Clinical oncology最新文献

{"title":"Avoiding Adjuvant Prophylactic Neck Irradiation in Lateralized Oral Cavity Cancer (APRON)","authors":"S. Sinha ,&nbsp;S. Ghosh Laskar ,&nbsp;S. Dhingra ,&nbsp;A. Kumar ,&nbsp;S. Mohanty ,&nbsp;A. Budrukkar ,&nbsp;M. Swain ,&nbsp;P.N. Bishnu ,&nbsp;I. Joy ,&nbsp;R. Ali ,&nbsp;S. Kannan ,&nbsp;N. Mummudi","doi":"10.1016/j.clon.2025.103980","DOIUrl":"10.1016/j.clon.2025.103980","url":null,"abstract":"<div><div>Oral cavity squamous cell carcinoma (OCSCC) is the second most common cancer in India with an age standardised ratio of 10.3 per 100,000 (both sexes combined) (1). Most patients (60%-80%) present in advanced stages with a high risk of nodal involvement. The current standard of care involves surgery followed by adjuvant radiotherapy (RT), often including elective nodal irradiation (ENI) even in pathologically node-negative patients. However, recent evidence suggests that well-selected patients with adequate surgical clearance may be adequately treated with limited volumes of ENI, potentially sparing them unnecessary toxicity.</div><div>The APRON study is a single-arm, phase II trial evaluating whether limiting ENI is non-inferior to standard adjuvant RT in carefully selected patients with lateralized oral cavity cancers. Eligible patients are adults with biopsy-proven squamous cell carcinoma of the bucco-alveolar region or oral tongue who have undergone margin-negative resection and adequate elective nodal dissection (≥18 nodes). Only well-lateralized tumours (≥1 cm from midline for tongue cancers) are included. The primary endpoint is regional control at 2 years, defined as any nodal recurrence (ipsilateral or contralateral). Secondary endpoints include swallowing function (MD Anderson Dysphagia Inventory; modified barium swallow), local and regional recurrence-free survival, disease-free and overall survival, acute/chronic toxicity, quality of life, salvage rates for recurrence, and dosimetry comparisons. The study also assesses the safety and efficacy of moderate hypofractionation (50 Gy/20 fractions) in the adjuvant setting.</div><div>A sample size of 106 patients is planned, with early stopping rules for safety. Statistical analysis will use the Clopper–Pearson method for nodal failure rates and propensity score matching with historical controls for non-inferiority testing. By limiting ENI in well-selected patients, APRON aims to reduce treatment-related morbidity while maintaining oncologic efficacy, potentially improving functional outcomes and preserving regional immune function. The study is expected to provide valuable evidence for de-escalated adjuvant strategies in OCSCC management.</div></div><div><h3>CTRI Number</h3><div>CTRI/2025/03/082341.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103980"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Prognostic Assessment in Elderly Non–small Cell Lung Cancer: The Importance of Dynamic Comorbidities and Comprehensive Biomarker Profiling","authors":"F. Huang ,&nbsp;M. Fang","doi":"10.1016/j.clon.2025.103969","DOIUrl":"10.1016/j.clon.2025.103969","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103969"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145621685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' Response to the Letter Titled: Enhancing Treatment Resilience in Palliative Oesophago-Gastric Cancer: Nutritional, Access, and Scoring Considerations","authors":"K. Datta ,&nbsp;A. Byrne ,&nbsp;D. Holland-Hart","doi":"10.1016/j.clon.2025.103998","DOIUrl":"10.1016/j.clon.2025.103998","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103998"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145862569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCR Meetings","authors":"","doi":"10.1016/S0936-6555(26)00012-9","DOIUrl":"10.1016/S0936-6555(26)00012-9","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 104041"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146034681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACE-RT, A Cloud-Based Tool for Remote Radiotherapy Contouring Support in Lower-Resourced Settings: A Pilot Evaluation","authors":"T. Hope-Johnson ,&nbsp;G.B. Prajogi ,&nbsp;E. Addison ,&nbsp;A. Cameron ,&nbsp;B. Chanda M'ule ,&nbsp;T. Dembrey ,&nbsp;S. Hughes ,&nbsp;T.M. Khaled ,&nbsp;P.J. Lewis ,&nbsp;A. Aggarwal","doi":"10.1016/j.clon.2025.103967","DOIUrl":"10.1016/j.clon.2025.103967","url":null,"abstract":"<div><h3>Aims</h3><div>Digital learning tools designed to improve radiotherapy contouring skills could help to increase training capacity in low- and middle-income countries (LMICs), where trainees face barriers to learning such as few clinicians and high workloads. Previous efforts to implement software to remotely review radiotherapy plans in LMICs have faced challenges such as poor internet connectivity and insufficient information technology infrastructure. We developed and evaluated a new cloud-based software to support radiotherapy planning, designed specifically for use in lower-resourced settings.