Clinical Microbiology and Infection最新文献

{"title":"Effectiveness of COVID-19 vaccines against post-COVID-19 condition/long COVID: systematic review and meta-analysis.","authors":"Caroline Peine, Anna Stoliaroff-Pepin, Ulrich Reinacher, Katharina Heldt, Giselle Sarganas, Vanessa Piechotta, Agata Mikolajewska, Antonia Pilic, Nina Barkowski, Daniel Bleve, Marie H Giebeler, Susanne Poser, Livia Searle, Elisabeth Kißner, Leonie Nitsche, Fatimanur Bayram, Waldemar Siemens, Annika Ziegler, Jörg J Meerpohl, Frank Sandmann, Ole Wichmann, Thomas Harder","doi":"10.1016/j.cmi.2025.07.026","DOIUrl":"10.1016/j.cmi.2025.07.026","url":null,"abstract":"<p><strong>Background: </strong>Persons infected with SARS-CoV-2 can develop long-term symptoms known as postCOVID-19 condition (PCC; symptoms ≥3 months after infection) or long COVID (LC; symptoms ≥1 month after infection). Vaccination against COVID-19 might prevent PCC/LC, but the extent of protection is unclear.</p><p><strong>Objectives: </strong>The aim of this systematic review was to evaluate the vaccine efficacy/effectiveness (VE) of COVID-19 vaccines given prior to SARS-CoV-2 infection in preventing PCC or LC.</p><p><strong>Methods data sources: </strong>Studies were identified in Embase, MEDLINE, PreView, COVID-19 L.OVE repository, and Cochrane Library up to August 1, 2024.</p><p><strong>Study eligibility criteria, participants, and interventions: </strong>Randomized controlled trials and nonrandomized studies of interventions (NRSI) that investigated immunization with a COVID-19 vaccine before SARS-CoV-2 infection were eligible, irrespective of participant age and sex.</p><p><strong>Assessment of risk of bias: </strong>Risk of bias was assessed using the ''Risk Of Bias In Nonrandomized Studies-of Interventions'' tool.</p><p><strong>Methods of data synthesis: </strong>Primary outcome was PCC, secondary outcomes were LC, time until reconvalescence, limitations in everyday activity, and quality of life. Meta-analyses were primarily conducted using the random-effects model.</p><p><strong>Results: </strong>A total of 6423 records were screened, and 65 NRSI reporting adjusted estimates were included, comprising >5.7 mio.</p><p><strong>Participants: </strong>VE for ≥1 vaccine dose against PCC was 41.0% (95% CI 27.8%; 51.7%; 22 NRSI, certainty of evidence: low). VE after 1, 2, or 3 doses versus unvaccinated was 19.1% (-119.4%; 70.2%, 3 NRSI), 43.2% (4.5%; 66.2%; 4 NRSI), and 70.0% (30.0%; 87.0%; 1 NRSI), respectively. In <18 years old, VE against PCC was 26% for ≥1 dose (-4%; 48%, 1 NRSI) and in >60 years old 41% (17%; 59%, 1 NRSI). VE after pre-Omicron-SARS-CoV-2 infection was 32.1% (-54.3%; 70.1%, 3 NRSI) and 20.9% (-10.1%; 43.3%, 2 NRSI) after Omicron infection. Sensitivity analyses indicated no influence of risk of bias and effect measure.</p><p><strong>Conclusions: </strong>COVID-19 vaccines may be moderately effective in preventing PCC/LC. VE may increase with the number of vaccine doses administered.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The importance of patient information and informed consent for unlicensed phage therapy.","authors":"Joshua D Jones, Helen J Stacey, Mehrunisha Suleman, Ross J Langley","doi":"10.1016/j.cmi.2025.07.032","DOIUrl":"10.1016/j.cmi.2025.07.032","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of COVID-19 vaccination among dialysis and kidney transplant patients compared with matched controls-a nationwide cohort study.","authors":"Hanna Helanne, Elisa Kortela, Jaakko Helve, Asko Järvinen, Erik Forsblom, Ruska Rimhanen-Finne, Tiina Karonen, Jukka Ollgren, Ilkka Helanterä, Patrik Finne","doi":"10.1016/j.cmi.2025.07.029","DOIUrl":"10.1016/j.cmi.2025.07.029","url":null,"abstract":"<p><strong>Objectives: </strong>Patients undergoing long-term kidney replacement therapy (KRT) have an increased risk of morbidity and mortality due to COVID-19. This study aimed to evaluate the real-world effectiveness of COVID-19 vaccination in reducing hospitalization and mortality due to COVID-19 among dialysis and kidney transplant patients.