{"title":"Malaria Treatment Using Oral Medkafin: Changes In Biochemical And Haematological Parameters In Nigerian Adults With Uncomplicated Plasmodium falciparum Malaria","authors":"E. Udosen, E. Akpan","doi":"10.4314/OJM.V15I2.29055","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29055","url":null,"abstract":"Objective: To observe the changes in the biochemical and haematological parameters of patients with uncomplicated Plasmodium falciparum malaria after treatment with oral medkafin. \u0000Method: The activities of aspartate aminotransferase (AST) E.C.2.6.1.1, alanine amino transferase (ALT) E.C.2.6.1.2, the levels of total and conjugated bilirubin, haemoglobin (Hb) and packed cell volume (PCV) in the serum of patients with uncomplicated malaria prior to (PT) and after treatment (AT) with oral medkafin, a new antimalarial drug, were assayed in consenting patients with plasmodium falciparum malaria treated at the University of Calabar Medical Centre in June 1997. \u0000Result: The activity of ALT and the level of Hb decreased significantly (p \u0000Conclusion: This study showed that the levels of ALT, Hb and PCV decreased while those of AST, total and conjugated bilirubin increased in males after treatment with oral medkafin. Key Words: Medkafin, Malaria, Falciparum malaria, Treatment of Malaria Orient Journal of Medicine Vol.15(3&4) 2003: 23-25","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115432399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between Onchocerciasis and Plasmodium falciparum malaria in Communities Endemic for Filariasis in South East Nigeria","authors":"G. Ndukwe","doi":"10.4314/OJM.V16I1.29066","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29066","url":null,"abstract":"Objective: To determine if there is a causal relationship between Plasmodium falciparum and clinical filariasis in individuals exposed to both infections. \u0000Methods: An onchocerciasis endemic community in Imo State, South East Nigeria was screened and persons showing overt clinical signs of onchocerciasis were selected for further study. Blood samples of selected persons were examined for presence of different forms of Plasmodium falciparum . \u0000Results: Of the 264 individuals [94 males (35%) and 170 females (65%)] 90 individuals (34.1%) had positive blood smears for Plasmodium falciparum . The association between the two parasitic infections although statistically significant does not seem to be causal. \u0000Conclusion: Persons who are infected with onchocerciasis seem to also be at the risk of infection with Plasmodium falciparum malaria. Key Words: Onchocerciasis, Endemicity, Malaria Orient Journal of Medicine Vol.16(1) 2004: 23-25","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114289755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Recent Severe Acute Respiratory Syndrome (SARS) Epidemic – A Critical Review","authors":"S. Ike, C. Chukwuka, M. Ohanu, E. Ofoegbu","doi":"10.4314/OJM.V16I1.29069","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29069","url":null,"abstract":"Severe Acute Respiratory syndrome (SARS) took the world by storm in the later part of February 2003.It is a syndrome characterized by fever, cough, sore throat , shortness of breath and malaise which may deteriorate very rapidly to respiratory failure and death. The symptoms of SARS are quite similar to those of common cold, malaria and respiratory tract infections all of which are common in our environment. SARS, being a new disease, has as yet neither a definite diagnostic test nor treatment. With the international transmission of SARS first reported in March 2003, it became evident that one did not need to travel to contact the disease. Nigerians travel a lot and our fragile health care facilities may not be able to contain an outbreak of SARS. It is quite fortunate that the country's inadequate health care facilities did not have to face the challenge of a SARS outbreak. Despite this, it is important that necessary facilities be put in place in case of a sudden outbreak of SARS or similar epidemics in Nigeria. Key Words: Severe Acute Respiratory Syndrome, Epidemic, Review. Orient Journal of Medicine Vol.16(1) 2004: 26-32","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127849937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Pattern of Admissions in the Medical Wards of Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi","authors":"T. O. Osuafor, P. U. Ele","doi":"10.4314/OJM.V16I1.29068","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29068","url":null,"abstract":"Objective: To determine the pattern of admissions in the adult medical wards of the Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi from December 1990 to December 1992 with particular focus on age, sex ratio, prevalence of local illnesses and duration of sojourn in hospital. \u0000Method: A retrospective analysis was done using the admissions register and folders of patients seen during the period. Results have been presented in tables and histograms. \u0000Results: The mean age at admission was 39 years, while 14.4% of cases were in the age group of 41 – 50 years and 61 – 70 years. Diabetes was the commonest indication for admission followed by congestive cardiac failure. The mean duration of sojourn in hospital was 12 days, while most (20.8%) cases were admitted for 11 –15 days followed by 20.3% of cases for 6 – 10 days. Despite the fact that the analysis spanned for only 2 years compared with longer duration in other studies, our findings were similar to those from other centres. \u0000Conclusion: In Nnewi, South-East of Nigeria, almost half (46.9%) of all medical admissions were due to chronic medical