Clinical Microbiology and Infection最新文献

{"title":"Effectiveness and safety of daptomycin versus vancomycin in methicillin-resistant Staphylococci left-side infective endocarditis. Results from a nationwide prospective multicenter cohort.","authors":"Jorge Calderón-Parra, Tziar Diego-Yagüe, Patricia Muñoz, María Carmen Fariñas-Alvarez, Noelia Ruiz-Alonso, Ana Alvarez-Uría, Manuel Martínez-Sellés, Maria Angeles Rodríguez-Esteban, Guillermo Ojeda-Burgos, Ane Josune Goikoetxea-Agirre, Aristides De Alarcón, Jose Maria Miró, Belen Loeches-Yagüe, Antonio Martínez-Ramos","doi":"10.1016/j.cmi.2026.04.027","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.027","url":null,"abstract":"<p><strong>Objective: </strong>The aim of the study was to compare the effectiveness and safety of daptomycin versus vancomycin treatment for left-sided infective endocarditis (IE) caused by methicillin-resistant staphylococci (MRS). We specifically aimed to explore the effectiveness of different daptomycin-based regimens.</p><p><strong>Methods: </strong>Prospective, multicenter cohort including consecutive patients with definite left-sided MRS-IE from January 2008 to December 2023. Patients were in two groups whether they received daptomycin or vancomycin as main antibiotic. Those patients in whom neither antibiotic could be considered the main antibiotic were excluded. The primary endpoint was in-hospital mortality. Multivariable logistic regression was used for adjusted in-hospital mortality and Cox regression for 1-year mortality RESULTS: A total of 617 patients were included: 421 (68.2%) received daptomycin-based and 196 (31.8%) received vancomycin-based regimens. In the adjusted analysis, daptomycin showed with similar in-hospital mortality compared to vancomycin (adjusted odds ratio [aOR] 0.79 [95% CI 0.48-1.28]). Daptomycin was associated with a significantly lower rate of adverse drug reactions (14.5% [61/421] vs 26.0% [51/196], p=0.001), mainly driven by less acute kidney injury (8.7% [36/421] vs 16.8% [32/196], p=0.003). In subgroup analyses, high-dose daptomycin (HDD, ≥8 mg/kg) in combination was associated with lower in-hospital mortality than other daptomycin regimens (aOR 0.55, 95% CI 0.31-0.98) without more adverse reactions (14.5% [34/234] vs 14.4% [27/187], p=1.000). Compared to vancomycin, HDD-based combination strategy was not associated with statistically significant difference in in-hospital mortality (aOR 0.66, 95%CI 0.38-1.09) but was associated with lower one-year mortality (adjusted hazard ratio 0.55; 95% CI 0.31-0.98). and lower rate of adverse reactions (14.5% [34/234] vs 26.0% [51/19], p=0.003).</p><p><strong>Conclusions: </strong>In this large, real-world cohort, daptomycin demonstrated comparable effectiveness to vancomycin. However, it was associated with lower adverse reactions. High-daptomycin dose-based combinations with a second agent could be associated with improved outcomes. This strategy could be considered as a therapeutic option for MRS-IE.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syphilis and the risk of stroke: a nationwide, population-based matched cohort study.","authors":"Laura Glismann, Emilie With Hall Petersen, Simone Høstgaard, Steen Hoffmann, Jørgen Skov Jensen, Jan Gorm Lisby, Lene H Harritshøj, Terese L Katzenstein, Maria Wessman, Kirsten Salado-Rasmussen, Lars Haukali Omland","doi":"10.1016/j.cmi.2026.04.025","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.025","url":null,"abstract":"<p><strong>Objectives: </strong>Syphilis has re-emerged globally recently. However, valid data on stroke risk following syphilis infection is limited. We aimed to assess the risk of stroke among patients with syphilis and to account for family related factors as well as confounding by test indication.</p><p><strong>Methods: </strong>We conducted a nationwide, population-based matched cohort study in Denmark using linked registry and laboratory data from 2000-2022. Individuals aged 16-80 years with a positive syphilis serology test were matched 1:9 on sex and date of birth to individuals from the general population. To address confounding by test indication, a syphilis test-negative cohort was matched 1:1 to the syphilis-positive cohort. To assess familial and shared environmental factors, sibling cohorts corresponding to each primary cohort were included. Stroke incidence was ascertained through hospital registries. Hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated using Cox regression, and cumulative incidence functions were used to estimate absolute risk.