{"title":"Tetanus Complicating Typhoid Ileal Perforation: A Case Report","authors":"Eze Jc","doi":"10.4314/OJM.V16I1.29064","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29064","url":null,"abstract":"Objective: Both tetanus and typhoid ileitis are endemic in poor developing nations. \u0000This presentation aims at contributing to the list of complications of typhoid intestinal perforation. \u0000Case Report: A 30-year old male had acute abdomen. Exploratory laparotomy revealed typhoid perforation with faecal contamination of the peritoneal cavity. Post operatively, patient initially improved until the 10th day when he developed tetanus. This resulted in his death 3 days after the onset of spasms. \u0000Conclusion: Faecal contamination of the peritoneal cavity is a potential cause of tetanus. \u0000The patient was neither immunized nor given adequate and appropriate antibiotics to which Clostridium tetani is sensitive. Ignorance and poverty contributed significantly to this mortality. Tetanus prophylaxis should be a routine component of the management of typhoid intestinal perforation. Key Words: Tetanus, Typhoid ileal perforation, Complication, Faecal contamination Orient Journal of Medicine Vol.16(1) 2004: 8-10","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121986366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Urethral Stone Associated With Posterior Urethral Valve -A Rare Finding","authors":"A. Osuigwe, J. Ebenebe, C. Okafor","doi":"10.4314/OJM.V15I2.29061","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29061","url":null,"abstract":"A 1yr 5 month old male was referred to our unit with the complaint of acute urinary retention for 3 days. The diagnosis by the referring paediatrician was posterior urethral valve (PUV). \u0000Examination revealed a hard mass in the posterior urethra. Intravenous urography with micturating cystourethrogram confirmed PUV. \u0000Urethral catheterization failed and a suprapubic cystostomy was made to drain urine and establish continuous drainage. \u0000Two days later the hard mass initially felt in the posterior urethra appeared in the urethral meatus and was extracted under sedation. It turned out to be a urethral stone measuring about 4mm in its widest diameter. \u0000Impacted urethral stone co-existing with PUV is rare. A high index of suspicion as well as advanced imaging techniques are needed to make the diagnosis. Key Words: Urethral stone, posterior urethral valve Orient Journal of Medicine Vol.15(3&4) 2003: 51-53","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"416 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124177457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis Of The Severely Anaemic Patients Using The Bone Marrow Aspiration Biopsy Technique","authors":"N. Halim","doi":"10.4314/OJM.V15I2.29054","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29054","url":null,"abstract":"Objective:To highlight the usefulness of bone marrow aspiration in the diagnosis of severely anaemic patients. \u0000Methods:Fifty two patients, 26 males and 26 females aged 16 to 40 years were drawn from the wards and clinics of University of Benin Teaching Hospital, Benin. The criteria for inclusion in the study were unexplained anaemia; suspicion of leukaemia and aplastic anaemia. Patients with easily diagnosable haemoglobinopathies such as HbSS were excluded from the study. \u0000Bone marrow aspirated from either the patients' anterior or posterior superior iliac spine were stained and examined. Smears were fixed in alcohol, stained with Leishman stain and examined under the microscope. Pearl's stain for haemosiderin was used to confirm presence of iron in the marrow. \u0000Results:The smears were suggestive of acute myeloblastic leukaemia in 21 out of 52 patients or 40.4%; acute lymphoblastic leukaemia in 10 out of 52 patients or 19.2%; and megaloblastic anaemia in 5 patients or 9.6%. Hypocellularity was confirmed in 15 (28.9%) patients. \u0000Conclusion:It is concluded that bone marrow aspiration with the Klime-Salah needle is a practical and cheap technique for the diagnosis of the severely anaemic patient. Key Words: Severe Anaemia, Bone Marrow Aspiration, Diagnostic Biopsy Orient Journal of Medicine Vol.15(3&4) 2003: 19-22","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114876378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cataract Extraction With Intraocular Lens Implant: Early Experience In University Of Nigeria Teaching Hospital (U.N.T.H.), Enugu, South-Eastern Nigeria","authors":"C. Chuka-okosa, B. Eze, U. Ezepue","doi":"10.4314/OJM.V15I2.29057","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29057","url":null,"abstract":"Objectives: To audit our early experience of cataract surgery with intraocular lens implant, in the University of Nigeria Teaching Hospital (U.N.T.H.), Enugu. \u0000Methods: In a retrospective, non-comparative case-series study, the records of all patients who had cataract extraction with intraocular lens implant between January 2001 and October 2002 and were followed up for at least eight weeks were analyzed. \u0000Information on age, sex, type of cataract, co-existing ocular and systemic disease, pre- and postoperative visual acuity and postoperative complications was collected. \u0000Results: Forty four eyes of 40 patients were studied; mean age of the patients was 