Knowledge mapping of plasmacytoid dendritic cells in systemic lupus erythematosus: a bibliometric analysis (2004-2023).

IF 2.8 3区医学 Q2 RHEUMATOLOGY

Clinical Rheumatology Pub Date : 2025-09-08 DOI:10.1007/s10067-025-07674-8

Yuan Tian, Kang Tao, Hongyan Zhou, Shifei Li, Xiaoqiang Chen, Mingwang Zhang, Zhifang Zhai

{"title":"Knowledge mapping of plasmacytoid dendritic cells in systemic lupus erythematosus: a bibliometric analysis (2004-2023).","authors":"Yuan Tian, Kang Tao, Hongyan Zhou, Shifei Li, Xiaoqiang Chen, Mingwang Zhang, Zhifang Zhai","doi":"10.1007/s10067-025-07674-8","DOIUrl":null,"url":null,"abstract":"Background: Plasmacytoid dendritic cells (pDCs) are a specialized subset of dendritic cells known for their ability to produce type I interferon (IFN I), contributing to antiviral defense and the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE). In SLE patients, pDCs are excessively activated, leading to overproduction of IFN-α, which plays a critical role in disease progression. However, no bibliometric analysis has been conducted on the relationship between pDCs and SLE. This study aims to map the knowledge structure and trends in research on pDCs in SLE through bibliometric analysis.Methods: We analyzed publications related to pDCs in SLE from 2004 to 2023 using the Web of Science Core Collection. Data were analyzed and visualized with VOSviewers, CiteSpace, and the R package bibliometrix, offering a comprehensive view of the research landscape.Results: The analysis included 1086 articles from 57 countries, with the USA leading in publication volume. Major contributing institutions include Uppsala University, University of Michigan, and Baylor Institute for Immunology Research. Among the 565 authors, Ronnblom Lars was the most prolific, while Elkon Keith B ranked highest in terms of network centrality. Key research themes focus on pDC mechanisms in SLE development and emerging therapeutic strategies. Trending topics include \"anifrolumab,\" \"mortality,\" and \"population.\"Conclusion: This bibliometric study provides a thorough overview of research trends on pDCs in SLE, identifying recent advances and key areas of interest, offering valuable insight for future research directions.Key points: • pDCs play a crucial role in systemic lupus erythematosus (SLE) through the overproduction of type I interferon (IFN-α). • This is the first bibliometric analysis mapping the research landscape of pDCs in SLE from 2004 to 2023. • Emerging research focuses on therapeutic strategies, including trending topics like \"anifrolumab\" and \"mortality\" in SLE. • This study offers valuable insights into key research themes and trends, guiding future investigations on pDCs in SLE.","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s10067-025-07674-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Plasmacytoid dendritic cells (pDCs) are a specialized subset of dendritic cells known for their ability to produce type I interferon (IFN I), contributing to antiviral defense and the pathogenesis of autoimmune diseases like systemic lupus erythematosus (SLE). In SLE patients, pDCs are excessively activated, leading to overproduction of IFN-α, which plays a critical role in disease progression. However, no bibliometric analysis has been conducted on the relationship between pDCs and SLE. This study aims to map the knowledge structure and trends in research on pDCs in SLE through bibliometric analysis.

Methods: We analyzed publications related to pDCs in SLE from 2004 to 2023 using the Web of Science Core Collection. Data were analyzed and visualized with VOSviewers, CiteSpace, and the R package bibliometrix, offering a comprehensive view of the research landscape.

Results: The analysis included 1086 articles from 57 countries, with the USA leading in publication volume. Major contributing institutions include Uppsala University, University of Michigan, and Baylor Institute for Immunology Research. Among the 565 authors, Ronnblom Lars was the most prolific, while Elkon Keith B ranked highest in terms of network centrality. Key research themes focus on pDC mechanisms in SLE development and emerging therapeutic strategies. Trending topics include "anifrolumab," "mortality," and "population."

Conclusion: This bibliometric study provides a thorough overview of research trends on pDCs in SLE, identifying recent advances and key areas of interest, offering valuable insight for future research directions.

Key points: • pDCs play a crucial role in systemic lupus erythematosus (SLE) through the overproduction of type I interferon (IFN-α). • This is the first bibliometric analysis mapping the research landscape of pDCs in SLE from 2004 to 2023. • Emerging research focuses on therapeutic strategies, including trending topics like "anifrolumab" and "mortality" in SLE. • This study offers valuable insights into key research themes and trends, guiding future investigations on pDCs in SLE.

查看原文本刊更多论文

系统性红斑狼疮患者浆细胞样树突状细胞的知识图谱：文献计量学分析（2004-2023）。

背景：浆细胞样树突状细胞（pDCs）是树突状细胞的一个特殊子集，以其产生I型干扰素（IFN I）的能力而闻名，有助于抗病毒防御和系统性红斑狼疮（SLE）等自身免疫性疾病的发病机制。在SLE患者中，pDCs被过度激活，导致IFN-α过量产生，而IFN-α在疾病进展中起着关键作用。然而，目前尚无文献计量学分析pDCs与SLE之间的关系。本研究旨在通过文献计量学分析，绘制SLE中pDCs研究的知识结构和趋势。方法：我们使用Web of Science Core Collection对2004年至2023年SLE中与pDCs相关的出版物进行分析。使用vosviewer、CiteSpace和R软件包bibliometrix对数据进行分析和可视化，提供了一个全面的研究景观视图。结果：分析纳入来自57个国家的1086篇文章，其中美国的发表数量最多。主要贡献机构包括乌普萨拉大学、密歇根大学和贝勒免疫学研究所。在565位作者中，Ronnblom Lars是最多产的，而Elkon Keith B在网络中心性方面排名最高。主要研究主题集中在狼疮发展中的pDC机制和新兴的治疗策略。热门话题包括“anifrolumab”、“死亡率”和“人口”。结论：这项文献计量学研究提供了系统性红斑狼疮中pDCs研究趋势的全面概述，确定了最近的进展和关键领域，为未来的研究方向提供了有价值的见解。•pDCs通过过量分泌I型干扰素（IFN-α）在系统性红斑狼疮（SLE）中发挥关键作用。•这是第一个文献计量分析，绘制了2004年至2023年SLE中pDCs的研究图景。•新兴研究侧重于治疗策略，包括SLE的“anifrolumab”和“死亡率”等热门话题。•本研究为关键研究主题和趋势提供了有价值的见解，指导了未来对SLE中pDCs的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Clinical Rheumatology 医学-风湿病学

CiteScore

6.90

自引率

2.90%

发文量

441

审稿时长

3 months

期刊介绍： Clinical Rheumatology is an international English-language journal devoted to publishing original clinical investigation and research in the general field of rheumatology with accent on clinical aspects at postgraduate level. The journal succeeds Acta Rheumatologica Belgica, originally founded in 1945 as the official journal of the Belgian Rheumatology Society. Clinical Rheumatology aims to cover all modern trends in clinical and experimental research as well as the management and evaluation of diagnostic and treatment procedures connected with the inflammatory, immunologic, metabolic, genetic and degenerative soft and hard connective tissue diseases.