Soft Matter最新文献_第2页

Scale-dependent sharpening of interfacial fluctuations in shape-based models of dense cellular sheets. 基于形状的致密细胞片模型中界面波动随尺度变化的锐化。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00804a

Haicen Yue, Charles R Packard, Daniel M Sussman

{"title":"Scale-dependent sharpening of interfacial fluctuations in shape-based models of dense cellular sheets.","authors":"Haicen Yue, Charles R Packard, Daniel M Sussman","doi":"10.1039/d4sm00804a","DOIUrl":"https://doi.org/10.1039/d4sm00804a","url":null,"abstract":"The properties of tissue interfaces - between separate populations of cells, or between a group of cells and its environment - has attracted intense theoretical, computational, and experimental study. Recent work on shape-based models inspired by dense epithelia have suggested a possible \"topological sharpening\" effect, by which four-fold vertices spatially coordinated along a cellular interface lead to a cusp-like restoring force acting on cells at the interface, which in turn greatly suppresses interfacial fluctuations. We revisit these interfacial fluctuations, focusing on the distinction between short length scale reduction of interfacial fluctuations and long length scale renormalized surface tension. To do this, we implement a spectrally resolved analysis of fluctuations over extremely long simulation times. This leads to more quantitative information on the topological sharpening effect, in which the degree of sharpening depends on the length scale over which it is measured. We compare our findings with a Brownian bridge model of the interface, and close by analyzing existing experimental data in support of the role of short-length-scale topological sharpening effects in real biological systems.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites. 规模依赖性相互作用使肌动蛋白-波形蛋白复合材料能够产生微流变应力响应。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00988f

Julie Pinchiaroli, Renita Saldanha, Alison E Patteson, Rae M Robertson-Anderson, Bekele J Gurmessa

{"title":"Scale-dependent interactions enable emergent microrheological stress response of actin-vimentin composites.","authors":"Julie Pinchiaroli, Renita Saldanha, Alison E Patteson, Rae M Robertson-Anderson, Bekele J Gurmessa","doi":"10.1039/d4sm00988f","DOIUrl":"10.1039/d4sm00988f","url":null,"abstract":"The mechanical properties of the mammalian cell regulate many cellular functions and are largely dictated by the cytoskeleton, a composite network of protein filaments, including actin, microtubules, and intermediate filaments. Interactions between these distinct filaments give rise to emergent mechanical properties that are difficult to generate synthetically, and recent studies have made great strides in advancing our understanding of the mechanical interplay between actin and microtubule filaments. While intermediate filaments play critical roles in the stress response of cells, their effect on the rheological properties of the composite cytoskeleton remains poorly understood. Here, we use optical tweezers microrheology to measure the linear viscoelastic properties and nonlinear stress response of composites of actin and vimentin with varying molar ratios of actin to vimentin. We reveal a surprising, nearly opposite effect of actin-vimentin network mechanics compared to single-component networks in the linear versus nonlinear regimes. Namely, the linear elastic plateau modulus and zero-shear viscosity are markedly reduced in composites compared to single-component networks of actin or vimentin, whereas the initial response force and stiffness are maximized in composites versus single-component networks in the nonlinear regime. While these emergent trends are indicative of distinct interactions between actin and vimentin, nonlinear stiffening and long-time stress response appear to both be dictated primarily by actin, at odds with previous bulk rheology studies. We demonstrate that these complex, scale-dependent effects arise from the varied contributions of network density, filament stiffness, non-specific interactions, and poroelasticity to the mechanical response at different spatiotemporal scales. Cells may harness this complex behavior to facilitate distinct stress responses at different scales and in response to different stimuli to allow for their hallmark multifunctionality.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":"9007-9021"},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of hydration water on bioresponsiveness of polymer interfaces revealed by analysis of linear and cyclic polymer-grafted substrates. 通过分析线性和环状聚合物接枝基底揭示水合水对聚合物界面生物反应性的影响。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00977k

Shin-Nosuke Nishimura, Naoya Kurahashi, Shohei Shiomoto, Yoshihisa Harada, Masaru Tanaka

