Clinical Microbiology and Infection最新文献

{"title":"Interplay of multiple carbapenemases and tigecycline resistance in Acinetobacter species: a serious combined threat.","authors":"Xinyang Li, Yilu Zhuang, Yawen Yu, Huiqiong Jia, Yingying Kong, Jun Zhang, Xinyou Xie, Eliana Guedes Stehling, João Pedro Rueda Furlan, Zhemin Zhou, Zhi Ruan","doi":"10.1016/j.cmi.2024.08.027","DOIUrl":"10.1016/j.cmi.2024.08.027","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"128-133"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Internal migrants as drivers of long-distance cross-regional transmission of tuberculosis in China.","authors":"Meng Li, Zhuo Quan, Peng Xu, Howard Takiff, Qian Gao","doi":"10.1016/j.cmi.2024.09.005","DOIUrl":"10.1016/j.cmi.2024.09.005","url":null,"abstract":"<p><strong>Objectives: </strong>Internal migrants in China frequently travel between their hometowns and the cities where they work, creating ample opportunities for cross-regional transmission of tuberculosis (TB). The aim of this study was to explore the role of internal migrants in transmitting TB across different regions and the contribution of cross-region transmission to China's TB burden.</p><p><strong>Methods: </strong>The study included a total of 8664 patients with TB and their Mycobacterium tuberculosis isolates, collected from two large cities and three rural regions. Genomic clusters were defined as having a genomic distance of ≤12-single nucleotide polymorphisms. Cross-regional clusters were defined as clusters containing patients from at least two regions, indicative of cross-regional transmission.</p><p><strong>Results: </strong>A total of 2403 clustered cases (27.7%) were grouped into 845 clusters, of which 142 (16.8%) were cross-regional. An increased risk for cross-regional transmission was found for internal migrants (adjusted OR (aOR), 1.45; 95% CI, 1.13-1.87), individuals aged <55 years (aOR, 2.73; 95% CI, 1.81-4.13), and housekeepers/factory workers (aOR, 1.16; 95% CI, 0.90-1.50). Among 200 cross-regional transmission events identified by transmission inference, 96 occurred between urban patients, 98 between urban and rural patients, and only six between rural patients. Notably, 93.5% (187/200) of cross-regional transmission events involved internal migrants. Epidemiological data showed that just 5.5% of cross-regional transmission events involved patients from the same township or neighbouring counties, where the transmission likely occurred.</p><p><strong>Discussion: </strong>The mobility of the internal migrant population appears to be responsible for most cross-regional transmission of TB in China. The magnitude and dynamics of cross-regional transmission should be addressed in future strategies to reduce the incidence of TB in China.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"71-77"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which trial do we need? A pragmatic randomized trial of trimethoprim-sulfamethoxazole vs. vancomycin for the treatment of methicillin-resistant Staphylococcus aureus bacteraemia in low-resource settings.","authors":"Judith Recht, Terry John Evans, Vilada Chansamouth, Koukeo Phommasone, Mayfong Mayxay, Elizabeth A Ashley","doi":"10.1016/j.cmi.2024.07.018","DOIUrl":"10.1016/j.cmi.2024.07.018","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"13-17"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to: assess patient suitability for unlicensed phage therapy in the United Kingdom.","authors":"Joshua D Jones, Helen J Stacey, John W Kennedy, Maya Merabishvilli, Melissa E K Haines, Oliver Blocker, Kumara Dharmasena, Andrew Gordon, Stuart A Hamilton, Ila Aggarwal, John Nagy, Don S Urquhart, Lesley M L Hall, Matthew J Young, Gordon MacGregor, Ross J Langley, Christine Peters, Daniela I Munteanu","doi":"10.1016/j.cmi.2024.07.022","DOIUrl":"10.1016/j.cmi.2024.07.022","url":null,"abstract":"<p><strong>Background: </strong>Bacteriophage (phage) therapy is a promising alternative antimicrobial approach that has the potential to transform the way we treat bacterial infections. The antibiotic resistance crisis is driving renewed interest in phage therapy. There are currently no licensed phage therapy medicinal products and phage therapy is used in small but growing patient numbers on an unlicensed basis.</p><p><strong>Objectives: </strong>This article provides guidelines on the assessment of patient suitability for unlicensed phage therapy for clinicians in the United Kingdom.</p><p><strong>Sources: </strong>This article builds on Health Improvement Scotland's recommendation for the consideration of phage therapy in difficult-to-treat infections and the experience of the author group, who have collectively assessed the suitability of 30 patients for phage therapy.