Clinical immunology最新文献_第8页

Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus 黑色素细胞的异常代谢参与了晕痣中树突状细胞的激活。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-29 DOI: 10.1016/j.clim.2024.110300

Ling Jiang , Yibo Hu , Yushan Zhang , Yuanyuan Zhao , Lijuan Gao , Yumeng Dong , Yixuan Liang , Haoran Guo , Songjiang Wu , Yuanmin Zhang , Jing Chen , Qinghai Zeng

{"title":"Abnormal metabolism in melanocytes participates in the activation of dendritic cell in halo nevus","authors":"Ling Jiang , Yibo Hu , Yushan Zhang , Yuanyuan Zhao , Lijuan Gao , Yumeng Dong , Yixuan Liang , Haoran Guo , Songjiang Wu , Yuanmin Zhang , Jing Chen , Qinghai Zeng","doi":"10.1016/j.clim.2024.110300","DOIUrl":"10.1016/j.clim.2024.110300","url":null,"abstract":"<div><p>A comprehensive analysis of spatial transcriptomics was carried out to better understand the progress of halo nevus. We found that halo nevus was characterized by overactive immune responses, triggered by chemokines and dendritic cells (DCs), T cells, and macrophages. Consequently, we observed abnormal cell death, such as apoptosis and disulfidptosis in halo nevus, some were closely related to immunity. Interestingly, we identified aberrant metabolites such as uridine diphosphate glucose (UDP-G) within the halo nevus. UDP-G, accompanied by the infiltration of DCs and T cells, exhibited correlations with certain forms of cell death. Subsequent experiments confirmed that UDP-G was increased in vitiligo serum and could activate DCs. We also confirmed that oxidative response is an inducer of UDP-G. In summary, the immune response in halo nevus, including DC activation, was accompanied by abnormal cell death and metabolites. Especially, melanocyte-derived UDP-G may play a crucial role in DC activation.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110300"},"PeriodicalIF":4.5,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LACC1 deficiency leading to juvenile arthritis and anemia LACC1 缺乏症会导致幼年关节炎和贫血。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-27 DOI: 10.1016/j.clim.2024.110290

Tingyan He , Linlin Wang , Xiaomei Huang, Ruohang Weng, Jun Yang

{"title":"LACC1 deficiency leading to juvenile arthritis and anemia","authors":"Tingyan He , Linlin Wang , Xiaomei Huang, Ruohang Weng, Jun Yang","doi":"10.1016/j.clim.2024.110290","DOIUrl":"10.1016/j.clim.2024.110290","url":null,"abstract":"<div><h3>Objective</h3><p>Juvenile arthritis caused by loss-of-function <em>LACC1</em> mutations is characterized by early onset of symmetric and chronic arthritis, associated with an elevation of inflammatory markers. We aimed to describe serum cytokine levels, explore the type I interferon pathway, and evaluate the efficacy of treatment in a patient presenting with polyarthritis and anemia caused by novel compound heterozygous variations in <em>LACC1</em>.</p></div><div><h3>Methods</h3><p>Clinical data of a patient with compound heterozygous variations in <em>LACC1</em> was collected. Serum cytokine levels and IFN-stimulated cytokine genes were analyzed at diagnosis, at disease flare, and after treatment. Full-length cDNA of <em>LACC1</em> was checked by RNA analysis. Single-cell RNA sequencing was performed in PBMCs.</p></div><div><h3>Results</h3><p>Two novel variants in the <em>LACC1</em> gene were identified in a patient presenting with polyarthritis and anemia. <em>LACC1</em>-cDNA was normally expressed in the healthy control, the target production at 1384 bp was not observed in the patient. Compared to nine patient controls with non-systemic juvenile idiopathic arthritis, serum interleukin(IL)-6 level was significantly elevated in the affected patient. The median IFN score for the patient, her mother, and controls were 118, 8, and 4.9, respectively. The combined treatment of JAK inhibitors with prednisone or tocilizumab led to a complete response, including remission of joint symptoms, resolution of anemia, reduced expression of IFN-stimulated cytokine genes, and normalized levels of inflammatory markers, including CRP, ESR, SAA, and serum IL-6.</p></div><div><h3>Conclusion</h3><p>LACC1 may play a crucial role in multiple inflammatory signaling pathways. The combination therapy of JAK inhibitors and tocilizumab may be effective for a subset of refractory patients.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110290"},"PeriodicalIF":4.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated multi-omics analysis and machine learning developed diagnostic markers and prognostic model based on Efferocytosis-associated signatures for septic cardiomyopathy 综合多组学分析和机器学习，开发出基于埃弗细胞增多症相关特征的脓毒性心肌病诊断标记和预后模型。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-27 DOI: 10.1016/j.clim.2024.110301

