Clinical Research in Cardiology最新文献

{"title":"Predictive value of Shanghai score system in patients with drug-induced type 1 Brugada electrocardiographic pattern.","authors":"Vincenzo Russo, Alfredo Caturano, Federico Migliore, Federico Guerra, Pietro Francia, Martina Nesti, Giulio Conte, Alessandro Paoletti Perini, Giuseppe Mascia, Stefano Albani, Procolo Marchese, Vincenzo Ezio Santobuono, Gregory Dendramis, Andrea Rossi, Andrea Ottonelli Ghidini, Pasquale Notarstefano, Luigi Sciarra, Zefferino Palamà, Enrico Baldi, Roberto Floris, Gerardo Nigro","doi":"10.1007/s00392-025-02738-w","DOIUrl":"https://doi.org/10.1007/s00392-025-02738-w","url":null,"abstract":"<p><strong>Background: </strong>The Shanghai score system was developed to enhance the risk stratification in Brugada Syndrome (BrS); however, its prognostic value in drug-induced type 1 BrS remains unclear.</p><p><strong>Methods: </strong>This study involved 698 patients with drug-induced type 1 BrS, confirmed via pharmacologic challenge (flecainide or ajmaline), from 21 centers in Italy and Switzerland. Patients were classified according to the Shanghai score system: probable/definite BrS (score ≥ 3.5) and possible BrS (score < 3.5). The primary outcome was appropriate ICD therapy or sudden cardiac death (SCD)/sustained ventricular arrhythmias; the secondary outcome includes the identification of clinical predictors of primary outcome events. Kaplan-Meier and Cox regression analyses were used.</p><p><strong>Results: </strong>Our study population included 239 patients (34.2%) with probable/definite BrS and 459 (65.8%) patients with possible BrS. During a median follow-up of 57.4 months, 20 patients (2.9%) experienced the primary outcome. Kaplan-Meier analysis revealed a significantly lower event rate in possible BrS (0.11% over 10 years) compared to probable/definite BrS (0.42%). SCN5A pathogenic variants were a significant predictor of primary endpoint in the possible BrS group (OR: 12.5).</p><p><strong>Conclusions: </strong>Shanghai score system for BrS diagnosis may be useful as a tool for risk stratification of life-threatening arrhythmias among patients with drug-induced type I BrS ECG. Identifying the SCN5A mutations is of pivotal importance for refining the risk stratification.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-reactive protein-to-albumin ratio in transcatheter tricuspid valve repair: methodological concerns and ınconsistencies.","authors":"Çağrı Zorlu","doi":"10.1007/s00392-025-02760-y","DOIUrl":"https://doi.org/10.1007/s00392-025-02760-y","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of age on outcomes after transcatheter tricuspid valve edge-to-edge repair: insights from EuroTR.","authors":"Julia Novotny, Lukas Stolz, Karl-Patrik Kresoja, Jennifer von Stein, Vera Fortmeier, Christoph Pauschinger, Wolfgang Rottbauer, Mohammad Kassar, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, Andreas Rück, Monika Zdanyte, Marianna Adamo, Philipp M Doldi, Ludwig T Weckbach, Thomas J Stocker, Flavien Vincent, Philipp Schlegel, Sebastian Rosch, Mirjam G Wild, Christian Besler, Stefan Toggweiler, Stephanie Brunner, Julia Grapsa, Tiffany Patterson, Holger Thiele, Tobias Kister, Giuseppe Tarantini, Giulia Masiero, Marco De Carlo, Alessandro Sticchi, Fabian Voss, Amin Polzin, Antonio Popolo Rubbio, Francesco Bedogni, Mathias H Konstandin, Eric Van Belle, Marco Metra, Tobias Geisler, Rodrigo Estévez-Loureiro, Amir Abbas Mahabadi, Nicole Karam, Francesco Maisano, Philipp Lauten, Fabien Praz, Mirjam Kessler, Daniel Kalbacher, Volker Rudolph, Christos Iliadis, Philipp Lurz, Jörg Hausleiter","doi":"10.1007/s00392-025-02702-8","DOIUrl":"https://doi.org/10.1007/s00392-025-02702-8","url":null,"abstract":"<p><strong>Objective: </strong>Age stratified data regarding symptomatic and survival outcome of patients undergoing transcatheter tricuspid valve edge-to-edge repair (T-TEER) for severe tricuspid regurgitation (TR) are scarce. Aim of this study was to evaluate TR reduction, symptomatic outcomes, and survival following T-TEER stratified by patient age at intervention.</p><p><strong>Methods: </strong>Using data from the large European Registry of Transcatheter Repair for Tricuspid Regurgitation (EuroTR registry, NCT06307262) we investigated the impact of patient age at intervention on procedural TR reduction, clinical outcome according to New York Heart Association (NYHA) class at latest available follow-up and two-year survival as well as two-year survival free from hospitalization for heart failure (HHF).