Clinical Research in Cardiology最新文献

{"title":"Treatment pathways of lipid-lowering therapies in Germany 2016-2022.","authors":"Julius L Katzmann, Claudia Grellmann, Beate Leppert, Irina Müller-Kozarez, Martin Schulz, Ulrich Laufs","doi":"10.1007/s00392-025-02686-5","DOIUrl":"https://doi.org/10.1007/s00392-025-02686-5","url":null,"abstract":"<p><strong>Background: </strong>Despite the availability of effective LDL cholesterol (LDL-C)-lowering drugs, only a minority of patients achieves the guideline-recommended treatment targets. This analysis describes treatment pathways of lipid-lowering therapy (LLT) in Germany.</p><p><strong>Methods: </strong>Health claims data were used to identify patients at high or very-high cardiovascular risk who received a LLT prescription 2016-2022. Treatment pathways and the time to switch or discontinue LLT were analysed for statins, ezetimibe, bempedoic acid (BA), and PCSK9 inhibitors (PCSK9i).</p><p><strong>Results: </strong>Out of 3,487,827 insured persons, 247,529 met the inclusion criteria. The most frequent first-line LLT were statins in 96.3%. Ezetimibe, BA, and PCSK9i were first-line LLT in only 0.9%, 0.061%, and 0.046%, respectively. Only few patients experienced a change in their treatment regimen following LLT initiation. Prescriptions of BA and PCSK9i were mainly second-, third-, or fourth-line add-on treatment. Termination of treatment with BA and PCSK9i was less frequent compared to statins and ezetimibe. The median time to treatment discontinuation was 1.45, 1.04, 0.60, and 2.45 years for statins, ezetimibe, BA, and PCSK9i, respectively, and the median time to switch therapy was 4.81 and 4.87 years for ezetimibe and PCSK9i, respectively (median not reached for statins and BA).</p><p><strong>Conclusions: </strong>Changes in LLT were only observed in a minority of patients. BA and PCSK9i were switched more frequently than statins and ezetimibe. BA was discontinued earlier, and PCSK9i later than the other agents. Continued efforts to maintain long-term adherence and overcome therapeutic inertia are needed to realise the potential of available LLT with proven cardiovascular benefit.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythropoietic response to oral iron with sodium-glucose co-transporter 2 inhibitors.","authors":"Pedro Marques, Paula Matias, Christoforos K Travlos, António Angélico-Gonçalves, Hugo Diniz, Francisco Vasques-Nóvoa, Milton Packer, Fernando Friões, Michael A Tsoukas, Thomas A Mavrakanas, Abhinav Sharma, João Pedro Ferreira","doi":"10.1007/s00392-025-02685-6","DOIUrl":"https://doi.org/10.1007/s00392-025-02685-6","url":null,"abstract":"<p><strong>Background: </strong>Anemia and iron deficiency are common in heart failure (HF) and chronic kidney disease (CKD). These conditions are associated with upregulation of hepcidin, which impairs the enteric absorption of iron, limiting the use of oral iron formulations in these populations. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are associated with enhanced erythropoiesis and have been shown to augment the erythropoietic response to intravenous iron. The effect of baseline SGLT2i therapy in the erythropoietic response following oral iron supplementation is currently not known.</p><p><strong>Objectives: </strong>To compare the erythropoietic response to oral iron supplementation in patients with HF or CKD, using and not using SGLT2i as background therapy.</p><p><strong>Methods: </strong>This is a retrospective analysis of ambulatory patients with HF or CKD followed in cardio-kidney-metabolic clinics from a quaternary care hospital in Canada and a tertiary care hospital from Portugal. An age- and sex-matched population of patients using (n = 76) and not using (n = 76) a SGLT2i was compared for changes in hemoglobin and hematocrit following oral iron supplementation. Secondary outcomes included changes in iron biomarkers, natriuretic peptides and kidney function.</p><p><strong>Results: </strong>Overall, the mean age was 75 ± 9 years, 49% were men, 119 (78%) had CKD, 107 (70%) HF, and 113 (74%) had anemia. After adjustment for baseline differences, SGLT2i users experienced a greater increase in hemoglobin and hematocrit compared to SGLT2i non-users: hemoglobin + 0.80 g/dL (95% confidence interval [CI] 0.39-1.21 g/dL, p < 0.001); hematocrit + 3.0% (95% CI 1.0-4.0%, p < 0.001). No significant differences on iron biomarkers or any of the secondary outcomes were found between the groups.</p><p><strong>Conclusions: </strong>Oral iron supplementation in patients with background therapy including a SGLT2i (vs. SGLT2i non-users) was associated with a greater increase in hemoglobin and hematocrit. These results suggest that patients with HF or CKD patients treated with SGLT2i might have an enhanced erythropoietic response to oral iron supplementation.