Clinical immunology最新文献_第7页

Overlapping syndrome with concomitant mGluR2-Ab and GFAP-Ab: A case report 重叠综合征伴mGluR2-Ab和gmap - ab 1例

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-26 DOI: 10.1016/j.clim.2025.110508

Yuan Xue, Yi Guo, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han

{"title":"Overlapping syndrome with concomitant mGluR2-Ab and GFAP-Ab: A case report","authors":"Yuan Xue, Yi Guo, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han","doi":"10.1016/j.clim.2025.110508","DOIUrl":"10.1016/j.clim.2025.110508","url":null,"abstract":"<div><div>An 11-year-old male patient presented with acute neurological deterioration, including meningitis, encephalitis, and myelitis. Initial testing detected antibody against metabotropic glutamate receptor 2 (mGluR2-Ab); retesting identified coexisting anti-glial fibrillary acidic protein antibody (GFAP-Ab). Pathogenic examinations were negative. The patient received a combination of immunotherapies, including intravenous methylprednisolone pulse therapy, human immunoglobulin pulse therapy, and plasma exchange. Five months after onset, the patient showed a favorable prognosis, though a residual neurogenic bladder remained. We present the first documented case of overlapping autoimmune syndrome with concurrent mGluR2-Ab and GFAP-Ab. The coexistence of these antibodies can lead to a wide range of clinical manifestations, including simultaneous GFAP-Ab-related meningoencephalomyelitis and mGluR2-Ab-related ataxia. This complexity complicates diagnosis and treatment, underscoring the need for a comprehensive understanding of the pathogenic mechanisms of these antibodies and timely combined immunotherapy. Additionally, this case suggests that mGluR2-Ab and GFAP-Ab may serve as the jointly responsible antibodies for this condition.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110508"},"PeriodicalIF":4.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring TH17-mediated inflammation in epidermolytic ichthyosis: Clinical and mechanistic insight 探索表皮松解性鱼鳞病中th17介导的炎症：临床和机制的见解

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-25 DOI: 10.1016/j.clim.2025.110494

Yidong Tan , Xuanyi Chen , Yihang Shen , Jinxiang Yang , Bing Wang , Yumeng Wang , Weinan Zhou , Qiuyi Han , Zhirong Yao , Huaguo Li , Jianying Liang

{"title":"Exploring TH17-mediated inflammation in epidermolytic ichthyosis: Clinical and mechanistic insight","authors":"Yidong Tan , Xuanyi Chen , Yihang Shen , Jinxiang Yang , Bing Wang , Yumeng Wang , Weinan Zhou , Qiuyi Han , Zhirong Yao , Huaguo Li , Jianying Liang","doi":"10.1016/j.clim.2025.110494","DOIUrl":"10.1016/j.clim.2025.110494","url":null,"abstract":"<div><div>Epidermolytic ichthyosis (EI) is a genetic skin disorder caused by mutations in the <em>KRT1</em> and <em>KRT10</em> genes, leading to severe skin abnormalities and inflammation. Current treatment options are limited, emphasizing the need for pathogenesis-based therapies. This study investigates the role of T helper type 17 (T<sub>H</sub>17) inflammatory responses in EI and explores the mechanisms underlying these responses. We found that patients from the family carrying both <em>KRT1</em> and <em>MPO</em> mutations exhibited varying degrees of psoriasis-like manifestations and significant therapeutic responses to anti-IL-17 A treatment. The treatment efficacy was also confirmed in patients with <em>KRT10</em> mutations. Mechanistically, Single-nucleus RNA sequencing revealed significantly elevated levels of T<sub>H</sub>-17 related cytokines in epidermis and CCR6<sup>+</sup> TH17 cell infiltration in the dermis. Additionally, we observed aberrant activation of the IκBα–JNK–c-Jun signaling pathway, leading to heightened IL-8 expression and exacerbated inflammation. Our findings underscore the critical role of T<sub>H</sub>17-mediated inflammation in the pathogenesis of EI and suggest potential therapeutic avenues targeting this pathway to improve patient outcomes.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110494"},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral T-cell subset activation in NMDAR encephalitis: Insights into pathogenesis and biomarker potential for disease monitoring NMDAR脑炎的外周t细胞亚群激活：疾病监测的发病机制和生物标志物潜力

