Clinical Neuroradiology最新文献

{"title":"Super-Bore Aspiration Catheters (≥ 0.088″) in Acute Ischemic Stroke: a Systematic Review and Meta-analysis.","authors":"Alperen Elek, Mohammed Seifuldin, Semra Yucel, Cem Bilgin, Ramanathan Kadirvel, David F Kallmes, Waleed Brinjikji","doi":"10.1007/s00062-026-01687-9","DOIUrl":"https://doi.org/10.1007/s00062-026-01687-9","url":null,"abstract":"<p><strong>Background: </strong>Super-bore aspiration catheters with an inner diameter ≥ 0.088 inches have been developed to enhance clot ingestion, improve first-pass reperfusion, and reduce the need for adjunctive thrombectomy techniques in acute ischemic stroke. A comprehensive synthesis of their technical performance, angiographic efficacy, and safety profile is lacking.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted in accordance with PRISMA guidelines. MEDLINE, Web of Science, and Scopus were searched from inception through December 7, 2025. Eligible studies included patients with acute ischemic stroke treated with super-bore aspiration catheters (inner diameter ≥ 0.088 inches). Pooled estimates were calculated using random-effects models.</p><p><strong>Results: </strong>Eleven studies comprising 835 patients were included. Successful delivery of the aspiration catheter to the target clot was achieved in 90.4% of cases (95% CI 84.82-94.13). Cross-over to stent retriever occurred in 11.95% (95% CI 4.89-26.37), and rescue therapy was required in 12.60% (95% CI 5.61-25.91). First pass effect (mTICI 2c-3) was achieved in 55.91% (95% CI 48.42-63.14), while modified first pass effect (mTICI ≥ 2b) occurred in 68.61% (95% CI 60.80-75.49). Final successful reperfusion (mTICI ≥ 2b) was achieved in 97.71% (95% CI 93.37-99.23), with near-complete or complete reperfusion (mTICI 2c-3) in 86.71% and complete reperfusion (mTICI 3) in 65.18% of cases. Symptomatic intracranial hemorrhage occurred in 1.93%, embolization to new territory in 1.62%, and total procedural complications in 3.80% of cases. Favorable functional outcome (mRS 0-2 at 90 days) was observed in 50.0%, while overall mortality was 16.87%.</p><p><strong>Conclusion: </strong>Super-bore aspiration catheters (≥ 0.088 inches) show high technical feasibility, comparable first pass reperfusion rates, and a favorable safety profile in the treatment of acute ischemic stroke.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Stent Stenosis After Surface-Modified Versus Uncoated Flow Diversion: a Randomized Trial (Derivo 2 Heal vs Derivo 2).","authors":"Malvina Garner, Frederik Fries, Alena Haussmann, Wolfgang Reith, Umut Yilmaz","doi":"10.1007/s00062-026-01676-y","DOIUrl":"https://doi.org/10.1007/s00062-026-01676-y","url":null,"abstract":"<p><strong>Background and purpose: </strong>Surface-modified flow diverters have been introduced to reduce thrombogenicity and potentially influence vascular healing. However, their impact on in-stent stenosis and aneurysm occlusion remains uncertain. We compared a coated flow diverter (Derivo 2 heal) with the corresponding uncoated device (Derivo 2) regarding in-stent stenosis development and aneurysm occlusion in a randomized clinical setting.</p><p><strong>Materials and methods: </strong>In this single-center randomized, open-label trial, 21 patients with unruptured internal carotid artery aneurysms were treated with either a coated (n = 10) or uncoated (n = 11) flow diverter. All patients received dual antiplatelet therapy and underwent digital subtraction angiography at 3 and 9 months. In-stent stenosis was assessed using a standardized ratio-based method. Device characteristics and oversizing were recorded. The presumed etiology of in-stent stenosis was categorized as intimal hyperplasia or stent deformity based on morphologic appearance.</p><p><strong>Results: </strong>Mean in-stent stenosis at 3 and 9 months did not differ between groups. Complete aneurysm occlusion at 9 months was lower in the coated group (40.0% vs 81.8%; two-sided Fisher's exact p = 0.080). Oversizing was not associated with in-stent stenosis but was numerically greater in patients with complete occlusion. Stent deformity was associated with higher in-stent stenosis than presumed intimal hyperplasia (3 months: 40.8% vs 21.7%, p = 0.007; 9 months: 30.1% vs 13.3%, p = 0.022).