Clinical Research in Cardiology最新文献

{"title":"Association of lipoprotein(a) with ischemia-reperfusion injury in patients with ST-elevation myocardial infarction.","authors":"Magdalena Holzknecht, Christina Tiller, Ivan Lechner, Fritz Oberhollenzer, Alex Kaser, Philipp Fischer, Anita Sandor, Can Gollmann-Tepeköylü, Agnes Mayr, Axel Bauer, Bernhard Metzler, Sebastian Johannes Reinstadler, Martin Reindl","doi":"10.1007/s00392-026-03044-9","DOIUrl":"https://doi.org/10.1007/s00392-026-03044-9","url":null,"abstract":"<p><strong>Background: </strong>Hypercholesterolemia adversely affects ischemia-reperfusion injury in acute ST-elevation myocardial infarction (STEMI). Lipoprotein(a) (Lp(a)) is an independent cardiovascular risk factor beyond traditional lipid markers; however, its impact on ischemic myocardial injury remains unclear. We therefore investigated the association of Lp(a) with myocardial and microvascular damage assessed by multiparametric cardiovascular magnetic resonance (CMR), as well as clinical outcomes in STEMI patients.</p><p><strong>Methods and results: </strong>In this prospective MARINA-STEMI (NCT04113356) cohort study, 518 STEMI patients (median age 59 years, 19% female) treated with primary percutaneous coronary intervention (PCI) were included. Lp(a) and lipid parameters, including low-density lipoprotein (LDL) cholesterol, were measured at hospital admission. CMR was performed at a median of 4 days (interquartile range (IQR) 3-5) and 4 months (IQR 4-5) after PCI. The primary objective was to assess the association of Lp(a) with infarct size (IS) and severe microvascular injury, defined as intramyocardial hemorrhage (IMH) on baseline CMR. The clinical endpoint was major adverse cardiovascular events (MACE: all-cause death, re-infarction, or new congestive heart failure). Median Lp(a) and LDL cholesterol levels were 27 nmol/l (IQR 20-90) and 141 mg/dl (IQR 117-166), respectively. LDL cholesterol correlated with IS at baseline (ρ = 0.114, p = 0.010) and was higher in patients with IMH (145 vs. 140 mg/dl, p = 0.031). In contrast, Lp(a) showed no correlation with IS (ρ = 0.051, p = 0.246) and no association with IMH (25 vs. 28 nmol/l, p = 0.632). Elevated Lp(a) (≥ 105 nmol/l) was not associated with MACE (8.7% vs. 8.8%, p = 0.966).</p><p><strong>Conclusions: </strong>While LDL cholesterol was significantly associated with IS and IMH, Lp(a) was not related to ischemia-reperfusion injury patterns or clinical outcomes in patients with STEMI treated with primary PCI.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardio-hepatic injury phenotypes and short-term outcomes in acute decompensated heart failure.","authors":"Gil Marcus, Shiri L Maymon, Ido Minha, Eran Kalmanovich, Gil Moravsky, Shmuel Fuchs, Sa'ar Minha, Avishay Grupper","doi":"10.1007/s00392-026-03043-w","DOIUrl":"https://doi.org/10.1007/s00392-026-03043-w","url":null,"abstract":"<p><strong>Background: </strong>Abnormal liver biochemistry is common in acute decompensated heart failure (ADHF), yet most studies evaluate individual markers rather than clinically meaningful patterns of hepatic involvement. We examined whether cardiohepatic injury phenotypes derived from routine liver tests identify distinct short-term prognostic profiles in patients hospitalized with ADHF.</p><p><strong>Methods: </strong>In this retrospective cohort study, we included consecutive adults hospitalized with ADHF between December 2006 and 2017. Using peak in-hospital values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total bilirubin, patients were classified into four phenotypes: no hepatic injury, hepatocellular injury, cholestatic injury, or combined injury. Associations with in-hospital mortality were evaluated using multivariable logistic regression. Post-discharge outcomes (30-day mortality, readmission, and their composite) were analyzed using Cox and Fine-Gray models.