Clinical Rheumatology最新文献

{"title":"Rare presentation of immunoglobulin G4-related disease as tracheal stenosis: a case report and review of the literature.","authors":"Emine Büşra Ata, Emre Tekgöz, Seda Çolak, Ebru Karaçalı, Fatih Mehmet Doğan, Muhammet Çınar, Sedat Yılmaz","doi":"10.1007/s10067-025-07541-6","DOIUrl":"https://doi.org/10.1007/s10067-025-07541-6","url":null,"abstract":"<p><p>Immunoglobulin G4-related disease (IgG4- RD) is a systemic inflammatory condition that can affect any part of the body, although airway involvements are rarely seen. Herein, we report a case of young female with tracheal involvement associated with IgG4-RD. She was a 16-year-old patient admitted to the hospital with dyspnea and treated with methylprednisolone and methotrexate. We reviewed the clinical characteristics of 18 previously reported cases of tracheal stenosis with IgG4-RD. The most common symptoms were dyspnea (63.2%), cough, and wheezing. Nine patients (47.4%) had isolated tracheal involvement, and five (26.3%) had organ involvement other than airway disease. Most of the patients (14, 73.7%) received systemic glucocorticoid therapy for remission induction, while surgical procedures (10, 52.6%) were the second preferred treatment options. No relapse was observed in any patient who received immunosuppressives and disease-modifying antirheumatic drugs (DMARDs) such as methotrexate, rituximab, azathioprine, tocilizumab, and cyclophosphamide during or after remission induction therapy. In conclusion, IgG4-RD should be kept in mind in the differential diagnosis of patients presenting with clinical findings of tracheal stenosis. This study has shown that although most IgG4-RD patients with tracheal stenosis are controlled with glucocorticoids or surgical procedures, steroid-sparing agents may be needed to prevent relapses.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relation between radiographic knee osteoarthritis severity and pain is stronger among more frail people.","authors":"Carson Halliwell, Sophie E Rayner, Jocelyn Waghorn, Brett Feltmate, Rebecca Moyer, Myles W O'Brien","doi":"10.1007/s10067-025-07546-1","DOIUrl":"https://doi.org/10.1007/s10067-025-07546-1","url":null,"abstract":"<p><strong>Introduction/objectives: </strong>Knee osteoarthritis is a leading cause of disability in older adults; with treatment complicated by inconsistent associations between radiographic and symptomatic severity. Frailty describes the heterogeneity in aging and is quantified via the accumulation of health deficits. We test if frailty moderates the relation between radiographic and symptomatic knee osteoarthritis.</p><p><strong>Method: </strong>This cohort study included participants (n = 3,271; 58% female, 45-79 years) from the Osteoarthritis Initiative were included. Radiographic severity was assessed using the Kellgren-Lawrence Grade (KLG). Frailty was quantified via a 31-item frailty index, categorizing participants as non-frail (≤ 0.10), very mild frailty (< 0.1-to- ≤ 0.2), mild frailty (< 0.2-to- ≤ 0.3), and moderate-to-severe frailty (> 0.3). Self-reported pain was assessed via the Knee Injury and Osteoarthritis Outcome Score (KOOS). Moderation models using generalized estimating equations adjusted for age, sex, and body mass index were performed to test the interaction between frailty and KLG on KOOS pain scores.</p><p><strong>Results: </strong>Radiographic severity (β = -3.82, 95%CI: -4.16:-3.49; p < 0.001) and frailty (β = -4.76, 95%CI: -5.36:-4.17; p < 0.001) were negatively associated with KOOS pain scores. Frailty moderated this relation (interaction term: β = -1.18, 95%CI: -1.63:-0.73, p < 0.001), where higher frailty strengthened the association between radiographic severity and pain. Simple slopes analysis indicated stronger associations between KLG and KOOS pain scores in participants with mild to moderate-to-severe frailty compared to non-frail and very mild frailty (non-frail: β = -2.71, 95%CI: -3.41:-2.02, p < 0.001; moderate-to-severe frailty: β = -5.57, 95%CI: -7.23:-3.87, p < 0.001).