Clinical Rheumatology最新文献

{"title":"Expression of miR-127 and miR-29 in Egyptian patients with Behçet disease and its clinical significance and relationship with disease activity.","authors":"Heba E Tolba, Yasser E Taha, Nermeen A Fouad, Omayma O Abdelaleem","doi":"10.1007/s10067-025-07470-4","DOIUrl":"10.1007/s10067-025-07470-4","url":null,"abstract":"<p><strong>Background: </strong>Behçet's disease (BD) is characterized by a variety of clinical involvements and unpredictable courses of remission and exacerbation. BD cannot be diagnosed based on any particular laboratory, histopathologic, or genetic data. After excluding other possible causes, the diagnosis of BD is mostly made based on clinical manifestations. This research aims to assess the expression of miR-127 and miR-29 in Behçet patients and to correlate this expression with different disease manifestations and disease activity.</p><p><strong>Methods: </strong>Seventy adult patients with Behçet disease and 30 matched controls were enlisted. Behçet's Disease Current Activity Form (BDCAF) was used to determine the patients' activity scores. Gene expressions of miR-127 and miR-29 were assessed using real-time PCR.</p><p><strong>Results: </strong>miR-29 was statistically significantly higher in cases when compared to controls with p < 0.001. Patients with oral ulcers, genital ulcers, and neurological manifestations had a significantly higher levels of miR-29b (p = 0.005, 0.008, 0.003, respectively). Expression level of miR-29b was higher in patients with active disease compared with those who were in inactive state (p = 0.003). Patients with high and moderate severity score had a statistically significant higher expression level of miR-29 when compared to patients with mild severity score. There was a statistically significant positive correlation between miR-29 and several study parameters including BDCAF (r = 0.440, p < 0.001) and severity score (r = 0.243, p = 0.043). miR-127 was statistically significantly lower in cases when compared to controls with p < 0.001. There were statistically significant negative correlations between miR-127 and each of ESR (r = - 0.361, p = 0.002) and BDCAF (r = - 0.350, p = 0.003).</p><p><strong>Conclusions: </strong>miR-29 expression level was statistically significantly higher while miR-127 was statistically significantly lower in patients with Behçet disease compared with control individuals. Furthermore, miR-29 was significantly positively correlated whereas miR-127 was significantly negatively correlated with BDCAF denoting their association with disease activity. Key Points • Behçet's disease (BD) is a systemic inflammatory disease with uncertain etiology. There is currently no diagnostic test for Behçet disease. Several miRNAs have been identified as powerful diagnostic biomarkers in many diseases. • Measuring the expression levels of miR-29 and miR-127 in serum of sample of patients with Behçet disease was performed in the current study. • miR-29 expression level was statistically significantly higher while miR-127 was statistically significantly lower in patients with Behçet disease compared with control individuals. Furthermore, miR-29 was significantly positively correlated whereas miR-127 was significantly negatively correlated with BDCAF denoting their association with disease activity.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2439-2445"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of rheumatology: knowledge structure and research trends of RNA-Binding proteins in rheumatic diseases.","authors":"Wei Zhang, Jiaqi Song, Shuyuan Xian, Sujie Xie, Yifan Liu, Yuntao Yao, Xirui Tong, Xinru Wu, Yuanan Li, Haoyu Zhang, Bingnan Lu, Jiajie Zhou, Yibin Zhou, Dayuan Xu, Runzhi Huang, Shizhao Ji","doi":"10.1007/s10067-025-07403-1","DOIUrl":"10.1007/s10067-025-07403-1","url":null,"abstract":"<p><strong>Background: </strong>Rheumatic disease is a kind of disease dominated by inflammatory lesions of connective tissue and abnormal immune function. It mostly belongs to autoimmune diseases or connective tissue diseases affecting multiple organs. Meanwhile, understanding the role of RNA-binding proteins (RBPs) in pathogenesis is rapidly developing. This study aims at summarizing the hotspots in rheumatology studies related to RBPs.</p><p><strong>Methods: </strong>Scientific papers on RBPs related to rheumatology between 1982 and 2022 were gathered from the Web of Science database. The data analysis and visualization were obtained using the Bibliometrix package. Bibliometrix package was used to analyze bibliometric indicators and visualize the trends and hotspots of the research.