Xuelian Li , Shijiu Jiang , Boyuan Wang , Shaolin He , Xiaopeng Guo , Jibin Lin , Yumiao Wei

{"title":"Integrated multi-omics analysis and machine learning developed diagnostic markers and prognostic model based on Efferocytosis-associated signatures for septic cardiomyopathy","authors":"Xuelian Li , Shijiu Jiang , Boyuan Wang , Shaolin He , Xiaopeng Guo , Jibin Lin , Yumiao Wei","doi":"10.1016/j.clim.2024.110301","DOIUrl":"10.1016/j.clim.2024.110301","url":null,"abstract":"<div><p>Septic cardiomyopathy (SCM) is characterized by an abnormal inflammatory response and increased mortality. The role of efferocytosis in SCM is not well understood. We used integrated multi-omics analysis to explore the clinical and genetic roles of efferocytosis in SCM. We identified six module genes (ATP11C, CD36, CEBPB, MAPK3, MAPKAPK2, PECAM1) strongly associated with SCM, leading to an accurate predictive model. Subgroups defined by EFFscore exhibited distinct clinical features and immune infiltration levels. Survival analysis showed that the C1 subtype with a lower EFFscore had better survival outcomes. scRNA-seq analysis of peripheral blood mononuclear cells (PBMCs) from sepsis patients identified four genes (CEBPB, CD36, PECAM1, MAPKAPK2) associated with high EFFscores, highlighting their role in SCM. Molecular docking confirmed interactions between diagnostic genes and tamibarotene. Experimental validation supported our computational results. In conclusion, our study identifies a novel efferocytosis-related SCM subtype and diagnostic biomarkers, offering new insights for clinical diagnosis and therapy.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110301"},"PeriodicalIF":4.5,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytomegalovirus infection is associated with thymic dysfunction and chronic graft-versus-host disease after pediatric hematopoietic stem cell transplantation 巨细胞病毒感染与小儿造血干细胞移植后胸腺功能障碍和慢性移植物抗宿主疾病有关。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-26 DOI: 10.1016/j.clim.2024.110302

Katrine Kielsen , Dina Leth Møller , Anders Elm Pedersen , Claus Henrik Nielsen , Marianne Ifversen , Lars Peter Ryder , Klaus Müller

{"title":"Cytomegalovirus infection is associated with thymic dysfunction and chronic graft-versus-host disease after pediatric hematopoietic stem cell transplantation","authors":"Katrine Kielsen , Dina Leth Møller , Anders Elm Pedersen , Claus Henrik Nielsen , Marianne Ifversen , Lars Peter Ryder , Klaus Müller","doi":"10.1016/j.clim.2024.110302","DOIUrl":"10.1016/j.clim.2024.110302","url":null,"abstract":"<div><p>Pediatric hematopoietic stem cell transplantation (HSCT) is challenged by chronic graft-versus-host disease (cGvHD) significantly affecting survival and long-term morbidity, but underlying mechanisms including the impact of post-HSCT CMV infection are sparsely studied.</p><p>We first investigated the impact of CMV infection for development of cGvHD in 322 children undergoing standard myeloablative HSCT between 2000 and 2018. Clinically significant CMV infection (<em>n</em> = 61) was an independent risk factor for chronic GvHD in a multivariable Cox regression analysis (HR = 2.17, 95% CI = 1.18–3.97, <em>P</em> = 0.013). We next explored the underlying mechanisms in a subcohort of 39 children. CMV infection was followed by reduced concentration of recent thymic emigrants (17.5 vs. 51.9 × 10<sup>6</sup>/L, <em>P</em> = 0.048) and naïve CD4+ and CD8+ T cells at 6 months post-HSCT (all <em>P</em> < 0.05). Furthermore, CD25<sup>high</sup>FOXP3+ Tregs tended to be lower in patients with CMV infection (2.9 vs. 9.6 × 10<sup>6</sup>/L, <em>P</em> = 0.055), including Tregs expressing the naivety markers CD45RA and Helios. CD8+ T-cell numbers rose after CMV infection and was dominated by exhausted PD1-expressing cells (66% vs. 39%, <em>P</em> = 0.023).</p><p>These findings indicate that post-HSCT CMV infection is a main risk factor for development of chronic GvHD after pediatric HSCT and suggest that this effect is caused by reduced thymic function with a persistently impaired production of naïve and regulatory T cells in combination with increased peripheral T-cell exhaustion.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110302"},"PeriodicalIF":4.5,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel inherited CARD9 deficiency in an otherwise healthy woman with CNS candidiasis 一名患有中枢神经系统念珠菌病的健康女性患有新型遗传性 CARD9 缺乏症。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-25 DOI: 10.1016/j.clim.2024.110293

