diets for 3 and 12 months. Group differences were analysed by constrained linear mixed effect modelling (cLMM).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;118 and 57 participants completed 3 and 12 months of the dietary intervention, respectively, with no significant group differences in weight loss at 12 months (5–7%). At 12 months, the mean daily fibre intake was 34 ± 7 g/day, 41 ± 14.3 g/day, and 18.5 ± 6 g/day on the A-HCLF, C-HCLF and LCHF diet, respectively, compared to 21 ± 7, 21 ± 7 and 20 ± 6 g/day at baseline. We observed no significant between-group difference in IBS-SSS sum score after 3 and 12 months. We found significant improvement in GerdQ score (change score [95 % CI]: −0.62 [−1.18, −0.048], &lt;em&gt;p&lt;/em&gt; = 0.034), and SF-NDI sum score (−1.88 [−3.22, −0.52], &lt;em&gt;p&lt;/em&gt; = 0.007) after 3 months on the LCHF diet compared to the A-HCLF diet, and GerdQ remained significant at 12 months (−1.03 [−1.88, −0.19], p = 0.017). Compared to the A-HCLF diet, the concentration of faecal butyric acid increased significantly more after 3 months on the C-HCLF diet (4.97 [1.71, 8.23] p = 0.003) and faecal acetic acid decreased more (−6.41 [−12.8, −0.047]. p = 0.048) on the LCHF diet. At 12 months the greater reduction in faecal acetic acid on the LCHF diet remained significant (−9.82 [−19.0, −0.67], p = 0.036), along with significantly greater reductions also in total SCFAs (−21.3 [−38.0, −4.56], p = 0.013), propionic (−4.42 [−7.79, −1.05], p = 0.010), and butyric acid (−5.05 [−9.60, −0.51], p = 0.030).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;In this sample of adults with obesity and mild GI symptoms at baseline, modest improvements were observed only for the LCHF diet in QoL (at 3 months) and reflux s","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Pages 54-64"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indices of healthy and unhealthy plant-based diets and the risk of selected digestive cancers","authors":"Federica Turati ,&nbsp;Silvia Mignozzi ,&nbsp;Giovanna Esposito ,&nbsp;Francesca Bravi ,&nbsp;Angela D'Angelo ,&nbsp;Gianfranco Alicandro ,&nbsp;Werner Garavello ,&nbsp;Livia S.A. Augustin ,&nbsp;Sara Vitale ,&nbsp;Attilio Giacosa ,&nbsp;Ettore Bidoli ,&nbsp;Jerry Polesel ,&nbsp;Eva Negri ,&nbsp;Monica Ferraroni ,&nbsp;Carlo La Vecchia","doi":"10.1016/j.clnu.2024.11.039","DOIUrl":"10.1016/j.clnu.2024.11.039","url":null,"abstract":"<div><h3>Background &amp; aims</h3><div>The relation between various types of plant-based diets and cancer risk is still unclear. We examined the association of the overall plant-based diet index (PDI) and healthy (hPDI) and unhealthy plant-based diet indices (uPDI) with the risk of selected digestive cancers.</div></div><div><h3>Methods</h3><div>We used data from a network of hospital-based case–control studies including 942 oral/pharyngeal, 304 esophageal, 230 stomach, 1953 colorectal, and 326 pancreatic cancer cases. We calculated PDI, hPDI, and uPDI from a validated food frequency questionnaire. We used multivariable logistic regression models to estimate the odds ratios (OR) of selected digestive cancers across the three indices (in quintiles, Q, or tertiles, T, and in continuous).</div></div><div><h3>Results</h3><div>The PDI was significantly inversely associated with oral/pharyngeal (OR_{Q5 vs Q1}=0.63, 95% confidence interval, CI, 0.47–0.84) and esophageal cancer risk (OR_{T3 vs T1}=0.47, 95% CI 0.31–0.72). The inverse associations appeared stronger for the hPDI (oral cavity/pharynx: OR_{Q5 vs Q1}=0.52; 95% CI 0.39–0.70; esophagus: OR_{T3 vs T1}=0.59, 95% CI 0.39–0.91; stomach: OR_{T3 vs T1}=0.42, 95% CI 0.27–0.67; colorectum: OR_{Q5 vs Q1}=0.69; 95% CI 0.57–0.84; pancreas: OR_{T3 vs T1}=0.60; 95% CI 0.41–0.89). In contrast, the uPDI was directly associated with the risk of oral/pharyngeal (OR_{Q5 vs Q1}=1.43, 95% CI 1.06-1.94), colorectal (OR_{Q5 vs Q1}=2.28, 95% CI 1.86–2.81), and pancreatic cancer (OR_{T3 vs T1}=1.74, 95% CI 1.14–2.65). Esophageal and stomach cancer risks were non-significantly increased by 34% and 46% respectively in the highest uPDI quantile.</div></div><div><h3>Conclusion</h3><div>A plant-based diet, especially a healthy plant-based diet, may reduce the risk of various digestive cancers, whereas an unhealthy plant-based diet may increase the risk. The quality of plant-based diets is important for digestive cancer risk evaluation and prevention.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Pages 76-85"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of trimethylamine N-oxide and metabolites with kidney function decline in patients with chronic kidney disease","authors":"Evelyn Cheng ,&nbsp;Szu-Chun Hung ,&nbsp;Ting-Yun Lin","doi":"10.1016/j.clnu.2024.12.001","DOIUrl":"10.1016/j.clnu.2024.12.001","url":null,"abstract":"<div><h3>Background</h3><div>Trimethylamine N-oxide (TMAO) is a gut microbial metabolite derived from dietary <span>l</span>-carnitine and choline. High plasma TMAO levels are associated with cardiovascular disease and overall mortality, but little is known about the associations of TMAO and related metabolites with the risk of kidney function decline among patients with chronic kidney disease (CKD).</div></div><div><h3>Methods</h3><div>We prospectively followed 152 nondialysis patients with CKD stages 3–5 and measured plasma TMAO and related metabolites (trimethylamine [TMA], choline, carnitine, and γ-butyrobetaine) via liquid chromatography‒mass spectrometry. An estimated glomerular filtration rate (eGFR) slope &gt;3 ml/min/per 1.73 m² per year was defined as a rapid decline. We performed logistic regression to determine the probability of rapid or slow eGFR decline, with each metabolite as the main predictor. The gut microbiota was profiled via whole metagenomic sequencing.</div></div><div><h3>Results</h3><div>The participants had a median age of 66 years, 41.4 % were women, 39.5 % had diabetes, and the median eGFR was 23 mL/min/1.73 m². A rapid decrease in the eGFR occurred in 65 patients (42.8 %) over a median follow-up of 3.3 years. After adjustment for baseline eGFR, proteinuria, and clinical factors, plasma TMAO levels were independently associated with increased odds of rapid eGFR decline (odds ratio, 2.42; 95 % CI, 1.36–4.32), whereas plasma TMA, choline, carnitine, and γ-butyrobetaine levels were not. Patients who exhibited rapid eGFR decline had a distinct gut microbial composition characterized by increased α-diversity and an abundance of TMA-producing bacteria, including those of the genera <em>Desulfovibrio</em> and <em>Collinsella tanakaei</em>, as well as increased expression of the TMA-producing enzymes bbuA and cutC.</div></div><div><h3>Conclusion</h3><div>Our findings suggest the relevance of plasma TMAO in the progression of kidney disease among patients with CKD.</div></div>","PeriodicalId":10517,"journal":{"name":"Clinical nutrition","volume":"44 ","pages":"Pages 239-247"},"PeriodicalIF":6.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}