</p><p><strong>Results: </strong>A total of 964 articles met the requirement. From 1982 to 2022, the USA and Anhui Medical University were the most productive country and institution, respectively, in this field. Arthritis and Rheumatism, Annals of the Rheumatic Diseases and Arthritis & Rheumatology were the top three periodicals obtained by Bradford's law. Co-word analysis divided the keywords into three clusters, focusing on diagnosis and classification of Systemic Lupus Erythematosus, pathogenesis of osteoarthritis and pathogenesis of Rheumatoid Arthritis, respectively. Trend topic analysis revealed that pathogenesis and classification of rheumatic diseases might be the research trend.</p><p><strong>Conclusion: </strong>Focusing on RBPs in rheumatic diseases, we illustrated the evolution of this field and predicted future research hotspots. The research trend topics have evolved towards clinical classification and pathogenesis at the molecular and genetic level. The pathogenic mechanism in rheumatic diseases will continue to be a hotspot in the future. Besides, the classification of Systemic Lupus Erythematosus patients may be another hotspot. Researchers are recommended to pay more attention to hotspots demonstrated in the future. Key Points • Bibliometrix package was used to analyze bibliometric indicators and visualize the trends and hotspots of the research. • Focusing on RBPs in rheumatic diseases, we illustrated the evolution of this field and predicted future research hotspots. • The research trend topics have evolved towards clinical classification and the pathogenesis at the molecular and genetic level. • The pathogenic mechanism in rheumatic diseases will continue to be a hotspot in the future.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2501-2516"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of nailfold videocapillaroscopy findings in children with ANCA-associated vasculitis.","authors":"Elif Kucuk, Feray Kaya, Lutfiye Koru, Zelal Aydin, Eda Nur Dizman, Hatice Kubra Dursun, Merve Ozen Balci, Nilufer Goknar, Saniye Girit, Fatih Haslak, Kubra Ozturk","doi":"10.1007/s10067-025-07463-3","DOIUrl":"10.1007/s10067-025-07463-3","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2577-2579"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic granulomatous mastitis: TNFi effectivity in a retrospective inception cohort.","authors":"Nihal Lermi, Ali Ekin, Burcu Yağız, Fatih Yıldırım, Fatih Albayrak, Saliha Sunkak, Selime Ermurat, Dilek Tezcan, Gülşah Yamancan, Şule Ketenci Ertaş, Mine Özşen, Mehmet Akif Ötegeçeli, Hamide Kart Köseoğlu, Bünyamin Kısacık, Süleyman Serdar Koca, Cemal Bes, Belkıs Nihan Coşkun, Yavuz Pehlivan, Ediz Dalkılıç","doi":"10.1007/s10067-025-07468-y","DOIUrl":"10.1007/s10067-025-07468-y","url":null,"abstract":"<p><strong>Objectives: </strong>Idiopathic granulomatous mastitis is a rare, chronic, inflammatory breast disease that can mimic breast carcinoma. Histologicaly there are giant cells and epitheloid histiocytes forming non-caseating granulomas. Corticosteroids, methotrexate, azathioprine, intralesional corticosteroid injection can be used as the first step drugs in the treatment of patients with Idiopathic granulomatous mastitis, but the next step is unclear in a group of patients who are resistant to these treatments. Many of these patients also undergo unnecessary surgical interventions. Tumor necrosis factor-alpha (TNF-α) plays a role in maintaining the granuloma structure. There is few case reports and very limited data in the literature regarding TNF-α inhibitor treatment in resistant patients. Our aim is to show that TNF-α inhibitors may be an alternative for refractory patients in the treatment of idiopathic granulomatous mastitis.</p><p><strong>Methods: </strong>The data of 25 female patients with idiopathic granulomatous mastitis who were refractory to conventional therapies and started TNF-α inhibitors were retrospectively analyzed. Pre- and post-treatment M scores of the patients were calculated.</p><p><strong>Results: </strong>We observed that the M-scores of our patients decreased as the duration of TNF-α inhibitors use increased.</p><p><strong>Conclusion: </strong>Our study contains the largest number of patients with data on the use of TNF-α inhibitors in the treatment of idiopathic granulomatous mastitis. We believe that our study will contribute to the development of idiopathic granulomatous mastitis treatment algorithms. Key Points • TNF-α inhibitors may be an alternative for refractory patients in the treatment of idiopathic granulomatous mastitis.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2553-2560"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erysipelas-like erythema on elbow in a child with familial Mediterranean fever: an unexpected localization.","authors":"Selçuk Yüksel, Gülten Yüksel","doi":"10.1007/s10067-025-07432-w","DOIUrl":"10.1007/s10067-025-07432-w","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2575-2576"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B lymphocyte subset-based stratification in primary Sjögren's syndrome: implications for lymphoma risk and personalized treatment.","authors":"Xuan Qi, Doudou Zhao, Naidi Wang, Yipeng Han, Bo Huang, Ruiling Feng, Yuebo Jin, Ruoyi Wang, Xiang Lin, Jing He","doi":"10.1007/s10067-025-07434-8","DOIUrl":"10.1007/s10067-025-07434-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to perform a detailed stratification analysis of B lymphocyte subsets in patients with primary Sjögren's syndrome (pSS) and to investigate their associations with lymphoma risk, clinical phenotypes, and disease activity.