Clinical Microbiology and Infection最新文献

{"title":"Tranexamic acid contamination and bloodstream infections due to Burkholderia cepacia complex and Pseudomonas aeruginosa: implications for clinical trials and good manufacturing processes for investigational products.","authors":"Trisha Peel, Jessica Wisniewski, Jane Hawkey, Ravali Theegala, Katherine Pragastis, Anton Y Peleg, Sophia Wallace, Paul Myles","doi":"10.1016/j.cmi.2025.03.023","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.023","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which trial do we need? Ampicillin versus ampicillin plus ceftriaxone for E. faecalis endocarditis: is it time to start re-considering monotherapy?","authors":"Emanuele Rando, Jesús Rodríguez Baño, Luis Eduardo López Cortés","doi":"10.1016/j.cmi.2025.03.020","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.020","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Broth microdilution susceptibility testing reveals underestimation of resistance to penicillin and high levels of resistance to ampicillin of Streptococcus pneumoniae clinical isolates in Sweden.","authors":"Alexandros Petropoulos, Eva Morfeldt, Kerstin Nyrén, Karin Blomqvist, Birgitta Henriques-Normark","doi":"10.1016/j.cmi.2025.03.019","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.019","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive Streptococcus Pneumoniae infections in Southern Switzerland: a preventable condition that is not actually prevented.","authors":"Niccolò Ramponi, Enos Bernasconi, Linda Mueller, Giorgio Merlani, Martine Gallacchi Bouvier, Marco Bongiovanni","doi":"10.1016/j.cmi.2025.03.021","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.021","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: 'Comparing Large Language Models for antibiotic prescribing in different clinical scenarios' by De Vito et al.","authors":"Daniele Roberto Giacobbe, Maurizio Sanguinetti, Matteo Bassetti","doi":"10.1016/j.cmi.2025.03.022","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.022","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow-up of individuals with Chagas disease treated with posaconazole and benznidazole in a non-endemic region: the CHAGASAZOL cohort.","authors":"Joan Roig-Sanchis, Pau Bosch-Nicolau, Aroa Silgado, Fernando Salvador, Adrián Sánchez-Montalvá, Marisa Aznar, Inés Oliveira, Juan Espinosa-Pereiro, Núria Serre-Delcor, Diana Pou, Joan Martínez-Campreciós, Elena Sulleiro, Israel Molina","doi":"10.1016/j.cmi.2025.03.018","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.018","url":null,"abstract":"<p><strong>Objectives: </strong>The CHAGASAZOL trial compared posaconazole and benznidazole for treating chronic Chagas Disease. Posaconazole showed poor short-term efficacy by means of qPCR compared to benznidazole, but few studies have reported long-term follow-up using this tool. The aim of the present study is to provide a more comprehensive analysis of the CHAGASAZOL cohort through 11 years of follow-up.</p><p><strong>Methods: </strong>This is a prospective observational cohort of individuals who were included in the CHAGASAZOL trial. Data was censored as of December 31, 2023. Subjects initially treated with posaconazole with a positive qPCR were offered re-treatment with Benznidazole. All patients underwent clinical and electrocardiographic evaluations as well as a qPCR at a six-month or one-year interval. The primary objective was parasitological failure, defined as any positive qPCR in peripheral blood at any time during follow-up.</p><p><strong>Results: </strong>Seventy-two participants were enrolled (median follow-up: 71 months, range 1-147). At baseline, 59 (82%) were classified as indeterminate form, 9 (12%) as cardiac, 2 (3%) as digestive and 2 (3%) as mixed forms. Forty-eight participants received posaconazole, 45 completing at least one follow-up visit. Up to 43/45 (95%) presented a positive qPCR, and of them, 35 accepted to be retreated with benznidazole. Considering those treated with benznidazole (either initially or as a re-treatment), only 3/51 (6%) showed a positive qPCR. Four (5.5%) participants showed cardiac progression after 3 to 10 years of follow-up, with an incident rate of 0.94 events per 100 person-years. Two of them had received the complete benznidazole treatment, 1 was partially treated (17 days) and 1 was only treated with posaconazole before clinical progression.