{"title":"伊维菌素在家兔体内的药动学","authors":"E. Shu, P. Okonkwo","doi":"10.4314/OJM.V15I2.29059","DOIUrl":null,"url":null,"abstract":"Objective: To establish the pharmacokinetics of ivermectin in the rabbit model as a basis for future screening of newly developed micro and macrofilaricides. \nMethod: Pharmacokinetic parameters of ivermectin were investigated in 5 rabbits after a single subcutaneous dose (150ug/kg), as a basis for screening micro- and macro-filaricides. Plasma ivermectin levels were measured by a sensitive High Performance Liquid Chromatography (HPLC) with fluorometric detection method. \nResults: The mean ±SEM pharmacokinetic parameters were as follows: time taken from dosing to maximum concentration (T max ), 1.4 ±0.4 hrs; maximum concentration (C max ), 34.0 ±1.6ng/ml; volume of distribution (V), 4.8 ±1.3L/kg; area under the plasma concentration-time curve (AUC), 475.6 ±5.4ng.hr/ml; plasma clearance (CI), 9.2 ±1.8ml/min and elimination half life (t), 10.4 ±2.3hrs. \nConclusion: The elimination phase of ivermectin pharmacokinetics reveals a secondary peak suggestive of an enterohepatic recycling. Key Words: HPLC, Pharmacokinetics, Ivermectin Orient Journal of Medicine Vol.15(3&4) 2003:42-45","PeriodicalId":104404,"journal":{"name":"Orient Journal of Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2004-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Pharmacokinetics of Ivermectin in Rabbit\",\"authors\":\"E. Shu, P. Okonkwo\",\"doi\":\"10.4314/OJM.V15I2.29059\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: To establish the pharmacokinetics of ivermectin in the rabbit model as a basis for future screening of newly developed micro and macrofilaricides. \\nMethod: Pharmacokinetic parameters of ivermectin were investigated in 5 rabbits after a single subcutaneous dose (150ug/kg), as a basis for screening micro- and macro-filaricides. Plasma ivermectin levels were measured by a sensitive High Performance Liquid Chromatography (HPLC) with fluorometric detection method. \\nResults: The mean ±SEM pharmacokinetic parameters were as follows: time taken from dosing to maximum concentration (T max ), 1.4 ±0.4 hrs; maximum concentration (C max ), 34.0 ±1.6ng/ml; volume of distribution (V), 4.8 ±1.3L/kg; area under the plasma concentration-time curve (AUC), 475.6 ±5.4ng.hr/ml; plasma clearance (CI), 9.2 ±1.8ml/min and elimination half life (t), 10.4 ±2.3hrs. \\nConclusion: The elimination phase of ivermectin pharmacokinetics reveals a secondary peak suggestive of an enterohepatic recycling. Key Words: HPLC, Pharmacokinetics, Ivermectin Orient Journal of Medicine Vol.15(3&4) 2003:42-45\",\"PeriodicalId\":104404,\"journal\":{\"name\":\"Orient Journal of Medicine\",\"volume\":\"46 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2004-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Orient Journal of Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4314/OJM.V15I2.29059\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Orient Journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4314/OJM.V15I2.29059","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Objective: To establish the pharmacokinetics of ivermectin in the rabbit model as a basis for future screening of newly developed micro and macrofilaricides.
Method: Pharmacokinetic parameters of ivermectin were investigated in 5 rabbits after a single subcutaneous dose (150ug/kg), as a basis for screening micro- and macro-filaricides. Plasma ivermectin levels were measured by a sensitive High Performance Liquid Chromatography (HPLC) with fluorometric detection method.
Results: The mean ±SEM pharmacokinetic parameters were as follows: time taken from dosing to maximum concentration (T max ), 1.4 ±0.4 hrs; maximum concentration (C max ), 34.0 ±1.6ng/ml; volume of distribution (V), 4.8 ±1.3L/kg; area under the plasma concentration-time curve (AUC), 475.6 ±5.4ng.hr/ml; plasma clearance (CI), 9.2 ±1.8ml/min and elimination half life (t), 10.4 ±2.3hrs.
Conclusion: The elimination phase of ivermectin pharmacokinetics reveals a secondary peak suggestive of an enterohepatic recycling. Key Words: HPLC, Pharmacokinetics, Ivermectin Orient Journal of Medicine Vol.15(3&4) 2003:42-45
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