</p><p><strong>Conclusions: </strong>In this randomized single-center study, the surface-modified Derivo 2 heal did not demonstrate reduced in-stent stenosis compared with the uncoated Derivo 2, while complete occlusion at 9 months was lower in the coated-device group. These findings warrant confirmation in larger comparative studies.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148175492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dangerous Ophthalmic Anastomoses During Middle Meningeal Artery Embolization: Anatomical Pitfalls, Hemodynamic Mechanisms, and an Illustrative Case of Delayed Visual Loss.","authors":"Qi Jia, Tao-Zi-Xuan Huang, Zheng-Wen Chen, Zhi-Xiang Fan, Yu-Hao Ding, Qing-Feng Huang","doi":"10.1007/s00062-026-01685-x","DOIUrl":"https://doi.org/10.1007/s00062-026-01685-x","url":null,"abstract":"<p><strong>Background: </strong>Middle meningeal artery embolization (MMAE) is increasingly used for chronic subdural hematoma (cSDH), but dangerous anastomoses between the middle meningeal artery and the ophthalmic circulation remain an underrecognized source of catastrophic visual complications. Standard screening with super-selective angiography and provocative testing may provide false reassurance when occult collaterals are not angiographically apparent.</p><p><strong>Methods: </strong>We performed a focused narrative review of the literature on MMA-ophthalmic dangerous anastomoses, emphasizing relevant vascular anatomy, angiographic warning signs, embolic hemodynamics, and preventive strategies. These findings were integrated with an illustrative case of delayed monocular blindness following Onyx embolization for cSDH despite negative angiographic and provocative screening.</p><p><strong>Results: </strong>This report integrates a single illustrative case nested within a focused narrative review of 30 studies. The reviewed literature and the illustrative case together suggest that negative angiography does not reliably exclude functionally relevant orbital collaterals. In particular, liquid embolics may behave differently from aqueous provocative agents, and pressure-dependent changes during embolization may open otherwise occult pathways to the ophthalmic circulation. In the present case, a 73-year-old man developed irreversible right visual loss approximately 6 h after MMAE, and urgent CT demonstrated punctate retrobulbar hyperdensities along the course of the ophthalmic and posterior ciliary arteries, consistent with non-target embolic deposition within this vascular territory.</p><p><strong>Conclusions: </strong>Dangerous MMA-ophthalmic collateralization may remain clinically relevant despite apparently negative pre-embolization screening. Embolization of the anterior MMA division therefore requires heightened caution, particularly when liquid embolics are used. A negative provocative test alone may not reliably exclude this risk.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148162049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Aneurysm Occlusion After Flow Diversion: The Role of Aneurysm-Parent Artery Geometry.","authors":"Hye Won Choi, Tae Keun Jee, Danbee Kang, Je Young Yeon, Keon Ha Kim, Pyoung Jeon, Jong-Soo Kim","doi":"10.1007/s00062-026-01668-y","DOIUrl":"10.1007/s00062-026-01668-y","url":null,"abstract":"<p><strong>Objective: </strong>Flow diverters (FD) have transformed complex aneurysm management, but incomplete aneurysm occlusion remains a significant concern, highlighting the need for practical predictors of successful treatment. While local flow dynamics are known to be critically influenced by parent artery-aneurysm (PA-aneurysm) geometry, their quantitative assessment in clinical settings is challenging. This study aimed to identify practical, readily measurable geometric predictors for complete aneurysm occlusion following FD treatment.