illnesses namely Diabetes, CCF, hypertension and CVA. This may reflect the fact that most cases of infections are treated at the primary and secondary care levels. Key Words: Medical Admission, Diseases Pattern, Age and Sex Distribution Orient Journal of Medicine Vol.16(1) 2004: 11-15","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130049067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrosive Oesophageal Stricture: A Preventable Scourge","authors":"Eze Jc","doi":"10.4314/OJM.V15I2.29052","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29052","url":null,"abstract":"Aim: This study aims to determine the nature and circumstances surrounding the ingestion of corrosive substances that resulted in oesophageal strictures among patients attending the University of Nigeria Teaching Hospital, Enugu. This is with a view to highlighting that corrosive oesophageal stricture is preventable. \u0000Methodology: A retrospective study of U.N.T.H. patients managed for corrosive oesophageal stricture between 1991 and 2001 was done using information extracted from their case records. \u0000Result: Sixty-nine eligible cases were seen out of which 33 records were retrieved. All ages and sexes were involved with youths and children topping the list. Caustic soda was involved in 12 patients, 7 patients drank acid and 14 were involved with other chemicals including drugs from “chemist” shop, native medicine etc. Twenty-six (26) were accidental, 4 were suicidal attempt and 3 attributed their problem to ingestion of medication. Thirty-two (32) had gastrostomy and subsequent colon transplant to replace the oesophagus. Duration of treatment and hospital admission was 4 months on the average. \u0000Conclusion: Since most cases of oesophageal stricture due to ingestion of corrosives occurred as a result of accidental ingestion, this problem and its costly consequences are preventable. Key Words: Corrosive Ingestion, Oesophagus, Scourge Complex, Preventable Orient Journal of Medicine Vol.15(3&4) 2003: 8-11","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"6 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128226102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Profile Of Hansen's Disease Patients In The Multidrug Therapy Era At The Unth, Enugu","authors":"E. Nnoruka","doi":"10.4314/OJM.V15I2.29053","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29053","url":null,"abstract":"Background: Leprosy continues to be one of the major public health problems in many countries including Nigeria. It is an infectious disease caused by Mycobacterium Leprae. After the commencement of the multi drug therapy (MDT) era and its accompanying anti-leprosy measures in Nigeria [through the National TB and Leprosy Control Programme (NTBLCP)], leprosy patients attending the Skin clinic of University of Nigeria Teaching hospital, Enugu, were assessed over a five year period (1997-2001). \u0000Objective: The aim of the study was to document the current profile of Hansen's disease in a tertiary hospital setting in this MDT era. \u0000Results: Four hundred and nineteen patients had leprosy and 271(64.7%) benefited from MDT: 21(5.1%) were children and 390 (94.8%) adults. The patients were aged between 5-81 years, with a female preponderance of 248 (60.3%). Main findings were prevalence of 3.9% for leprosy with new case detection rate ranging from 0.4 in 1997 to 0.73 in 2001. \u0000New cases presented more regularly to the skin clinic since 2000 (p \u0000Conclusion: Although the NTBL control generated a lot of awareness and positive impact on leprosy control within communities around Enugu, early diagnosis of leprosy is still problematic. The spectrum of the disease is still wide in Nigeria. Key Words: Leprosy, clinical profile, MDT (Multi Drug Therapy) Era, Nigeria Orient Journal of Medicine Vol.15(3&4) 2003: 12-18","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129543463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pattern of Eclampsia in Onitsha, Nigeria","authors":"N. Obiechina, G. Udigwe","doi":"10.4314/OJM.V16I1.29065","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29065","url":null,"abstract":"Objective: To ascertain the incidence, pattern and outcome of eclampsia in mothers attending and using the obstetric services of the St. Charles Borromeo Hospital, Onitsha. \u0000Methods: A retrospective study of 102 patients that had eclampsia between January 1991 and December 2000, a ten-year period was done. \u0000Information extracted from the case-notes included maternal age, parity, booking status, maternal morbidity and mortality. Statistical analysis was with the Chi-square distribution. \u0000Results: The study revealed a hospital incidence of eclampsia was 0.65% of all deliveries. The incidence for the unbooked (1.31%) patients was higher than for the booked (0.54%) patients (X 2 =16.67, P 2 = 17.12, P \u0000Conclusion: Eclampsia is still a major health problem facing obstetric practice in this area. Good antepartum care and intensive surveillance of patients after delivery will reduce eclampsia and its complications. Key Words: Eclampsia, Postpartum surveillance Orient Journal of Medicine Vol.16(1) 2004: 16-20","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131422122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Response To Pericardiectomy At UNTH, Enugu Nigeria","authors":"Eze Jc, Upc Ugwuanyi","doi":"10.4314/OJM.V16I1.29063","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29063","url":null,"abstract":"Objective: Pericardiectomy as a means of surgical treatment is a standard procedure to improve the quality of life for patients with features of cardiac restriction. The aim of the study was