Clinical Research in Cardiology最新文献

{"title":"Comment on \"Cardiac biomarkers in women with high-risk pregnancies: short-term outcomes from the Heidelberg Cardio-Obstetrics Registry\".","authors":"Khushhali M Pandey","doi":"10.1007/s00392-026-02964-w","DOIUrl":"https://doi.org/10.1007/s00392-026-02964-w","url":null,"abstract":"","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediabetes and the risk of atrial fibrillation and heart failure: a propensity-matched analysis in a real-world cohort.","authors":"Kohei Ukita, Lotta Nowak, Franziska Schmelter, Christian Sina, Roland Richard Tilz","doi":"10.1007/s00392-026-03013-2","DOIUrl":"https://doi.org/10.1007/s00392-026-03013-2","url":null,"abstract":"<p><strong>Background: </strong>Although diabetes is a recognized risk factor for atrial fibrillation (AF) and heart failure (HF), the cardiovascular consequences of prediabetes remain unclear, particularly regarding AF subtypes and HF development.</p><p><strong>Objective: </strong>This study aimed to evaluate the association of prediabetes with new-onset AF, including subtype specificity, and its association with HF development using an international, real-world cohort.</p><p><strong>Methods: </strong>We analyzed de-identified electronic health records from the TriNetX network, including adults aged 18-79 years without prior AF or atrial flutter. Prediabetes was defined as hemoglobin A1c (HbA1c) 5.7-6.4% or a documented diagnosis; normoglycemic controls had normal HbA1c (≤ 5.6%). Propensity score matching (1:1) was applied to match the cohorts. Primary outcome was new-onset AF, stratified by paroxysmal and persistent AF. Secondary outcome was HF incidence. Follow-up extended from 90 days to 5 years post-index.</p><p><strong>Results: </strong>After matching, 207,385 patients were included in each cohort. During the follow-up period, prediabetes was associated with a modestly increased risk of new-onset AF (risk ratio [RR] 1.154, 95% confidence interval [CI] 1.035-1.286, P=0.010), primarily driven by persistent AF (RR 1.411, 95% CI 1.085-1.835, P=0.010), while paroxysmal AF incidence was unaffected. Prediabetes was also associated with increased HF incidence among individuals without established AF (RR 1.296, 95% CI 1.119-1.500, P=0.001) but not in those with concomitant AF.</p><p><strong>Conclusion: </strong>Prediabetes was associated with a modestly increased risk of new-onset AF, particularly persistent AF, and was associated with HF development among individuals without established arrhythmia.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac screening of amyloid TTR pathogenic variant carriers: complementary value of echocardiographic global longitudinal strain imaging and bone scintigraphy.","authors":"Sandra Sanders-van Wijk, Sebastiaan H C Klaassen, Jerremy Weerts, Anouk Achten, Marish I F J Oerlemans, Hendrea S A Tingen, Michelle Michels, Paul A van der Zwaag, Riemer H J A Slart, Mathijs van Gemert, Dirk J van Veldhuisen, Hans L A Nienhuis, Christian Knackstedt, Maarten P van den Berg","doi":"10.1007/s00392-026-02998-0","DOIUrl":"https://doi.org/10.1007/s00392-026-02998-0","url":null,"abstract":"<p><strong>Background: </strong>Cardiac involvement is the major determinant of mortality in variant TTR amyloidosis (ATTRv). Treatment options have recently become available, which make early diagnosis important. Several imaging modalities for screening are proposed including bone scintigraphy, conventional, and strain echocardiography but data on their relative value is limited in this population.</p><p><strong>Objectives: </strong>To investigate the value of left ventricular global longitudinal strain (LV-GLS) for screening for cardiac involvement in a population of transthyretin (TTR) pathogenic variant carriers.</p><p><strong>Methods: </strong>Fifty-three TTR pathogenic variant carriers from two Dutch academic hospitals underwent transthoracic echocardiography (TTE) and bone scintigraphy as part of routine out-patient care to assess cardiac involvement. LV-GLS was measured by two blinded reviewers. Abnormalities in LV-GLS (cut-off - 21.5%) and other TTE parameters were evaluated in bone scintigraphy positive (≥ grade 1) and negative cases.