</p><p><strong>Methods: </strong>We obtained data on all patients receiving KRT from the Finnish Registry for Kidney Diseases. For each patient, 10 controls from the Finnish population registry were matched by age, sex, and municipality. Hazard ratios of hospitalizations and deaths due to COVID-19 were calculated by vaccination status among dialysis patients, kidney transplant recipients, and controls to estimate vaccine effectiveness.</p><p><strong>Results: </strong>In total, 5755 KRT patients, including 2547 on dialysis and 3208 kidney transplant recipients, were compared with 57 253 controls. Overall, 784 (30.8%) dialysis patients, 929 (29.0%) kidney transplant recipients, and 10 702 (18.7%) controls were infected with SARS-CoV-2 between 1 January 2020 and 31 December 2022. With 2-3 vaccine doses, vaccine effectiveness against hospitalization due to COVID-19 was 47% (95% CI: 12-68%) in dialysis patients, 50% (95% CI: 26-66%) in kidney transplant recipients, and 76% (95% CI: 69-82%) in controls. In kidney transplant recipients, receiving more than three vaccine doses reduced COVID-19-related mortality by 62% (95% CI: 14-83%), whereas the reduction in mortality in dialysis patients was not statistically significant.</p><p><strong>Discussion: </strong>Vaccination was associated with significantly reduced hospitalization due to COVID-19 among KRT patients, and more than three vaccine doses were associated with reduced mortality in kidney transplant recipients, highlighting the importance of booster vaccinations in this vulnerable group.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomenclature, definitions, and methodological approaches to estimate the association between antimicrobial treatment and clinical outcomes of drug-resistant bloodstream infections.","authors":"Nasreen Hassoun-Kheir, Miriam Roncal Redin, Appiah-Korang Labi, Michael Loftus, Andrew J Stewardson, Stephan Harbarth, Leonard Leibovici, Mical Paul, Koen B Pouwels, Mike Sharland, Alexander M Aiken, Marlieke E A de Kraker","doi":"10.1016/j.cmi.2025.07.033","DOIUrl":"10.1016/j.cmi.2025.07.033","url":null,"abstract":"<p><strong>Background: </strong>Antimicrobial resistance increases the risk of misaligned initial antibiotic treatment (IAT), as susceptibility data are typically delayed. The causal effect on patient outcomes, however, is unclear due to reliance on observational studies with methodological heterogeneity.</p><p><strong>Objectives: </strong>To describe the terminology and definitions for IAT misalignment and evaluate methods used to analyse its association with mortality and hospital length of stay (LOS) for patients with drug-resistant bloodstream infections (BSIs).</p><p><strong>Methods: </strong>A systematic review.</p><p><strong>Data sources: </strong>PubMed and EMBASE: January 1990 to August 2024.</p><p><strong>Study eligibility criteria: </strong>We included studies on drug-resistant BSIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species, and other Enterobacterales). Eligible studies defined IAT misalignment and assessed its effect on mortality/LOS.</p><p><strong>Participants: </strong>Patients with drug-resistant BSIs.</p><p><strong>Exposure: </strong>(mis)aligned IAT.</p><p><strong>Assessment of risk of bias: </strong>Revised versions of the Joanna Briggs Institute tools.</p><p><strong>Methods of data synthesis: </strong>Qualitative synthesis.