</p><p><strong>Content: </strong>In the United Kingdom, unlicenced medicines, including phages, may be considered to meet special clinical needs. The use of unlicenced medicines is governed by national legislation and local National Health Service trust policies. Phages can be used in any National Health Service trust and decisions about suitability should be made through existing local clinical management pathways. This article sets out guidelines to support local clinical teams in the assessment of patient suitability for phage therapy. Clinical and microbiological considerations are presented, including allergy and pregnancy.</p><p><strong>Implications: </strong>The assessment of patient suitability for phage therapy is within the scope of local clinical teams. Local assessment through existing clinical management pathways will develop confidence and competence in phage therapy among clinical teams nationally and ensure timely patient care.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"57-61"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting diagnostics: erythrocyte sedimentation rate and C-reactive protein: it is time to stop the zombie tests.","authors":"Brad Spellberg, Travis B Nielsen, Matthew C Phillips, Bassam Ghanem, Tom Boyles, Boris Jegorović, Brent Footer, Jordan K Mah, Anthony Lieu, Jake Scott, Noah Wald-Dickler, Todd C Lee, Emily G McDonald","doi":"10.1016/j.cmi.2024.08.017","DOIUrl":"10.1016/j.cmi.2024.08.017","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"1-4"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142104998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to 'TMPRSS2 inhibitors for the treatment of COVID-19 in adults: a systematic review and meta-analysis of randomized clinical trials of nafamostat and camostat mesylate' [Clin Microbiol Infect (30) (2024) 743-754].","authors":"María Patricia Hernández-Mitre, Susan C Morpeth, Balasubramanian Venkatesh, Thomas E Hills, Joshua Davis, Robert K Mahar, Grace McPhee, Mark Jones, James Totterdell, Steven Y C Tong, Jason A Roberts","doi":"10.1016/j.cmi.2024.08.005","DOIUrl":"10.1016/j.cmi.2024.08.005","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"141"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141912061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: 'Nirmatrelvir/ritonavir treatment and risk for post-acute sequelae of COVID-19 infection in older Singaporeans' by Wee et al.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1016/j.cmi.2024.09.022","DOIUrl":"10.1016/j.cmi.2024.09.022","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"138"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cefiderocol-resistant hypervirulent Klebsiella pneumoniae with CirA deficiency and co-production of KPC-2 and SHV-12.","authors":"Peng Lan, Ye Lu, Weichao Liao, Yunsong Yu, Ying Fu, Jiancang Zhou","doi":"10.1016/j.cmi.2024.08.014","DOIUrl":"10.1016/j.cmi.2024.08.014","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"125-127"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections in immunocompromised hosts: progress made and challenges ahead.","authors":"Joseph Sassine, Chrysanthi Skevaki, Roy F Chemaly","doi":"10.1016/j.cmi.2024.10.017","DOIUrl":"10.1016/j.cmi.2024.10.017","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"22-23"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of long-term corticosteroid use on susceptibility to respiratory viruses: a narrative review.","authors":"Paraskevi C Fragkou, Dimitra Dimopoulou, Charalampos D Moschopoulos, Chrysanthi Skevaki","doi":"10.1016/j.cmi.2024.09.014","DOIUrl":"10.1016/j.cmi.2024.09.014","url":null,"abstract":"<p><strong>Background: </strong>Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.</p><p><strong>Objectives: </strong>The aim of this review is to provide an insightful overview of the most up-to-date evidence regarding the extent to which the use of corticosteroids (CSs) influences the risk of RVIs.</p><p><strong>Sources: </strong>The PubMed database was searched for studies on the association between CSs and RVIs from inception until 15 December 2023.</p><p><strong>Content: </strong>CSs have differing impacts on the risk of RVIs in asthma and chronic obstructive pulmonary disease, influenced by both the specific virus and the type and dose of CSs. Furthermore, current data demonstrate that CSs may increase the risk of RVIs in patients with systemic lupus erythematosus, rheumatoid arthritis, vasculitis, solid tumours, haematological malignancies, and among transplant recipients.</p><p><strong>Implications: </strong>Large-scale studies are imperative to inform a more accurate and personalized risk stratification for RVIs. This, in turn, will point towards new strategies for RVI prevention and associated morbidity and mortality in high-risk populations.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":"43-48"},"PeriodicalIF":10.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}