</p><p><strong>Results: </strong>Among 8332 ADHF admissions, 6792 (81.5%) had sufficient data for phenotype classification: 58.1% had no hepatic injury, 22.1% hepatocellular injury, 13.1% cholestatic injury, and 6.7% combined injury. In-hospital mortality differed markedly across phenotypes (3.5%, 16.3%, 9.0%, and 24.3%, respectively; p < 0.001). After adjustment, all injury phenotypes independently predicted in-hospital death compared with no injury. Among 6128 patients included in adjusted post-discharge analyses, hepatocellular and combined injury were independently associated with higher 30-day mortality and the composite outcome, whereas isolated cholestatic injury was not. Hepatocellular and combined injury independently predicted 30-day readmission.</p><p><strong>Conclusions: </strong>Routine liver test patterns identify clinically meaningful cardiohepatic phenotypes in ADHF. While all hepatic injury phenotypes are associated with increased in-hospital mortality, only phenotypes with hepatocellular involvement predict adverse early post-discharge outcomes. Pattern-based interpretation of liver tests may improve early risk stratification in patients hospitalized with ADHF.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seasonal variation and extreme cold exposure in heart failure with mildly reduced ejection fraction.","authors":"Henning Johann Steffen, Michael Behnes, Daniel Duerschmied, Ibrahim Akin, Tobias Schupp","doi":"10.1007/s00392-026-03038-7","DOIUrl":"https://doi.org/10.1007/s00392-026-03038-7","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional strain patterns in patients with mitral valve prolapse.","authors":"Jeffrey Ji-Peng Li, Shing Ching, Annette Aigner, Frank Edelmann, Stefanie Maria Werhahn, Rebecca Beyer, Jeanette Schulz-Menger, Jennifer Erley, Misael Estepa, Cyrill Meuwly, Ann-Sophie Eggers, Christian Stehning, Djawid Hashemi, Natalia Solowjowa, Christoph Klein, Ingo Hilgendorf, Sebastian Kelle, Patrick Doeblin","doi":"10.1007/s00392-026-03033-y","DOIUrl":"https://doi.org/10.1007/s00392-026-03033-y","url":null,"abstract":"<p><strong>Purpose: </strong>Echocardiographic studies have shown that patients with mitral valve prolapse (MVP) exhibit altered regional contraction patterns. With cardiovascular magnetic resonance (CMR) becoming increasingly important in the evaluation of global and regional cardiac function, we aimed to quantify the regional contraction patterns of patients with MVP using CMR feature tracking (FT) strain analysis in comparison to a control group.</p><p><strong>Methods: </strong>Of all patients who underwent CMR scans from 2013 to 2022 at our institution, 132 patients with MVP were identified and compared to 50 controls without any cardiac condition. CMR scans were performed on 1.5-T and 3-T scanners, and CMR-FT strain analysis was performed on cine images using MEDIS QStrain 4.1. The primary endpoints were regional peak left ventricular (LV) longitudinal strain values. Secondary endpoints included LV global circumferential strain (GCS) and global longitudinal strain (GLS) and left atrial (LA) reservoir strain and right ventricular (RV) free wall longitudinal strain. Differences between groups were assessed using linear regression models, adjusting for age and sex.</p><p><strong>Results: </strong>Patients with MVP showed worse regional peak longitudinal strain compared to controls in the basal and part of the medial LV segments, especially in segments S1, S4, S6, S7, and S12. In contrast, the apical segments S13, S14, S15, and S16 showed better strain values. Additionally, LA reservoir strain was reduced in MVP patients. LV GCS, LV GLS, and RV free wall longitudinal strain were similar between both groups.</p><p><strong>Conclusion: </strong>While patients with MVP showed preserved LV GCS and GLS compared to controls, LV regional longitudinal strain analysis showed impaired strain in the basal segments and increased strain in the apical segments.