</p><p><strong>Results: </strong>Carriers with a positive bone scintigraphy (n = 20/53) were 16 years older than those with a negative scan (n = 33/53). In 17 out of 20 (85%) of patients with a positive bone scintigraphy, LV-GLS was abnormal. When bone scintigraphy was negative, LV-GLS was abnormal in 11 cases (38%). Although most of these patients had no obvious alternative explanation for the reduced LV-GLS, the clinical significance of this finding remains uncertain. LV-GLS as a single echo parameter was equally sensitive to detect an abnormal bone scintigraphy versus all other TTE parameters together.</p><p><strong>Conclusions: </strong>LV-GLS and bone scintigraphy provided complementary information in TTR pathogenic variant carriers. Discordant findings between both modalities warrant further evaluation, as abnormal LV-GLS may reflect early ATTRv-related changes but is not disease-specific. These findings are exploratory and hypothesis-generating and warrant confirmation in prospective studies incorporating additional reference standards.LV-GLS was the most sensitive single echo parameter, making it useful for repeated assessment in this population.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular endothelial dysfunction and echocardiographic changes in male and female patients with Fabry disease: a single-center observational study.","authors":"Radosław Dziedzic, Piotr Kuszmiersz, Magdalena Szuścik, Anna Drynda, Magdalena Celińska-Löwenhoff, Agnieszka Padjas, Renata Pacholczak-Madej, Lech Zaręba, Jan G Bazan, Stanisława Bazan-Socha, Jerzy Dropiński","doi":"10.1007/s00392-026-02987-3","DOIUrl":"10.1007/s00392-026-02987-3","url":null,"abstract":"<p><strong>Introduction: </strong>Fabry disease (FD) is a progressive X-linked lysosomal storage disorder characterized by the accumulation of pathological glycosphingolipids in a wide range of cells, leading, among others, to vascular endothelial dysfunction. Advanced atherosclerosis, indicated by increased intima-media thickness (IMT), and endothelial injury, characterized by impaired arterial flow-mediated dilatation (FMD), are associated with a higher cardiovascular risk seen in these patients. Next, echocardiography may provide non-invasive insight into cardiac changes that may also correlate with endothelial dysfunction in FD. However, evidence on that relationship is scarce, especially regarding sex differences. Therefore, we aimed to evaluate endothelial function together with echocardiographic changes in a cohort of Polish FD patients.</p><p><strong>Patients and methods: </strong>We assessed brachial artery FMD, measured common carotid artery IMT, and performed transthoracic echocardiography to evaluate cardiac involvement in 31 FD patients without cardiovascular events in medical history (17 male and 14 female patients) and 31 controls matched by age, sex, and body mass index (BMI).</p><p><strong>Results: </strong>FD patients exhibited a 54.8% reduction in FMD response and a 25.0% increase in IMT thickness compared to controls (p < 0.001 for both, also after adjustment for sex, age, and BMI). In echocardiography, FD exhibited increased left ventricular wall thickness, a slightly reduced ejection fraction, and a higher pulmonary artery systolic pressure compared to the controls (p < 0.001 for all, also after adjustment for sex, age, and BMI). There were several associations between FMD/IMT and echocardiographic parameters. No differences in FMD or IMT were observed when comparing male and female FD patients.</p><p><strong>Conclusions: </strong>Fabry disease is associated with vascular endothelial dysfunction and subclinical arterial wall thickening, as reflected by reduced FMD and increased IMT, respectively. No significant sex-related differences in FMD or IMT were observed in our FD patient group. Overall, these parameters were associated with echocardiographic abnormalities characteristic for FD. Importantly, all of these parameters can be assessed using non-invasive diagnostic methods.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early catheter ablation of atrial fibrillation in patients with heart failure with preserved ejection fraction-real-world evidence.","authors":"Maximilian Moersdorf, Michel Abou-Khalil, Carlo El Khoury, Qussay Marashly, Alex El Darzi, Christian Massad, Yara Menassa, Han Feng, Mohammad Montaser Atasi, Rodolfo Montiel, Philipp Sommer, Amitabh C Pandey, Christian Sohns, Nassir Marrouche","doi":"10.1007/s00392-026-02982-8","DOIUrl":"https://doi.org/10.1007/s00392-026-02982-8","url":null,"abstract":"<p><strong>Introduction: </strong>Catheter ablation for atrial fibrillation (AF) has been shown to reduce mortality and heart failure (HF) progression in patients with AF and HF with reduced ejection fraction; however, outcomes in HF with preserved ejection fraction (HFpEF), especially the optimal timing of ablation, remain uncertain.