</p><p><strong>Methods: </strong>This retrospective study analyzed 119 intracranial aneurysms treated with FD between 2014 and 2023 at our center. Morphological and geometric parameters-including maximal diameter, PA-aneurysm inlet and outlet angles, and branch artery incorporation-were quantitatively measured from 3D rotational Digital Subtraction Angiography (DSA). Angiographic outcomes, categorized as complete occlusion or persistence, were assessed at a minimum of 18 months of follow-up without additional intervention. Independent predictors were identified using univariable and multivariable logistic regression.</p><p><strong>Results: </strong>Aneurysm occlusion was achieved in 89 (74.8%) cases during a median angiographic follow-up of 19.8 months (interquartile range [IQR], 12.2-34.7). In multivariable analysis, a lower likelihood of aneurysm occlusion was significantly associated with a larger PA-aneurysm inlet angle (OR, 0.82 per 10° increase; 95% CI, 0.69-0.98; p = 0.045) and the presence of branch artery incorporation (OR, 0.25; 95% CI, 0.10-0.63; p = 0.004). While a larger neck diameter (OR, 0.94; 95% CI, 0.85-1.03) was also associated with a lower occlusion rate, this association did not reach statistical significance (p = 0.175). The developed multivariable model demonstrated acceptable predictive performance (AUC = 0.743; 95% CI, 0.632, 0.855).</p><p><strong>Conclusions: </strong>A smaller PA-aneurysm inlet angle and absence of branch artery incorporation are independent predictors of aneurysm occlusion after flow diversion. These readily measurable geometric parameters from diagnostic DSA may serve as practical and useful indicators for predicting FD treatment outcomes.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Microplastics in Acute Ischemic Stroke: Feasibility, Variability, and Exploratory Comparisons with Healthy Individuals.","authors":"Sophia Hohenstatt, Gabriele Maliandi, Dominik F Vollherbst, Michael O Breckwoldt, Niclas Schmitt, Fabian Preisner, Kianush Karimian-Jazi, Susanne Bonekamp, Martin Bendszus, Markus A Möhlenbruch","doi":"10.1007/s00062-026-01673-1","DOIUrl":"https://doi.org/10.1007/s00062-026-01673-1","url":null,"abstract":"<p><strong>Background: </strong>Microplastics (MPs) have been detected in human tissues and implicated in vascular injury in preclinical models, but evidence on circulating MPs in humans is scarce. Surgical and autopsy samples have provided most data to date but are unsuitable for large-scale biomonitoring to clarify potential cardiovascular relevance.</p><p><strong>Methods: </strong>We conducted a prospective pilot study applying a contamination-controlled, plastic-free protocol to quantify MPs in whole blood. Thirty-five participants were enrolled: 20 with ischemic stroke and 15 healthy controls. Samples were analyzed by micro-Fourier transform infrared spectroscopy to determine particle counts, polymer types, and size distributions. To contextualize findings, we performed an exploratory pooled comparison with a reference of healthy individuals derived from two published datasets using weighted combination of reported means and standard deviations.</p><p><strong>Results: </strong>Overall, MPs were detected in 94% of participants (median 11.0 MPs/mL; IQR 4-22; mean ± SD, 12.6 ± 9.7; range 0-35). Within this pilot cohort, median MP counts were numerically higher in stroke (13.5 MPs/mL [IQR 6-23]) than in healthy controls (7.0 MPs/mL [IQR 2-18]), but group differences were not statistically significant in direct, within-study comparisons (p = 0.21, Mann-Whitney U). In an exploratory analysis, stroke patients exhibited significantly higher mean MP concentrations than a pooled healthy reference derived from external datasets (13.95 ± 8.73 vs 5.11 ± 7.31 MPs/mL; Welch's t = 3.69, p = 0.0016). Polyethylene, polypropylene, and polyethylene terephthalate were the most abundant polymers, and smaller particles (20-100 µm) predominated. MP burden showed no consistent association with age, sex, or vascular risk factors.