Clinical immunology最新文献_第8页

Infection risk associated with hypogammaglobulinemia in patients with systemic lupus erythematosus: Real-world evidence from 2014 to 2024 系统性红斑狼疮患者感染风险与低丙种球蛋白血症相关：2014年至2024年的真实世界证据

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-20 DOI: 10.1016/j.clim.2025.110568

Yang Liu , Sumiao Liu , Ying Liu, Qian Li, Ke Xu

{"title":"Infection risk associated with hypogammaglobulinemia in patients with systemic lupus erythematosus: Real-world evidence from 2014 to 2024","authors":"Yang Liu , Sumiao Liu , Ying Liu, Qian Li, Ke Xu","doi":"10.1016/j.clim.2025.110568","DOIUrl":"10.1016/j.clim.2025.110568","url":null,"abstract":"<div><h3>Objectives</h3><div>To evaluate infection risk associated with hypogammaglobulinemia in patients with systemic lupus erythematosus (SLE).</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 242 cases of hypogammaglobulinemia identified among 3565 hospitalized SLE patients between 2014 and 2024. Of these, 133 experienced infections, while 109 remained infection-free and served as controls.</div></div><div><h3>Results</h3><div>Infection rates were comparable among patients with low IgG (60.0 %), IgM (56.3 %) and IgA (57.7 %) levels. Multivariate logistic regression identified low body weight, fever, medication discontinuation, lymphopenia, reduced lymphocyte count, elevated CRP levels, and decreased Th cell and NK cell counts as independent predictors of infection. During follow-up, immunoglobulin levels recovered in most patients, with rates at two years of 76.0 % for IgA, 43.8 % for IgG, and 26.2 % for IgM. Immunoglobulin normalization was associated with reduced infection risk.</div></div><div><h3>Conclusion</h3><div>Hypogammaglobulinemia increases infection risk in SLE due to multifactorial immune dysfunction. Modifiable clinical and immunologic factors, along with immunoglobulin recovery, may represent actionable targets for intervention.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110568"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-associated neutrophils: a complex role in cancer 肿瘤相关中性粒细胞：在癌症中的复杂作用。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-07 DOI: 10.1016/j.clim.2025.110558

Xukang Gao , Min Xu , Hao Xiao , Zeping Han , Zhutao Wang , Guoqiang Sun , Dai Zhang , Qiu Shuangjian , Ning Ren , Chenhao Zhou , Yong Yi

引用次数: 0

Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium 有和没有HIV的肾移植供者的炎症：多中心希望在行动联盟。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-11 DOI: 10.1016/j.clim.2025.110563

Fatima Zaman , Xianming Zhu , Joanne H. Hunt , Gracie Rozek , Yolanda Eby , Sarah Hussain , Niraj M. Desai , Sander Florman , Meenakshi M. Rana , Rachel Friedman-Moraco , Marcus R. Pereira , Shikha Mehta , Peter Stock , Alexander Gilbert , Jonathan Hand , Michele I. Morris , Valentina Stosor , Sapna A. Mehta , Catherine B. Small , Joanna Schaenman , Aaron A.R. Tobian

{"title":"Inflammation among kidney transplant donors with and without HIV: Multicenter HOPE in Action Consortium","authors":"Fatima Zaman , Xianming Zhu , Joanne H. Hunt , Gracie Rozek , Yolanda Eby , Sarah Hussain , Niraj M. Desai , Sander Florman , Meenakshi M. Rana , Rachel Friedman-Moraco , Marcus R. Pereira , Shikha Mehta , Peter Stock , Alexander Gilbert , Jonathan Hand , Michele I. Morris , Valentina Stosor , Sapna A. Mehta , Catherine B. Small , Joanna Schaenman , Aaron A.R. Tobian","doi":"10.1016/j.clim.2025.110563","DOIUrl":"10.1016/j.clim.2025.110563","url":null,"abstract":"<div><div>Kidney transplantation from donors with HIV has recently become standard clinical practice, but the plasma inflammatory profile is not well characterized. Thirty-two cytokines and chemokines were evaluated among donors with HIV (<em>n</em> = 63) and without HIV (<em>n</em> = 41). Wilcoxon rank sum test was used to compare cytokines between groups. Donors with and without HIV were generally similar in terms of characteristics, except those with HIV had a non-significantly lower kidney donor profile index, reflecting better graft survival, creatinine, and body mass index. Most cytokine and chemokine levels were similar between groups. However, median IL-8 levels were higher (<em>p</em> < 0.0015) in donors without HIV (32.6 pg/mL, IQR = 13.8–394.9) compared to donors with HIV (15.1 pg/mL, IQR = 8.4–35.5). There were no significant correlations between cytokine and chemokine concentrations and CD4 counts or HIV viral load. In summary, inflammatory profiles were similar or lower among donors with HIV compared to donors without HIV supporting the safety of this emerging kidney transplantation practice.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110563"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-dimensional immune profiling identifies circulating NK and T cell subpopulations associated with asymptomatic COVID-19 and absence of multiple long-term symptoms 高维免疫谱识别与无症状COVID-19和无多种长期症状相关的循环NK和T细胞亚群。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-11 DOI: 10.1016/j.clim.2025.110564