</p><p><strong>Methods: </strong>In this retrospective study, we analyzed data from 137 patients with pSS. We employed machine learning approaches, specifically principal component analysis (PCA) and k-means clustering, to examine B lymphocyte subset distributions from flow cytometry data and immunoglobulin IgG and complement (C3, C4) levels. The optimal cluster number was determined using the Elbow Method in R software. Based on these 10 variables, patients were categorized into distinct subgroups. We then comprehensively compared clinical characteristics, laboratory parameters, and disease activity indices among these identified subgroups.</p><p><strong>Results: </strong>Four distinct subgroups were identified. Cluster A exhibited a significantly higher lymphoma incidence rate of 20%, compared to 3.39% in Cluster B and 0% in Clusters C and D (p = 0.007). Cluster A also had the highest percentage of double-negative B cells (32.26 ± 17.96%) and plasma cells (2.02 ± 1.92%). ESSDAI scores indicated that disease activity was highest in Cluster A (9.00, 6.00-20.00), followed by Clusters B (7.00, 3.50-14.00), C (6.00, 1.25-17.50), and D (5.00, 1.50-9.00), respectively.</p><p><strong>Conclusion: </strong>This innovative stratification method revealed the critical role of B cell subset imbalance in the pathogenesis of pSS and provided new evidence for predicting lymphoma risk and guiding personalized treatment. Key Points • Identifying a distinct patient subgroup with elevated lymphoma risk and increased disease activity could aid in risk prediction. • Applying machine learning techniques to stratify B cell populations provides insights into pSS pathogenesis. • A proposed framework for personalized treatment approaches based on B cell subset imbalances in pSS.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2403-2412"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis and the risk of sleep apnea: a general population-based cohort study.","authors":"Yanqiu Zhu, Qiao Jiang, Yuqing Zhang, Dongxing Xie, Zidan Yang, Na Lu, Chao Zeng, Guanghua Lei, Jie Wei, Tuo Yang","doi":"10.1007/s10067-025-07457-1","DOIUrl":"10.1007/s10067-025-07457-1","url":null,"abstract":"<p><strong>Objective: </strong>Osteoarthritis (OA) is the most common joint disease, leading to pain and inflammation, two risk factors for sleep apnea (SA). We aimed to examine whether OA may increase the risk of incident SA, a common source of mortality and sudden death.</p><p><strong>Method: </strong>Using data from the IQVIA Medical Research Database, we conducted three cohort studies (i.e., knee, hip, and hand cohort) among individuals aged 50 years or older. For each patient with incident OA, up to five non-OA individuals were matched by age, sex, entry-time, and BMI. We calculated the incidence rate of SA for the OA and non-OA cohorts, respectively, and examined the relation of OA to the risk of incident SA using a Cox proportional hazard model adjusting for potential confounders.</p><p><strong>Results: </strong>During the follow-up, 869 SA cases occurred in 58,674 patients with knee OA and 2,186 in 235,850 non-OA individuals (2.29 vs. 1.41/1000 person-years). Compared with the non-OA cohort, the multivariable-adjusted hazard ratio (HR) of SA in the knee OA cohort was 1.45 (95% confidence interval [CI]: 1.34-1.56). A higher risk of SA was also observed among patients with incident hip OA (adjusted HR: 1.45, 95%CI: 1.28-1.66) and hand OA (adjusted HR: 1.50, 95%CI: 1.26-1.78) than the matched non-OA individuals.</p><p><strong>Conclusions: </strong>This general population-based study provides the first evidence that patients with knee, hip, and hand OA may have an increased risk of incident SA. Strategies aimed at screening, prevention, and treatment of SA could be developed to reduce the disease burden in OA patients.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2109-2117"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of zoledronate for treating diffuse sclerosing osteomyelitis of the mandible in adult patients.","authors":"Junya Kusumoto, Shungo Furudoi, Yumi Muraki, Moeka Warabi, Daisuke Takeda, Masaya Akashi","doi":"10.1007/s10067-025-07438-4","DOIUrl":"10.1007/s10067-025-07438-4","url":null,"abstract":"<p><strong>Introduction: </strong>Diffuse sclerosing osteomyelitis (DSO) is a rare nonbacterial bone disease associated with recurrent pain and swelling, and its pathogenesis remains unknown. Despite the absence of an established treatment for DSO, bisphosphonates have recently been considered effective in managing this condition. However, the use of zoledronate is off-label, with limited reported cases. Therefore, this study aimed to investigate the effects of zoledronate on pain suppression in DSO.