</p><p><strong>Results: </strong>The study included 2340 patients divided into four groups according to quartiles of age at intervention (1st quartile: 668 patients [69.9 ± 7.2 years] up to 4th quartile: 561 patients [86.2 ± 2.2 years]). Most common TR etiology in all groups was secondary TR with 83.6%-90.1%. TR reduction from baseline to discharge was similar in all groups (TR ≤2+ 77.3% 1st quartile, 82% 2nd quartile, 79.5% 3rd quartile and 82.8% 4th quartile, p = 0.085). TR severity at follow-up was also comparable (TR ≤2+ 68.1% 1st quartile, 72.1% 2nd quartile, 76.7% 3rd quartile and 73.7% 4th quartile, p = 0.135). Regarding NYHA class patients in all groups benefited equally. Overall two-year survival and two-year survival free from HHF after intervention did not differ between age groups.</p><p><strong>Conclusions: </strong>T-TEER effectively reduces TR in elderly patients. Irrespective of age, patients showed symptomatic benefit and comparable two-year survival free from HHF.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroids reduce pacemaker implantation after alcohol septal ablation in oHCM patients.","authors":"Max Potratz, Kawa Mohemed, Cédric Coppée, Lothar Faber, Volker Rudolph, Charles Davidson, Jan-Christian Reil, Smita Scholtz","doi":"10.1007/s00392-025-02752-y","DOIUrl":"https://doi.org/10.1007/s00392-025-02752-y","url":null,"abstract":"<p><strong>Background: </strong>Alcohol septal ablation (ASA) is a valuable treatment option for patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). While generally safe, ASA can lead to conduction abnormalities, including complete atrioventricular block (CHB), potentially necessitating permanent pacemaker implantation. This study investigated the impact of post-procedural corticosteroid administration on the need for permanent pacemaker implantation in oHCM patients who developed complete heart block after ASA.</p><p><strong>Methods: </strong>From a single-center cohort of 512 consecutive patients undergoing alcohol septal ablation (ASA) between 2005 and 2023, we retrospectively analyzed the 82 patients (16%) who developed complete atrioventricular (AV) block. Patients received either oral prednisolone (1 mg/kg) for at least three days or no corticosteroid therapy at the discretion of the physician. The primary endpoint was the need for permanent pacemaker implantation during the index hospitalization.</p><p><strong>Results: </strong>Permanent pacemaker implantation was required in 25 of the 82 patients (30.5%). The incidence of PPM implantation was significantly lower in the corticosteroid group (7 of 41 patients; 17.1%) compared to the no-corticosteroid group (18 of 41 patients; 43.9%; p = 0.008). After multivariable adjustment, corticosteroid use was independently associated with a significantly lower risk of pacemaker implantation (OR: 0.21, 95% CI: 0.07-0.66, p = 0.007).</p><p><strong>Conclusion: </strong>In this retrospective analysis, post-procedural corticosteroid administration was associated with a significant reduction in the need for permanent pacemaker implantation in oHCM patients with CHB after ASA. Further research is needed to confirm these findings and establish optimal corticosteroid treatment protocols.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DGK Herztage 2025 : 25.-27. September 2025, Congress Center Hamburg.","authors":"","doi":"10.1007/s00392-025-02737-x","DOIUrl":"https://doi.org/10.1007/s00392-025-02737-x","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of oscillatory whole-body vibration training on exercise capacity and physical performance in aortic valve stenosis patients prior to transcatheter aortic valve implantation: a randomized clinical trial.","authors":"Johannes Klaus, Felix Gerhardt, Stephan Nienaber, Victor Mauri, Kathrin Möllenhoff, Richard Nies, Elmar Kuhn, Stephen Gerfer, Ilija Djordjevic, Samuel Lee, Henning Guthoff, Christos Iliadis, Stephan Baldus, Christopher Hohmann, Matti Adam, Hendrik Wienemann","doi":"10.1007/s00392-025-02744-y","DOIUrl":"https://doi.org/10.1007/s00392-025-02744-y","url":null,"abstract":"<p><strong>Background: </strong>Exercise training is generally discouraged in patients with severe symptomatic aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) due to safety concerns. However, whole-body vibration (WBV) exercise could offer a novel approach to improve exercise capacity and quality of life, though its effects remain unclear in this population.</p><p><strong>Methods: </strong>Thirty patients with AS scheduled for TAVI were prospectively and randomly assigned to either the WBV group (12 sessions, 30 min each over 4 weeks) or a control group. Assessments of cardiopulmonary exercise testing (CPET), 6-min walking distance (6MWD) and health-related quality of life (HRQoL) questionnaires were conducted at baseline (V1), one day before TAVI (V2) and at short-term follow-up (V3). WBV was conducted between V1 and V2.