Johanna Bodin , Anja Bråthen Kristoffersen , Tove Karin Herstad , Gro Tunheim , Sabin Bhandari , Anna Hayman Robertson , Ratnadeep Mukherjee , Unni Cecilie Nygaard , Fredrik Oftung , Lisbeth M. Næss

{"title":"High-dimensional immune profiling identifies circulating NK and T cell subpopulations associated with asymptomatic COVID-19 and absence of multiple long-term symptoms","authors":"Johanna Bodin , Anja Bråthen Kristoffersen , Tove Karin Herstad , Gro Tunheim , Sabin Bhandari , Anna Hayman Robertson , Ratnadeep Mukherjee , Unni Cecilie Nygaard , Fredrik Oftung , Lisbeth M. Næss","doi":"10.1016/j.clim.2025.110564","DOIUrl":"10.1016/j.clim.2025.110564","url":null,"abstract":"<div><div>While severe COVID-19 is well-characterized, immune profiles of non-hospitalized, non-vaccinated individuals are less investigated. High-dimensional single-cell profiling and multiplex serum marker analysis characterized immune profiles according to outcome during acute infection and six months later. Lower IL-1RA and HGF levels, higher CD57<sup>+</sup>TIGIT<sup>+</sup>NKT, CD57<sup>+</sup>GrB<sup>+</sup>NKT, CD16<sup>+</sup>TIGIT<sup>+</sup>NK and CD4<sup>+</sup>CD57<sup>+</sup>GrB<sup>+</sup> effector T-cell levels characterized asymptomatic infection. PMA + ionomycin induced higher frequencies of polyfunctional CD4<sup>+</sup> and CD8<sup>+</sup> effector T-cells in asymptomatic compared to moderate disease. Absence of multiple long-term symptoms was associated with higher CD16<sup>+</sup>TIGIT<sup>+</sup>NK-cell frequency, lower HGF levels and persisting high memory B and regulatory NK subpopulation levels. Higher frequency of CD16<sup>+</sup>TIGIT<sup>+</sup> NK cells was in common for non-infected, asymptomatic, and individuals without multiple long-term symptoms. Compared to infected individuals, non-infected cases showed higher pre-existing T-cell responses to hCoV and SARS-CoV-2 peptides. This study contributes to increased understanding of protective immune responses in non-hospitalized COVID-19 cases, emphasizing the role of defined NK and T-cell subpopulations.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110564"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analyses of peripheral blood NK cells in response to anti-PD-1 therapy in metastatic melanoma patients 转移性黑色素瘤患者外周血NK细胞对抗pd -1治疗的反应分析。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-09 DOI: 10.1016/j.clim.2025.110557

Katarina Mirjačić Martinović , Ana Vuletić , Nevena Tišma Miletić , Milica Nedeljković , Suzana Matković , Vladimir Jurišić

