Soft Matter最新文献_第2页

Covalent cross-linking approaches for all-trans retinoic acid-loaded thermo-responsive hydrogels. 全反式维甲酸负载热响应水凝胶的共价交联方法。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-23 DOI: 10.1039/d5sm00228a

Xueli Mei, Robert C Stewart, Xiao Zhen Zhou, Kun Ping Lu, Elizabeth R Gillies

{"title":"Covalent cross-linking approaches for all-trans retinoic acid-loaded thermo-responsive hydrogels.","authors":"Xueli Mei, Robert C Stewart, Xiao Zhen Zhou, Kun Ping Lu, Elizabeth R Gillies","doi":"10.1039/d5sm00228a","DOIUrl":"https://doi.org/10.1039/d5sm00228a","url":null,"abstract":"All-trans retinoic acid (ATRA) is a promising therapeutic for the treatment of a wide range of cancers. However, its short half-life, poor water-solubility, and low stability in vivo hinder its use. The development of injectable controlled release systems for ATRA delivery can potentially address these challenges. Building on a poly(caprolactone-co-lactide)-poly(ethylene glycol)-poly(caprolactone-co-lactide) (PCLA-PEG-PCLA) triblock copolymer system that undergoes thermo-responsive gelation at 37 °C, we explore and compare different approaches to stabilize the gels through covalent bonding. The attempted cross-linking of methacrylate end-capped PCLA-PEG-PCLA through thiol-Michael addition reactions using small molecule and 4-arm-PEG thiols led to precipitation rather than gelation. However, azide end-capped PCLA-PEG-PCLA was gelled using 5 kg mol-1 4-arm-PEG with terminal dibenzocyclooctyne (DIBAC) groups by strain-promoted azide-alkyne cycloaddition. This hydrogel was then compared with previously reported methacrylate end-capped PCLA-PEG-PCLA hydrogels cross-linked by free radical chemistry, as well as non-covalently cross-linked hydrogels. The azide-alkyne hydrogels exhibited properties intermediate between the free radical and non-covalently cross-linked gels. Incorporation of ATRA substantially disrupted the free radical cross-linking, but imparted only modest changes in the azide-alkyne gels. ATRA was released over about two weeks. The proliferation of MDA-MB-468 cells in the presence of ATRA-loaded and control azide-alkyne gels was investigated. The ATRA-loaded gel released active drug, while the unloaded gel did not affect proliferation.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelation behavior of short protected peptides in organic medium. 短保护肽在有机介质中的凝胶行为。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-23 DOI: 10.1039/d5sm00275c

Thomas M FitzSimons, Israt Jahan Duti, Nathaniel Conrad, Paridhi Agrawal, Alexandria Niemoeller, Emily Guinn, Jingyao Wang, Anastasiia Vasiukhina-Martin, Adrianne M Rosales

{"title":"Gelation behavior of short protected peptides in organic medium.","authors":"Thomas M FitzSimons, Israt Jahan Duti, Nathaniel Conrad, Paridhi Agrawal, Alexandria Niemoeller, Emily Guinn, Jingyao Wang, Anastasiia Vasiukhina-Martin, Adrianne M Rosales","doi":"10.1039/d5sm00275c","DOIUrl":"10.1039/d5sm00275c","url":null,"abstract":"Peptide gelators have been widely explored in aqueous systems due to their prevalence in biological and medical applications. However, gelation behavior of peptides is less understood in organic medium, despite the extensive use of organic solvents in solid phase peptide synthesis, hybrid synthesis protocols, and the formation and application of organogels. Here, peptides with a short aqueous gelator sequence, lysine-tyrosine-phenylalanine or KYF, were investigated for the ability to form gels in dichloromethane (DCM) when their side groups are protected. Protected KYF-containing peptides formed gels in DCM at similar concentrations to deprotected KYF peptides in water. Structural characterization via Fourier transform infrared spectroscopy indicated the presence of antiparallel β-sheets in both the protected and the deprotected KYF gels. However, transmission electron microscopy and dynamic light scattering indicated the protected KYF gels in DCM consisted of short, anisotropic particles at the mesoscale, whereas the deprotected KYF gels in water showed entangled fibers. The protected KYF gels in DCM exhibited similar rheological properties to colloidal gels, namely an increasing resistance to flow at higher shear rates, a shear thinning profile, and a gel-to-fluid transition with increasing strain. Altogether, this study provides critical insights on the assembly behavior and structure of a tripeptide motif and its variants in organic medium, which can facilitate optimizing the processing conditions of similar peptides in organic solvents during synthesis or end-use applications.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion specific effects on the rheology of cellulose nanofibrils in the presence of salts. 离子对盐存在下纤维素纳米原纤维流变学的影响。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-22 DOI: 10.1039/d5sm00339c