52.2 years (range: 8-87 years). \u0000Thirty seven eyes had age-related (senile) cataract; 2 post-uveitis cataract and 5 traumatic cataract. Associated systemic diseases were diabetes mellitus (4); hypertension (4); asthma (1); rheumatism (1) and diabetes and hypertension (1). \u0000Preoperative visual acuity was \u0000Eight weeks post-surgery 14 eyes had no data on presenting (uncorrected) visual acuity while 9 had presenting visual acuity of >/=6/18. With refraction those with visual acuity of >/= 6/18 increased to 14 out of the 18 who had refraction (77.8%). \u0000Cause of persistent poor visual acuity was ascertained in only 1 eye and was endophthalmitis. Postoperative complications included corneal oedema/striae (91%); astigmatism (18.2%); poor wound apposition (18.2%) and endophthalmitis (2.3%). \u0000Conclusion: The final visual outcome in 77.8% of patients who had refraction post-surgery was good (>/= 6/18.) confirming that Cataract surgery with IOL implant is safe and effective in restoring vision to the cataract blind in this part of the world. \u0000Most of the cases of postoperative astigmatism were corrected with refraction. Key Words: cataract extraction; intraocular lens implant Orient Journal of Medicine Vol.15(3&4) 2003: 31-38","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121833416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal Mortality At St. Charles Borromeo Hospital, Onitsha: A Six Year Review","authors":"N. Obiechina, C. Udegbe","doi":"10.4314/OJM.V15I2.29056","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29056","url":null,"abstract":"Objective: To determine the causes and rate of maternal mortality at St. Charles Borromeo Hospital Onitsha and compare these with other parts of the country. \u0000Methods: A retrospective analysis of maternal deaths over a six year period at St. Charles Borromeo Hospital, Onitsha was done. \u0000Results: Between period January 1995 and December 2000, 6179 births were recorded, the maternal deaths were 49, giving a maternal mortality rate of 793/100,000 births. The ages of the dead mothers ranged from 16 - 46 years, with a mean of 28.43 years, standard deviation of 8.68. Causes of maternal deaths include haemorrhage (37%), septic abortion (17.4%), anaemia (13%), pre-eclampsia/eclampsia (8.7%), genital sepsis (6.5%), while the least were anaesthetic death (2.2%) and cerebral malaria (2.2%). Booked patients constituted (41.3%) while unbooked patients accounted for (58.7%) of the maternal death. \u0000Conclusion: Major causes of maternal death identified in this study are preventable. Measures to reduce maternal deaths include education of the women to use obstetric facilities, early referral of patients to specialist centres, and provision of blood transfusion services. Key Words: Maternal death, Prevention of maternal death, Causes of mortality Orient Journal of Medicine Vol.15(3&4) 2003: 26-30","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114340055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Pharmacokinetics of Ivermectin in Rabbit","authors":"E. Shu, P. Okonkwo","doi":"10.4314/OJM.V15I2.29059","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29059","url":null,"abstract":"Objective: To establish the pharmacokinetics of ivermectin in the rabbit model as a basis for future screening of newly developed micro and macrofilaricides. \u0000Method: Pharmacokinetic parameters of ivermectin were investigated in 5 rabbits after a single subcutaneous dose (150ug/kg), as a basis for screening micro- and macro-filaricides. Plasma ivermectin levels were measured by a sensitive High Performance Liquid Chromatography (HPLC) with fluorometric detection method. \u0000Results: The mean ±SEM pharmacokinetic parameters were as follows: time taken from dosing to maximum concentration (T max ), 1.4 ±0.4 hrs; maximum concentration (C max ), 34.0 ±1.6ng/ml; volume of distribution (V), 4.8 ±1.3L/kg; area under the plasma concentration-time curve (AUC), 475.6 ±5.4ng.hr/ml; plasma clearance (CI), 9.2 ±1.8ml/min and elimination half life (t), 10.4 ±2.3hrs. \u0000Conclusion: The elimination phase of ivermectin pharmacokinetics reveals a secondary peak suggestive of an enterohepatic recycling. Key Words: HPLC, Pharmacokinetics, Ivermectin Orient Journal of Medicine Vol.15(3&4) 2003:42-45","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122097506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute Appendicitis in Port Harcourt, Nigeria","authors":"E. Mangete, B. Kombo","doi":"10.4314/OJM.V16I1.29062","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29062","url":null,"abstract":"Objective: To determine the pattern of occurrence of acute appendicitis in the University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria. \u0000Methods: A prospective study of patients who were admitted for acute appendicitis at the University of Port Harcourt Teaching Hospital in the 6 year period from 1984 to 1989 was undertaken. \u0000Results: Appendix pathology was confirmed in 76.6% of the patients admitted for acute appendicitis during the study period. A false diagnosis of acute appendicitis led to Appendicectomy in 23.4% of the patients, mostly females with pelvic pathology. Acute appendicitis was found to be commoner in females than males and the commonest age range was in the 11 to 30 years old group. Acute Appendicitis