Clinical oncology最新文献

{"title":"Overview of Adverse Reactions of Radiopharmaceuticals","authors":"M.R. Mititelu ,&nbsp;V. Stanulovic ,&nbsp;A. Mitoi ,&nbsp;S. Bucurica ,&nbsp;M. Hodolic ,&nbsp;K. Kairemo","doi":"10.1016/j.clon.2025.103857","DOIUrl":"10.1016/j.clon.2025.103857","url":null,"abstract":"<div><h3>Aims</h3><div>Theranostics utilizes the nuclear properties of radioactive isotopes, especially for molecular imaging and targeted therapy. Radiopharmaceuticals (RPs), which combine a pharmaceutical ligand with a radionuclide, enable accurate diagnosis and treatment of various diseases through modalities such as PET and SPECT imaging.</div><div>The aim of this papare is to review adverse reactions associated with diagnostic and therapeutic radiopharmaceuticals, with an emphasis on their severity and clinical management.</div></div><div><h3>Materials and methods</h3><div>This review evaluates documented adverse effects (AEs) related to RPs used in nuclear medicine imaging (PET and SPECT) and radionuclide therapy, focusing on their severity and clinical management strategies. It also considers the mechanisms of RPs toxicity, distinguishes between general and specific AEs, and highlights the limitations in current adverse drug reaction (ADR) assessment tools.</div><div>The methodology used was the research and synthesis of most relevant published literature data; most relevant papers were synthesized regarding the reporting system of ARs and categorized by the specific and systemic adverse effects of RPs.</div></div><div><h3>Results</h3><div>Side effects from diagnostic RPs are relatively rare and typically minimal. Therapeutic RPs, selected for their high-energy radiation properties, can cause DNA damage to malignant cells while minimizing harm to healthy tissues. Although adverse effects do occur, they are generally fewer and less severe compared to conventional therapies. Severe toxicity is rare and often preventable. Both patient- and provider-reported ADRs offer important safety insights, though validated assessment instruments remain limited.</div></div><div><h3>Conclusion</h3><div>Radionuclide therapy offers a targeted approach that is a less invasive alternative to conventional treatments with a favorable safety profile. Continued evaluation of adverse reactions and the development of standardized ADR assessment tools are essential for improving patient outcomes and RP safety monitoring.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"43 ","pages":"Article 103857"},"PeriodicalIF":3.2,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Medicine and Genomics in Cancer of Unknown Primary","authors":"I.S. Boon ,&nbsp;J.S. Lim ,&nbsp;T.P.T. Au Yong ,&nbsp;C.S. Boon","doi":"10.1016/j.clon.2025.103854","DOIUrl":"10.1016/j.clon.2025.103854","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"43 ","pages":"Article 103854"},"PeriodicalIF":3.2,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning Auto-Segmentation of Organs at Risk in a Real-World Head and Neck Cancer Proton Beam Radiotherapy Planning","authors":"M. Ward ,&nbsp;K. Oguejiofor ,&nbsp;V. Craciun ,&nbsp;I.S. Boon","doi":"10.1016/j.clon.2025.103849","DOIUrl":"10.1016/j.clon.2025.103849","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"43 ","pages":"Article 103849"},"PeriodicalIF":3.2,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypo-Fractionated Radiotherapy to the Cavity for Resected Brain Metastases: A UK Series","authors":"C.L. Barker ,&nbsp;T. Shane ,&nbsp;C. Hodgson ,&nbsp;M. Jameson ,&nbsp;J. King ,&nbsp;P. Sanghera ,&nbsp;S. Meade ,&nbsp;R.J. Colaco ,&nbsp;H. Benghiat","doi":"10.1016/j.clon.2025.103847","DOIUrl":"10.1016/j.clon.2025.103847","url":null,"abstract":"<div><h3>Aims</h3><div>With improved systemic disease control, the incidence of brain metastases in patients with cancer is increasing. Neurosurgical resection is recommended in selected cases, although local control following surgery remains an ongoing concern. Both fractionated radiotherapy and stereotactic radiosurgery (SRS) improve local control after surgical resection. Although postoperative SRS can avoid whole brain radiotherapy-associated toxicity, due to lack of survival and quality of life data, the optimum strategy remains debated. Furthermore, some cavities may be too large for SRS.</div></div><div><h3>Materials and methods</h3><div>In this multicentre study, patients following surgery for brain metastases were treated with a hypo-fractionated radiotherapy regimen (25Gy given in 5 fractions/30Gy in 6 fractions) to the surgical cavity.</div></div><div><h3>Results</h3><div>Sixty-five patients were identified from electronic patient notes with a median follow-up of 23.6 months (95% CI: 20.1–28.6). The 6-, 12-, 24- and 36-month freedom from local failure rates were 92.7% (95% CI: 81.7–97.2%), 77.3% (95% CI: 61.0–87.4%) and 70.6% (both 24- and 36-months, 95% CI: 52.9–82.5%), respectively. The 6-, 12- and 24-month overall survival rates were 80.0% (95% CI: 68.0–87.9%), 53.7% (95% CI: 40.6–65.2%) and 27.7% (95% CI: 16.0–40.7%), respectively. During follow-up, 10.8% (7/65 patients) developed leptomeningeal disease (LMD) and 3% (2/65 patients) developed radiation necrosis (RN). Treatment with hypo-fractionated radiotherapy to the surgical cavity was well tolerated; there was one episode of grade 3 toxicity (vomiting) in this patient cohort.