</p><p><strong>Conclusion: </strong>These findings underscore the importance of incorporating frailty assessments into knee osteoarthritis management, as individuals with similar radiographic severity may experience substantially worse pain if they have higher frailty levels.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehospitalization to evaluate outcomes during clinical courses in patients with elderly-onset idiopathic inflammatory myositis: a retrospective single-center study.","authors":"Jun-Ichi Kurashina, Yasuhiro Shimojima, Dai Kishida, Takanori Ichikawa, Yoshiki Sekijima","doi":"10.1007/s10067-025-07540-7","DOIUrl":"https://doi.org/10.1007/s10067-025-07540-7","url":null,"abstract":"<p><strong>Objectives: </strong>The features of rehospitalization, associated with the long-term clinical outcome, remain uncertain in idiopathic inflammatory myositis (IIM). We evaluated the frequency and causes of rehospitalization in patients with elderly (≥ 65 years)-onset IIM, EOM compared to those with young (< 65 years)-onset IIM (YOM).</p><p><strong>Method: </strong>Electronic medical records of patients with IIM were reviewed over 6 years. Rehospitalization was defined as first admission during outpatient care following successful induction and maintenance of IIM treatment. Opportunities, causes, and relevant factors for hospitalization were obtained for patients with EOM and those with YOM.</p><p><strong>Results: </strong>There were 108 patients identified: 34 with EOM (median age, 71 years; 22 women) and 74 with YOM (median age, 49 years; 52 women). Rehospitalization was significantly higher in patients with EOM (n = 25, 73.5%) compared to those with YOM (n = 36, 48.6%) during a 2-year observation period (p < 0.05). In the rehospitalized patients with EOM, there was a significantly lower deterioration in disease activity (n = 8; p < 0.05) but higher incidence of infections present (n = 5; p < 0.05) compared to those with YOM. The Cox proportional hazards model indicated a significant association between increased age and rehospitalization (hazard ratio, 1.024; 95% confidence interval, 1006‒1.042; p < 0.05).</p><p><strong>Conclusions: </strong>Patients with EOM were more likely to experience rehospitalization, and infections were identified more significantly compared to those with YOM. These findings may be useful for managing the long-term clinical outcome in IIM. Key Points • Patients with elderly-onset idiopathic inflammatory myositis (IIM) are more likely to be rehospitalized than those with young-onset IIM. • Among patients who experienced rehospitalization, those with elderly-onset IIM had a significantly higher rate of remission than those with young-onset IIM. • As a cause of rehospitalization, infections were significantly more common in patients with elderly-onset IIM than in those with young-onset IIM.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying clinically relevant subgroups of patients with knee pain flares for ibuprofen treatment: a secondary analysis.","authors":"R U Sharma, J Runhaar, P K Bos, D M J Dorleijn, P J E Bindels, S M A Bierma-Zeinstra","doi":"10.1007/s10067-025-07539-0","DOIUrl":"https://doi.org/10.1007/s10067-025-07539-0","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate whether subgroups with more severe inflammatory symptoms during a knee pain flare benefited more from a high dose ibuprofen treatment than subgroups with less severe inflammatory symptoms.</p><p><strong>Methods: </strong>This secondary analysis included adults with ≥ 1 flares of knee pain in the last year, who experienced a new episode within 24 h and randomized into two treatment groups of daily ibuprofen 1200 mg or 2400 mg for 5 days. A multilevel regression analysis was used to assess interaction effects between intervention groups and pre-defined subgroups, based on osteoarthritis related symptoms (severity of morning stiffness, swelling, and pain). The primary outcome was the difference in treatment effect between subgroups on pain severity (0-10 on the numeric rating scale (NRS)) after 5 days. Differences in treatment effect between subgroups after 3 days (NRS) and 5 days (Western Ontario and McMaster Universities Osteoarthritis (WOMAC) scale) were secondary outcomes.