</p><p><strong>Conclusion: </strong>Even if benznidazole showed parasitological efficacy, lifelong follow-up should be offered to individuals living with CD, as both parasitological failure and clinical progression can occur many years after diagnosis and treatment.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial pressure management in pneumococcal meningitis: first, do no harm","authors":"Matthijs C. Brouwer,&nbsp;Diederik van de Beek","doi":"10.1016/j.cmi.2025.03.016","DOIUrl":"10.1016/j.cmi.2025.03.016","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 6","pages":"Pages 885-887"},"PeriodicalIF":10.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro isolation of contemporary Treponema pallidum strains directly from clinical samples of syphilis patients","authors":"Juraj Bosák ,&nbsp;Matěj Hrala ,&nbsp;Filip Skokan ,&nbsp;Miroslav Nečas ,&nbsp;Radim Strnadel ,&nbsp;Eliška Vrbová ,&nbsp;Petra Pospíšilová ,&nbsp;Hana Jedličková ,&nbsp;David Šmajs","doi":"10.1016/j.cmi.2025.03.017","DOIUrl":"10.1016/j.cmi.2025.03.017","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Treponema pallidum</em> subsp. <em>pallidum</em> (<em>T. pallidum</em>) is the etiological agent of syphilis, a sexually transmitted disease of global public health importance. The objective of this study was to introduce a novel <em>in vitro</em> protocol for isolation of <em>T. pallidum</em> directly from patients' clinical samples, eliminating the need for rabbit propagation.</div></div><div><h3>Methods</h3><div>Four oral and five genital swabs were collected from nine epidemiologically unrelated patients at two hospitals in Brno, Czech Republic. Swabs were submerged in TpCM-2 medium for transport. Samples were then placed on a 0.4 μm filters and incubated for 2.5 hours. During this period, spiral <em>T. pallidum</em> cells passed through the filter pores to the well containing TpCM-2 medium and rabbit feeder cells (Sf1Ep). Stable <em>T. pallidum</em> cultures (containing &gt;1 × 10⁷ treponemes) were achieved by subculturing every 7 days into fresh well.</div></div><div><h3>Results</h3><div>A successful protocol for <em>in vitro</em> isolation of <em>T. pallidum</em> was established. From the nine clinical specimens processed, six <em>T. pallidum</em> cultures (MU1–MU6) were derived after 14 to 112 days of cultivation. Five of these strains (MU1–MU5) belonged to SS14-like cluster and shared the same allelic profile 1.3.1. The remaining strain (MU6) was identified as a Nichols-like strain with an allelic profile 9.16.3.</div></div><div><h3>Discussion</h3><div>The introduced <em>in vitro</em> protocol enables isolation of <em>T. pallidum</em> from clinical material, including frozen samples, without the need for experimental rabbits. This method facilitates the isolation of contemporary, clinically relevant treponemal strains.</div></div>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 6","pages":"Pages 1061-1065"},"PeriodicalIF":10.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prenatal testing program among future fathers in a Paris metropolitan area maternity reveals a high proportion of undiagnosed and not linked to care chronic viral hepatitis B","authors":"Pauline Penot ,&nbsp;Annabel Desgrées du Loû ,&nbsp;Valérie-Anne Letembet ,&nbsp;Yazdan Yazdanpanah","doi":"10.1016/j.cmi.2025.03.015","DOIUrl":"10.1016/j.cmi.2025.03.015","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 6","pages":"Pages 1073-1074"},"PeriodicalIF":10.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ESCMID 2025-2029 Pipeline of Clinical Practice Guidelines: planning ahead for a greater impact.","authors":"Luigia Scudeller","doi":"10.1016/j.cmi.2025.03.005","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.005","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}