</p><p><strong>Objectives: </strong>To evaluate long-term outcomes of catheter ablation in patients with AF and HFpEF based on the temporal correlation between the AF diagnosis and the ablation procedure utilizing real-world data.</p><p><strong>Methods: </strong>In this observational cohort study using the U.S. Collaborative Network in TriNetX, adults with AF and HFpEF between October 2018 and October 2024 were identified. After 1:1 propensity score matching, 5550 patients were included. The primary endpoint was a composite of cardioversion, new antiarrhythmic drug (AAD) therapy, or repeat AF ablation after a 3-month blanking period. Secondary endpoints included hospitalization, mortality, HF exacerbation, and AAD use up to 4 years of follow-up. Outcomes were compared between patients undergoing ablation within 1 year of AF diagnosis and those having ablation after 1 year.</p><p><strong>Results: </strong>Over a mean follow-up of 742 ± 489 days, early AF ablation was associated with lower risks of the primary endpoint (hazard ratio (HR) 0.81, 95% CI 0.76-0.87, p < 0.001), reduced hospitalization (HR 0.77, 95% CI 0.70-0.87, p < 0.001), and lower AAD Class I or III use (HR 0.82, 95% CI 0.77-0.88, p < 0.001). No significant differences were observed in HF exacerbations (HR 0.99, 95% CI 0.89-1.00, p = 0.950) or mortality (HR 1.18, 95% CI 0.91-1.53, p = 0.211).</p><p><strong>Conclusion: </strong>Early catheter ablation was associated with a decreased all-cause hospitalization and AF recurrence in HFpEF patients but did not reduce HF exacerbations or mortality.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of risk factors for ischaemic and major bleeding events in chronic coronary syndrome: a SWEDEHEART registry study.","authors":"Sergio Buccheri, Giovanna Sarno, Lars Pål Hasvold, Henrik Renlund, Stefan James, Kasper Andersen","doi":"10.1007/s00392-026-02995-3","DOIUrl":"https://doi.org/10.1007/s00392-026-02995-3","url":null,"abstract":"<p><strong>Aim: </strong>In patients with chronic coronary syndrome, risk factors for ischaemic events and bleeding tend to overlap. However, the combined effects of these factors have scarcely been studied in contemporary real-world settings.</p><p><strong>Methods: </strong>All patients in Sweden undergoing elective PCI for chronic coronary syndrome between 2006 and 2014 enrolled in the SWEDEHEART registry were included. Six risk factors (age ≥ 65 years, chronic kidney disease, diabetes, multivessel disease (MVD), prior bleeding, and prior acute myocardial infarction (AMI)) were assessed in relation to the risk of ischaemic (cardiovascular death/AMI/stroke) and major bleeding events.</p><p><strong>Results: </strong>We studied 24,051 patients, of whom 59% had ≥ 2 risk factors. During a median follow-up of 3.7 years, 3604 (15.0%) patients experienced ischaemic events and 2076 (8.6%) experienced major bleeding events . Higher numbers of risk factors were associated with a stepwise increase in the incidence of both ischaemic and bleeding events, being more substantial for ischaemic compared to bleeding events. In adjusted Cox models, prior bleeding was of less importance as compared to other risk factors for new ischaemic events. For bleeding events, diabetes, MVD, and prior AMI had limited relevance compared with other risk factors. When excluding patients with prior major bleeding, the increase in ischaemic risk with an increasing number of risk factors was more pronounced, whereas the increase in bleeding incidence was attenuated.    .</p><p><strong>Conclusions: </strong>Among patients with angiographically confirmed chronic coronary syndrome, the majority had two or more established risk factors. An increasing number of risk factors was associated with a higher rate of ischaemic and bleeding events, being more substantial for ischaemic compared to bleeding events.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vessel fractional flow reserve (vFFR) vs. optical coherence tomography in chronic coronary syndromes (VISION-FFR).","authors":"Piotr Baruś, Adrian Bednarek, Karol Sadowski, Karol Artur Sadowski, Łukasz Kołtowski, Adam Rdzanek, Arkadiusz Pietrasik, Grzegorz Opolski, Marcin Grabowski, Janusz Kochman, Mariusz Tomaniak","doi":"10.1007/s00392-026-02991-7","DOIUrl":"https://doi.org/10.1007/s00392-026-02991-7","url":null,"abstract":"<p><strong>Background: </strong>Fractional flow reserve (FFR) is the gold standard for evaluating the functional significance of coronary stenosis. With advances in methods based on computational fluid dynamics and three-dimensional vessel reconstructions, non-invasive assessment using indices such as vessel FFR (vFFR) has become feasible.