</p><p><strong>Results: </strong>The study included 3, 593 syphilis test-positive individuals, 3,590 syphilis test-negative individuals and 32,629individuals from the general population contributing over 300,000 person-years of follow-up. Median age was 36 years, 81% were male. The 10-year cumulative risk of stroke among syphilis-positive individuals was 1.8% (95% CI: 1.3-2.4). Stroke risk was markedly higher among syphilis-positive individuals compared with the general population (HR 5.4 (95% CI: 3.7-7.7), but not compared with syphilis-negative individuals (HR 1.5 (95% CI: 0.9-2.4). Siblings of syphilis-positive individuals also had an increased risk of stroke compared with siblings from the general population (HR 2.2; 95% CI 1.4-3.6), but not compared with siblings of syphilis-negative individuals.</p><p><strong>Conclusion: </strong>Individuals tested for syphilis - regardless of test result- have a higher risk of stroke than the general population. These findings suggest that confounding by test indication and shared familial factors, rather than syphilis infection itself, contribute substantially to the observed association.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Nocardia farcinica infection in a post-transplant supraspinatus abscess.","authors":"Dr Jyotiprakash Panda","doi":"10.1016/j.cmi.2026.04.026","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.026","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plectosphaerella cucumerina fungal keratitis in an uncommon presentation.","authors":"Lipeng Wang, Lihua Jiang, Shujun Liu, Maoli Yi","doi":"10.1016/j.cmi.2026.04.024","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.024","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CALL FOR EDITOR IN VIROLOGY.","authors":"Jesús Rodríguez-Baño","doi":"10.1016/j.cmi.2026.04.028","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.028","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-immunity to therapeutic Kayvirus staphylophages reveals conserved immunogenic epitopes in patients.","authors":"Mireia Bernabéu-Gimeno, Alonso Felipe-Ruiz, Pilar García, Benjamin K Chan, Paul E Turner, Pilar Domingo-Calap","doi":"10.1016/j.cmi.2026.04.023","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.023","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between early SARS-CoV-2 viral rebound and post-COVID conditions among immunocompromised patients: cohort study.","authors":"Guozhang Lin, Yuchen Wei, Carlos King Ho Wong, Xi Xiong, Huwen Wang, Christopher Boyer, Chi Tim Hung, Conglu Li, Carrie Ho Kwan Yam, Tsz Yu Chow, Shi Zhao, Zihao Guo, Kehang Li, Qiaoge Chi, Aimin Yang, Chris Ka Pun Mok, David S C Hui, Eng Kiong Yeoh, Ka Chun Chong","doi":"10.1016/j.cmi.2026.03.036","DOIUrl":"10.1016/j.cmi.2026.03.036","url":null,"abstract":"<p><strong>Objectives: </strong>Immunocompromised status has been shown to be a risk factor for SARS-CoV-2 viral rebound. However, no studies have assessed the long-term clinical consequences of viral rebound in the immunocompromised population. This study aimed to examine the association of early viral rebound with postacute conditions among immunocompromised patients.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using territory-wide electronic health records from the Hospital Authority and the Department of Health in Hong Kong. The study cohort consisted of immunocompromised adults aged 18 years or older who tested positive for SARS-CoV-2 between 26 February 2022 and 9 November 2023, and who were hospitalized with COVID-19. Patients were classified as having early viral rebound or not having early viral rebound based on the cycle threshold values within 21 days of the positive RT-PCR test result. The primary outcome was postacute all-cause inpatient death, evaluated starting from 21 days after the positive RT-PCR test.