</div></div><div><h3>Conclusion</h3><div>In this multicentre series of postoperative hypo-fractionated radiotherapy to the surgical cavity following resection of a brain metastasis, we demonstrated good rates of local control, with low risk of LMD and RN. Therefore, this radiotherapy regimen is a reasonable alternative to cavity SRS in patients with large cavity volumes or complete gross total resection within the UK. This should be investigated further within a prospective trial.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"43 ","pages":"Article 103847"},"PeriodicalIF":3.2,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating Adjuvant Therapy in Early-Stage Breast Cancer: Insights and Limitations From a Subtype Analysis","authors":"Q. Xu ,&nbsp;Y. Gao","doi":"10.1016/j.clon.2025.103848","DOIUrl":"10.1016/j.clon.2025.103848","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"43 ","pages":"Article 103848"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single Centre Review of the Management of Testicular Sex Cord-Stromal Cell Tumours","authors":"C. Thompson,&nbsp;Z. Rajan,&nbsp;A. Reid,&nbsp;S. Hazell,&nbsp;E. Mayer,&nbsp;D. Nicol,&nbsp;R. Huddart","doi":"10.1016/j.clon.2025.103846","DOIUrl":"10.1016/j.clon.2025.103846","url":null,"abstract":"<div><h3>Aims</h3><div>Sex cord stromal cell tumours (SCSCT) are a rare subset of testicular tumours, the majority of which are benign but a small proportion can be malignant. It has been demonstrated that certain histopathological risk factors can be useful in identifying those with malignant potential. However currently the absence of pathological risk factors is not used to exclude malignancy and this study aimed to investigate whether patients with one or fewer risk factors would relapse. We aim to confirm the hypothesis that no patient with one or fewer identified pathological risk factors predicting malignancy will develop metastatic disease.</div></div><div><h3>Materials and Methods</h3><div>This was a retrospective analysis of all patients from a single centre with a diagnosis of SCSCT over a 20-year period. Cases were reviewed for the presence or absence of risk factors. Relapse rates and overall survival between the groups with and without risk factors were compared using a Kaplan-Meier analysis.</div></div><div><h3>Results</h3><div>76 SCSCTs were identified, of which 56 were deemed low-risk due to the presence of one or fewer pathological risk factors predictive of malignancy. None of the 56 patients relapsed with metastatic disease and, when compared with the 20 patients who had 2 or more risk factors for malignancy, relapse rates were significantly higher (<em>p</em> &lt; 0.0001) and overall survival lower (<em>p</em> = 0.0003) in those who had risk factors. A key limitation is our sample size.</div></div><div><h3>Conclusion</h3><div>These findings, supported by the available literature on SCSCTs, suggest that malignancy can be accurately predicted based on pathological findings. There is potential that these findings can be used to tailor follow up of low-risk patients accordingly.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"42 ","pages":"Article 103846"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143922843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR meetings","authors":"","doi":"10.1016/S0936-6555(25)00099-8","DOIUrl":"10.1016/S0936-6555(25)00099-8","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"41 ","pages":"Article 103844"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An audit of non-NHS commissioning through evaluation-funded SABR for oligometastasis: a single-network study","authors":"Rebecca Johnson ,&nbsp;Philip Webb ,&nbsp;Rebecca Muirhead","doi":"10.1016/j.clon.2025.103821","DOIUrl":"10.1016/j.clon.2025.103821","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103821"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing lower urinary tract symptoms (LUTS) during pelvic radiotherapy: a quality improvement project","authors":"Christina Peters,&nbsp;Sally Appleyard","doi":"10.1016/j.clon.2025.103813","DOIUrl":"10.1016/j.clon.2025.103813","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103813"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical screening accessibility for healthcare staff: an improvement project at University Hospitals Bristol and Weston NHS Foundation Trust","authors":"Isabelle Wood,&nbsp;Miranda Worth,&nbsp;Eva Larkai,&nbsp;Hannah Compton,&nbsp;Amy Patel","doi":"10.1016/j.clon.2025.103815","DOIUrl":"10.1016/j.clon.2025.103815","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"40 ","pages":"Article 103815"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}