Ravisara Wattana, Daehwan Park, Chinedum O Osuji

{"title":"Ion specific effects on the rheology of cellulose nanofibrils in the presence of salts.","authors":"Ravisara Wattana, Daehwan Park, Chinedum O Osuji","doi":"10.1039/d5sm00339c","DOIUrl":"https://doi.org/10.1039/d5sm00339c","url":null,"abstract":"Cellulose nanofibrils (CNFs) are high-aspect-ratio semiflexible filaments that can modify the rheology of fluids in which they are suspended. This work addresses the role of ionic strength in the rheology of CNF suspensions and the ion-specific nature of such rheology. Salt-free CNF suspensions exhibit viscoelastic, shear-thinning behavior. The concentration dependences of the storage modulus and specific viscosity exhibit similar power-law relationships in two regimes, G' ∼ ηsp ∼ ca, with exponents of a ≈ 1 and a ≈ 5 below and above, respectively, a critical concentration of roughly 0.5 wt% that delineates \"dilute\" and \"semi-dilute\" characteristics. In the semi-dilute regime, salt addition increases the elastic modulus due to increased filament-filament association enabled by electrostatic screening of the repulsive interactions between weakly charged filaments. In the dilute regime, the intrinsic viscosity decreases with ionic strength, reflecting the adoption of more compact conformations at the single-filament level due to screened electrostatics. At a fixed ionic strength, both storage modulus and intrinsic viscosity show a marked dependence on ion identity, for which ion hydration enthalpy is used as a proxy. The storage modulus decreases with the enthalpy of hydration, whereas the intrinsic viscosity increases. Notably, the orderings of both parameters mimic the ion sequence of the Hofmeister series. This highlights a strong correlation between the ability of different ions to modify the hydrogen-bonding-network structure of water and their ability to screen inter- and intra-filament electrostatic interactions. This work provides new insight into ion-specific effects in CNF suspension rheology that can be used to rationally modify the properties of CNF-based complex fluids.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repulsions and attractions between membrane-deforming spheres, Janus-particles, and opposite tube-like deformations in giant unilamellar vesicles. 在巨大的单层囊泡中，膜变形球体、双面粒子和相反的管状变形之间的排斥和吸引。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-22 DOI: 10.1039/d4sm01415d

Ali Azadbakht, Daniela J Kraft

{"title":"Repulsions and attractions between membrane-deforming spheres, Janus-particles, and opposite tube-like deformations in giant unilamellar vesicles.","authors":"Ali Azadbakht, Daniela J Kraft","doi":"10.1039/d4sm01415d","DOIUrl":"https://doi.org/10.1039/d4sm01415d","url":null,"abstract":"Lipid membrane deformations have been predicted to lead to indirect forces between the objects that induce these deformations. Recent experimental measurements have found an attractive interaction between spherical particles that all induce a deformation towards the inside of a giant unilamellar vesicle. Here, we complement these experimental observations by investigating the interactions between deformations pointing in opposite directions with respect to the membrane normal vector. This is experimentally realized by a particle deforming the membrane towards the inside of the GUV and pulling a membrane tube towards the outside of the membrane. Particles completely wrapped by the membrane are repelled from the tube with a strength of 3 kBT at a distance of 0.5 μm. However, particles that strongly curve the membrane by adhering only to a patch of about 50% of its surface area are attracted to the center of the tube with a strength of -5.3 kBT at a minimum distance of about 1 μm. We find that such Janus particles also experience attractive interactions when both deforming the membrane in the same way. These quantitative experimental observations provide new insights into interactions between oppositely membrane deforming objects, important for cooperative protein assembly at or interactions of microplastics with cell membranes.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the background flow on motility-induced phase separation. 背景流对运动性相分离的影响。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-21 DOI: 10.1039/d5sm00362h

