Clinical oncology最新文献

{"title":"From table to couch: audit of time to postoperative radiotherapy for head and neck SCC in The Royal Marsden head and neck network","authors":"David Hunt, Ben O’Leary, Shreerang Bhide, Kee Wong","doi":"10.1016/j.clon.2025.103829","DOIUrl":"10.1016/j.clon.2025.103829","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103829"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reirradiation for head and neck cancer: a single-centre experience","authors":"Pavithra Gayani Liyanaarachchi Abeywardanalage, Devashish Tripathi, Michelle Poulton, Sarah Williams, Lee Price, Douglas Northover","doi":"10.1016/j.clon.2025.103830","DOIUrl":"10.1016/j.clon.2025.103830","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103830"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of genomic testing into biliary tract cancer management and creation of a standard East Midlands treatment algorithm: a retrospective analysis of clinical outcomes and molecular profiling at Nottingham University Hospitals (NUH) and Leicester University Hospitals (UHL)","authors":"Bahaaeldin Baraka , Maurice Dungey , Sean Dulloo , Suresh Venkatachalapathy , Guru Aithal , Arvind Arora","doi":"10.1016/j.clon.2025.103827","DOIUrl":"10.1016/j.clon.2025.103827","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103827"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimising the use of tissue-equivalent bolus in post-mastectomy radiotherapy (PMRT) at Rosemere Cancer Centre, Lancashire Teaching Hospitals NHS Foundation Trust","authors":"Sarah Findlay, Keara McDonough, Martin McKeown","doi":"10.1016/j.clon.2025.103811","DOIUrl":"10.1016/j.clon.2025.103811","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103811"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audit and service evaluation of a new high-dose-rate brachytherapy service for treatment of non-melanoma skin cancer","authors":"Kate Channell, Pauline Humphrey, Amarnath Challapalli","doi":"10.1016/j.clon.2025.103826","DOIUrl":"10.1016/j.clon.2025.103826","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103826"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Audit of changing the hydration protocol for head and neck oncology patients receiving concomitant radiotherapy and weekly cisplatin","authors":"Claire Mortimer, Rowena Cazalet, Ketan Shah, Donna Constantine","doi":"10.1016/j.clon.2025.103822","DOIUrl":"10.1016/j.clon.2025.103822","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103822"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the experience of returning to clinical oncology training through an educational day for out-of-programme trainees","authors":"Wahyu Wulaningsih , Clare Kane , Rubyyat-A Hakim , Sarah Needleman","doi":"10.1016/j.clon.2025.103814","DOIUrl":"10.1016/j.clon.2025.103814","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103814"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the palliative radiotherapy training experience of junior clinical oncology trainees","authors":"Alexandra Maling, Jenny Mckeon","doi":"10.1016/j.clon.2025.103819","DOIUrl":"10.1016/j.clon.2025.103819","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103819"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Third Course of Radical Intent Conformal Radiation in Patients with Primary Brain Tumors","authors":"M. Jeeva ,&nbsp;A. Dasgupta ,&nbsp;A. Chatterjee ,&nbsp;A. Sahu ,&nbsp;E. Sridhar ,&nbsp;A. Moiyadi ,&nbsp;G. Chinnaswamy ,&nbsp;T. Gupta","doi":"10.1016/j.clon.2025.103841","DOIUrl":"10.1016/j.clon.2025.103841","url":null,"abstract":"<div><h3>Aims</h3><div>Reirradiation is increasingly considered in patients with recurrent primary brain tumours. However, second course of radical reirradiation (RT2) or third course of radiation (RT3) delivering higher doses is uncommon. The current study was undertaken to report the clinical outcomes after the third course of radical radiation.