{"title":"Effects of hydration water on bioresponsiveness of polymer interfaces revealed by analysis of linear and cyclic polymer-grafted substrates.","authors":"Shin-Nosuke Nishimura, Naoya Kurahashi, Shohei Shiomoto, Yoshihisa Harada, Masaru Tanaka","doi":"10.1039/d4sm00977k","DOIUrl":"https://doi.org/10.1039/d4sm00977k","url":null,"abstract":"Given that the hydration water of polymer matrices may differ from that of outermost polymer surfaces, processes at biomaterial-biofluid interfaces and role of hydration water therein cannot be adequately examined using most conventional characterization methods. To bridge this gap, a gold substrate was herein modified with linear and cyclic poly(2-methoxyethyl acrylate) to prepare gl-PMEA and gc-PMEA surfaces, respectively, as models for the outermost surfaces of blood-contacting medical devices. Both surfaces suppressed the adhesion of human platelets but differed in the adhesion behaviors of normal and tumor cells despite having the same areal density of fixed-end units. The surfaces were analyzed using quartz crystal microbalance (QCM), frequency modulation atomic force microscopy (FM-AFM), and X-ray emission spectroscopy (XES) measurements under wet conditions to clarify the relationship between bioresponsivity and hydration water. QCM measurements provided evidence that both grafted-PMEA were hydrated. FM-AFM observations revealed that the swelling layer was thicker for gc-PMEA. To rationalize the differences in the surface hydration states, we performed XES measurements under conditions enabling control over the number of hydration water molecules. In the low-water-content region, hydrogen bonds or interactions between water molecules developed in the vicinity of gl-PMEA but not gc-PMEA. Thus, the initial hydration behavior of the gc-PMEA surface, which promoted intermediate water formation, was different from that of the gl-PMEA surface. The results suggested that the adjustment and optimization of the hydration state of outermost biomaterial surfaces enable the control of bioresponsivity, including the selective isolation of tumor cells.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142674509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multi-scale framework for predicting α-cyclodextrin assembly on polyethylene glycol axles. 预测α-环糊精在聚乙二醇轴上组装的多尺度框架。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm01048e

Cameron D Smith, Chenfeng Ke, Wenlin Zhang

{"title":"A multi-scale framework for predicting α-cyclodextrin assembly on polyethylene glycol axles.","authors":"Cameron D Smith, Chenfeng Ke, Wenlin Zhang","doi":"10.1039/d4sm01048e","DOIUrl":"10.1039/d4sm01048e","url":null,"abstract":"Controlling the distribution of rings on polymer axles, such as α-cyclodextrin (αCD) on polyethylene glycol (PEG), is paramount in imparting robust mechanical properties to slide-ring gels and polyrotaxane-based networks. Previous experiments demonstrated that the functionalization of polymer ends could modulate the coverage of αCDs on PEG. To explore the design rule, we propose a multi-scale framework for predicting αCD assembly on bare and functionalized PEG. Our approach combines all-atom molecular dynamics with two-dimensional (2D) umbrella sampling to compute the free energy landscapes of threading αCDs onto PEG with ends functionalized by various moieties. Together with the predicted free energy landscapes and a lattice treatment for αCD and polymer diffusion in dilute solutions, we construct a kinetic Monte Carlo (kMC) model to predict the number and intra-chain distribution of αCDs along the polymer axle. Our model predicts the effects of chain length, concentration, and threading barrier on the supramolecular structure of end-functionalized polypseudorotaxane. With simple modifications, our approach can be extended to explore the design rule of polyrotaxane-based materials with advanced network architectures.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":"9068-9082"},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Controllable biomolecule release from self-assembled organic nanotubes with asymmetric surfaces: pH and temperature dependence. 更正：具有不对称表面的自组装有机纳米管的可控生物分子释放：pH 值和温度依赖性。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm90187h

Naohiro Kameta, Hiroyuki Minamikawa, Mitsutoshi Masuda, Go Mizuno, Toshimi Shimizu

引用次数: 0

Geometrical impacts of platonic particles on nematic liquid crystal dynamics. 柏拉图粒子对向列液晶动力学的几何影响

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00870g

Stiven Villada-Gil, Monirosadat Sadati, Juan D Ospina-Correa, Daniel A Olaya-Muñoz, Juan P Hernández-Ortiz, José A Martínez-González