was also found to be commoner in the better educated social classes. The duration of hospitalization and postoperative complications were affected by late presentation to surgery but not by the status of the operating surgeon. \u0000Conclusion: Acute appendicitis was diagnosed more often in females than in males in the ratio of 2:1. Over the period of study, the incidence of acute appendicitis showed a rising trend. Key Words: Acute Appendicitis, Appendicectomy, Acute Surgical Abdomen Orient Journal of Medicine Vol.16(1) 2004: 1-3","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123783926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secondary Amenorrhoea and Haematometria Following Emergency Caesarean Section","authors":"T. Oguanuo, H. Ezegwui","doi":"10.4314/OJM.V16I1.29067","DOIUrl":"https://doi.org/10.4314/OJM.V16I1.29067","url":null,"abstract":"Objective: To call attention to a rare cause of curable haematometria and secondary amenorrhoea. \u0000Case Report: A 28 year old primaparous patient developed cyclic abdominal pains and secondary amenorrhoea 9 months after an emergency Caesarean section for prolonged obstructed labour. \u0000Examination revealed that the os cervix was covered by a thick avascular membrane with a bluish apex. \u0000Sonography confirmed haematometria. \u0000Incision of the membrane was curative and restored normal menstrual flow. \u0000Conclusion: The haematometria and resultant secondary amenorrhoea followed puerperal sepsis. The causative inflammatory membrane was at the os cervix and, as there were no intrauterine adhesions, incising the membrane was curative. Key Words: Secondary Amenorrhoea, Haematometria, Caesarean Section Orient Journal of Medicine Vol.16(1) 2004: 21-22","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129497087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence Of Onchocerciasis In Umuowaibu Community Of Imo State, South East Nigeria","authors":"G. Ndukwe","doi":"10.4314/OJM.V15I2.29058","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29058","url":null,"abstract":"Objectives:To determine the prevalence of onchocerciasis in individuals residing in the Umuowaibu community of Imo state in South East Nigeria and that of mixed filarial infections among persons with clinical signs of onchocerciasis. \u0000Method:An onchocerciasis endemic community in Imo State, South East Nigeria was screened and persons showing overt clinical signs were selected for further study. Blood samples of selected persons were examined for microfilaria. \u0000Results:Out of a total population of 750, 264 (35.2%) individuals had signs of clinical filariasis. The exhibited signs include pruritus in 46 persons (16.7%), skin nodules in 71 (27%), leopard skin in 30 (11.23%), skin tumour in 16 (6%), loss of vision in 72 (27.1%) and worms in the eye in 13 (4.5%). No individual exhibited microfilaria in the peripheral blood. \u0000Conclusion:The occurrence of clinical signs and the presence of known insect vectors in the area were considered indicators of continuing active disease transmission despite community control measures. Absence of microfilaraemia in patients with overt onchocerciasis suggests the absence of mixed infections probably as a result of immunological, genetic, pathological, nutritional and other mechanisms. Key Words: Onchocerciasis, Endemicity, Microfilaraemia Orient Journal of Medicine Vol.15(3&4) 2003: 39-41","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"244 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117135662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinic Attendance Compliance Pattern of Adult Hypertensive Nigerians Seen at UNTH, Enugu","authors":"S. Ike, B. Anisiuba, B. Onwubere, V. Ikeh","doi":"10.4314/OJM.V15I2.29051","DOIUrl":"https://doi.org/10.4314/OJM.V15I2.29051","url":null,"abstract":"Objective: A number of factors affect the clinic attendance compliance of the average adult Nigerian. The consequent default from treatment could affect the management outcome of such patients. This study was therefore, undertaken to evaluate the clinic attendance compliance pattern of adult hypertensive patients being seen at the UNTH Enugu, and the factors affecting this. \u0000Method: Records of consecutive adult hypertensive patients attending the Cardiac Clinics of the University of Nigeria Teaching Hospital, Enugu, in a total study period from 1989 to 1999 were retrospectively studied. Data were collected from patients' case records using a proforma that had been specifically designed for the study. \u0000Results: Four hundred and ten patients were reviewed. Forty percent of the patients had already defaulted by the 3rd visit. The default rate was significantly affected by the number of antihypertensive drugs the patients were taking ( P \u0000Conclusion: This study shows a high default rate at clinic attendance. Age, severity of hypertension at first visit and the number of antihypertensive drugs appear to affect the clinic compliance pattern. Efforts should be geared at addressing these factors in the bid to ensure a better management outcome for hypertensive patients. Key Words: Clinic Compliance, Adult Hypertensive Nigerians Orient Journal of Medicine Vol.15(3&4) 2003: 1-7","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130547594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}