Clinical oncology最新文献

{"title":"Ultra-low-dose FDG-PET imaging in pregnancy-associated breast cancer: Expanded UK tertiary centre experience","authors":"Petros Fessas , Emma Spurrell , Elisavet Papadimitraki , Fharat Raja , Rebecca Roylance , Diego Ottaviani , Joanna Franks , Dibendu Betal , Mahwash Babar , Irene Athanasiou , Massimilano Cariati , Neill Patani , Sirwan Hadad , Yusuf Kayani , Darren Walls , Catherine Scott , Marilena Rega , Mubarik Arshad , Jamshed Bomanji , Stefan Vöö , Karen Desouza","doi":"10.1016/j.clon.2025.104010","DOIUrl":"10.1016/j.clon.2025.104010","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104010"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local Control With Moderately Hypofractionated Definitive Radiotherapy Delivered With a Simultaneous Integrated Boost Technique to Non-extremity Soft Tissue and Bone Sarcomas","authors":"J.D. Towler,&nbsp;C. David,&nbsp;O. Willis,&nbsp;N. Lalli,&nbsp;H. Grimes,&nbsp;F. Le Grange,&nbsp;A. Pilar,&nbsp;B.M. Seddon,&nbsp;M. Ahmed","doi":"10.1016/j.clon.2025.103999","DOIUrl":"10.1016/j.clon.2025.103999","url":null,"abstract":"<div><h3>Aims</h3><div>While surgery is the primary treatment for soft tissue sarcomas (STS) and primary bone sarcomas, a notable proportion of patients with non-extremity tumours do not undergo resection. Outcome data for definitive radiotherapy in this context are limited, as is evidence on the use of hypofractionation at non-extremity sites near sensitive organs at risk. We report our institutional experience delivering moderately hypofractionated definitive radiotherapy (MHDRT) to patients with inoperable non-extremity STS and bone sarcomas including those who were unfit for, or declined, surgery.</div></div><div><h3>Materials and Methods</h3><div>Fifty-nine adult sarcoma patients received MHDRT to non-extremity disease between July 2021 and September 2024 in 60 treatment courses (54 photon, 6 proton). Radiotherapy was delivered over 28 fractions at two dose levels, with 50.4 Gy to the low-dose target volume and a simultaneous integrated boost (SIB) to the high-dose target volume of 63 Gy for STS and 70 Gy for bone sarcomas. Two patients received treatment over 30 fractions to a comparable dose with a SIB of ≥2.2 Gy per fraction.</div></div><div><h3>Results</h3><div>With a median follow-up of 17.7 months, local control at 1 year was 90.8% for STS (n = 37), 100% for chordoma (n = 14) and 55.6% for high-grade primary bone sarcomas (n = 9). Acute and late grade 3 toxicities were observed in 5 (8.3%) and 6 (10%) patients respectively.</div></div><div><h3>Conclusion</h3><div>These data indicate that MHDRT can be delivered to inoperable non-extremity sarcomas with acceptable toxicity and encouraging early local control rates, representing an important radical treatment option in this patient group.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 103999"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customized Non-invasive Brachytherapy With Tailored Surface Moulds: An Experience From a Tertiary Care Centre","authors":"N. Lall ,&nbsp;S. Choudhary ,&nbsp;L.M. Aggarwal ,&nbsp;A. Mourya ,&nbsp;G. Priean V ,&nbsp;S. Sachin ,&nbsp;G. Bui ,&nbsp;D. Nandi ,&nbsp;A.K. Jaiswal ,&nbsp;R. Ranjan","doi":"10.1016/j.clon.2026.104033","DOIUrl":"10.1016/j.clon.2026.104033","url":null,"abstract":"<div><h3>Aim</h3><div>Surface mould brachytherapy (SMBT) is an effective non-invasive treatment option for patients with skin cancer and other superficial tumours. We describe the detailed technique of uniquely treated patients of various histology using customized tailor-made surface moulds and evaluated clinical outcomes, toxicity profile, and quality of life of patients treated with SMBT.</div></div><div><h3>Materials and methods</h3><div>In this retrospective study, we have evaluated nine patients treated with surface moulds using iridium-192-based high-dose-rate brachytherapy.</div></div><div><h3>Results</h3><div>The median age was 34 years. The histopathological diagnosis included squamous cell carcinoma (n=4), followed by giant cell tumour (n=2), and 1 each of angiosarcoma, dermatofibrosarcoma protuberans, and clear cell sarcoma. The most common radiotherapy dose schedule was 60–66 Gray at 2 Gray per fraction. After a median follow-up of 24 months, local control was 100%. At the end of five years, overall survival (OS) and disease-free survival (DFS) were 88.89%. The maximum acute skin and subcutaneous toxicity grade II was observed in 5 (55.6%) patients and grade III in 4 (44.4%) patients, maximum late toxicity was grade III in 3 (33.3%) patients. Poorer Dermatology Life Quality Index scores were statistically significantly associated with higher overdose index (&gt;0) (<em>P</em>=.039), and V_150% &gt;40% (<em>P</em>=.039).</div></div><div><h3>Conclusion</h3><div>SMBT is an effective modality to achieve excellent local control in patients of skin and superficial tumours. After five years, OS and DFS both were 88.89%. It was well tolerated with manageable grade II,III acute and late skin toxicities.