Ling-Hong Zhou , Wen-Jia Qiu , Chun-Xing Que , Jia-Hui Cheng , Rong-Sheng Zhu , Jun-Tian Huang , Ying-Kui Jiang , Hua-Zhen Zhao , Xuan Wang , Xun-Jia Cheng , Li-Ping Zhu

{"title":"A novel inherited CARD9 deficiency in an otherwise healthy woman with CNS candidiasis","authors":"Ling-Hong Zhou , Wen-Jia Qiu , Chun-Xing Que , Jia-Hui Cheng , Rong-Sheng Zhu , Jun-Tian Huang , Ying-Kui Jiang , Hua-Zhen Zhao , Xuan Wang , Xun-Jia Cheng , Li-Ping Zhu","doi":"10.1016/j.clim.2024.110293","DOIUrl":"10.1016/j.clim.2024.110293","url":null,"abstract":"<div><p>Patients with caspase-associated recruitment domain-9 (<em>CARD9</em>) deficiency are more likely to develop invasive fungal disease that affect CNS. However, the understanding of how <em>Candida</em> invades and persists in CNS is still limited. We here reported a 24-year-old woman who were previously immunocompetent and diagnosed with CNS candidiasis. A novel autosomal recessive homozygous <em>CARD9</em> mutation (c.184 + 5G > T) from this patient was identified using whole genomic sequencing. Furthermore, we extensively characterized the impact of this <em>CARD9</em> mutation on the host immune response in monocytes, neutrophils and CD4 + T cells, using single cell sequencing and in vitro experiments. Decreased pro-inflammatory cytokine productions of CD14 + monocyte, impaired Th17 cell differentiation, and defective neutrophil accumulation in CNS were found in this patient. In conclusion, this study proposed a novel mechanism of CNS candidiasis development. Patients with CNS candidiasis in absence of known immunodeficiencies should be analyzed for <em>CARD9</em> gene mutation as the cause of invasive fungal infection predisposition.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110293"},"PeriodicalIF":4.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological evidence of MAPK pathway activation across subtypes of adult orbital xanthogranulomatous disease irrespective of the detection of oncogenic mutations 无论是否检测到致癌基因突变，成人眼眶黄疽性疾病各亚型均有MAPK通路激活的组织学证据。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-25 DOI: 10.1016/j.clim.2024.110299

S.E. Detiger , D. Paridaens , P.G. Kemps , A.G.S. van Halteren , P.M. van Hagen , J.A.M. van Laar , R.M. Verdijk

