Clinical Microbiology and Infection最新文献

{"title":"Compromised access to antibiotics: addressing pediatric challenges in availability and responsible use.","authors":"Elio Castagnola","doi":"10.1016/j.cmi.2025.03.011","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.011","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publishing Infectious Disease Research from Low- and Middle-Income Countries.","authors":"Erlangga Yusuf, Flaminia Olearo","doi":"10.1016/j.cmi.2025.03.010","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.010","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The challenge to improving and standardising training in infectious diseases in Europe.","authors":"Jesus Rodríguez-Baño, Robert L Skov, Jon S Friedland, Carlos Del Río, Murat Akova, Annelies S Zinkernagel","doi":"10.1016/j.cmi.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.007","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is a human H5N1 pandemic inevitable?","authors":"Effrossyni Gkrania-Klotsas, Anne L Wyllie, Pikka Jokelainen, Nitin Gupta, Aleksandra Barac, José Ramón Paño-Pardo, Marta Mora-Rillo, Martin P Grobusch, Charles B Holmes, Marion Koopmans, Francois-Xavier Lescure","doi":"10.1016/j.cmi.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.003","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of the Alethia® Malaria LAMP positivity during Post-treatment Follow-up of Patients with imported Malaria.","authors":"Emilie Sitterlé, Céleste Lambert, Anthony Marteau, Sophie Brun, Eric Dannaoui, Marie-Elisabeth Bougnoux","doi":"10.1016/j.cmi.2025.03.008","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.008","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of pertussis vaccination in pregnancy and effectiveness in infants: A Danish national cohort study 2019-2023.","authors":"Helene Kildegaard, Andreas Jensen, Peter H S Andersen, Tine Dalby, Mie Agermose Gram, Øjvind Lidegaard, Lone Graff Stensballe","doi":"10.1016/j.cmi.2025.03.014","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.014","url":null,"abstract":"<p><strong>Objectives: </strong>Recent surges in pertussis spread have renewed focus on pertussis vaccination strategies. Denmark implemented pertussis vaccination during pregnancy in 2019 to protect infants under three months. This nationwide study assessed the real-world safety and effectiveness of acellular pertussis vaccination during pregnancy.</p><p><strong>Methods: </strong>Using nationwide Danish registers, we included all pregnancies beyond 24 gestational weeks and all liveborn children from November 1, 2019, to June 1, 2023, with follow-up until December 31, 2023. Maternal safety outcomes included hypertension, preeclampsia, chorioamnionitis, preterm birth, and stillbirth. Infant safety outcomes included neonatal mortality, neonatal intensive care unit admission and sepsis. Vaccine effectiveness was evaluated against laboratory-confirmed pertussis and related hospital contacts. For maternal safety, vaccinated individuals were matched 1:1 to unvaccinated individuals based on gestational days, calendar week and region. Infant outcomes were assessed among the cohort of all liveborn children with follow-up until 3 months of age. Analyses were adjusted for a range of demographic, socioeconomic and medical characteristics.</p><p><strong>Results: </strong>Among 50,851 vaccinated and 50,851 unvaccinated individuals during pregnancy, initial analyses showed an increased risk of hypertension and preeclampsia following pertussis vaccination. However, after adjusting for influenza and Covid-19 vaccination during pregnancy, pertussis vaccination was not associated with increased risks of any maternal safety outcomes including hypertension (incidence rate ratio (IRR) 0.98, 0.94-1.02), mild preeclampsia (0.97, 0.92-1.02), and severe preeclampsia or HELLP syndrome (0.95, 0.86-1.05). Among 215,974 liveborn children, 108,350 were exposed to the vaccine. Vaccination was not associated with adverse infant outcomes and yielded a 72% (42%-87%) effectiveness against laboratory-confirmed pertussis (9 vs. 32 events).</p><p><strong>Conclusion: </strong>Pertussis vaccination in pregnancy was effective in preventing infant pertussis and was not associated with adverse pregnancy or infant outcomes. Future studies should, however, examine whether other vaccines or the administration of multiple vaccines during pregnancy pose an increased maternal risk of hypertensive disorders in pregnancy.