</p><p><strong>Results: </strong>Participants (N = 308) had a mean age of 52.4 ± 12.9 (SD) years with 41% female subjects. No significant interaction was found between the pre-defined subgroups and intervention groups on pain severity after day 5 (all p-values ≥ 0.28) or on the secondary outcomes (all p-values ≥ 0.38). Given the potential lack of power, the absolute and adjusted mean differences between treatment arms were compared for each subgroup; none of the differences reached clinical significance.</p><p><strong>Conclusion: </strong>Between subgroups with more and less severe inflammatory symptoms during knee pain flares, no significant nor clinical benefit was found from a higher dose of ibuprofen compared to a lower dose. Keypoints • Despite the overall superiority of the higher dose, patients with severe inflammatory knee symptoms do not benefit more from an anti-inflammatory dose of ibuprofen than patients with less severe symptoms. • A higher dose of ibuprofen is not indicated for patients with severe inflammatory knee symptoms. • Given the heterogeneity among patients with knee osteoarthritis, potential subgroups should be explored in future research.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical variables and lung ultrasonography for the screening of interstitial lung disease in patients with rheumatoid arthritis.","authors":"Schneeberger Emilce Edith, Perandones Miguel, Rosemffet Marcos Gabriel, Otaola María, Cazenave Tomás, Barbich Tatiana, Carrizo Abarza Virginia, Balcazar Jonathan, Citera Gustavo","doi":"10.1007/s10067-025-07510-z","DOIUrl":"https://doi.org/10.1007/s10067-025-07510-z","url":null,"abstract":"<p><p>The best screening way to detect interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA) is still debated.</p><p><strong>Objectives: </strong>To evaluate the performance of scores to identify patients with ILD in patients with RA.</p><p><strong>Methods: </strong>Cross-sectional study, adult outpatients with RA were included and those with any disease that can affect lung ultrasonography (LUS) evaluation were excluded. Sociodemographic, clinical, and therapeutic variables were recorded. All patients underwent chest x-rays, pulmonary function tests (PFT), LUS, and high-resolution chest tomography (HRCT). Univariate and multivariate analyses and ROC curves.</p><p><strong>Results: </strong>107 patients with RA, median age of 62 years (IQR 36-84), 82.2% female, and median disease duration 14 years (IQR 1-42). A total of 30 patients (29.5%) had ILD by HRCT. The classic cutoff value of ≥ 5 B lines in the LUS (ILD by HRCT as the gold standard) showed an AUC of 0.86 (95% CI 0.78-0.94), Se 87.1%, and Sp 74.3% for the detection of ILD. A clinical score made up of 5 variables to identify the presence of ILD, based on the strength of association in the multivariate analysis: male sex, crackles, age ≥ 60 years, RF + , anti-CCP + . Range 0-11, cutoff value ≥ 5.5, AUC 0.80 (95% CI 0.70-0.89), Se 75%, and Sp 71%. When we added the LUS variable to this score: lines B ≥ 5, the range was 0-15, a cutoff value ≥ 7.5, AUC 0.88 (95% CI 0.81-0.94), Se improved to 84.4%, and Sp 75%. However, this last score did not exceed the performance of isolated LUS.</p><p><strong>Conclusions: </strong>LUS is a good tool for detecting ILD in patients with RA. Key Points • Interstitial lung disease (ILD) is an extra-musculoskeletal manifestation with high morbidity and mortality in patients with rheumatoid arthritis (RA). Early detection could improve the prognosis of these patients. • High-resolution chest tomography (HRCT) is the gold standard for ILD diagnosis, but high radiation and limited access hinder its use. • Lung ultrasound (LUS) is an excellent tool for detecting ILD in RA patients and performs better than clinical scores. • LUS provides a method of screening for ILD in patients with RA in a simple, cheap, safe, and effective way.