COVID-19患者对SARS-CoV-2的免疫反应是一种易受免疫印迹影响的回忆反应：一项前瞻性队列研究

IF 4.5 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-01-20 DOI:10.1016/j.clim.2025.110429

Daniel Alvarez-Sierra , Mónica Martínez-Gallo , Adrián Sánchez-Montalvá , Marco Fernández-Sanmartín , Roger Colobran , Juan Espinosa-Pereiro , Elísabet Poyatos-Canton , Coral Zurera-Egea , Alex Sánchez-Pla , Concepción Violan , Rafael Parra , Hammad Alzayat , Ana Vivancos , Francisco Morandeira-Rego , Blanca Urban-Vargas , Eva Martínez-Cáceres , Manuel Hernández-González , Jordi Bas-Minguet , Peter D. Katsikis , Aina Teniente-Serra , Ricardo Pujol-Borrell

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引用次数: 0

摘要

对SARS-CoV-2的抗体反应不遵循初次反应的免疫球蛋白同型模式，这与目前对COVID-19的解释相矛盾。方法：对来自第二波COVID-19的191例SARS-CoV-2感染病例和44例对照进行前瞻性队列研究。该研究按严重程度对患者进行分层，并分析了SARS-CoV-2抗体和多种免疫变量的轨迹。结果：SARS-CoV-2的同型特异性抗体病程谱显示94.2% %的病例存在回忆反应模式。质母细胞、B细胞、cTfh高分辨率亚群和细胞因子的时间过程谱显示了继发性反应。转录组学数据显示该队列与当代队列具有严格的可比性。结论：在大多数情况下，对SARS-CoV-2的免疫反应是一种召回反应。这构成了大多数COVID-19病例受到地方性冠状病毒免疫印记的有利情况，这反过来又可以影响对SARS-CoV-2的免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The immune response to SARS-CoV-2 in COVID-19 as a recall response susceptible to immune imprinting: A prospective cohort study

查看原文本刊更多论文

The immune response to SARS-CoV-2 in COVID-19 as a recall response susceptible to immune imprinting: A prospective cohort study

The antibody response to SARS-CoV-2 does not follow the immunoglobulin isotype pattern of primary responses, conflicting with the current interpretation of COVID-19.

Methods

Prospective cohort study of 191 SARS-CoV-2 infection cases and 44 controls from the second wave of COVID-19. The study stratified patients by severity and analyzed the trajectories of SARS-CoV-2 antibodies and multiple immune variables.

Results

Isotype-specific antibody time course profiles to SARS-CoV-2 revealed a pattern of recall response in 94.2 % of cases. The time course profiles of plasmablasts, B cells, cTfh high-resolution subsets, and cytokines indicated a secondary response. The transcriptomic data showed that this cohort is strictly comparable to contemporary cohorts.

Conclusions

In most cases, the immune response to SARS-CoV-2 is a recall response. This constitutes a favorable scenario for most COVID-19 cases to be subjected to immune imprinting by endemic coronavirus, which, in turn, can influence the immune response to SARS-CoV-2.

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.