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of left ventricular ejection fraction on the clinical outcome of percutaneous coronary interventions in heart transplant patients.","authors":"Luisa Elbinger, Tobias Schupp, Michael Behnes, Ibrahim Akin, Angelika Costard-Jäckle, Rene Schramm, Tanja Rudolph, Volker Rudolph, Mohamed Ayoub","doi":"10.1007/s00392-026-03032-z","DOIUrl":"https://doi.org/10.1007/s00392-026-03032-z","url":null,"abstract":"<p><strong>Background: </strong>Although cardiac allograft vasculopathy (CAV) represents a common complication in heart transplantation (HTX) recipients, data investigating predictors of prognosis in patients with CAV are limited. The study sought to investigate the prognostic impact of left ventricular ejection fraction (LVEF) undergoing percutaneous coronary intervention (PCI) in HTX recipients.</p><p><strong>Methods: </strong>Patients with HTX who underwent PCI between January 2011 and June 2023 were included retrospectively at one center. Baseline characteristics, as well as lesion and interventional characteristics were compared between patients with LVEF > 50% and ≤ 50%, further risk stratification was performed comparing patients with LVEF ≥ 50, 41-49 and ≤ 40% and LVEF as continuous variable (per % increase). The primary endpoint was all-cause mortality at 3 years, the key secondary endpoint was major adverse cardiac and cerebrovascular events (MACCE).</p><p><strong>Results: </strong>One hundred fifty-nine HTX recipients undergoing PCI were included with a median LVEF of 55% (i.e., LVEF > 50%: 67%; LVEF ≤ 50%: 33%). Patients with a reduced LVEF were younger (mean 54.1 vs. 59.3 years, p = 0.045), had a higher body mass index (mean 28.1 vs. 26.2 kg/m², p = 0.012) and presented with a higher ISHLT class (p < 0.001). In the adjusted analysis, a reduced LVEF was associated with lower technical (OR = 0.350; 95% CI 0.124 -0.991; p = 0.048) and procedural success (OR = 0.334; 95% CI 0.120 - 0.928; p = 0.035). Patients with a LVEF ≤ 50% had a higher risk of all-cause mortality at 3 years (42.31% vs. 19.63%, p = 0.003), which was still evident after multivariable adjustment (adjusted hazard ratio (HR) = 2.684; 95% CI 1.395 - 5.167; p = 0.003). In line, the risk of MACCE at 3 years was higher in patients with reduced LVEF (adjusted HR = 1.803; 95%CI 1.055-3.079; p = 0.031).</p><p><strong>Conclusion: </strong>In patients undergoing PCI after HTX, a reduced LVEF was an independent predictor of lower technical and procedural success, and was independently associated with impaired long-term prognosis.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central retinal artery occlusion: meta-analysis of the risk of new-onset atrial fibrillation and ischemic stroke.","authors":"Prakash Gupta, Rita Anjos, Ana Miguel, Prateeti Bekoju, Ram Chandra Panthi, Jonathan Salangsang, Vasileios Arsenios Lioutas, Sebastian Hilbert, Timm Seewöster, Kerstin Bode, Andreas Bollmann, Sotirios Nedios","doi":"10.1007/s00392-026-03012-3","DOIUrl":"https://doi.org/10.1007/s00392-026-03012-3","url":null,"abstract":"<p><strong>Background: </strong>Central retinal artery occlusion (CRAO) causes irreversible blindness. Atrial fibrillation (AF) is a recognized cause that may not be present at the time of the event.</p><p><strong>Objective: </strong>We aimed to assess the relation of CRAO with new-onset AF and ischemic stroke.</p><p><strong>Methods: </strong>We systematically searched the literature, utilizing the search terms \"atrial fibrillation\" and \"retinal artery occlusion\". We used a random effects model to calculate the pooled odds ratio (OR) and 95% confidence intervals (CI) of new-onset AF risk and new-onset ischemic stroke risk in CRAO patients compared to matched controls, as well as the new-onset AF risk compared to ischemic stroke patients. Analysis was performed with Rev-Man 5.4.1.</p><p><strong>Results: </strong>We included 1479 patients with CRAO, 9843 matched controls without CRAO and stroke at baseline, and 7058 patients with ischemic stroke for meta-analysis. There were 115 cases of new-onset AF (14%) during a follow-up of 34 months. CRAO was associated with a higher risk for new-onset AF (OR:1.47, 95% CI:1.18-1.83; p = 0.0006) and new ischemic stroke (OR:2.10, 95% CI:1.57-2.82; p < 0.00001) when compared to control patients. The risk of new-onset AF after CRAO was similar to that observed after ischemic stroke (OR:0.80, 95% CI:0.40-1.61; p = 0.54). Follow-up duration and timing of outcome detection varied.