</p><p><strong>Objectives: </strong>To evaluate the association between vFFR and optical coherence tomography (OCT)-derived parameters in patients with chronic coronary syndromes (CCS).</p><p><strong>Methods: </strong>In this single-center, prospective, observational study, patients with CCS and intermediate coronary stenoses (40-80% lesions in coronary angiography), undergoing FFR, vFFR, and OCT assessments were enrolled. FFR and vFFR ≤ 0.8 was considered hemodynamically significant.</p><p><strong>Results: </strong>A total of 106 patients with 120 lesions were enrolled. Sixty-two patients had vFFR ≤ 0.8, and 44 patients presented with vFFR > 0.8. The median vFFR in the vFFR-positive group was 0.72 (0.70-0.77) and in the vFFR-negative group 0.88 (0.85-0.92), p < 0.001. The sensitivity of vFFR for identifying FFR-positive lesions was 88.5% with 92.5% specificity, the area under curve was 0.905. On OCT analysis lesions with vFFR ≤ 0.8 had smaller minimal lumen area (MLA) (1.83 ± 0.92 mm² vs. 2.53 ± 1.33 mm², p = 0.001) and were longer (16.38 ± 9.66 mm vs. 10.79 ± 6.41 mm, p < 0.001). Multivariate analysis adjusted for gender, age, and left anterior descending artery location revealed that lower vFFR value was an independent predictor of smaller MLA (Exp(B) for logMLA = 0.92, p < 0.001).</p><p><strong>Conclusions: </strong>vFFR cutoff value of 0.8 presents high accuracy associated with longer and more severe stenosis assessed by OCT in patients with chronic coronary syndromes.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID: NCT06844942.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of atrioventricular valve regurgitation following transcatheter aortic valve replacement for severe aortic stenosis.","authors":"Kornelia Löw, Nike Knufinke, Julius Steffen, Lukas Stolz, Carolin Fröhlich, Julius Fischer, Philipp M Doldi, Magda Haum, Luisa Freyer, Hans Theiss, Konstantin Stark, Jörg Hausleiter, Steffen Massberg, Simon Deseive","doi":"10.1007/s00392-026-02999-z","DOIUrl":"https://doi.org/10.1007/s00392-026-02999-z","url":null,"abstract":"<p><strong>Background: </strong>Concomitant mitral (MR) and/or tricuspid regurgitation (TR) in patients with aortic stenosis (AS) is often regarded as a late-stage disease manifestation, resulting from left ventricular damage, pulmonary hypertension, and right heart dysfunction. However, we assume that atrioventricular valve regurgitation in the context of severe AS may often develop as an independent entity, but knowledge regarding these patients and their risk factors is scarce.</p><p><strong>Objectives: </strong>The aim of this study was to characterize patients who develop atrioventricular valve regurgitation after transcatheter aortic valve replacement (TAVR) and its impact on mortality.</p><p><strong>Methods: </strong>We analyzed patients with severe AS but without concomitant atrioventricular valve disease undergoing TAVR between January 2016 and December 2021. Novel MR and/or TR ≥ grade 2 and its impact on 3-year all-cause and cardiovascular mortality were evaluated.</p><p><strong>Results: </strong>A total of 1034 TAVR patients without preexisting atrioventricular valve regurgitation were included in the study. Of these, 114 patients (11.0%) developed relevant mitral and/or tricuspid regurgitation. Among them, 17 patients experienced combined MR and TR, 75 patients had isolated MR, and 22 patients had isolated TR. The development of atrioventricular valve regurgitation after TAVR was associated with significantly increased 3-year all-cause (p < 0.01) and cardiovascular mortality (p < 0.001).</p><p><strong>Conclusions: </strong>In patients with severe AS but without concomitant atrioventricular valve disease at baseline, a relevant proportion of patients developed MR and/or TR after TAVR despite the relief of outflow obstruction. Moreover, patients with new-onset atrioventricular valve regurgitation had a significantly higher 3-year all-cause and cardiovascular mortality.