引用次数: 0

Rolling and ordering of micro rods in shear flow induced by rod wall interactions. 微棒在棒壁相互作用诱导的剪切流中的滚动和排序。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00999a

Martin Wittmann, Igor M Kulić, Antonio Stocco, Juliane Simmchen

引用次数: 0

Long-lived unidirectional flow of active particles within long narrow channels. 活性颗粒在狭长通道内长期单向流动。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm00879k

Man Xu, Ying Lan, Yuehua Yang, Hongyuan Jiang

{"title":"Long-lived unidirectional flow of active particles within long narrow channels.","authors":"Man Xu, Ying Lan, Yuehua Yang, Hongyuan Jiang","doi":"10.1039/d4sm00879k","DOIUrl":"10.1039/d4sm00879k","url":null,"abstract":"Revealing the mechanism of directed transport of active matter is critical for advancing our fundamental understanding of non-equilibrium physics. Asymmetric microstructures are commonly used to rectify random movement of active particles. However, it remains unclear as to how to achieve unidirectional movement of active particles in long narrow channels. Here, we study the dynamics of active particles in a device which is divided into two chambers by V-shaped barriers and connected by a narrow channel. We find three distinct movement modes of active particles within this symmetric channel, including stochastic movement, self-sustained oscillation, and long-lived unidirectional flows. We demonstrate that the three movement modes are determined by the competition between the ratchet effect induced by the V-shaped barriers and the particle transport mediated by the long-narrow channel. Finally, we show that the unidirectional particle flow can serve as an \"energy battery\" to continuously supply energy for the directed transport of other objects. Our findings offer valuable insights into a unique approach for realizing unidirectional movement of active matter and open new avenues for application in microfluidics and material transport.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":"9022-9027"},"PeriodicalIF":2.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ring-shaped nanoparticle assembly and cross-linking on lipid vesicle scaffolds. 脂质囊支架上的环形纳米粒子组装和交联。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-20 DOI: 10.1039/d4sm01010h

Gizem Karabiyik, Aldo Jesorka, Irep Gözen

引用次数: 0

Reversible pH-responsive supramolecular aggregates from viologen based amphiphiles - a molecular design perspective. 基于紫罗兰烯的双亲化合物的可逆 pH 响应超分子聚合体--一种分子设计视角。

IF 2.9 3区化学

Soft Matter Pub Date : 2024-11-18 DOI: 10.1039/d4sm00695j

Redhills L Narendran, Archita Patnaik

{"title":"Reversible pH-responsive supramolecular aggregates from viologen based amphiphiles - a molecular design perspective.","authors":"Redhills L Narendran, Archita Patnaik","doi":"10.1039/d4sm00695j","DOIUrl":"https://doi.org/10.1039/d4sm00695j","url":null,"abstract":"pH responsive self-assembled supramolecular systems in water hold tremendous promise spanning across the various realms of science and technology. Herein, we report the design and synthesis of benzyl viologen (BV) based amphiphiles and their ability to form pH responsive aggregates with a water soluble anionic dye (electron donor), a polyelectrolyte (PE), and a surfactant. To counter the low solubility of viologen derivatives, β-cyclodextrin (β-CD) was employed as a solubility promoter and the host-guest complexes were characterized by NMR spectroscopy. The impacts of increasing the number of benzyl units on (i) the water solubility of viologens, (ii) the response of the aggregates of viologens with pyranine, PE, and surfactants towards pH, and (iii) the influence of β-CD on the pH-responsive nature of BV-pyranine, BV-PE, BV-surfactant, etc. were investigated. Apart from improving the solubility of viologens, β-CD also imparted pH-responsive dissolution/aggregation behavior to the viologen-anionic polyelectrolyte and viologen-anionic surfactant complexes. The pH switchable behaviour of the soft supramolecular aggregates in water was rationalized in light of a delicate balance prevailing between multiple non-covalent interactions. Based on the results, we propose an elegant molecular design principle to generate pH responsive colloidal aggregates from amphiphiles and oppositely charged molecular systems.","PeriodicalId":103,"journal":{"name":"Soft Matter","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0