</p><p><strong>Methods: </strong>This single-arm retrospective study evaluated adult patients diagnosed with mandibular DSO and treated with zoledronate. Patient demographics, pain suppression effect, recurrence, number of zoledronate administration, adverse reactions to zoledronate, and imaging findings were investigated.</p><p><strong>Results: </strong>The study included 18 patients (median age of 59.5 years). Zoledronate effectively suppressed pain in all patients, with a median duration of effect onset of 1 day. Symptom recurrence was observed in 66.7% of patients, with a median time of 29 months from the first zoledronate administration to recurrence. Zoledronate was administered multiple times to 44.7% of patients. The median duration of response was 80 months for patients who experienced relief after a single administration of zoledronate compared to 32 months for those who received multiple administrations (p < 0.001). Adverse reactions, including flu-like symptoms, were observed in 72.2% of the patients, and no medication-related osteonecrosis of the jaw was observed during the follow-up period.</p><p><strong>Conclusions: </strong>Zoledronate is a relatively safe and effective treatment option for DSO of the mandible. Key Points • Zoledronate effectively suppresses pain in mandibular diffuse sclerosing osteomyelitis. • All condylar lesions recurred after zoledronate administration. • Patients with mandibular canal enlargement required multiple doses of zoledronate. • Adverse reactions to zoledronate administration were minor.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2463-2475"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's response to letter to editor.","authors":"Linlin Huang, Chen Chen, Yi Cheng, Lingbiao Wang, Wenjing Ye, Haihua Yang, Wanqin Wu, Sen Yang, Weiguo Wan, Xiaoxia Zhu, Yu Xue, Yiyun Yu, Xiangjun Chen, Hejian Zou, Minrui Liang","doi":"10.1007/s10067-025-07430-y","DOIUrl":"10.1007/s10067-025-07430-y","url":null,"abstract":"<p><p>Authors' Response to Letter to Editor from Yan Shen and Xianxian Fu.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2581-2582"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity, sedentary behaviour and health-related quality of life in 929 women with primary Raynaud's phenomenon.","authors":"Saskia Corine van de Zande, Karin Eijkelenkamp, Amaal Eman Abdulle, Andries Jan Smit, Johannes Zwerver, Inge van den Akker-Scheek, Douwe Johannes Mulder","doi":"10.1007/s10067-025-07416-w","DOIUrl":"10.1007/s10067-025-07416-w","url":null,"abstract":"<p><strong>Introduction: </strong>Women with primary Raynaud's phenomenon (RP) often experience a decreased health-related quality of life (HRQoL). A physically active lifestyle could improve vascular function and HRQoL.</p><p><strong>Objective: </strong>This study aimed to quantify the amount and type of physical activity (PA) and sedentary behaviour, as well as HRQoL and stress, in women with primary RP from a large population-based cohort (Lifelines).</p><p><strong>Methods: </strong>A total of 19,820 adult (≥ 18 years) women from the Lifelines cohort were included; 929 of these were classified as having RP based on the connective tissue disease (CTD) screening questionnaire. Participant characteristics, data on PA and sedentary behaviour, HRQoL and stress were retrieved from the database.</p><p><strong>Results: </strong>Women with RP reported 300 min/week minutes of moderate-to-vigorous physical activity (MVPA), which was more than women without RP (255 min/week, p ≤ .001). Women (74%) with RP complied to health enhancing PA guidelines (70% of women without RP, p = .003). Sedentary time was comparable. Women with RP had a low score on almost all eight domains of the HRQoL questionnaire. The Long-term Difficulties Inventory (LDI) showed a high stress level in the RP group (p < .001).</p><p><strong>Conclusion: </strong>Most women with RP reported to spent a sufficient amount of time on MVPA and thus comply to health enhancing PA guidelines. The PA and sedentary behaviour of women with RP seems comparable to that of women without RP. However, HRQoL was lower and stress levels were higher in women with RP; more research is needed to elucidate the relation between PA and HRQoL in RP. Key Points • Experiencing symptoms of Raynaud's phenomenon seem no obstacle for being physically active. • Focus on women with symptoms of Raynaud's phenomenon in a large cohort. • Nearly 75% of the women with symptoms of Raynaud's phenomenon comply to the physical activity guidelines. • Women with symptoms of Raynaud's phenomenon have low levels of health-related quality of life and experience a high stress level.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":"2101-2107"},"PeriodicalIF":2.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143961735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}