</p><p><strong>Conclusion: </strong>CRAO is associated with a higher risk of new-onset AF and ischemic stroke. The risk of AF after CRAO is similar to that after an ischemic stroke. Thus, CRAO may be seen as a stroke-equivalent prompting closer follow-up with screening and eventually anticoagulation.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular deformation predicts major adverse cardiac events following acute myocardial infarction independently of afterload and ventricular-arterial coupling.","authors":"Sören J Backhaus, Jan S Wolter, Thomas Stiermaier, Alexander Schulz, Torben Lange, Shelby Kutty, Maren Weferling, Julia M Treiber, Johannes T Kowallick, Gerd Hasenfuß, Andreas Rolf, Samuel Sossalla, Holger Thiele, Ingo Eitel, Andreas Schuster","doi":"10.1007/s00392-025-02666-9","DOIUrl":"10.1007/s00392-025-02666-9","url":null,"abstract":"<p><strong>Background: </strong>Load dependence on left ventricular (LV) strain is under constant debate with its interference with prognostic implications remaining unclear. Consequently, we sought to investigate their interaction and prognostic value following acute myocardial infarction (AMI) using state-of-the-art cardiac magnetic resonance (CMR) imaging.</p><p><strong>Methods: </strong>In total, 1235 patients (n = 795 ST-elevation [STEMI] and 440 non-STEMI) underwent CMR in median 3 days following AMI. Infarct characteristics were described by CMR using tissue characterisation (infarct size, microvascular obstruction, area at risk) and deformation imaging including LV global longitudinal and circumferential strain (GLS/GCS). Non-invasive haemodynamic indices included effective arterial elastance Ea (end-systolic pressure (ESP)/stroke volume) and the non-geometric LV end-systolic afterload index NGI [(ESP × LV end-systolic volume (ESV))/LV mass] for estimation of LV afterload. LV contractility was assessed using end-systolic elastance Ees (ESP/LV ESV). Ventriculo-arterial coupling was described as Ea/Ees. Major adverse cardiac events (MACE) were recorded within the first year.</p><p><strong>Results: </strong>All haemodynamic indices were impaired in patients with MACE during follow-up compared to patients without (p < 0.001-0.005). Ventriculo-arterial coupling showed the highest correlation to infarct properties (infarct size r = 0.51, p < 0.001) and deformation imaging (GLS r = 0.54, GCS r = 0.72, p < 0.001). GLS and GCS were associated with MACE independently of all haemodynamic indices (p < 0.001 for all except of GCS-Ea/Ees p = 0.024).</p><p><strong>Conclusions: </strong>Non-invasive haemodynamic indices are associated with outcome following AMI with ventriculo-arterial coupling showing the most prominent association to infarct properties and outcome. GCS showed higher correlation to haemodynamic indices compared to GLS whilst both are independent predictors for MACE.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":"1735-1746"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13562202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral vessel tortuosity index and prognosis in patients undergoing transcatheter aortic valve implantation.","authors":"Hector A Alvarez-Covarrubias, Martin Jurisic, Masaru Seguchi, Charlotte Salzmann, Karsten Hug, Judith Hübner, Fabian Starnecker, Finn Syryca, Ferdinand Haug, Costanza Pellegrini, Tobias Rheude, N Patrick Mayr, Salvatore Cassese, Adnan Kastrati, Erion Xhepa, Michael Joner","doi":"10.1007/s00392-026-03035-w","DOIUrl":"https://doi.org/10.1007/s00392-026-03035-w","url":null,"abstract":"<p><strong>Background and aims: </strong>The peripheral vessel tortuosity index (TI) was proposed to discriminate procedural success in patients undergoing transcatheter endovascular aortic replacement but not in those undergoing transcatheter aortic valve implantation (TAVI). We aimed to investigate the TI and its prognostic relevance in patients undergoing transfemoral (Tf) TAVI.