Clinical Microbiology and Infection最新文献

{"title":"Malaria, the never ending fight.","authors":"Emmanuel Bottieau, Christophe Van Dijck","doi":"10.1016/j.cmi.2026.08.044","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.044","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Screening for multi-drug resistance carriage and appropriate initial antibiotic treatment of ICU-acquired bloodstream infections' - Author's reply.","authors":"Nasreen Hassoun-Kheir, Alexis Tabah, Hannah Wozniak, Jean-François Timsit, Niccolò Buetti","doi":"10.1016/j.cmi.2026.08.041","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.041","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspergillus udagawae cerebral aspergillosis in a patient with chronic lymphoid leukaemia.","authors":"Alfredo Maldonado-Barrueco, Juan Carlos Ramos-Ramos, Patricia Baltasar-Tello, Sara Galván-Platas, Rita M Regojo, Ana Alastruey-Izquierdo, Laura Alcázar-Fuoli, Inmaculada Quiles-Melero, Julio García-Rodríguez","doi":"10.1016/j.cmi.2026.08.042","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.042","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Extended-pulsed fidaxomicin versus conventional dosing in patients at high risk of recurrence of Clostridioides difficile infection' - Author's reply.","authors":"Elena Rubio-Martín, Rosa Escudero-Sánchez, Javier Cobo","doi":"10.1016/j.cmi.2026.08.039","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.039","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic EBV Infection in T Cells Identifies Reduced Therapeutic Responsiveness and Immune Dysfunction After Allogeneic Hematopoietic Stem Cell Transplantation.","authors":"Zhifan Zhao, Zhuojun Liu, Qiang Huang, Zhipeng Zhou, Mengjia Li, Meng Lv, Yuqian Sun, Xiaodong Mo, Lanping Xu, Yu Wang, Xiaohui Zhang, Liang Chen, Xiangyu Zhao, Zhilei Bian, Xiaojun Huang, Xuying Pei","doi":"10.1016/j.cmi.2026.08.037","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.037","url":null,"abstract":"<p><strong>Objectives: </strong>EBV reactivation after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is typically monitored by plasma viral load, but this fails to capture cellular reservoirs. Lineage-specific testing, though usually performed in high-risk patients, may identify biologically distinct disease states. We aimed to evaluate the clinical and biological significance of lineage-specific EBV quantification especially ectopic EBV infection in T cells in allo-HSCT recipients with EBV reactivation.</p><p><strong>Methods: </strong>We analyzed 144 allo-HSCT recipients with EBV reactivation who underwent lineage-specific EBV quantification, assessed whether T-cell tropic EBV burden identifies a phenotype with reduced responsiveness to rituximabtherapy, an increased risk of post-transplant lymphoproliferative disorder (PTLD), and specific features of underlying immune dysfunction.</p><p><strong>Results: </strong>Among the tested high-risk patients with high EBV loads and clinical symptoms, 66.6% exhibited T-cell tropic EBV infection. Compared with non-T-cell tropic infection, T-cell tropism was associated with higher rituximab courses and lower complete response rates (67% vs. 81%, P=0.029), suggesting insufficient efficacy of CD20-directed therapy. Patients with T-cell tropic infection had a significantly higher 1-year cumulative incidence of PTLD compared to the non-T-cell tropic group(77% vs. 41.6%; P < 0.001). Single-cell RNA sequencing and mass cytometry analyses revealed an exhausted T-cell phenotype with diminished stemness in T-cell tropic EBV infected patients.</p><p><strong>Conclusions: </strong>These findings suggest that T-cell EBV quantification distinguishes a therapeutically challenging subtype of EBV reactivation characterized by immune dysfunction and reduced responsiveness to rituximab-based therapy. Incorporating assessment of cellular viral reservoirs into post-transplant EBV monitoring strategies may facilitate early risk stratification and support timely therapeutic escalation beyond rituximab alone.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infective endocarditis due to nontuberculous mycobacteria: A six-case series and review of recent literature.","authors":"Manuel Martínez-Sellés, Mercedes Marín-Arriaza, Belén Loeches-Yagüe, Jorge Calderón-Parra, Elisa Garcia Vazquez, Patricia Munoz","doi":"10.1016/j.cmi.2026.08.038","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.038","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond eligibility: optimising randomized controlled trials for older adults.","authors":"Kin On Kwok, Wan In Wei","doi":"10.1016/j.cmi.2026.08.040","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.040","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148886460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of skin involvement in neutropenic patients with P. aeruginosa bloodstream infection - a 20-year retrospective study.","authors":"Dominic Rauschning, Simone Anna Keimburg, Frederike Krus, Tim Michael Golletz, Bernd Franke, Katharina Leuchte, Isabelle Suàrez, Jonel Trebicka, Clara Lehmann, Norma Jung, Jörg Janne Vehreschild, Julia Fischer","doi":"10.1016/j.cmi.2026.08.032","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.032","url":null,"abstract":"<p><strong>Objectives: </strong>Skin involvement in Pseudomonas aeruginosa bloodstream infection (PA-BSI) is a clinically important but understudied manifestation in neutropenic patients that may indicate a more severe course or distinct risk profile. We aimed to identify factors associated with skin involvement among neutropenic patients with PA-BSI in a retrospective cohort.