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cocaine-induced acute myocardial infarction: angiographic features and outcomes.","authors":"Michael Würdinger, Davide Di Vece, Victor Schweiger, Iva Koleva, Barbara E Stähli, Jelena-Rima Ghadri, Erik W Holy, Christian Templin","doi":"10.1007/s00392-025-02677-6","DOIUrl":"https://doi.org/10.1007/s00392-025-02677-6","url":null,"abstract":"<p><strong>Background: </strong>Cocaine is a global health burden and the cause of a significant number of emergency department consultations. Its association with acute myocardial infarction (AMI) is known, however, data are still rare. The aim of this study was to define causative pathologies behind cocaine-induced AMI (CI-AMI) and to analyze their clinical features.</p><p><strong>Methods: </strong>Patients with the diagnosis of CI-AMI were retrospectively identified at the University Hospital Zurich between 1997 and 2023. The angiograms were reviewed to confirm the diagnosis. Coronary microvascular dysfunction (CMD) was separately evaluated by an angiography-based analysis (AngioPlus Core, Microport Medical Co.). The primary endpoint was rates of major adverse cardiovascular events (MACE) at 30 days, 1 year, and 2 years.</p><p><strong>Results: </strong>Forty-five cases of CI-AMI were identified. Twelve patients (27%) were diagnosed with plaque rupture and intraluminal thrombus, eight (18%) with coronary artery disease (CAD) without thrombus formation, eight (18%) with spontaneous coronary artery dissection, six (13%) with CMD, four (9%) with coronary vasospasm, and four patients (9%) with Takotsubo syndrome. The cause of CI-AMI remained unclear in three patients (6%). No clinically useful predictors of CAD were identified. 91% of patients had values associated with CMD during angiography-based analysis, independently from the etiology of CI-AMI. 49% of cases were treated by revascularization, and the number of MACE was high (16%, 28%, and 34% at 30 days, 1 year, and 2 years).</p><p><strong>Conclusions: </strong>CI-AMI is a rare, but important cause of acute coronary syndromes (ACS). CAD represents the most frequent etiology of AMI, but there is a broad range of other entities. Patients suffer from a significant number of adverse events.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving trends and persistent challenges in chronic left ventricular heart failure management: insights from a 9-year analysis of in-hospital outcomes in Germany.","authors":"Anastasia Janina Hobbach, Jannik Feld, Jürgen Reinhard Sindermann, Holger Reinecke","doi":"10.1007/s00392-025-02679-4","DOIUrl":"https://doi.org/10.1007/s00392-025-02679-4","url":null,"abstract":"<p><strong>Aims: </strong>Chronic left ventricular heart failure (CLHF) represents a significant public health challenge globally, marked by high morbidity and mortality. CLHF is a leading cause of hospitalization, placing considerable strain on healthcare systems. This study aims to analyze in-hospital outcomes for CLHF patients in Germany over nine years (2014-2022), examining trends in morbidity, mortality, healthcare costs, and complications.</p><p><strong>Methods and results: </strong>Data were sourced from the Federal Statistical Office (DESTATIS), covering 2,616,462 inpatient CLHF cases (ICD-10-GM I50.11-I50.14) in Germany from 2014 to 2022. CLHF hospitalizations increased from 288,019 in 2014 to 311,782 in 2019, then declined in 2020 but started again to rise from 2021 to 2022. The proportion of patients with advanced CLHF (NYHA stage IV) decreased slightly from 54.09% in 2014 to 50.36% in 2020 (p < 0.0001). Notable comorbidity trends included rising rates of atrial fibrillation and chronic kidney disease. Complications such as cardiogenic shock and acute kidney injury increased over time (both p < 0.0001). Despite a decrease in mortality rates from 2014 to 2019 (p < 0.0001), in-hospital mortality rose to 8.84% in 2022 (p < 0.0001). Median revenue volume and hospitalization duration showed a pre-pandemic increase but declined in 2020.</p><p><strong>Conclusion: </strong>The study highlights a complex interplay of factors affecting CLHF management in Germany, as a representative example for a high-income country. While advancements in treatment have improved some outcomes, the COVID-19 pandemic significantly impacted hospitalization trends and in-hospital mortality. The findings underscore the need for ongoing improvements in CLHF management and resilient healthcare strategies to address future challenges.