</p><p><strong>Results: </strong>For the analysis at V1 and V2 16 patients in the WBV group and 14 in the control group were included. Mean age was 79.7 ± 5.22 years, with a mean aortic valve area of 0.75 ± 0.21 cm². Peak V'O₂ increased by 0.3 mL*min^-1*kg^-1 in the WBV group versus a decrease of - 1.4 mL*min^-1*kg^-1 in the control group (difference, 1.7 mL*min^-1*kg^-1; 95% CI, [0.2 to 3.2], p = 0.03). Peak power improved by 5.1 W in the WBV group compared to a decline of - 4.5 W in the control group (difference, 9.6 W; 95% CI, [2.1 to 17.1], p = 0.01). The WBV group also showed a non-significant improvement in 6MWD (34 m vs. - 8 m in the control group; difference, 42 m; 95% CI, [-10 to 93], p = 0.11). No serious adverse events occurred in the WBV group.</p><p><strong>Conclusion: </strong>This pilot study demonstrated that a WBV exercise program is feasible, safe, and showed potential to preserve exercise capacity as well as physical performance in AS patients scheduled for TAVI.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Stent Expansion Indices for Predicting Outcomes in PCI of Calcified Coronary Lesions.","authors":"Eleni Ntantou, Alexandros A Siskos, William Camilleri, Martin Roos, Quinten Wolff, Thomas Kok, Isabella Kardys, Joost Daemen, Roberto Diletti, Jeroen M Wilschut, Rutger-Jan Nuis, Nicolas M Van Mieghem, Wijnand K den Dekker","doi":"10.1007/s00392-025-02753-x","DOIUrl":"https://doi.org/10.1007/s00392-025-02753-x","url":null,"abstract":"<p><strong>Background: </strong>There is a lack of established stent expansion criteria to predict long-term outcomes following percutaneous coronary intervention (PCI) in calcified coronary lesions.</p><p><strong>Aims: </strong>The aim of this study was to evaluate the relationship between various stent expansion indices and clinical outcomes including target lesion failure (TLF) following PCI in patients with calcified coronary lesions.</p><p><strong>Methods: </strong>This study was a retrospective single-center study. Patients with native calcified coronary artery lesions treated with imaging guided PCI and the availability of final intravascular ultrasound or optical coherence tomography images were included. The association between eight stent expansion indices and long-term TLF was evaluated.</p><p><strong>Results: </strong>A total of 280 lesions from 221 patients were analyzed. The median patient age was 71 years (Interquartile Range: 63-77), and 155 (70.1%) were male. Of the eight stent expansion indices, only the minimum stent area (MSA) > 100% of distal reference lumen area (HR 0.29; 95% CI 0.13-0.65; p = 0.003), MSA > 90% of distal reference area (HR 0.45; 95% CI 0.25-0.84; p = 0.012) and MSA > 5.0 mm² or > 90% of distal reference lumen area criteria (HR 0.41; 95% CI 0.22-0.75; p = 0.004) demonstrated a significant association with lower risk of long-term TLF.</p><p><strong>Conclusions: </strong>In the present retrospective analysis, a final MSA > 100% relative to the distal reference lumen area and MSA > 5.0 mm² or > 90% of distal reference lumen area criteria were most accurate in predicting TLF after PCI of calcified coronary lesions.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote assessment of coronary stenosis - a valid alternative to invasive testing for non-culprit lesions?","authors":"Ulrike Baumer, Maria-Luisa Straßmeir, Lorenz Koller, Alexander Niessner","doi":"10.1007/s00392-025-02754-w","DOIUrl":"https://doi.org/10.1007/s00392-025-02754-w","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right-sided cardiogenic shock from acute pulmonary tumor thrombotic microangiopathy: a rare but deadly cardio-oncologic and metabolic emergency.","authors":"Stefanie Andreß, Rima Melnic, Hannes Christow, Dominik Buckert, Philipp Marcel Jan Mohr, Benjamin Mayer, Wolfgang Rottbauer, Armin Imhof, Sascha d'Almeida","doi":"10.1007/s00392-025-02746-w","DOIUrl":"https://doi.org/10.1007/s00392-025-02746-w","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal but treatable condition characterized by the rapid development of pulmonary hypertension (PH) in patients with possibly unknown adenocarcinoma. PTTM is mostly diagnosed post-mortem and considered a rare disease since its acute onset and misdiagnosis provides significant diagnostic and therapeutic challenges.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We conducted a retrospective analysis of patients who presented with unclear sudden cardiac death and acute right heart failure that had an incidental very recent or unknown malignant cancer, identified eight patients with PTTM and reported the results. Patients were considered from 2009 to 2024 and analyzed at Ulm University Heart Center, Germany with the aim to describe the fatal consequences of unknown acute PTTM with right heart failure and discuss diagnostic and therapeutic strategies.