</p><p><strong>Methods: </strong>Factors for skin involvement in PA-BSI were by using a single-centre, retrospective cohort study including 142 patients with PA-BSI (April 2003 and April 2023) from the Cologne Cohort of Neutropenic Patients study (CoCoNut) database, which comprises 2794 bloodstream infection episodes.</p><p><strong>Results: </strong>Skin involvement occurred in 30/142 patients (21.1%). Patients with skin involvement were more likely to have acute myeloid leukemia (AML) (20/30 vs. 43/112; p = 0.006), recurrent PA-BSI (7/30 vs. 7/112; p = 0.005), longer neutropenia duration (median 27 days vs. 16 days; p = 0.022), and hospital stay (median 47.5 days vs. 36.5 days; p = 0.017). In multivariate analysis, AML (OR 3.430, 95% CI: 1.181 - 9.961; adjusted p = 0.023) and recurrent PA-BSI (OR 6.168, 95% CI: 1.709 - 22.261; adjusted p = 0.005) remained independently associated with skin involvement, while pre-existing cardiovascular disease was inversely associated (OR 0,359, 95% CI: 0.147 - 0.908; adjusted p = 0.031).</p><p><strong>Conclusions: </strong>In this cohort skin involvement was present in one-fifth of neutropenic patients with PA-BSI and was independently associated with underlying AML and PA-BSI recurrence. Prolonged neutropenia and hospitalization appear to be associated with a more complicated clinical course. Increased awareness of these factors may facilitate earlier recognition of skin lesions and prompt targeted management of PA-BSI in high-risk populations.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148825673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: 'Impact of low-dose chest CT and multiplex PCR on antibiotic usage for community-acquired pneumonia' by Zhang et al.","authors":"Wolfgang Bauer, Eva Diehl-Wiesenecker, Lisa Anita Selbmann, Till Bunse, Oliver Liesenfeld","doi":"10.1016/j.cmi.2026.08.035","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.08.035","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148825676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical phenotyping of bloodstream infections: a review of current evidence.","authors":"Natasha Marcella Vaselli, Burcu Isler, Adam Stewart, Philipp Mathé, Laura Escolà-Vergé, Siegbert Rieg","doi":"10.1016/j.cmi.2026.07.056","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.07.056","url":null,"abstract":"<p><strong>Background: </strong>Bloodstream infections (BSIs) are a leading cause of morbidity and mortality, yet their clinical heterogeneity continues to challenge effective patient stratification and treatment optimisation. In other heterogeneous conditions such as sepsis, data-driven clinical subphenotyping has identified reproducible subgroups with distinct outcomes and treatment responses. Whether similar approaches can be applied to BSIs to improve clinical management and trial design is an area of growing interest.</p><p><strong>Objectives: </strong>We aimed to review the current evidence on the use of data-driven phenotyping and unsupervised machine learning techniques to identify clinical subphenotypes in BSIs. Methodological approaches used to derive subphenotypes, and their implications for clinical practice and trial design are elucidated.</p><p><strong>Sources: </strong>A literature search was performed using PubMed/MEDLINE and the Semantic Scholar AI-assisted search tool. Reference lists of included studies were hand-searched to identify additional publications.</p><p><strong>Content: </strong>Data-driven subphenotyping has been most extensively studied in Staphylococcus aureus bacteraemia (SAB), where latent class analysis and cluster analysis point towards distinct subphenotypes with significantly different mortality rates across independent international cohorts. Emerging evidence extends to mixed-pathogen BSI cohorts in the intensive care unit and in immunocompromised populations including solid organ transplant recipients. Bedside tools including online calculators, and simplified scoring systems have been developed to facilitate rapid phenotype assignment. However different studies use varying methodological approaches and there is limited data on validation of these.</p><p><strong>Implications: </strong>Clinical subphenotyping offers a promising framework for personalising antimicrobial therapy, improving risk stratification, and enriching clinical trial populations. Future key priorities include extending phenotyping to underrepresented BSI aetiologies, integrating clinical phenotypes with biological endotypes, and conducting phenotype-stratified interventional trials.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148825625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}