{"title":"Histological evidence of MAPK pathway activation across subtypes of adult orbital xanthogranulomatous disease irrespective of the detection of oncogenic mutations","authors":"S.E. Detiger , D. Paridaens , P.G. Kemps , A.G.S. van Halteren , P.M. van Hagen , J.A.M. van Laar , R.M. Verdijk","doi":"10.1016/j.clim.2024.110299","DOIUrl":"10.1016/j.clim.2024.110299","url":null,"abstract":"<div><p>Adult orbital xanthogranulomatous disease (AOXGD) is a spectrum of histiocytoses with four subtypes. Mitogen-activated protein kinase (MAPK) pathway mutations have been detected in various histiocytic neoplasms, little is known about this in AOXGD. Targeted regions of cancer- and histiocytosis-related genes were analyzed and immunohistochemical staining of phosphorylated ERK (pERK), cyclin D1 and PU.1 was performed in 28 AOXGD and 10 control xanthelasma biopsies to assess MAPK pathway activation.</p><p>Mutations were detected in 7/28 (25%) patients. Positive staining for pERK and/or cyclin D1 was found across all subtypes in 17/27 (63%) patients of whom 12/17 (71%) did not harbour a mutation. Xanthelasma tissue stained negative for pERK and cyclin D1. Relapse occurred in 5/7 (71%) patients with a MAPK pathway mutation compared to 8/21 (38%) patients in whom no mutation could be detected.</p><p>Molecular analysis and evaluation for systemic disease is warranted to identify patients at risk of recurrent xanthomatous disease.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110299"},"PeriodicalIF":4.5,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Domain 5 of Beta 2 glycoprotein I: Friend or foe in health? Context matters Beta 2 糖蛋白 I 的结构域 5：健康的敌人还是朋友？背景很重要。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-23 DOI: 10.1016/j.clim.2024.110282

Bill Giannakopoulos , Steven A. Krilis

引用次数: 0

Evaluating patient immunocompetence through antibody response to pneumococcal polysaccharide vaccine using a newly developed 23 serotype multiplexed assay 使用新开发的 23 种血清型多重检测法，通过肺炎球菌多糖疫苗抗体反应评估患者的免疫能力。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-22 DOI: 10.1016/j.clim.2024.110295

Thomas B. Martins , Harry R. Hill , Lisa K. Peterson

{"title":"Evaluating patient immunocompetence through antibody response to pneumococcal polysaccharide vaccine using a newly developed 23 serotype multiplexed assay","authors":"Thomas B. Martins , Harry R. Hill , Lisa K. Peterson","doi":"10.1016/j.clim.2024.110295","DOIUrl":"10.1016/j.clim.2024.110295","url":null,"abstract":"<div><p>Assessing T-cell independent antibody response to polysaccharide vaccines is crucial for diagnosing humoral immune deficiencies. However, immunocompetence criteria based on <em>S. pneumoniae</em> vaccination remain unclear. We evaluated IgG antibody vaccine response in healthy individuals to establish interpretive criteria. Pre- and 4-week post-vaccination sera were collected from 79 adults. Antibody concentrations to PNEUMOVAX 23 serotypes were measured using a multiplexed platform. Immunocompetence was determined by fold increase in post-vaccination response, percentage of serotypes achieving 4- or 2-fold antibody ratio, and post-vaccination concentration ≥ 1.3 μg/mL. Immunogenicity varied widely across the 23 serotypes (26.6% to 94.9% for ≥4-fold increase, 51.9% to 98.7% for ≥2-fold increase). Immunocompetence based on historic criteria of ≥4-fold increase in antibody ratio to ≥70% of serotypes was low (72.2%), but increased to 98.7% with criteria of at least a 2-fold increase and/or post-vaccination concentration ≥ 1.3 μg/mL. Current criteria for assessing immunocompetence may be overly stringent and require updating.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110295"},"PeriodicalIF":4.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MiR-17∼92 is involved in NF-κB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL 在 ABC-DLBCL 中，MiR-17~92 通过靶向泛素编辑蛋白介导 RIP1 复合物多泛素化参与 NF-κB 激活。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-22 DOI: 10.1016/j.clim.2024.110297

Xiaoyan Zhang , Xuan Zhang , Xin Huang , Javeed Iqbal , Timothy W. McKeithan , Wing C. Chan , Julie M. Vose , Chengfeng Bi , Xiaofan Zhu , Kai Fu