Soni D Prajapati, Akshay Bhatnagar, Anupam Gupta

{"title":"Effect of the background flow on motility-induced phase separation.","authors":"Soni D Prajapati, Akshay Bhatnagar, Anupam Gupta","doi":"10.1039/d5sm00362h","DOIUrl":"https://doi.org/10.1039/d5sm00362h","url":null,"abstract":"We simulate active Brownian particles (ABPs) with soft-repulsive interactions subjected to a four-roll-mill flow. In the absence of flow, this system exhibits motility-induced phase separation (MIPS). To investigate the interplay between MIPS and flow-induced mixing, we introduce dimensionless parameters: a scaled time, τ, and a scaled speed, V, characterizing the ratio of ABP to fluid time and speed scales, respectively. The parameter space defined by τ and V reveals three distinct ABP distribution regimes. At low speeds, V ≪ 1, flow dominates, leading to a homogeneous mixture. Conversely, at high speeds, V ≫ 1, motility prevails, resulting in MIPS. In the intermediate regime (V ∼ 1), the system's behavior depends on τ. For τ < 1, a moderately mixed homogeneous phase emerges, while for τ > 1, a novel phenomenon, termed flow-induced phase separation (FIPS), arises due to the combined effects of flow topology and ABP motility and size. To characterize these phases, we analyze drift velocity, diffusivity, mean-squared displacement, giant number fluctuations, radial distribution function, and cluster-size distribution.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brillouin microscopy analysis of the fibroblast mechanical response to substrate's stiffness. 纤维母细胞对基质刚度的力学响应的布里渊显微镜分析。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-21 DOI: 10.1039/d5sm00315f

Vsevolod Cheburkanov, Vladislav V Yakovlev

{"title":"Brillouin microscopy analysis of the fibroblast mechanical response to substrate's stiffness.","authors":"Vsevolod Cheburkanov, Vladislav V Yakovlev","doi":"10.1039/d5sm00315f","DOIUrl":"10.1039/d5sm00315f","url":null,"abstract":"Cancer mechano-adaptation remains poorly understood due to the lack of imaging technologies capable of quantifying both mechanical and biochemical properties of cells and their microenvironment in 3D culture and in vivo. This challenge arises primarily due to the invasiveness of existing mechanical measurement techniques and their inability to assess mechanical properties in highly heterogeneous structures such as living tissues. Brillouin microscopy is an emerging, label-free technique that enables measurements of local mechanical properties with microscopic spatial resolution. In this study, we non-invasively imaged the elastic properties of monolayer 4T1 murine fibroblast cells using Brillouin microscopy and analyzed their response to variations in the mechanical properties of the external environment. Our findings demonstrate a significant correlation between the mechanical properties of the extracellular matrix and cancer cells, as assessed through Brillouin microspectroscopy in a non-invasive and safe manner. These results highlight the potential of Brillouin spectroscopy as a robust and effective technique for the characterization of biomechanical properties in cancer cells, offering valuable insights into their mechanical behavior.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and dynamical impacts of water dilution on egg yolk properties. 水稀释对蛋黄性质的结构和动力学影响。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-20 DOI: 10.1039/d5sm00289c

Floriane Gerony, Agathe Fanost, Zlanseu R Tan, Natalie Malikova, Laurent Michot, Marie Poirier-Quinot, Laurence de Viguerie, Maguy Jaber, Guillaume Mériguet, Anne-Laure Rollet

引用次数: 0

Effect of pressure on the micellar structure and aggregation behavior of PMMA-b-PNIPAM diblock copolymers in a water/methanol mixture. 压力对水/甲醇混合物中PMMA-b-PNIPAM二嵌段共聚物胶束结构和聚集行为的影响

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-20 DOI: 10.1039/d5sm00160a

Pablo A Alvarez Herrera, Feifei Zheng, Peiran Zhang, Julija Reitenbach, Heinz Amenitsch, Cristiane Henschel, André Laschewsky, Peter Müller-Buschbaum, Alfons Schulte, Christine M Papadakis