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-25 DOI: 10.1016/j.clim.2025.110506

Minjin Wang , Jierui Wang , Jianzhao Zhai , Yangyi He , Yuwen Ma , Zhiyin Wang , Yan Ren , Binwu Ying , Dong Zhou , Jinmei Li

{"title":"Peripheral T-cell subset activation in NMDAR encephalitis: Insights into pathogenesis and biomarker potential for disease monitoring","authors":"Minjin Wang , Jierui Wang , Jianzhao Zhai , Yangyi He , Yuwen Ma , Zhiyin Wang , Yan Ren , Binwu Ying , Dong Zhou , Jinmei Li","doi":"10.1016/j.clim.2025.110506","DOIUrl":"10.1016/j.clim.2025.110506","url":null,"abstract":"<div><h3>Background</h3><div><em>N</em>-methyl-<span>d</span>-aspartate receptor encephalitis (NMDAR-E) is a severe autoimmune disorder characterized by neuropsychiatric symptoms and immune dysregulation ，involves T-cell dysregulation, but specific T-cell subset roles remain unclear. This study analyzed peripheral blood T-cell subsets as biomarkers for monitoring and severity prediction.</div></div><div><h3>Methods</h3><div>Peripheral blood samples from 32 NMDAR-E patients, 31 antibody-mediated encephalitis, 26 viral encephalitis patients, and 23 healthy controls were analyzed using flow cytometry. Key markers of T-cell activation and co-stimulation were assessed. Clinical outcomes were correlated with immune profiles to develop a predictive model.</div></div><div><h3>Results</h3><div>NMDAR-E patients showed elevated CD4+ T-cell activation, with increased CD28, CD38, and HLA-DR expression versus controls, indicating immune hyperactivation with compensatory regulation. The T-cell-based model predicted severe cases with high accuracy (AUC = 0.91).</div></div><div><h3>Conclusion</h3><div>CD4+ T-cell activation is central to NMDAR-E pathogenesis, highlighting diagnostic/therapeutic potential. Future studies must validate the model in larger cohorts and address peripheral blood analysis limitations.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110506"},"PeriodicalIF":4.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID CD8+ T细胞的高反应性和IL-3的高表达与Long-COVID的发生和严重程度相关

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-24 DOI: 10.1016/j.clim.2025.110502

Kerstin Renner , Franz Stauffenberg , Moritz Paulus , Sophia Neumayer , Frederike Winter-Köhler , Simone Buchtler , Daniel Schmalenberger , Stefan Blaas , Arno Mohr , Michael Pfeifer , Maximilian V. Malfertheiner , Thomas Loew , Martina Sester , Robert Bals , David Peterhoff , Barbara Schmidt , Matthias Mack

{"title":"Hyper-reactivity of CD8+ T cells and high expression of IL-3 correlates with occurrence and severity of Long-COVID","authors":"Kerstin Renner , Franz Stauffenberg , Moritz Paulus , Sophia Neumayer , Frederike Winter-Köhler , Simone Buchtler , Daniel Schmalenberger , Stefan Blaas , Arno Mohr , Michael Pfeifer , Maximilian V. Malfertheiner , Thomas Loew , Martina Sester , Robert Bals , David Peterhoff , Barbara Schmidt , Matthias Mack","doi":"10.1016/j.clim.2025.110502","DOIUrl":"10.1016/j.clim.2025.110502","url":null,"abstract":"<div><div>Following SARS-CoV-2 infection, some individuals develop Long-COVID-syndrome lasting for more than 3 months. We analyzed blood samples from patients with Long-COVID, controls without persistent symptoms following SARS-CoV-2-infection and non-infected donors without a history of infection. Long-COVID patients showed clear signs of T cell hyper-activation predominantly in the CD8<sup>+</sup> T cell subset with a 4-fold higher expression of CD25 and 2-fold more effector-memory T cells. Following polyclonal T cell stimulation, we found a 2-fold stronger upregulation of CD25 and a 7-fold higher release of IL-3 in Long-COVID. Intracellular staining revealed 5-fold more IL-3-expressing CD8<sup>+</sup> T cells in Long-COVID, while GM-CSF, IFN-γ and IL-2 were much less upregulated. These changes correlated with the severity of Long-COVID and persisted for up to 18 months after infection. Our data reveal a pronounced and long-lasting CD8<sup>+</sup> T cell hyper-activation and hyper-reactivity in Long-COVID and speak for a trial of T cell-immunosuppression in patients with Long-COVID.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"277 ","pages":"Article 110502"},"PeriodicalIF":4.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allogeneic hematopoietic stem cell transplantation in a patient with combined immunodeficiency caused by IRF4 mutation 同种异体造血干细胞移植治疗IRF4突变合并免疫缺陷1例