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The throne of health care: detection of cardiac arrhythmias on a toilet-seat.","authors":"Christian Thilo, Stephan Achenbach, Claudia Lueg, Laurin Kochinke, Jan Kaufmann, Norman Pfeiffer, Nadine R Lang-Richter, Tobias S Zech, Alice Steiner, Sarah Fiedelak, David Hartmann, Armin Stroebel, Markus Richter, Heribert Schunkert, Lars Anneken","doi":"10.1007/s00392-026-03000-7","DOIUrl":"https://doi.org/10.1007/s00392-026-03000-7","url":null,"abstract":"<p><strong>Background: </strong>Early detection of atrial fibrillation (AF) may reduce the risk of complications such as stroke. This study evaluated the diagnostic performance of a toilet seat-integrated electrocardiogram (TS-ECG) for AF detection under controlled clinical conditions.</p><p><strong>Methods: </strong>This prospective multicentre feasibility study included 83 participants (mean age 64 years, 55% male) recruited at two cardiology centres in Germany. Participants were assigned to sinus rhythm (n = 50), AF (n = 28), or other non-AF arrhythmias (n = 5). Each participant underwent simultaneous recordings using a standard 12-lead ECG and the TS-ECG. Recordings were independently interpreted by four experienced cardiologists blinded to device type. The primary endpoint was diagnostic agreement for AF detection between TS-ECG and the reference ECG.</p><p><strong>Results: </strong>Compared with the 12-lead ECG, the TS-ECG demonstrated a mean sensitivity of 96% (95% CI: 93-98%) and specificity of 95% (92-97%) across readers. When majority voting was applied, sensitivity increased to 99% (98-100%) and specificity to 97% (96-99%). Overall diagnostic accuracy was high across all readers.</p><p><strong>Conclusion: </strong>The TS-ECG demonstrated high diagnostic agreement with standard 12-lead ECG for AF detection under controlled clinical conditions. These findings support further evaluation of the system in longitudinal and home-based studies to assess real-world feasibility and clinical utility.</p><p><strong>Trial registration: </strong>DRKS00035167.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a sirolimus-eluting balloon with phospholipid nanocarriers in the treatment of long de novo coronary artery disease: the prospective GINGER trial.","authors":"Alfonso Ielasi, Mauro Gitto, Stefano Galli, Giuseppe Massimo Sangiorgi, Rodolfo Caminiti, Pier Pasquale Leone, Antonio Mangieri, Gerlando Preti, Francesco Grigioni, Matteo Montorfano, Maurizio Tespili, Antonio Colombo","doi":"10.1007/s00392-026-02997-1","DOIUrl":"https://doi.org/10.1007/s00392-026-02997-1","url":null,"abstract":"<p><strong>Background: </strong>Sirolimus-coated balloons (SCB) may offer improved antiproliferative efficacy over paclitaxel-coated balloons; however, data regarding their performance in de novo coronary lesions are limited.</p><p><strong>Objectives: </strong>The GINGER study aimed to evaluate the angiographic efficacy and clinical safety of a SCB (Magic Touch®) in the treatment of long (≥ 25 mm) de novo coronary artery lesions.</p><p><strong>Methods: </strong>This observational, prospective, multicenter, single-arm cohort study enrolled patients with at least one long de novo lesion treated with SCB. Co-primary endpoints were late lumen loss (LLL) and net lumen gain at 9 months. Secondary endpoints included: procedural success, periprocedural myocardial infarction, binary restenosis and a device-oriented composite endpoint (DOCE), defined as the composite of cardiac death, target vessel myocardial infarction (TV-MI) and clinically-driven target lesion revascularization (CD-TLR). The study was registered at ClinicalTrials.gov (NCT05471245).</p><p><strong>Results: </strong>A total of 104 patients was enrolled at 8 centers. Mean lesion length was 28.9 ± 16.0 mm and reference vessel diameter was 2.3 ± 0.6 mm. Procedural success was achieved in all cases. At 9-month angiographic follow-up, LLL was 0.28 ± 0.68 mm, net lumen gain 0.62 ± 0.63 mm, and binary restenosis was observed in 33.3% of lesions. Clinical events at 12-month included DOCE in 6.7% of patients, cardiac death in 1.0%, TV-MI in 4.8% and CD-TLR in 3.8%. No lesion thrombosis was reported.</p><p><strong>Conclusions: </strong>In a real-world cohort of patients with long de novo coronary lesions, the Magic Touch SCB was associated with a LLL of 0.28 mm, which should be interpreted in light of the high complexity of treated lesions. Future randomized trials are warranted to evaluate its clinical efficacy in comparison with new-generation drug-eluting stents.</p>","PeriodicalId":10474,"journal":{"name":"Clinical Research in Cardiology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}