Association of the ABCG2 Q141K variant with gout in Kinh Vietnamese: a cross-sectional study.

Abstract

Background: Gout is a form of microcrystalline arthritis caused by chronic hyperuricemia, leading to monosodium urate crystal deposition. The ABCG2 gene, particularly the Q141K polymorphism, is a significant genetic factor influencing gout susceptibility and the therapeutic response to allopurinol. However, the association of Q141K with gout in the Vietnamese population remains undefined. This study investigates the relationship between the ABCG2 Q141K polymorphism and gout susceptibility among Kinh Vietnamese individuals.

Materials and methods: This cross-sectional study includes 468 participants, comprising 234 gout patients and 234 controls. The basic clinical and paraclinical characteristics of all the participants were collected. Genomic DNA was extracted from peripheral blood samples and genotyped for the ABCG2 Q141K polymorphism using real-time PCR. The association of ABCG2 Q141K with gout and clinical characteristics was analyzed.

Results: The ABCG2 Q141K polymorphism is significantly associated with gout in dominant, recessive, and additive genetic models. Specifically, the A allele was identified as a risk factor, observed in 46.8% of gout patients compared to 25% of healthy controls.

Conclusion: The ABCG2 Q141K polymorphism significantly increases gout susceptibility among the Kinh Vietnamese population. The high frequency of the A allele in Vietnamese gout patients highlights the potential utility of genetic screening for appropriate preventive strategies. Key Points • The data regarding the contributions of genetic factors in gout of Vietnamese population remain insufficient. • This study showed that the ABCG2 Q141K polymorphism significantly increases gout susceptibility among the Kinh Vietnamese population.