{"title":"Analyses of peripheral blood NK cells in response to anti-PD-1 therapy in metastatic melanoma patients","authors":"Katarina Mirjačić Martinović , Ana Vuletić , Nevena Tišma Miletić , Milica Nedeljković , Suzana Matković , Vladimir Jurišić","doi":"10.1016/j.clim.2025.110557","DOIUrl":"10.1016/j.clim.2025.110557","url":null,"abstract":"<div><div>Therapeutical blockade of programmed cell death protein 1 (PD-1) axis may enhance anti-tumor immunity and especially natural killer (NK) cells activity. In 32 BRAF wild type (wt) metastatic melanoma (MM) patients before and after every 12 weeks of therapy with PD-1 inhibitor, Pembrolizumab, we analyzed the percentage of T cell subsets, NK cells and CD14<sup>+</sup>HLA-DR<sup>−</sup> monocytes, the expression of CD107a degranulation marker, activating NKG2D, NKp46, DNAM-1 and inhibitory CD158a receptors on NK cells by Flow cytometry, until one year or disease progression (DP). The patients with disease control (non-DP patients) had significant increase in lymphocyte count, percentage of NK cells, increased expression of CD107a, NKG2D, NKp46, but decreased CD158a on NK cells during Pembrolizumab therapy compared to pretherapy values. Patients with DP had increased neutrophil number, increased percentage of immunosuppressive CD14<sup>+</sup>HLA-DR<sup>−</sup> monocytes, as well as increased CD158a expression on NK cells. In MM patients with disease control, contrary to DP patients blocking of PD-1 inhibitory molecule may increase NK cell cytotoxicity through enhancement of NK cell degranulation and activating receptor expression. Therefore, our findings show that NK cells and their receptors in MM patients may be potential biomarkers of response to Pembrolizumab.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110557"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LSP1 deficiency increases IL-17-expressing T cells and accelerates primary Sjögren's syndrome LSP1缺乏增加表达il -17的T细胞，加速原发性Sjögren综合征。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-06-28 DOI: 10.1016/j.clim.2025.110548

Jayhyun Kim , Jung Gon Kim , Yingjin Li , Sungyong You , Naeun Lee , Wan-Uk Kim

引用次数: 0

Origin, functions, heterogeneity and associated diseases of B-1 cells B-1细胞的起源、功能、异质性和相关疾病。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-10 DOI: 10.1016/j.clim.2025.110561

Weicheng Shen , Shengyan Cui , Yanqi Xia , Luo Duan , Yunpeng Dou , Han Zhao , Leixin Liu , Wei Wang , Ye Cui , Yan Chen , Jie Liu , Zhe Lv , Chris J. Corrigan , Huihui Yuan , Ying Sun

{"title":"Origin, functions, heterogeneity and associated diseases of B-1 cells","authors":"Weicheng Shen , Shengyan Cui , Yanqi Xia , Luo Duan , Yunpeng Dou , Han Zhao , Leixin Liu , Wei Wang , Ye Cui , Yan Chen , Jie Liu , Zhe Lv , Chris J. Corrigan , Huihui Yuan , Ying Sun","doi":"10.1016/j.clim.2025.110561","DOIUrl":"10.1016/j.clim.2025.110561","url":null,"abstract":"<div><div>B-1 cells are derived from a subpopulation of B lymphocytes which have a specific developmental process, unique phenotype and location, and distinct functions in comparison with conventional B-2 cells. The origin of B-1 cells is not completely clear, with two existing hypotheses concerning their lineage and differentiation pathways. B-1 cells are located principally in the peritoneal and pleural cavities, but are also distributed in secondary lymphoid tissues, at mucosal sites and in the blood and bone marrow. B-1 cells regulate immune responses and maintain homeostasis by secretion of natural antibodies (nAbs), and participate in the adaptive immune response through phagocytosis and presentation of antigens to T cells. B-1 cells are associated with many diseases including autoimmune, infectious and inflammatory diseases. This review focuses on the origin and biological functions of B-1 cells as well as their involvement in human disease, and discusses advances in the understanding of the heterogeneity of B-1 cells under specific pathophysiological features, as partly clarified by single-cell sequencing analysis.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"280 ","pages":"Article 110561"},"PeriodicalIF":4.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144616549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron-dependent cell death: Unlocking Ferroptosis as a key to multiple myeloma therapy 铁依赖性细胞死亡：解锁铁下垂作为多发性骨髓瘤治疗的关键。

IF 3.8 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-16 DOI: 10.1016/j.clim.2025.110570

Fatemeh Karimian , Melika Khademi , Amirsalar Nikkhah Bahrami , Maryam Nabigol , Fatemeh Mikanik , Mehdi Bakhtiyaridovvombaygi , Nader Vazifeh Shiran

引用次数: 0

The role of signaling lymphocytic activation molecule (SLAM) family receptors in health and disease progression: Focusing on cancer and therapy 信号淋巴细胞活化分子（SLAM）家族受体在健康和疾病进展中的作用：聚焦于癌症和治疗

IF 3.8 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-26 DOI: 10.1016/j.clim.2025.110574

Guhan Luo , Rong Ni , Xuanwei Huang , Yuanhui Li , Dingcun Luo

引用次数: 0

Animal models of IgG4-related disease igg4相关疾病的动物模型。

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-11-01 Epub Date: 2025-07-06 DOI: 10.1016/j.clim.2025.110559

Manqi Tang , Weicheng Shen , Yanying Liu

引用次数: 0