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-22 DOI: 10.1016/j.clim.2025.110505

Ping Wang , Xiaowen Qian , Wenjin Jiang , Hongsheng Wang , Jinqiao Sun , Xiaochuan Wang , Xiaowen Zhai

引用次数: 0

A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency 一种新的半合子无义DOCK11变异引起全身炎症和免疫缺陷

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-22 DOI: 10.1016/j.clim.2025.110504

Abdulwahab Elsayed , Sandra von Hardenberg , Faranaz Atschekzei , Paul Siek , Torsten Witte , Georgios Sogkas , Felix C. Ringshausen

{"title":"A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency","authors":"Abdulwahab Elsayed , Sandra von Hardenberg , Faranaz Atschekzei , Paul Siek , Torsten Witte , Georgios Sogkas , Felix C. Ringshausen","doi":"10.1016/j.clim.2025.110504","DOIUrl":"10.1016/j.clim.2025.110504","url":null,"abstract":"<div><div>Hemizygous germline loss-of-function variants in <em>DOCK11</em>, the gene encoding the dedicator of cytokinesis 11 (DOCK11) have been recently identified to cause variable immunodeficiency and immune dysregulation. Features of immune dysregulation have been reported in all so far identified male patients with damaging variants in <em>DOCK11</em>, commonly manifesting with autoimmune cytopenias, inflammatory bowel disease, benign lymphoproliferation and systemic inflammation. In this study, we identified a novel variant in <em>DOCK11</em> (c.3754C > T, p.(Q1252*)), leading to loss of protein expression, in a patient with a history of recurrent pneumonia, bronchiectasis, infection-triggered hyperinflammation and persistent systemic inflammation. Reevaluation of all previously identified patients and the current case, reveals that variants leading to the complete loss of DOCK11 expression and consequently function rather associate with autoinflammation and recurrent pneumonias, while missense variants, primarily associate with autoantibody-related autoimmune features.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"276 ","pages":"Article 110504"},"PeriodicalIF":4.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1000-plex antibody array proteomic screen uncovers PGRPS, Haptoglobin, Serpin A4 and Fibrinogen as potential stool biomarkers of pediatric inflammatory bowel disease 1000 plex抗体阵列蛋白质组学筛选发现PGRPS， Haptoglobin， Serpin A4和fibrin原是儿童炎症性肠病的潜在粪便生物标志物

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-17 DOI: 10.1016/j.clim.2025.110495

Ryan Pereira , Sanam Soomro , Kamala Vanarsa , Jessica Castillo , Vinaika Maruvada , Subra Kugathasan , Chandra Mohan