to review the clinical response to pericardiectomy. \u0000Methods: A retrospective study of patients who had pericardiectomy between May 1995 and April 2000 was done. Records of relevant clinical features of the disorder necessitating pericardiectomy; diagnostic and prognostic investigations conducted were extracted from the case records. \u0000Results: A total of 36 patients were identified in the register as having had pericardiectomy in the period of review but only 21 (58.3%) case records were found. The clinical features noted were mainly of shortness of breath, abdominal, facial and feet swelling, ascites, low pulse pressure and tender hepatomegaly. There were pericardial effusion in 12(57%) and constrictive pericarditis 9 (42.9%) of the patients respectively. Sixteen patients (76.2%) had left anterolateral thoracotomy approach while 5 patients (23.8%) had sternotomy approach. Operative findings included thickened pericardium with or without effusion, pyopericardium, haemopericardium and calcified pericardium. Four months post surgery 14 patients (66.7%) had good clinical response while 4 patients (19%) had not responded favorably. Five patients (23.8%) were lost to follow-up after discharge. \u0000Conclusion: Pericardiectomy is beneficial to patients who have constrictive pericarditis. Poverty is alimitation to uptake of pericardiectomy. Key Words: Constrictive Pericarditis; Pericardiectomy; Clinical Response Orient Journal of Medicine Vol.16(1) 2004: 4-7","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115468177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cholesterol Profile of Adults Resident in Eastern Nigeria","authors":"J. Igweh, C. Aloamaka","doi":"10.4314/OJM.V15I2.29060","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29060","url":null,"abstract":"Objective: The present study aims to determine a cholesterol profile for people living in this part of Eastern Nigeria. This will enable recommendation of a range of normal Cholesterol levels for the people living in this part of the world. \u0000Method: Total serum cholesterol, HDL, LDL, VLDL and triglycerides levels were determined in about 200 apparently healthy subjects – males and females. Both enzymatic and mathematical methods were used to achieve these results. \u0000Results: Mean total serum cholesterol level for male was 4.39 ± 0.21 (mmol/l) while value obtained for females was 4.5 ± 0.22. The difference observed was not statistically significant. The values obtained for cholesterol fractions include – HDL 2.07 ± .01 for males and that obtained for females was 1.28 ± .06. LDL levels were 2.75 ± 0.13 for males and 2.98 ± 0.14 for females. VLDL values showed 0.27 ± 0.02 for males and 0.25 ± 0.02 for females. Values obtained for triglycerides were 0.29 ± 0.09 for males and females 0.25 ± 0.01. The difference observed in the values for the male and female subjects were not statistically significant. \u0000Conclusion: Cholesterol values for males and females in this part of Eastern Nigeria are similar. The values, however, seem lower than those for Europeans and Americans. Key Words: Cholesterol Profile, Eastern Nigeria Orient Journal of Medicine Vol.15(3&4) 2003: 46-50","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115695748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"End Stage Renal Disease: Racial Differences","authors":"A. Chijioke, A. Adeniyi","doi":"10.4314/OJM.V15I1.29042","DOIUrl":"https://doi.org/10.4314/OJM.V15I1.29042","url":null,"abstract":"Objectives: The prevalence and aetiological of end stage renal disease (ESRD) differ from race to race and from location to location even among people of the same race. There is paucity of data on the comparison of ESDR in whites and blacks living in their native environment. The study was undertaken to retrospectively define the differences in manifestation of ESRD in whites and blacks in their natural environment. \u0000Methods: Case records of consecutive patients in chronic renal failure that were seen at the University of Ilorin Teaching Hospital, Ilorin, Nigeria and Guy's Hospital, London, England over a four year (1996 to 1999) and two year periods respectively were reviewed. Data collected included data on sex, age, race, aetiology and usual features of ESRD. \u0000Results: A total of 127 blacks (76 males, 51 females) and 125 Caucasians (74 males, 51 females) were recruited and categorized into groups. The commonest disease causing ESRD in Caucasians was diabetic nephropathy [(DN), 26.4%] followed by chronic glomerulonephritis [(CGN), 16.8%] and hypertensive nephrosclerosis [(HTN), 10.6%]. Amongst blacks, however, CGN (38.6%) was the commonest cause, followed by HTN (26%) and DN (7.05%). In 14% and 9% of blacks and whites respectively, the cause of ESRD was unknown. Most blacks with CGN and HTN reached ESRD in the 2nd and 3rd decades; in any case earlier than whites. DN was thrice commoner in whites with the majority in the 5th and 6th decades in both races. \u0000Conclusion: This study tends to validate the notion that the spectrum of renal diseases in the tropics is generally the same as in the temperate environments, but the prevalence, natural history and major Aetiological factors do vary from race to race and in location. Diabetic nephropathy which was thought to be rare in blacks is becoming a major problem. It is disturbing that a high proportion of blacks reached ESRD within their 2nd to 4th decades when they are still very productive. Key Words: ESRD, Race, Prevalence, Aetiology Orient Journal of Medicine Vol.15(1&2) 2003: 24-31","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132631622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}