</p><p><strong>Results: </strong>From 3627 screened publications, 187 studies were included, predominantly cohort studies (n = 183). The most common terminology for IAT misalignment was \"(in)appropriate\" (n = 139, 74.3%), followed by \"(in)adequate\" (n = 34, 18.2%). Definitions primarily considered in vitro susceptibility to prescribed antibiotic(s) (n = 184, 98.4%), with up to nine additional criteria. Impact of (in)appropriate IAT on mortality (n = 186) was mostly evaluated using logistic or Cox regression, including various confounder selection methods, showing an association in 122 of 186 studies (65.6%). Admission-to-infection time and infection-to-treatment time were rarely considered. Impact of (in)appropriate IAT on LOS was shown in two of nine studies. Only four studies explicitly analysed postinfection LOS. No study scored a low risk of bias, due to residual confounding and time-dependent bias.</p><p><strong>Discussion: </strong>Wide variability of IAT definitions and impact analysis was observed, with a high risk of bias, hindering data aggregation and limiting understanding of the causal effect of inappropriate IAT on clinical outcomes. Guidelines are required to improve study quality and harmonize future research.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A quasi-experimental study of a bundled diagnostic stewardship intervention for ventilator-associated pneumonia” [Clin Microbiol Infect 30 (2024) 499–506]","authors":"Owen R. Albin ,&nbsp;Jonathan P. Troost ,&nbsp;Louis Saravolatz II ,&nbsp;Michael P. Thomas ,&nbsp;Robert C. Hyzy ,&nbsp;Mark A. Konkle ,&nbsp;Andrew J. Weirauch ,&nbsp;Robert P. Dickson ,&nbsp;Krishna Rao ,&nbsp;Keith S. Kaye","doi":"10.1016/j.cmi.2025.07.030","DOIUrl":"10.1016/j.cmi.2025.07.030","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 10","pages":"Page 1762"},"PeriodicalIF":8.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbes know no borders: importation of macrolide-resistant Bordetella pertussis into France in 2024: author's reply.","authors":"Valérie Bouchez, Noémie Lefrancq, Julie Toubiana, Carla Rodrigues, Sylvain Brisse","doi":"10.1016/j.cmi.2025.07.028","DOIUrl":"10.1016/j.cmi.2025.07.028","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enterobacterales gut colonization and late-onset sepsis in neonates: a multicentre prospective study across 18 neonatal intensive care units in six countries.","authors":"Lucia Barcellini, Lodovico Sterzi, Francesco Comandatore, Simona Panelli, Federica Forlanini, Elisa Crivellaro, Anna Banfi, Alice La Mendola, Stella Papaleo, Mike Sharland, Gianvincenzo Zuccotti, Laura Folgori","doi":"10.1016/j.cmi.2025.07.025","DOIUrl":"10.1016/j.cmi.2025.07.025","url":null,"abstract":"<p><strong>Objectives: </strong>Gram-negative bacteria cause a significant proportion of neonatal late-onset sepsis (LOS) and are associated with high mortality. Emerging evidence implicates the gut as a reservoir for invasive pathogens; however, the mechanisms of gut-to-blood translocation and the role of virulence factors remain unclear.</p><p><strong>Methods: </strong>We conducted a secondary analysis of microbiological samples from the NeoMero-1 trial, a multicentre study of neonatal LOS. Whole-genome sequencing was performed on paired blood and faecal Enterobacterales isolates from 22 neonates with gram-negative bacteria bloodstream infection and concurrent gut samples. Genetic relatedness was assessed using multilocus sequence typing and species-specific single-nucleotide polymorphism thresholds. Virulence gene profiles were characterized using the virulence factor database.</p><p><strong>Results: </strong>In 18 of 22 cases (82%), blood and gut isolates were genetically highly related, supporting gut-to-blood translocation. All invasive Escherichia coli (7 over 7) strains consistently harboured haemolysin genes (hlyA-D), absent in all the noninvasive strains (2/2 p 0.028). Extremely preterm and low birth weight neonates were overrepresented among those with translocation.