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Reflections on idiopathic granulomatous mastitis.","authors":"Pin Wang","doi":"10.1007/s10067-025-07547-0","DOIUrl":"https://doi.org/10.1007/s10067-025-07547-0","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical value of metagenomic next-generation sequencing in patients with connective tissue diseases co-infections: a single-center study from southern hospital in China.","authors":"Yuan-Yuan Xiao, Ai-Ling Lu, Han-You Mo, Zhen-Dong He, Jia-Le Wen, Xuan Yin","doi":"10.1007/s10067-025-07525-6","DOIUrl":"10.1007/s10067-025-07525-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the clinical value of metagenomic next-generation sequencing (mNGS) in patients with connective tissue diseases (CTDs) co-infections, thereby establishing a foundation for early infection identification and the development of anti-infective regimens.</p><p><strong>Methods: </strong>This retrospective study analyzed 304 CTD patients with suspected infections at the First Affiliated Hospital of Guangxi Medical University between October 2020 and April 2024. The study compared the diagnostic efficacy between mNGS and conventional microbiological testing (CMT), examined pathogen detection rates across different periods and pathogen types, and evaluated the clinical outcomes of mNGS-guided antimicrobial regimen adjustments.</p><p><strong>Results: </strong>Among the 180 confirmed infections (Group I), mNGS demonstrated superior diagnostic performance compared to conventional microbiological testing (CMT). mNGS exhibited significantly higher sensitivity (89.6% vs. 57.0%; OR = 6.5, 95% CI: 3.7-11.0, p < 0.001), with a specificity of 81.5%, positive predictive value (PPV) of 97.2%, and negative predictive value (NPV) of 52.4%. mNGS outperformed CMT in detecting bacterial and viral pathogens (p < 0.05). Viral infections were the most common. Compared to prior studies, mNGS exhibited improved pathogen detection rates. mNGS-guided treatment optimization significantly enhanced clinical outcomes, with higher cure rates, lower mortality, and shorter hospital stays.</p><p><strong>Conclusion: </strong>Current evidence suggests that while mNGS demonstrates superior diagnostic performance over CMT for detecting infections in CTD patients, their combined use provides optimal pathogen identification accuracy and enhanced clinical management. Key Points • This is the larger-scale retrospective study of mNGS application in patients with CTDs co-infections following the Coronavirus Disease 2019 (COVID-19). • We found that the distribution of pathogens and positivity rates have changed in recent years, especially after the COVID-19. • The clinical value of mNGS was further demonstrated through its impact of mNGS results on antibiotic regimens and the analysis of negative samples.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying common genes and immune infiltration characteristics between systemic sclerosis and atherosclerosis.","authors":"Yanqing Pan, Binbing Shi, Fangnan Zang, Yi Ji, Xiuli Zhang, Changxi Zhang, Qi Sun, Chenyang Li, Hong Zhu, Defeng Pan","doi":"10.1007/s10067-025-07479-9","DOIUrl":"10.1007/s10067-025-07479-9","url":null,"abstract":"<p><strong>Background: </strong>Clinical and epidemiological studies suggest a notably higher incidence of atherosclerosis (AS) in systemic sclerosis (SSc) patients, yet their shared molecular mechanisms remain unclear. Therefore, this research was designed to investigate the shared pathogenic mechanisms underlying both SSc and AS.</p><p><strong>Methods: </strong>SSc and AS datasets were acquired from the Gene Expression Omnibus (GEO) database to identify common differentially expressed genes (DEGs). Subsequently, enrichment analyses, protein-protein interaction (PPI) network analysis, coexpression analysis, and TF-mRNA-miRNA regulatory network construction were performed on these common DEGs. Finally, the hub genes were validated using external datasets. Additionally, immune cell infiltration in both SSc and AS was analyzed via the CIBERSORT algorithm, and the relationships between hub genes and immune cell infiltration were assessed.</p><p><strong>Results: </strong>A total of 104 DEGs were identified, with 99 upregulated and 5 downregulated genes. Functional enrichment analysis indicated that the pathogenic mechanisms of these genes are related to immune processes. Through comprehensive bioinformatics analysis, three hub genes (ITGB2, CD163, and CCR5) were identified. Comparative analysis revealed marked upregulation of these genes in pathological specimens relative to controls, highlighting their diagnostic biomarker potential. Furthermore, immune profiling demonstrated macrophage and T lymphocyte predominance in disease microenvironments, implicating these immune populations in SSc and AS pathogenesis.