</div></div><div><h3>Materials and methods</h3><div>The patients undergoing three courses of cranial radiation were obtained from the radiation oncology database. The clinical and treatment details were obtained by reviewing electronic medical records and radiation charts and plans when available. Treatment outcomes, including disease status and radionecrosis, were assessed by reviewing imaging. Analysis was done using descriptive statistics and survival outcomes using Kaplan–Meier survival plots.</div></div><div><h3>Results</h3><div>Eight patients were identified between 2015 and 2023 treated with a third course of radiotherapy (second reirradiation). Histopathology included ependymoma in seven and glioblastoma in one patient. The median age during first radiation was 13.5 years (range: 4–31 years) with interquartile range (IQR) of 7–26 years, and during RT3 was 22 years (range: 9–43 years, IQR: 14–32 years). The median doses at RT1, RT2, and RT3 were 59.4 Gy (IQR: 54.80–60 Gy), 54 Gy (IQR: 51.3–54.0 Gy), and 50.4 Gy (IQR: 50.0–50.4 Gy), respectively. The median interval between RT1 and RT2 was 37 months (IQR: 29–63 months), RT2 and RT3 was 39 months (IQR: 25–67 months). The median cumulative EQD2 from three courses was <span><math><mrow><msub><mrow><mn>153</mn><mspace></mspace><mi>G</mi><mi>y</mi></mrow><mrow><mn>2</mn><mspace></mspace></mrow></msub></mrow></math></span> (IQR: 148.7–159.1 <span><math><mrow><msub><mrow><mi>G</mi><mi>y</mi></mrow><mn>2</mn></msub></mrow></math></span>). After 3rd course, the median follow-up was 25 months (IQR: 15–37 months) with a 2-year overall survival of 85%. One patient had developed symptomatic radionecrosis 14 months after RT3 and was treated with bevacizumab.</div></div><div><h3>Conclusion</h3><div>The third course of radical dose of radiation can be considered a reasonable approach for tumours with local recurrence after a reasonable interval of at least two years between each course, allowing for tissue recovery.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"42 ","pages":"Article 103841"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncotype DX Breast DCIS Score® Test: Impact on Radiotherapy Recommendations and Patient Decisional Anxiety","authors":"S. Muktar ,&nbsp;A. Kirby ,&nbsp;I. Locke ,&nbsp;S. Settatree ,&nbsp;G. Kothari ,&nbsp;S. Nimalasena ,&nbsp;A. Ranger ,&nbsp;K. Mohammed ,&nbsp;F. Reid ,&nbsp;G. Ross ,&nbsp;N. Roche","doi":"10.1016/j.clon.2025.103839","DOIUrl":"10.1016/j.clon.2025.103839","url":null,"abstract":"<div><h3>Aims</h3><div>Treatment for Ductal Carcinoma <em>in Situ</em> (DCIS) includes surgery followed by radiotherapy (RT) to reduce local recurrence (LR) risk, though RT may be overtreatment for some patients. The Oncotype DX Breast DCIS Score® test is a genomic test that provides individualised LR risk estimates. This study evaluates the impact of the Oncotype test on RT recommendations, patient anxiety and decisional conflict.</div></div><div><h3>Material and methods</h3><div>Women aged ≥45 years with DCIS up to 25mm treated with breast-conserving surgery were invited to participate. Initial RT recommendations and 10-year LR risk predictions were made before Oncotype testing. Post Oncotype testing, final RT recommendations were recorded. Patients completed decisional conflict and anxiety questionnaires before and after receiving Oncotype results.</div></div><div><h3>Results</h3><div>A total of 71 participants were included with a median age of 59. Ninety percent of DCIS was intermediate/high-grade with a median size of 12mm. Oncologists changed RT recommendations in 28% (20/71) of cases after receiving the Oncotype result; 21% changed from RT to no RT and 7% from no RT to RT. In 79% of cases, the oncologists’ LR estimates were higher than Oncotype predictions. Post Oncotype testing, patient decisional conflict and anxiety decreased.</div></div><div><h3>Conclusion</h3><div>The Oncotype test changed treatment recommendations regarding adjuvant RT in almost a third of patients. Additionally, the assay was associated with reduced treatment-related decisional conflict and anxiety in patients. LR risk predictions by oncologists were higher than the Oncotype predictions highlighting a need for additional tools to aid decision-making.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"42 ","pages":"Article 103839"},"PeriodicalIF":3.2,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}