{"title":"1000-plex antibody array proteomic screen uncovers PGRPS, Haptoglobin, Serpin A4 and Fibrinogen as potential stool biomarkers of pediatric inflammatory bowel disease","authors":"Ryan Pereira , Sanam Soomro , Kamala Vanarsa , Jessica Castillo , Vinaika Maruvada , Subra Kugathasan , Chandra Mohan","doi":"10.1016/j.clim.2025.110495","DOIUrl":"10.1016/j.clim.2025.110495","url":null,"abstract":"<div><div>Easy to obtain and in close proximity to the affected areas, fecal samples offer significant potential for the advancement of non-invasive diagnostic methods for inflammatory bowel disease (IBD). A cross-sectional antibody array-based proteomic screen of 1000 fecal protein biomarkers was conducted using stool from treatment naïve control, Crohn's disease (CD), and ulcerative colitis (UC) subjects (control = 24, CD = 39, UC = 10). 71 proteins were significantly elevated in IBD stool (<em>p</em> < 0.05; FC > 2), pointing to cytokine signaling, inflammatory response and extra-cellular matrix functional pathways. Several proteins outperformed fecal calprotectin in distinguishing IBD from control stool, including Haptoglobin, IL-1 R9, GDF-15, PGRPS, Serpin A4, INSRR, SSEA-1, Fibrinogen, IGFBP-1, and TGF-β RI/ALK-5. Upon ELISA validation, PGRPS (AUC = 0.96), Haptoglobin (AUC = 0.91), Serpin A4 (AUC = 0.73), emerged as the most discriminatory biomarkers. Taken together with previous cross-sectional and longitudinal studies, the present findings authenticate stool PGRPS, Haptoglobin, Serpin A4 and fibrinogen as potential stool biomarkers of UC and CD, worthy of further prospective studies to identify more reliable and accurate non-invasive biomarkers for IBD.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"276 ","pages":"Article 110495"},"PeriodicalIF":4.5,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel STING1-activating mutation is identified in a patient with childhood-onset systemic lupus erythematosus 一种新的sting - 1激活突变在儿童发病的系统性红斑狼疮患者中被发现

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-11 DOI: 10.1016/j.clim.2025.110493

Ting Li , Siming Peng , Yu Zhou, Caihui Zhang, Gexuan Feng, Zhongxun Yu, Yiwen Xu, Meiying Quan, Wei Wang , Hongmei Song

引用次数: 0

Neutralizing antibody responses after a two-dose regimen with BNT162b2, CoronaVac or ChAdOx1-S in Brazil: Differential neutralization of SARS-CoV-2 omicron variants 在巴西，BNT162b2、CoronaVac或ChAdOx1-S两剂量方案后的中和抗体反应：SARS-CoV-2组粒变体的差异中和

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-02 DOI: 10.1016/j.clim.2025.110492

Isabela Pazotti Daher , Bianca da Silva Almeida , Guilherme Antonio de Souza-Silva , Rodolfo Ferreira Marques , Gustavo Henrique Corrêa Soares , Robert Andreata-Santos , Ana Moretti , Mariângela de Oliveira Silva , Viviane Schuch , Greyce Luri Sasahara , Andréia Kuramoto , Marcio Yamamoto , Luís Carlos de Souza Ferreira , Keity Santos , Verônica P.C.V. Coelho , Jorge Kalil , Daniela Santoro Rosa , Edecio Cunha-Neto , Silvia Beatriz Boscardin

{"title":"Neutralizing antibody responses after a two-dose regimen with BNT162b2, CoronaVac or ChAdOx1-S in Brazil: Differential neutralization of SARS-CoV-2 omicron variants","authors":"Isabela Pazotti Daher , Bianca da Silva Almeida , Guilherme Antonio de Souza-Silva , Rodolfo Ferreira Marques , Gustavo Henrique Corrêa Soares , Robert Andreata-Santos , Ana Moretti , Mariângela de Oliveira Silva , Viviane Schuch , Greyce Luri Sasahara , Andréia Kuramoto , Marcio Yamamoto , Luís Carlos de Souza Ferreira , Keity Santos , Verônica P.C.V. Coelho , Jorge Kalil , Daniela Santoro Rosa , Edecio Cunha-Neto , Silvia Beatriz Boscardin","doi":"10.1016/j.clim.2025.110492","DOIUrl":"10.1016/j.clim.2025.110492","url":null,"abstract":"<div><div>The emergence of SARS-CoV-2 variants has reduced antibody effectiveness, affecting vaccine protection. This study evaluated neutralizing antibodies against Wuhan strain and several variants, including Alpha, Beta, Gamma, Delta, and Omicron, in Brazilians vaccinated twice with CoronaVac, ChAdOx1-S, or BNT162b2 before Delta and Omicron emerged. After the booster, strong antibody responses to the Wuhan strain were seen in all groups, but BNT162b2 resulted in higher anti-Spike and anti-RBD IgG levels. While all vaccines showed some cross-neutralization against Alpha, Beta, Gamma, and Delta, only BNT162b2 was effective against Omicron BA.2 and BA.4/5 subvariants. Furthermore, BNT162b2 vaccination showed a positive correlation between Wuhan RBD-specific IgG and Omicron neutralizing antibodies. This group demonstrated distinct clustering patterns of neutralizing antibodies against all variants, unlike those from CoronaVac and ChAdOx1-S. The findings suggest BNT162b2 offers broader neutralization capability, highlighting the benefit of booster shots with bivalent mRNA vaccines to enhance immune responses against emerging variants.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"276 ","pages":"Article 110492"},"PeriodicalIF":4.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoantibodies neutralizing type I interferons remain a significant risk factor for critical COVID-19 pneumonia in vaccinated patients 中和I型干扰素的自身抗体仍然是接种疫苗患者发生COVID-19重症肺炎的重要危险因素