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular deformation predicts major adverse cardiac events following acute myocardial infarction independently of afterload and ventricular-arterial coupling.","authors":"Sören J Backhaus, Jan S Wolter, Thomas Stiermaier, Alexander Schulz, Torben Lange, Shelby Kutty, Maren Weferling, Julia M Treiber, Johannes T Kowallick, Gerd Hasenfuß, Andreas Rolf, Samuel Sossalla, Holger Thiele, Ingo Eitel, Andreas Schuster","doi":"10.1007/s00392-025-02666-9","DOIUrl":"https://doi.org/10.1007/s00392-025-02666-9","url":null,"abstract":"<p><strong>Background: </strong>Load dependence on left ventricular (LV) strain is under constant debate with its interference with prognostic implications remaining unclear. Consequently, we sought to investigate their interaction and prognostic value following acute myocardial infarction (AMI) using state-of-the-art cardiac magnetic resonance (CMR) imaging.</p><p><strong>Methods: </strong>In total, 1235 patients (n = 795 ST-elevation [STEMI] and 440 non-STEMI) underwent CMR in median 3 days following AMI. Infarct characteristics were described by CMR using tissue characterisation (infarct size, microvascular obstruction, area at risk) and deformation imaging including LV global longitudinal and circumferential strain (GLS/GCS). Non-invasive haemodynamic indices included effective arterial elastance Ea (end-systolic pressure (ESP)/stroke volume) and the non-geometric LV end-systolic afterload index NGI [(ESP × LV end-systolic volume (ESV))/LV mass] for estimation of LV afterload. LV contractility was assessed using end-systolic elastance Ees (ESP/LV ESV). Ventriculo-arterial coupling was described as Ea/Ees. Major adverse cardiac events (MACE) were recorded within the first year.</p><p><strong>Results: </strong>All haemodynamic indices were impaired in patients with MACE during follow-up compared to patients without (p < 0.001-0.005). Ventriculo-arterial coupling showed the highest correlation to infarct properties (infarct size r = 0.51, p < 0.001) and deformation imaging (GLS r = 0.54, GCS r = 0.72, p < 0.001). GLS and GCS were associated with MACE independently of all haemodynamic indices (p < 0.001 for all except of GCS-Ea/Ees p = 0.024).</p><p><strong>Conclusions: </strong>Non-invasive haemodynamic indices are associated with outcome following AMI with ventriculo-arterial coupling showing the most prominent association to infarct properties and outcome. GCS showed higher correlation to haemodynamic indices compared to GLS whilst both are independent predictors for MACE.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term results of transcatheter aortic valve replacement in degenerated surgical aortic valves-a propensity score matched analysis.","authors":"Kornelia Löw, Julius Steffen, Nike Knufinke, Carolin Fröhlich, Julius Fischer, Magda Haum, Hans Theiss, Sven Peterss, Konstantin Stark, Jörg Hausleiter, Steffen Massberg, Simon Deseive","doi":"10.1007/s00392-025-02670-z","DOIUrl":"https://doi.org/10.1007/s00392-025-02670-z","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to analyse long-term valve function and all-cause mortality of patients undergoing transcatheter aortic valve replacement (TAVR) due to degenerated surgical aortic valve (SAV) bioprostheses.</p><p><strong>Methods: </strong>In this single-center study, all consecutive patients undergoing TAVR between December 2012 and December 2020 were included. Long-term echocardiographic results, functional status and 5-year all-cause mortality were analysed in patients with TAV-in-SAV and native valve TAVR in a propensity score matched analysis.</p><p><strong>Results: </strong>Out of 3423 patients who were eligible for the study, 136 experienced bioprosthetic valve dysfunction, whereas 3287 patients underwent native valve TAVR. After 2:1 propensity score matching, baseline characteristics without relation to prior SAVR were comparable between both groups. Regarding 5-year all-cause mortality, no difference was observed between patients with prior SAVR and native valve TAVR, in either unadjusted analysis, or after propensity score matching (corresponding hazard ratio: 0.95, 95% CI: 0.70-1.30, p = 0.75). In addition, while pressure gradients were higher in patients with TAV-in-SAV in long-term echocardiographic follow-up, moderate or severe hemodynamic valve deterioration did not occur more often in this group.</p><p><strong>Conclusions: </strong>In this propensity score matched analysis, long-term all-cause mortality and echocardiographic valve function of patients with TAVR in prior bioprosthesis were comparable to patients with native valve TAVR.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma chemokines indicate enhanced bleeding in patients with chronic coronary syndrome undergoing percutaneous coronary stenting.","authors":"Tobias Harm, Shqipdona Lahu, Katharina Mayer, Dominik Rath, Tobias Geisler, Karin Anne Lydia Müller, Marion Janisch, Kristin Adler, Götz Münch, Steffen Massberg, Adnan Kastrati, Meinrad Paul Gawaz","doi":"10.1007/s00392-025-02675-8","DOIUrl":"https://doi.org/10.1007/s00392-025-02675-8","url":null,"abstract":"<p><strong>Background: </strong>Patients with coronary artery disease (CAD) are at increased risk of developing ischemic events and contemporary antiplatelet therapy often leads to bleeding events following percutaneous coronary intervention (PCI). Glycoprotein VI (GPVI) is the key receptor of collagen-dependent thrombus formation and crucial for platelet homeostasis.