{"title":"Effect of pressure on the micellar structure and aggregation behavior of PMMA-b-PNIPAM diblock copolymers in a water/methanol mixture.","authors":"Pablo A Alvarez Herrera, Feifei Zheng, Peiran Zhang, Julija Reitenbach, Heinz Amenitsch, Cristiane Henschel, André Laschewsky, Peter Müller-Buschbaum, Alfons Schulte, Christine M Papadakis","doi":"10.1039/d5sm00160a","DOIUrl":"https://doi.org/10.1039/d5sm00160a","url":null,"abstract":"The pressure-induced changes of the micellar structures and aggregation behavior of a thermoresponsive diblock copolymer, consisting of a short poly(methyl methacrylate) (PMMA) and a long poly(N-isopropylacrylamide) (PNIPAM) block, in a 90 : 10 v/v water/methanol mixture, are characterized in the temperature-pressure frame. The phase diagram of the polymer solution is established by turbidimetry. The maximum of the coexistence line is found at 33.7 °C and 83.3 MPa. Synchrotron small-angle X-ray scattering is used to determine the micellar structure and correlation over a temperature and pressure range of 28 to 36 °C and 10 to 250 MPa, respectively. In the one-phase region, the core size steadily decreases with increasing pressure, while the micellar shell slightly shrinks after featuring an initial swelling up to ca. 75 MPa. The micellar swelling is attributed to the higher degree of hydration of the PNIPAM blocks due to the weakening of the preferential binding of methanol with PNIPAM. In the two-phase region, two pressure regimes are found: At pressures up to ca. 75 MPa (low-pressure regime), the core size and shell thickness increase while the correlation between micelles diminishes with increasing pressure. Conversely, at pressures between 75 and 250 MPa (high pressure regime), these parameters exhibit the opposite behavior. This behavior in the high-pressure regime of the two-phase region occurs regardless of whether the pressure is increased across the coexistence line or occurs entirely within the two-phase region.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-limiting states of polar misfits: frustrated assembly of warped-jigsaw particles. 极性不匹配的自我限制状态：扭曲的拼图粒子的受挫组装。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-20 DOI: 10.1039/d5sm00136f

Michael Wang, Gregory M Grason

{"title":"Self-limiting states of polar misfits: frustrated assembly of warped-jigsaw particles.","authors":"Michael Wang, Gregory M Grason","doi":"10.1039/d5sm00136f","DOIUrl":"https://doi.org/10.1039/d5sm00136f","url":null,"abstract":"We study the ground state thermodynamics of a model class of geometrically frustrated assemblies, known as warped-jigsaw particles. While it is known that frustration in soft matter assemblies has the ability to propagate up to mesoscopic, multi-particle size scales, notably through the selection of the self-limiting domain, little is understood about how the symmetry of shape-misfit at the particle scale influences emergent morphologies at the mesoscale. Here we show that polarity in the shape-misfit of warped-jigsaw puzzles manifests at a larger scale in the morphology and thermodynamics of the ground-state assembly of self-limiting domains. We use a combination of continuum theory and discrete particle simulations to show that the polar misfit gives rise to two mesoscopically distinct polar, self-limiting ribbon domains. Thermodynamic selection between the two ribbon morphologies is controlled by a combination of the binding anisotropy along distinct neighbor directions and the orientation of polar shape-misfit. These predictions are valuable as design features for ongoing efforts to program self-limiting assemblies through the synthesis of intentionally frustrated particles, further suggesting a generic classification of frustrated assembly behavior in terms of the relative symmetries of shape-misfit and the underlying long-range inter-particle order it frustrates.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blockage effects in the chemotaxis of diffusiophoretic particles. 扩散电泳颗粒趋化性中的阻断效应。

IF 2.9 3区化学

Soft Matter Pub Date : 2025-05-20 DOI: 10.1039/d5sm00270b

Zehao Song, Matthew Farnese, Ahis Shresth, Monica Olvera de la Cruz

{"title":"Blockage effects in the chemotaxis of diffusiophoretic particles.","authors":"Zehao Song, Matthew Farnese, Ahis Shresth, Monica Olvera de la Cruz","doi":"10.1039/d5sm00270b","DOIUrl":"https://doi.org/10.1039/d5sm00270b","url":null,"abstract":"Transport mechanisms at the micro- and nano-scale play an essential role in regulating intracellular organization. Recent work indicates that directed motion of constituents inside cells can emerge through diffusiophoretic transport, in which colloidal particles move under the influence of chemical gradients. Here, we examine how blockers-passive or actively consuming-reshape those gradients and thereby influence the motion of diffusiophoretic particles. By combining analytical solutions with finite element simulations, we first show that a single blocker can distort a background gradient enough to create or eliminate stagnation points, significantly modifying particle transport. We then introduce a second, explicitly sized blocker at one of these stagnation points and measure how its finite radius alters the diffusiophoretic velocity field for a test particle. Even moderate changes in the second blockers size can cause noticeable shifts in the substrate distribution, highlighting the importance of accounting for explicit particle radii under crowded or consumption-driven conditions. Our findings underscore that subtle geometric variations-such as the radii and positions of two or more blockers-can profoundly affect diffusiophoretic motion, providing a more complete picture of how blocking and crowding phenomena shape intracellular transport.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0