{"title":"MiR-17∼92 is involved in NF-κB activation via targeting the ubiquitin-editing proteins to mediate RIP1 complex polyubiquitinations in ABC-DLBCL","authors":"Xiaoyan Zhang , Xuan Zhang , Xin Huang , Javeed Iqbal , Timothy W. McKeithan , Wing C. Chan , Julie M. Vose , Chengfeng Bi , Xiaofan Zhu , Kai Fu","doi":"10.1016/j.clim.2024.110297","DOIUrl":"10.1016/j.clim.2024.110297","url":null,"abstract":"<div><p>Activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) is an aggressive lymphoma characterized by constitutive NF-κB activation, but whether miR-17∼92 contributes to this activation remains unclear. Herein, we sought to evaluate the role of miR-17∼92 in the process of NF-κB activation in ABC-DLBCL. We found that the expression of miR-17∼92 primary transcript was positively correlated with NF-κB activity, miR-17∼92 activated the NF-κB signaling in ABC-DLBCL, and its over-expression promoted ABC-DLBCL cell growth, accelerated cell G1 to S phase transition and enhanced cell resistance to NF-κB inhibitor. Importantly, miR-17∼92 promoted NF-κB activation through directly targeting multiple ubiquitin-editing regulators to lead to increase the K63-linked polyubiquitination and decrease the K48-linked polyubiquitination of RIP1 complex in ABC-DLBCL. We further found that miR-17∼92 selectively activated IκB-α and NF-κB p65 but not NF-κB p52/p100, and high miR-17∼92 expression was also associated with poorer outcome in ABC-DLBCL patients. Overall, our results showed that miR-17∼92 selectively activated the canonical NF-κB signaling via targeting ubiquitin-editing regulators to lead to constitutively NF-κB activation and poorer outcome in ABC-DLBCL. These findings uncovered an innovative function of miR-17∼92 and previously unappreciated regulatory mechanism of NF-κB activation in ABC-DLBCL. Targeting miR-17∼92 may thus provide a novel bio-therapeutic strategy for ABC-DLBCL patients.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110297"},"PeriodicalIF":4.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nomogram to predict the risk of proliferative lupus nephritis in patients with systemic lupus erythematosus involving the kidneys 预测系统性红斑狼疮患者肾脏增生性狼疮肾炎风险的提名图。

IF 4.5 3区医学

Clinical immunology Pub Date : 2024-06-22 DOI: 10.1016/j.clim.2024.110296

Panyu Yang , Xi Tang , Penghao Li , Zhongyu Liu , Chao Zhang , Yuxiang Wu , Xiaoxi Zeng , Yongkang Wu

{"title":"A nomogram to predict the risk of proliferative lupus nephritis in patients with systemic lupus erythematosus involving the kidneys","authors":"Panyu Yang , Xi Tang , Penghao Li , Zhongyu Liu , Chao Zhang , Yuxiang Wu , Xiaoxi Zeng , Yongkang Wu","doi":"10.1016/j.clim.2024.110296","DOIUrl":"10.1016/j.clim.2024.110296","url":null,"abstract":"<div><p>Proliferative lupus nephritis (PLN) is a serious organ-threatening manifestation of systemic lupus erythematosus (SLE) that is associated with high mortality and renal failure. Here, we analyzed data from 1287 SLE patients with renal manifestations, including 780 of which were confirmed as proliferative or non-proliferative LN patients by renal biopsy, divided into a training cohort (547 patients) and a validation cohort (233 patients). By applying a least absolute shrinkage and selection operator (LASSO) regression approach combined with multivariate logistic regression analysis to build a nomogram for prediction of PLN that was then assessed by receiver operating characteristic (ROC) curves, calibration curves, and clinical decision curves (DCA) in both the training and validation cohorts. The area under the ROC curve (AUC) of the model in the training cohort was 0.921 (95% confidence interval (CI): 0.895–0.946), the AUC of internal validation in the training cohort was 0.909 and the AUC of external validation was 0.848 (95% CI: 0.796–0.900). The nomogram showed good performance as evaluated using calibration and DCA curves. Taken together, our results indicate that our nomogram that comprises 12 significantly relevant variables could be clinically valuable to prognosticate on the risk of PLN in SLE, so as to improve patient prognoses.</p></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"265 ","pages":"Article 110296"},"PeriodicalIF":4.5,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141445775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0