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104033"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The B-Raf proto-oncogene, serine/threonine kinase (BRAFV600E) Mutation Enhances Age-Based Prognostic Stratification in Radioiodine-Treated Papillary Thyroid Cancer: A Retrospective Cohort Study","authors":"H. Ali","doi":"10.1016/j.clon.2026.104046","DOIUrl":"10.1016/j.clon.2026.104046","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104046"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncoflash - Research Updates in a Flash!","authors":"D. Shor ,&nbsp;K. Thippu Jayaprakash","doi":"10.1016/j.clon.2026.104062","DOIUrl":"10.1016/j.clon.2026.104062","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104062"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Anthracycline versus Non-Anthracycline Neoadjuvant Chemotherapy in HER2 positive Early Breast Cancer: A retrospective study in Northern Ireland","authors":"Eva Urbankova ,&nbsp;Hebaallah Elsandoby ,&nbsp;Raafat Malek ,&nbsp;Rosalie Douglas ,&nbsp;Conor O'neill","doi":"10.1016/j.clon.2025.104027","DOIUrl":"10.1016/j.clon.2025.104027","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104027"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding Complications of BRAF Inhibitors","authors":"G. Gurumurthy ,&nbsp;J. Kropidlowska ,&nbsp;L. Reynolds ,&nbsp;R. Parkar","doi":"10.1016/j.clon.2026.104045","DOIUrl":"10.1016/j.clon.2026.104045","url":null,"abstract":"<div><div>Targeted inhibition of the mitogen-activated protein kinase (MAPK) pathway with BRAF inhibitors has been crucial in improving outcomes for <em>BRAF</em>-variant melanoma. However, clinically significant bleeding has recently been reported in the literature. Bleeding on BRAF inhibitors is uncommon but heterogeneous. Across trials, any-grade bleeding has been reported. Grade ≥3 events and fatal intracranial haemorrhage are rare but noted. Mechanistically, BRAF inhibitors can paradoxically activate MAPK signalling in the normal endothelium. This destabilises junctions and promotes microvascular leak. In addition, BRAF inhibitors may reduce tissue factor (TF)–dependent procoagulant activity. Management should focus on regimen-specific labelling with general haemorrhage principles. A baseline appraisal of bleeding risk, assessing for central nervous system (CNS) disease and concomitant antithrombotics use, should be undertaken prior to therapy initiation. Patients should be counselled on bleeding symptoms. There is a paucity of evidence in the literature to guide BRAF therapy use in bleeding events. In general, prompt intervention for bleeding events includes local haemostasis control and continuation for low-grade mucosal bleeds. Therapy should be suspended and multidisciplinary care input sought for major and intracranial haemorrhage. Evidence to guide rechallenge is sparse. Resumption after minor events may be reasonable with dose modification and close monitoring, whereas major or intracranial bleeding generally warrants discontinuation unless a compelling oncologic indication exists and multidisciplinary consensus supports cautious reinitiation after shared-decision making.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104045"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146075314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Oncology Data Systems for Equitable Care in Asia-Pacific: Current Practices and Future Directions","authors":"V. Batumalai ,&nbsp;M. Zhou ,&nbsp;M. Chilkuri ,&nbsp;S. Costello ,&nbsp;D. Fraser ,&nbsp;S. Ghosh-Laskar ,&nbsp;Handoko ,&nbsp;A. Liao ,&nbsp;A. Teyateeti ,&nbsp;G. Xiong ,&nbsp;M.L. Yap","doi":"10.1016/j.clon.2026.104051","DOIUrl":"10.1016/j.clon.2026.104051","url":null,"abstract":"<div><h3>Aims</h3><div>Effective oncology data management through oncology information systems (OIS) is essential for high-quality cancer care, yet adoption across the Asia-Pacific (APAC) region varies widely. This study benchmarked OIS utilisation, data capture, and integration across APAC to identify gaps and inform targeted improvements.</div></div><div><h3>Materials and methods</h3><div>A regional survey was distributed to radiotherapy professionals in 19 APAC countries. The questionnaire assessed OIS utilisation, data capture, IT support, training, and system integration. Responses were analysed descriptively and stratified by World Bank income group: low-middle-income countries (L-MIC), upper-middle-income countries (U-MIC), and high-income countries (HIC).</div></div><div><h3>Results</h3><div>A total of 149 responses were analysed. OIS functionality was limited in L-MICs and U-MICs, with only 34% and 59% of centres, respectively, using OIS beyond basic record-and-verify functions. Basic demographic data such as date of birth (83% L-MIC, 90% U-MIC) and sex at birth (98% L-MIC, 91% U-MIC) were consistently captured, but equity-related data were poorly documented (ethnicity 48% U-MIC, 59% HIC; disadvantaged group status rarely recorded in 78% of L-MICs). Radiotherapy data including treatment site (84% to 98%), intent (77% to 90%), and modality (86% to 95%) were consistently documented. However, the location of data capture varied: radiotherapy data were more frequently entered into OIS structured fields (35% L-MIC/U-MIC, 50% HIC), while demographic and diagnosis data showed lower structured capture in OIS (18% to 24% in L-MICs). Reliance on paper records remained widespread in L-MICs and U-MICs.</div></div><div><h3>Conclusion</h3><div>Marked disparities in OIS utilisation and data quality exist across APAC. Regional strategies should prioritise comprehensive training and standardised datasets to improve cancer care quality and equity.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104051"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR Meetings","authors":"","doi":"10.1016/S0936-6555(26)00052-X","DOIUrl":"10.1016/S0936-6555(26)00052-X","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104081"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can we predict significant toxicity in older patients receiving curative chemotherapy for early stage breast cancer?","authors":"Niall Moon,&nbsp;Philippa Smith,&nbsp;Eilidh White,&nbsp;Alastair Thomson","doi":"10.1016/j.clon.2025.104019","DOIUrl":"10.1016/j.clon.2025.104019","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104019"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}