IF 4.5 3区医学

Clinical immunology Pub Date : 2025-04-02 DOI: 10.1016/j.clim.2025.110491

Arnau Antolí , José Luis Gómez-Vázquez , Angels Sierra-Fortuny , Carla Bermudez-Carre , Mario Framil , Edgar Creus-Bachiller , Julen Viana-Errasti , Paula Rofes , Gemma Rocamora-Blanch , Lara Hidalgo-Peña , Lydia García-Serrano , Raúl Rigo-Bonnin , Lidia Feliubadaló , Jesús del Valle , Laura Calatayud , Francisco Morandeira , Conxi Lázaro , Xavier Solanich

{"title":"Autoantibodies neutralizing type I interferons remain a significant risk factor for critical COVID-19 pneumonia in vaccinated patients","authors":"Arnau Antolí , José Luis Gómez-Vázquez , Angels Sierra-Fortuny , Carla Bermudez-Carre , Mario Framil , Edgar Creus-Bachiller , Julen Viana-Errasti , Paula Rofes , Gemma Rocamora-Blanch , Lara Hidalgo-Peña , Lydia García-Serrano , Raúl Rigo-Bonnin , Lidia Feliubadaló , Jesús del Valle , Laura Calatayud , Francisco Morandeira , Conxi Lázaro , Xavier Solanich","doi":"10.1016/j.clim.2025.110491","DOIUrl":"10.1016/j.clim.2025.110491","url":null,"abstract":"<div><h3>Background</h3><div>Neutralizing autoantibodies against type I interferons were strongly linked to severe COVID-19 in unvaccinated patients; however, this has yet to be evaluated in vaccinated individuals.</div></div><div><h3>Objective</h3><div>To analyze how these autoantibodies influences disease variability in vaccine breakthrough COVID-19 pneumonia patients.</div></div><div><h3>Methods</h3><div>Clinical and laboratory data; autoantibodies blocking interferon-α2 and –ω; and humoral response to SARS-CoV-2 vaccine were collected from all vaccinated COVID-19 pneumonia patients admitted from April 2021 to December 2022 at Bellvitge University Hospital, Spain.</div></div><div><h3>Results</h3><div>458 patients developed COVID-19 pneumonia despite an appropriate antibody response to SARS-CoV-2 vaccination. Autoantibodies neutralizing interferons were significantly more prevalent in patients with critical pneumonia compared to those with milder forms (8.8 % vs. 3.6 %; <em>p</em> = 0.037). Having these autoantibodies was an independent predictor for critical COVID-19 pneumonia (OR 2.88 [95 %CI 1.18–6.98]).</div></div><div><h3>Conclusion</h3><div>Vaccination considerably reduces the severity of COVID-19; however, patients with type I interferon autoantibodies remain at increased risk of severe disease.</div></div>","PeriodicalId":10392,"journal":{"name":"Clinical immunology","volume":"276 ","pages":"Article 110491"},"PeriodicalIF":4.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143769018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0