</p><p><strong>Conclusion: </strong>Our study revealed common biomarkers and immune-related pathways that may contribute to the pathogenesis of both SSc and AS. These findings suggest potential immunological mechanisms underlying the development of AS in patients with SSc, providing new insights into the pathological links between these two diseases. Key Points • ITGB2, CD163, and CCR5 may be new diagnostic biomarkers for SSc and AS. • Macrophages and T lymphocytes as key mediators in SSc and AS pathogenesis.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication effects on uric acid levels in rheumatoid arthritis studies.","authors":"Amir Reza Akbari, Benyamin Alam","doi":"10.1007/s10067-025-07538-1","DOIUrl":"10.1007/s10067-025-07538-1","url":null,"abstract":"","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hip denervation: an approach for relieving pain, restoring function, and reducing inflammation in juvenile idiopathic arthritis patients.","authors":"Khalifa A, Elsaman A M, Hamed M, Aly H, Maaty A","doi":"10.1007/s10067-025-07490-0","DOIUrl":"https://doi.org/10.1007/s10067-025-07490-0","url":null,"abstract":"<p><strong>Background: </strong>Juvenile idiopathic arthritis (JIA) frequently involves the hip joint, leading to significant pain, functional impairment, and long-term joint damage. Conventional treatment strategies, including pharmacologic therapy and intra-articular injections, may not provide adequate control. Hip denervation (HD) has emerged as a potential interventional approach for pain management in various musculoskeletal conditions, but its role in JIA-associated hip arthritis remains unclear. This study aimed to evaluate the effect of HD in JIA patients with unilateral hip arthritis on pain, function, and inflammatory parameters.</p><p><strong>Methods: </strong>One hundred twenty JIA patients were diagnosed according to the ILAR criteria with unilateral hip arthritis. They were assigned randomly into three groups: group 1 received hip denervation, group 2 received subcutaneous saline, and group 3 received intra-articular triamcinolone. Visual analog scale (VAS), sonography of large joints in rheumatology (SOLAR) score, tenderness, and Harris Hip score (HHS) were assessed at 0-, 2-, and 16-week intervals. Tenderness was evaluated by a semi-quantitative score at the same intervals. Juvenile Arthritis Disease Activity Score (JADAS) was assessed at baseline.</p><p><strong>Results: </strong>Over the 16-week study period, HD delivered remarkable outcomes, with VAS dropping from 5.48 ± 2.04 at baseline to 0.83 ± 0.50 (p < 0.0001), tenderness scores decreasing from 1.80 ± 0.82 to 0.80 ± 0.41 (p < 0.0001), and SOLAR score significantly reduced from 1.38 ± 0.59 to 0.15 ± 0.06 (p < 0.0001). Functional recovery was equally impressive, as HHS soared from 59.60 ± 9.89 to 83.27 ± 6.42 (p < 0.0001), surpassing outcomes seen with intra-articular steroids and placebo. Favorable responses were strongly associated with shorter disease duration, higher baseline VAS and SOLAR scores, and the oligoarticular subtype, while RF positivity predicted diminished improvement.</p><p><strong>Conclusion: </strong>Hip denervation showed promising results in regaining functions, alleviating pain, tenderness, and inflammation of the hip joint in JIA patients. Key Points • This study is the first to evaluate HD in JIA, showing its potential to alleviate pain, improve function, and reduce inflammation. • HD demonstrated sustained benefits at 16 weeks, surpassing intra-articular steroids in controlling symptoms and modifying the inflammatory cascade. • It offers a minimally invasive, effective alternative for JIA-related hip arthritis, addressing the limitations of conventional therapies.</p>","PeriodicalId":10482,"journal":{"name":"Clinical Rheumatology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}