</p><p><strong>Methods: </strong>Retrospective, observational single-center study, including patients undergoing Tf-TAVI from April 2011 to January 2023 at the TUM University Hospital, German Heart Centre, and available computed tomography angiography (CTA). Peripheral vessel measurements were performed using dedicated software (3mensio, Pie Medical). TI was determined dividing true central lumen vessel length from centerline reconstruction and direct distance from the aorto-iliac bifurcation to the epigastric artery. TI was dichotomized based on severity according to EVAR guidelines, where a TI of 1.5 is considered discriminatory for nonsevere tortuosity [< 1.5 for low TI (LTI)] and > 1.5 for high TI (HTI)]. Valve Academic Research Consortium 3 definitions were applied to describe procedural and follow-up outcomes. Mortality at 6-month follow-up was evaluated.</p><p><strong>Results: </strong>We included 2002 patients. Overall age was 81 years [77, 85], 45.2% were female, EuroScore II was 4.22 [2.39, 7.60]. Age (p < 0.001), female sex (p < 0.001), diabetes (p < 0.001), peripheral artery disease (p = 0.002), myocardial infarction (p = 0.013), and creatinine (p = 0.001) were associated with tortuosity. Adjusted 6-month analysis showed that TI > 1.50 was associated with increased mortality [hazard ratio (HR) 1.679, 95% CI (1.098-2.567), p = 0.017].</p><p><strong>Conclusions: </strong>TI > 1.50 may determine a higher-risk population in patients undergoing Tf-TAVI. Further study is required to validate our findings.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between potassium fluctuation and in-hospital mortality in acute myocardial infarction patients: a retrospective analysis of the MIMIC-IV database.","authors":"Ying Zhou, Yang Chen, Shangyan Liang, Yanling Li, Changlin Zhao, Zhen Wu","doi":"10.1007/s00392-025-02613-8","DOIUrl":"10.1007/s00392-025-02613-8","url":null,"abstract":"<p><strong>Background: </strong>Serum potassium levels are recognized for their prognostic significance in patients presenting with acute myocardial infarction (AMI). However, the correlation between potassium level fluctuations and mortality rates among AMI patients remains unclear.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using the MIMIC-IV database, including deidentified data from patients admitted to the Beth Israel Deaconess Medical Center from 2008 to 2022. Potassium fluctuation was assessed using parameters including mean postadmission serum potassium levels (K⁺[mean]), first measurable value upon admission (K⁺[admission]), minimum (K⁺[min]) and maximum (K⁺[max]) measurable values, and coefficient of variation (K⁺[CV]). The primary outcome was all-cause in-hospital mortality; secondary outcomes included ventricular tachycardia or fibrillation (VT/VF) and cardiac arrest. Restricted cubic spline models and logistic regression models were used to assess the associations between potassium fluctuation and clinical outcomes.</p><p><strong>Results: </strong>A J-shaped correlation between serum potassium levels and the risk of in-hospital mortality was identified. Both high and low potassium levels were significantly associated with increased mortality. Specifically, K⁺[mean] levels below 3.5 mmol/L and above 4.5 mmol/L were associated with higher mortality. Elevated K⁺[CV] values were also associated with higher in-hospital mortality in both univariate and multivariate analyses. Increased potassium variability was correlated with elevated risks of both VT/VF and cardiac arrest.</p><p><strong>Conclusions: </strong>Serum potassium fluctuation is an independent predictive factor for in-hospital mortality among AMI patients. These findings underscore the importance of maintaining potassium homeostasis in the management of AMI, suggesting that monitoring and stabilizing potassium levels are crucial for reducing in-hospital mortality.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":"1710-1722"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"Cocaine-induced acute myocardial infarction: angiographic features and outcomes\".","authors":"Syeda Samia Fatima, Maha Faraz, Syed Muhammad Ahmed, Ayesha Amin","doi":"10.1007/s00392-025-02750-0","DOIUrl":"10.1007/s00392-025-02750-0","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":"1884-1885"},"PeriodicalIF":3.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}