Neutralizing antibody responses after a two-dose regimen with BNT162b2, CoronaVac or ChAdOx1-S in Brazil: Differential neutralization of SARS-CoV-2 omicron variants

IF 4.5 3区医学 Q2 IMMUNOLOGY

Clinical immunology Pub Date : 2025-04-02 DOI:10.1016/j.clim.2025.110492

Isabela Pazotti Daher , Bianca da Silva Almeida , Guilherme Antonio de Souza-Silva , Rodolfo Ferreira Marques , Gustavo Henrique Corrêa Soares , Robert Andreata-Santos , Ana Moretti , Mariângela de Oliveira Silva , Viviane Schuch , Greyce Luri Sasahara , Andréia Kuramoto , Marcio Yamamoto , Luís Carlos de Souza Ferreira , Keity Santos , Verônica P.C.V. Coelho , Jorge Kalil , Daniela Santoro Rosa , Edecio Cunha-Neto , Silvia Beatriz Boscardin

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引用次数: 0

Abstract

The emergence of SARS-CoV-2 variants has reduced antibody effectiveness, affecting vaccine protection. This study evaluated neutralizing antibodies against Wuhan strain and several variants, including Alpha, Beta, Gamma, Delta, and Omicron, in Brazilians vaccinated twice with CoronaVac, ChAdOx1-S, or BNT162b2 before Delta and Omicron emerged. After the booster, strong antibody responses to the Wuhan strain were seen in all groups, but BNT162b2 resulted in higher anti-Spike and anti-RBD IgG levels. While all vaccines showed some cross-neutralization against Alpha, Beta, Gamma, and Delta, only BNT162b2 was effective against Omicron BA.2 and BA.4/5 subvariants. Furthermore, BNT162b2 vaccination showed a positive correlation between Wuhan RBD-specific IgG and Omicron neutralizing antibodies. This group demonstrated distinct clustering patterns of neutralizing antibodies against all variants, unlike those from CoronaVac and ChAdOx1-S. The findings suggest BNT162b2 offers broader neutralization capability, highlighting the benefit of booster shots with bivalent mRNA vaccines to enhance immune responses against emerging variants.

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在巴西，BNT162b2、CoronaVac或ChAdOx1-S两剂量方案后的中和抗体反应：SARS-CoV-2组粒变体的差异中和

SARS-CoV-2变体的出现降低了抗体的有效性，影响了疫苗的保护作用。本研究评估了在Delta和Omicron出现之前，两次接种CoronaVac、ChAdOx1-S或BNT162b2疫苗的巴西人对武汉毒株和几种变体（包括Alpha、Beta、Gamma、Delta和Omicron）的中和抗体。增强后，各组对武汉毒株均有较强的抗体反应，但BNT162b2导致抗spike和抗rbd IgG水平升高。虽然所有疫苗对α、β、γ和δ都表现出一定的交叉中和作用，但只有BNT162b2对欧米克隆BA.2和BA.4/5亚变体有效。此外，接种BNT162b2疫苗显示武汉rbd特异性IgG与Omicron中和抗体呈正相关。与来自CoronaVac和ChAdOx1-S的抗体不同，该组显示出针对所有变体的中和抗体的明显聚类模式。研究结果表明，BNT162b2具有更广泛的中和能力，突出了二价mRNA疫苗加强注射增强对新出现变体的免疫反应的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical immunology 医学-免疫学

CiteScore

12.30

自引率

1.20%

发文量

212

审稿时长

34 days

期刊介绍： Clinical Immunology publishes original research delving into the molecular and cellular foundations of immunological diseases. Additionally, the journal includes reviews covering timely subjects in basic immunology, along with case reports and letters to the editor.