</p><p><strong>Methods: </strong>We analysed the influence of GPVI inhibition with revacept in a randomized double-blinded trial enrolling 334 patients with CAD undergoing elective PCI. Ex vivo platelet function analyses were assessed alongside plasma chemokine concentrations. We then elucidate changes of GPVI-dependent chemokine concentrations in patients with bleeding events during the 30-day clinical follow-up.</p><p><strong>Results: </strong>Changes in platelet function occur in patients with revacept treatment and are associated with a characteristic alteration of circulating chemokine concentrations. Further, patients with adverse bleeding events share a distinct fingerprint of chemokines that is associated with modulation of in vitro platelet functions. In addition, assessment of GPVI-associated changes in chemokine signalling and platelet functions demonstrated an increased diagnostic value in patients with CAD and might improve early risk discrimination for bleeding events.</p><p><strong>Conclusion: </strong>The composition of platelet-derived chemokines correlated with platelet functions following antiplatelet treatment. Thus, assessment of chemokines may offer the perspective to identify patients at increased risk for bleeding events. Likewise, modulation of platelet chemokines in patients with revacept treatment contributes to the efficacy of antiplatelet treatment and might attenuate pathophysiological cascades leading to haemorrhagic diathesis in patients with CAD.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Sex-specific outcomes in myocardial infarction: a dual-cohort analysis using clinical and real-world data.","authors":"Johannes Krefting, Christian Graesser, Sophie Novacek, Felix Voll, Aldo Moggio, Nils Krueger, Christian Friess, Marius Schwab, Frank Offenborn, Teresa Trenkwalder, Sebastian Kufner, Erion Xhepa, Michael Joner, Salvatore Cassese, Heribert Schunkert, Gjin Ndrepepa, Adnan Kastrati, Moritz von Scheidt, Thorsten Kessler, Hendrik B Sager","doi":"10.1007/s00392-025-02678-5","DOIUrl":"https://doi.org/10.1007/s00392-025-02678-5","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing technical success and clinical outcomes in patients with pulmonary embolism treated with ultrasound-assisted catheter-directed thrombolysis (USAT): a retrospective, single-center cohort study.","authors":"Marius Wessinger, Nadine Gauchel, Daniel Strobel, Dawid L Staudacher, Tobias Wengenmayer, Constantin von Zur Mühlen, Hans-Jörg Busch, Katrin Fink, Katharina Müller-Peltzer, Fabian Bamberg, Klaus Kaier, Dirk Westermann, Christoph B Olivier","doi":"10.1007/s00392-025-02643-2","DOIUrl":"https://doi.org/10.1007/s00392-025-02643-2","url":null,"abstract":"<p><strong>Background: </strong>Ultrasound-assisted catheter-directed thrombolysis (USAT) is a treatment option for patients with intermediate-high- or high-risk pulmonary embolism (PE). This study aimed to describe the use of USAT and its clinical outcomes.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, all USAT procedures performed between May 2019 and June 2022 were included. Data were collected from electronic health records. The primary outcome was reduction in right vs. left ventricular diameter (RV/LV ratio). Secondary outcomes were in-hospital mortality and bleeding.</p><p><strong>Results: </strong>A total of 107 patients underwent USAT for PE. The median age was 64 (IQR 53-75) years and 59% were male. Technical success of USAT was achieved in 105 (98%) cases. In 32 cases data on RV/LV ratio changes were available. RV/LV ratio decreased by 0.29 ± 0.19 from 1.19 (1.02-1.35) to 0.89 (0.78-1.00). 12 (11%) patients had a fatal outcome. Bleeding complications were observed in 28 (26%) patients, including 14 (13%) major bleedings and 0 (0%) fatal. Both, death and bleeding rates were significantly higher in high-risk patients.</p><p><strong>Conclusion: </strong>We observed a high technical success of USAT in patients with intermediate-high- and high-risk pulmonary embolism, along with a significant early reduction of RV/LV ratio following treatment.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCSK9i and atherosclerotic plaque regression assessed by coronary computed tomography angiography: a meta-analysis.","authors":"Marios Sagris, Leopoldo Pérez de Isla, Grigorios Korosoglou","doi":"10.1007/s00392-025-02672-x","DOIUrl":"https://doi.org/10.1007/s00392-025-02672-x","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}