</p><p><strong>Results: </strong>A total of 1296 immunocompromised adults were included in this study (46.4% [601 of 1296] were female; median [interquartile range] age, 68 [59-76] years). In all, 22.3% (289 of 1296) patients were categorized as having early viral rebound. Haematological malignancy was significantly associated with early viral rebound (hazard ratio 1.52, 95% CI 1.09-2.12, p 0.014). Early viral rebound was significantly associated with a higher risk of postacute inpatient death (hazard ratio 1.53, CI 1.16-2.02, p 0.002).</p><p><strong>Conclusions: </strong>This study demonstrated an association between early viral rebound and post-COVID mortality among immunocompromised individuals.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147643983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a rapid, visual fingerstick serology self-test for Helicobacter pylori detection and typing: A prospective multicenter diagnostic accuracy study.","authors":"Jing Chen, Tingting Wang, Song Liu, Jing Xiang, Yuhan Qi, Hao Zhou, Yuan Yue, Zimeng Jiang, Peng Yang, Youjing Zhan, Yunyi Liu, Xueran Mei, Jinliang Diao, Ou Peng, Bingmei Wu, Hui Lin, Chaoqiang Fan, Xia Xie, Mingdong Hu, Xubiao Nie, Yuyang Chen, Xin Zhang, Jun Yang, Ye Xiao, Changjiang Hu","doi":"10.1016/j.cmi.2026.04.020","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.020","url":null,"abstract":"<p><strong>Objectives: </strong>Type I Helicobacter pylori (H. pylori) strains exhibit high levels of virulence. In this study, a rapid, visual self-testing kit for H. pylori typing using one drop of finger blood was developed based on the latex agglutination test (LAT). A prospective multicenter diagnostic accuracy study (ChiCTR2400082329) was conducted to evaluate its performance.</p><p><strong>Methods: </strong>Each participant recruited from the Department of Gastroenterology or the Physical Examination Center of four centers performed the novel LAT and interpreted the results independently. The performance of the novel LAT for H. pylori typing in screening population (individuals voluntarily undergoing H. pylori infection screening, regardless of the presence of gastrointestinal symptoms) was evaluated using the consistent results of the ¹³C-urea breath test (¹³C-UBT), quantum dot-based immunofluorescence (QD) assay and immunoblotting (IB) assay conducted by professionals as the reference standard. This strict reference standard was adopted to ensure diagnostic accuracy for both active infection and strain typing.</p><p><strong>Results: </strong>A total of 1,330 participants with consistent diagnostic data (¹³C-UBT, QD, and IB assays) were included in the final analysis. Compared with the reference standard, the novel LAT achieved a sensitivity, specificity, and accuracy of 93.67% [95% CI, 88.35%-96.75%], 97.86% [95% CI, 96.82%-98.59%], and 97.37% [95% CI, 96.44%-98.16%], respectively in identifying type I H. pylori infection.</p><p><strong>Conclusions: </strong>The novel LAT developed in this study can potentially be used for the identification of type I H. pylori infection in home self-screening and large-scale population screening.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLM-26-32217 - First autochthonous mpox virus clade Ib outbreak in Italy linked to sexual transmission.","authors":"Valentina Mazzotta, Andrea Bongiovanni, Licia Bordi, Marco Ridolfi, Gabriella De Carli, Rebecca Jo Steiner, Francesca Colavita, Gabriella d'Ettorre, Rozenn Esvan, Cesare Ernesto Maria Gruber, Giorgio Nicolo' Malatesta, Luigi Coppola, Sara Covino, Maria Beatrice Valli, Ilaria Mastrorosa, Maria Concetta Fusco, Fabrizio Carletti, Katia Casinelli, Loredana Sarmati, Enrico Girardi, Andrea Siddu, Claudio Maria Mastroianni, Fabrizio Maggi, Andrea Antinori, Francesco Vairo","doi":"10.1016/j.cmi.2026.04.021","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.021","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic prophylaxis: a sharp tool that could be blunted easily.","authors":"Marek Stefan, Marcela Krutova","doi":"10.1016/j.cmi.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.cmi.2026.04.018","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}