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Large Language Models for antibiotic prescribing in different clinical scenarios: which perform better?","authors":"Andrea De Vito, Nicholas Geremia, Davide Fiore Bavaro, Susan K Seo, Justin Laracy, Maria Mazzitelli, Andrea Marino, Alberto Enrico Maraolo, Antonio Russo, Agnese Colpani, Michele Bartoletti, Anna Maria Cattelan, Cristina Mussini, Saverio Giuseppe Parisi, Luigi Angelo Vaira, Giuseppe Nunnari, Giordano Madeddu","doi":"10.1016/j.cmi.2025.03.002","DOIUrl":"https://doi.org/10.1016/j.cmi.2025.03.002","url":null,"abstract":"<p><strong>Objectives: </strong>Large language models (LLMs) show promise in clinical decision-making, but comparative evaluations of their antibiotic prescribing accuracy are limited. This study assesses the performance of various LLMs in recommending antibiotic treatments across diverse clinical scenarios.</p><p><strong>Methods: </strong>Fourteen LLMs, including standard and premium versions of ChatGPT, Claude, Copilot, Gemini, Le Chat, Grok, Perplexity, and Pi.ai, were evaluated using 60 clinical cases with antibiograms covering ten infection types. A standardised prompt was used for antibiotic recommendations focusing on drug choice, dosage, and treatment duration. Responses were anonymised and reviewed by a blinded expert panel assessing antibiotic appropriateness, dosage correctness, and duration adequacy.</p><p><strong>Results: </strong>A total of 840 responses were collected and analysed. ChatGPT-o1 demonstrated the highest accuracy in antibiotic prescriptions, with 71.7%(43/60) of its recommendations classified as correct and only one (1.7%) incorrect. Gemini and Claude 3 Opus had the lowest accuracy. Dosage correctness was highest for ChatGPT-o1 (96.7%, 58/60), followed by Perplexity Pro (90.0%, 54/60) and Claude 3.5Sonnet (91.7%, 55/60). In treatment duration, Gemini provided the most appropriate recommendations (75.0%, 45/60), while Claude 3.5 Sonnet tended to over-prescribe duration. Performance declined with increasing case complexity, particularly for difficult-to-treat microorganisms.</p><p><strong>Conclusions: </strong>There is significant variability among LLMs in prescribing appropriate antibiotics, dosages, and treatment durations. ChatGPT-o1 outperformed other models, indicating the potential of advanced LLMs as decision-support tools in antibiotic prescribing. However, decreased accuracy in complex cases and inconsistencies among models highlight the need for careful validation before clinical utilisation.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global impact of US policy changes: the ESCMID perspective.","authors":"","doi":"10.1016/j.cmi.2025.03.001","DOIUrl":"10.1016/j.cmi.2025.03.001","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human alveolar echinococcosis-global, regional, and national annual incidence and prevalence rates.","authors":"Britta Lundström-Stadelmann, Ali Rostami, Caroline F Frey, Paul R Torgerson, Seyed Mohammad Riahi, Kimia Bagheri, Marc Kaethner, Anja Lachenmayer, Guido Beldi, Robin B Gasser, Andrew Hemphill","doi":"10.1016/j.cmi.2025.01.034","DOIUrl":"10.1016/j.cmi.2025.01.034","url":null,"abstract":"<p><strong>Background: </strong>Alveolar echinococcosis (AE) of humans is a disease caused by the larval (metacestode) stage of the 'fox tapeworm' Echinococcus multilocularis. AE primarily affects the liver and, like cancer, can spread to surrounding or distant organs. Its slow progression and resemblance to malignant tumours emphasise the critical importance of early detection and intervention, as there is no highly effective vaccine against AE. Although recognised as a neglected disease, there has been no recent, comprehensive review of the distribution, incidence and prevalence of AE in humans around the world.</p><p><strong>Objectives: </strong>To estimate the global, regional, and national annual incidence rates and prevalences of human AE in endemic countries.</p><p><strong>Sources: </strong>Incidence and prevalence data were obtained from published articles from 1980 to 2024, accessible via public databases.</p><p><strong>Content: </strong>This article provides a brief background on E. multilocularis, its biology and impact; reviews the geographic distribution and incidence of AE; and gives a perspective on the prevention and control of this neglected disease in humans.</p><p><strong>Implications: </strong>The AE burden in humans is substantial and emphasises the need for enhanced public awareness, surveillance, prevention, and control, particularly in under-resourced communities to mitigate the health, economic, and psychological impact of AE.</p>","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reprint of: From medical editors: a call to the global infectious diseases and clinical microbiology community","authors":"Angela Huttner,&nbsp;Marc Bonten,&nbsp;Joshua Davis,&nbsp;Leonard Leibovici,&nbsp;Thomas Tängdén,&nbsp;Ilan Schwartz","doi":"10.1016/j.cmi.2025.02.020","DOIUrl":"10.1016/j.cmi.2025.02.020","url":null,"abstract":"","PeriodicalId":10444,"journal":{"name":"Clinical Microbiology and Infection","volume":"31 4","pages":"Pages 492-493"},"PeriodicalIF":10.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}