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The median age was 47 years (41-84 years); gender was equally distributed. The latest median body mass index (BMI) was elevated with 28.4 kg/m&lt;sup&gt;2&lt;/sup&gt; (25-36 kg/m&lt;sup&gt;2&lt;/sup&gt;). All patients presented as an emergency and died in our hospital due to right heart failure caused by adenocarcinoma in various locations. Median high-sensitivity troponin T was elevated (42.5 (3-179, normal &lt; 14) ng/L), median NT-pro-BNP (5375 (3100-14,000), normal &lt; 800 for all age groups, in pg/mL), and d-dimer values (7.74 (1.1-21), normal &lt; 0.5 for patients younger than 50 years and &lt; 1 for all other age groups, in mg/FEU) were strongly elevated. Median HbA1c was slightly elevated 7.4% (normal &lt; 6.5%). Median time from last hospital admission to death was 8 days (1-23 days). At admission, median systolic arterial pressure (sPAP) estimated by echocardiography was 65 (46-115) mmHg. Low NT-proBNP and sPAP values as well as pre-mortem adenocarcinoma diagnosis and (therewith associated) adenocarcinoma-type cancer of unknown primary (CUP) correlated best with longer survival in days (ρ and r-values: - 0.88, - 0.76, 0.58, 0.89 respectively). Initiation of specific therapy (chemotherapy or anticoagulation) was correlated with survival (ρ = 0.786, p = 0.02).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Our data suggest that the combination of elevated hsTnT, NT-proBNP, d-dimer, and HbA1c values in patients with unexplained acute right heart failure may indicate PTTM. Our findings also emphasize the diagnostic challenge posed by PTTM, and imply that targeted therapy, enabled by a timely diagnosis, may improve survival. Therefore, acute and fatal right heart failure in the adult in absence of coronary artery disease, pulmonary embolism, or any other apparent cause, especially in patients with uncontrolled metabolic syndrome, should prompt an urgent diagnostic work-up to rule out unknown cancer with treatable pulmonary tumor embolism, beginning with more extensive imaging (e.g., computed tomography (CT) and magnetic resonance tomography (MRI)","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TAVI plus PCI versus SAVR plus CABG: Long-term outcome of a multicentre-registry.","authors":"A Stundl, L Preuss, A Prinzing, J C Voran, H Seoudy, I Mesanovic, V Obermeier, G Lutter, M Potratz, G Buglio, A Pohlmeyer, R Thalmann, P Hoppmann, C Bradaric, H Ruge, M Erlebach, R Lange, K L Laugwitz, T Pühler, T Rudolph, S Bleiziffer, M Krane, D Frank, C Kupatt","doi":"10.1007/s00392-025-02755-9","DOIUrl":"https://doi.org/10.1007/s00392-025-02755-9","url":null,"abstract":"<p><strong>Background: </strong>In elderly patients with severe aortic stenosis (AS), concomitant coronary artery disease (CAD) is common. Escpecially for intermediate-risk patients eligible for both interventional and surgical treatment, long-term benefit of either approach remains unclear.</p><p><strong>Objectives: </strong>To compare long-term outcomes of TAVI + PCI versus SAVR + CABG in intermediate-risk AS-CAD patients (logistic EuroSCORE 10-20%, EuroSCORE II 4-9%).</p><p><strong>Methods: </strong>This retrospective multicentre study included 366 patients treated between 2012 and 2020: 211 underwent TAVI + PCI and 155 received SAVR + CABG. The primary endpoint was all-cause mortality up to three years; secondary outcomes followed VARC-3 criteria.</p><p><strong>Results: </strong>Mortality rates were similar at 30 days (4.8% vs. 8.4%, p = 0.16), six months (12.4% each), one year (18.1% vs. 15.7%) and two years (24.9% vs. 20.1%). At three years, mortality was higher after TAVI + PCI (37.1% vs. 25.5%, p = 0.02), though CAD complexity was greater in the SAVR + CABG group (SYNTAX Score 22.2 vs. 15.9, p < 0.001). TAVI + PCI patients were older (81.1 vs. 78.5 years, p < 0.001), but surgical risk was comparable (EuroSCORE II 6.4% vs. 6.2%). Surgical patients experienced more complications, including delirium, stroke, acute kidney injury, major bleedings and transfusion needs. After propensity score matching (154 patients per group), 3-year mortality no longer differed significantly (33.8% vs. 25.9%, p = 0.14).</p><p><strong>Conclusion: </strong>Both TAVI + PCI and SAVR + CABG yield comparable long-term outcomes in intermediate-risk AS-CAD patients. Although early complications were more common with surgery, there was a trend towards improved long-term survival.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}