Clinical oncology最新文献

{"title":"147 - A Single-Centre IGRT Experience in Head and Neck Cancer: The Role of Weekly Mini MDTs in Identifying Replanning Triggers","authors":"Pavithra Gayani Liyanaarachchi Abeywardanalage, Sarah Williams, Melanie Palmer, Sarah Morris, Mano Joseph","doi":"10.1016/j.clon.2026.104132","DOIUrl":"10.1016/j.clon.2026.104132","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"56 ","pages":"Article 104132"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR Meetings","authors":"","doi":"10.1016/S0936-6555(26)00189-5","DOIUrl":"10.1016/S0936-6555(26)00189-5","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"55 ","pages":"Article 104218"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI Conference Journal Ad July Issue_01","authors":"","doi":"10.1016/S0936-6555(26)00190-1","DOIUrl":"10.1016/S0936-6555(26)00190-1","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"55 ","pages":"Article 104219"},"PeriodicalIF":2.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in UK Oesophageal Radiotherapy Practice - Cause for Concern or Opportunity for Harmonisation?","authors":"K. Sabzevari , C. Brunner , O. Nicholas , T.D.L. Crosby , S. Gwynne","doi":"10.1016/j.clon.2026.104065","DOIUrl":"10.1016/j.clon.2026.104065","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"52 ","pages":"Article 104065"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146161893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Checkpoint Blockade of CTLA-4 and PD-1 Overcomes Low–Tumour Mutational Burden Resistance","authors":"M. Zheng","doi":"10.1016/j.clon.2026.104061","DOIUrl":"10.1016/j.clon.2026.104061","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"52 ","pages":"Article 104061"},"PeriodicalIF":3.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146161894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Treatment Resilience in Patients With Oesophago-gastric Cancers Undergoing Palliative Chemotherapy: A Rapid Review","authors":"K. Datta ,&nbsp;A. Byrne ,&nbsp;D. Holland-Hart","doi":"10.1016/j.clon.2025.103963","DOIUrl":"10.1016/j.clon.2025.103963","url":null,"abstract":"<div><h3>Aims</h3><div>Oesophago-gastric cancers are the fifth most common in the UK. Most patients present with advanced disease and are unsuitable for curative surgery, instead receiving palliative treatment to improve prognosis and symptom burden. Treatment resilience refers to the ability of patients to tolerate their anti-cancer treatment. Palliative chemotherapy can result in significant toxicity; almost 40% of patients are unable to complete their chemotherapy regimen, with this proportion rising significantly in older and frailer patients. Despite most cases occurring in patients over 70, older and frailer patients are often excluded from clinical trials, resulting in limited evidence to guide which patients are most likely to benefit from palliative chemotherapy. This review therefore aimed to appraise evidence regarding treatment resilience to guide clinicians in identifying the most suitable candidates for palliative chemotherapy.</div></div><div><h3>Materials and Methods</h3><div>This study was conducted using modified systematic methods. Search results were limited to articles from the last 10 years. Pretreatment characteristics influencing treatment resilience were assessed, as measured by completion rates, dose reductions and toxicities.</div></div><div><h3>Results</h3><div>Of the 931 papers returned, 14 reports of 13 studies were included in this review. Factors assessed included age, performance status, frailty, lymphopenia and sarcopenia. Frailty and body composition appear potentially reliable indicators of chemotherapy toxicity. Poor performance status may be a possible indicator of treatment non-completion. There was no clear relationship between treatment resilience and age or lymphopenia.</div></div><div><h3>Conclusion</h3><div>Although this review was unable to specify patient characteristics to reliably predict patient tolerance of palliative chemotherapy, potential factors were identified. Future research should focus on prospective investigation of these factors to support a precision medicine algorithmic approach by multidisciplinary teams in assessing treatment resilience. Age should not necessarily be a barrier to receiving chemotherapy. Decisions regarding palliative treatment may be guided by these factors as well as patient preference.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 103963"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real world evidence of sacituzumab govitecan in unresectable or metastatic triple negative breast cancer","authors":"Mohamed Sheeraz Mohamed Azhar ,&nbsp;Oghenevwede Okuma ,&nbsp;Yetunde Owoseni ,&nbsp;Oyeyemi Akala ,&nbsp;Rabia Gul ,&nbsp;Husam Yassin ,&nbsp;Olubukola Ayodele","doi":"10.1016/j.clon.2025.104018","DOIUrl":"10.1016/j.clon.2025.104018","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104018"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single centre, retrospective analysis of pathological complete response rates by ER status after neoadjuvant dual HER2 targeted therapy","authors":"Keti Eremeishvili ,&nbsp;Jae-Ram Song ,&nbsp;Catherine Harper-Wynne ,&nbsp;Charlotte Moss","doi":"10.1016/j.clon.2025.104014","DOIUrl":"10.1016/j.clon.2025.104014","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104014"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Pneumonitis with Concurrent Trastuzumab Emtansine (T-DM1) and Radiotherapy in HER2-Positive Breast Cancer: A retrospective review","authors":"Estabrak Jiad,&nbsp;Charlotte Westbury,&nbsp;Nihal Shah","doi":"10.1016/j.clon.2025.104017","DOIUrl":"10.1016/j.clon.2025.104017","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104017"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world timing and incidence of haematologic adverse events with adjuvant abemaciclib: Implications for clinical practice","authors":"Amit Samani,&nbsp;Roshni Dasgupta,&nbsp;Yuting Gao,&nbsp;Samanthi Prematilaka,&nbsp;Dao Yi Wong,&nbsp;David Miles,&nbsp;Andreas Makris,&nbsp;Nihal Shah,&nbsp;Muhammed Baki,&nbsp;Stephanie Sutherland,&nbsp;Amy Guppy","doi":"10.1016/j.clon.2025.104012","DOIUrl":"10.1016/j.clon.2025.104012","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"51 ","pages":"Article 104012"},"PeriodicalIF":3.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147448863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}