</p><p><strong>Conclusions: </strong>Our findings support the role of gut-derived Enterobacterales in the pathogenesis of neonatal LOS. These insights may inform infection control and targeted preventive strategies. Further prospective studies are needed to validate these findings and guide interventions for high-risk neonates.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternaria infection manifesting as violaceous skin lesions in a solid organ transplant recipient.","authors":"Auriane Collin, Eleonor Goubeau, Anaïs Gouteron, Marie-Hélène Aubriot-Lorton, Stephane Valot, Sandrine Grosjean, Mathieu Blot, Thibault Sixt","doi":"10.1016/j.cmi.2025.07.027","DOIUrl":"10.1016/j.cmi.2025.07.027","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confront cholera crisis after the Myanmar earthquake.","authors":"Xiangyu Yan, Zhuo Li, Biao Kan, Shun Zha, Linhui Hao, Tiejun Shui","doi":"10.1016/j.cmi.2025.07.023","DOIUrl":"10.1016/j.cmi.2025.07.023","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HHV8-related diseases in solid organ transplantation: a case series and systematic literature review.","authors":"Cecilia Bonazzetti, Matteo Rinaldi, Federico Giovagnorio, Pelin İrkören, Martina Casarini, Alessandra Cascavilla, Maria Cristina Morelli, Luca Vizioli, Paolo Pianta, Giorgia Comai, Matteo Ravaioli, Luciano Potena, Liliana Gabrielli, Tiziana Lazzarotto, Nicola Alvaro, Pierluigi Viale, Maddalena Giannella","doi":"10.1016/j.cmi.2025.07.019","DOIUrl":"10.1016/j.cmi.2025.07.019","url":null,"abstract":"<p><strong>Background: </strong>The true burden of HHV-8 in solid organ transplant (SOT) setting remains difficult to quantify and there are several uncertainties about the best prevention and management of HHV-8 related complications.</p><p><strong>Objectives: </strong>To describe epidemiology and impact on outcome of HHV-8 related diseases in patients undergoing SOT, we reviewed all episodes diagnosed at our hospital over 8-year period and performed a narrative systematic literature review.</p><p><strong>Sources: </strong>A search on PubMed, Scopus and Cochrane Library, according to Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines, was done. All types of studies, published in any language from January 2000 to January 2025, focused on HHV-8 related diseases in adult and paediatric SOT recipients were considered. Due to heterogeneity among studies, the evidence synthesis was descriptive.</p><p><strong>Content: </strong>Ninety-one studies conducted across 26 countries were included. Overall, 337 HHV-8 cases were reported among 19,283 transplant recipients, including 215 (63.8%) kidney, 80 (23.7%) liver, 22 (6.5%) lung, 13 (3.9%) heart and 5 (1.5%) combined transplants. Considering only cohort studies, a prevalence of 1.1% was estimated. The median time from transplant to disease was 11 months. For cases with available data, mismatch D+/R- was common (41/63, 65.1%). Main diseases included cutaneous Kaposi Sarcoma (KS) (49.7%) and visceral KS (33.4%), Kaposi Sarcoma Inflammatory Cytokine Syndrome (KICS) accounted for 4.7%. Management of immunosuppressive regimens mostly consisted in in reduction of maintenance regimen (169/209, 80.9%) and switch from tacrolimus to mTOR (79/209, 37.9%). Twenty-five studies reported antiviral use in 48/70 (68.6%) patients consisting in ganciclovir/valganciclovir (21 cases), foscarnet (17 cases) and/or cidofovir (10 cases). Rituximab was used for both oncological and non-oncological HHV-8 related diseases. Overall, 90-day mortality was 19.7%, reaching 29% excluding cutaneous KS.</p><p><strong>Implications: </strong>HHV-8 related diseases after SOT are relatively uncommon, but associated with high mortality rates. Standardized management protocols for HHV-8 diseases are needed.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}