</div></div><div><h3>Materials and methods</h3><div>A cloud-based training software, ‘ACE-RT’, was co-designed with radiotherapy professionals in Ghana, Zambia and the United Kingdom to facilitate remote feedback on contours and form a portfolio to record a clinician's skill development. The co-development involved assessing bandwidth, user interface, and functionality to meet needs in an LMIC setting. The software is noncommercial, designed for educational use. ACE-RT was evaluated by a radiation oncology consultant and trainee in Indonesia between April and September 2023.</div></div><div><h3>Results</h3><div>The resident successfully uploaded and received feedback on six plans over the evaluation period. Both consultant and trainee found ACE-RT made it easier to provide and receive tailored feedback compared to their previous practice and that the quality of feedback improved. The trainee reported that the quantity of feedback was greater when using ACE-RT. Both found the portfolio function useful, appreciating the educational value of reviewing previous contours. The main implementation barriers identified were poor internet connectivity and the complexity of exporting files from the treatment planning system.</div></div><div><h3>Conclusion</h3><div>This evaluation of a cloud-based educational portfolio tool to improve training in radiotherapy contouring found it to be feasible, acceptable, and appropriate for use in a resource-limited setting. Unstable internet connectivity was the main barrier identified. Further work is recommended to improve the software’s performance with variable internet speeds and evaluate the implementation in a range of centres.</div></div>","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103967"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145621684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostate Cancer: Artificial Intelligence Advancements in Diagnosis and Early Detection","authors":"A. Shahzad,&nbsp;M. Waqar,&nbsp;T. Imran,&nbsp;M. Faisal","doi":"10.1016/j.clon.2025.103984","DOIUrl":"10.1016/j.clon.2025.103984","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103984"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cure or Truce? Rethinking Cancer Dormancy in Modern Oncology","authors":"M. Mehfooz,&nbsp;H. Raza,&nbsp;A. Javed,&nbsp;M. Aslam","doi":"10.1016/j.clon.2025.103973","DOIUrl":"10.1016/j.clon.2025.103973","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103973"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Parametric Boundaries: Rethinking the Distributed Lag Nonlinear Model in Meteorological Modelling for Oncology Emergencies","authors":"S. Oka ,&nbsp;K. Yoshida ,&nbsp;Y. Takefuji","doi":"10.1016/j.clon.2025.103970","DOIUrl":"10.1016/j.clon.2025.103970","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103970"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145577367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Treatment Resilience in Palliative Oesophagogastric Cancer: Nutritional, Access, and Scoring Considerations","authors":"M. Wajid Siddique ,&nbsp;M.A. Cheema","doi":"10.1016/j.clon.2025.103985","DOIUrl":"10.1016/j.clon.2025.103985","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103985"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The QuinteT Recruitment Intervention and its Role in Oncology Randomised Controlled Trials","authors":"L. Wallis ,&nbsp;J. Wade ,&nbsp;N. Farrar ,&nbsp;L. Rooshenas ,&nbsp;C. Conefrey ,&nbsp;N. Mills ,&nbsp;V. Shepherd ,&nbsp;L.S. Nixon ,&nbsp;M. Carucci ,&nbsp;A. White ,&nbsp;C.A. Harwood ,&nbsp;A. Rembielak","doi":"10.1016/j.clon.2025.103976","DOIUrl":"10.1016/j.clon.2025.103976","url":null,"abstract":"","PeriodicalId":10403,"journal":{"name":"Clinical oncology","volume":"49 ","pages":"Article 103976"},"PeriodicalIF":3.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}