</p><p><strong>Conclusions: </strong>This proof-of-concept study demonstrates the feasibility of blood-based MP quantification under clinical conditions and provides a preliminary, hypothesis-generating observation that circulating MP levels may be elevated in acute ischemic stroke. Because the apparent difference relied on an exploratory pooled comparison across heterogeneous datasets, confirmation in larger, harmonized studies is essential before any inference about disease-specific elevation or clinical relevance is justified.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Societies' Communications.","authors":"","doi":"10.1007/s00062-026-01658-0","DOIUrl":"10.1007/s00062-026-01658-0","url":null,"abstract":"","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"799-802"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Related Differences in Outcomes of Endovascular Treatment of Distal Medium Vessel Occlusion Strokes.","authors":"Hamza Adel Salim, Vivek Yedavalli, Dhairya Lakhani, Fathi Milhem, Basel Musmar, Nimer Adeeb, Davide Simonato, Yan-Lin Li, Orabi Hajjeh, Muhammed Amir Essibayi, Nils Henninger, Sri Hari Sundararajan, Anna Luisa Kühn, Jane Khalife, Sherief Ghozy, Luca Scarcia, Leonard Ll Yeo, Benjamin Yq Tan, Robert W Regenhardt, Jeremy J Heit, Aymeric Rouchaud, Jens Fiehler, Sunil Sheth, Ajit S Puri, Christian Dyzmann, Marco Colasurdo, Leonardo Renieri, João Pedro Filipe, Pablo Harker, Răzvan Alexandru Radu, Mohamad Abdalkader, Piers Klein, Takahiro Ota, Ashkan Mowla, Kareem El Naamani, Pascal Jabbour, Arundhati Biswas, Frédéric Clarençon, James E Siegler, Thanh N Nguyen, Ricardo Varela, Amanda Baker, David Altschul, Nestor R Gonzalez, Markus A Möhlenbruch, Vincent Costalat, Benjamin Gory, Christian Paul Stracke, Constantin Hecker, Gaultier Marnat, Hamza Shaikh, Christoph J Griessenauer, David S Liebeskind, Alessandro Pedicelli, Andrea M Alexandre, Tobias D Faizy, Illario Tancredi, Erwah Kalsoum, Boris Lubicz, Aman B Patel, Maurizio Fuschi, Max Wintermark, Adrien Guenego, Adam A Dmytriw","doi":"10.1007/s00062-026-01632-w","DOIUrl":"10.1007/s00062-026-01632-w","url":null,"abstract":"<p><strong>Background: </strong>Sex-related differences in outcomes after mechanical thrombectomy (MT) for distal medium vessel occlusion (DMVO) stroke remain uncertain. While unadjusted differences have been reported in stroke populations, it is unclear whether biological sex independently influences outcomes after accounting for major prognostic factors.</p><p><strong>Methods: </strong>We performed a retrospective, multicenter analysis of the MAD-MT registry. Patients with acute DMVO who underwent MT were included. Propensity score matching (PSM) was employed. The primary outcome was functional independence (modified Rankin Scale [mRS] score 0-2) at 90 days. Secondary outcomes included excellent outcome (mRS 0-1), day 1 NIHSS shift, and reperfusion success. Safety outcomes included mortality and symptomatic intracerebral hemorrhage.</p><p><strong>Results: </strong>Before matching, 1147 females and 1062 males were included. After 1:1 PSM (748 patients in each group), the groups were balanced in baseline characteristics. The median age was 75 years in both groups. At 90 days, 51% of females and 54% of males achieved mRS 0-2 (P = 0.38). NIHSS shift from baseline to day 1 was similar (median -2 in both groups), and successful reperfusion (Thrombolysis in Cerebral Infarction 2b-3) was achieved in 86% of females and 89% of males (P = 0.18). Mortality was 18.4% in females and 15.5% in males (P = 0.11). Symptomatic intracerebral hemorrhage occurred in 8.3% of females and 7.7% of males (P = 0.67).</p><p><strong>Conclusions: </strong>After adjustment for age, baseline disability, and vascular risk factors, biological sex was not independently associated with functional or safety outcomes following mechanical thrombectomy for DMVO stroke.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"757-770"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Assessment of Signal Intensity in PETRA-MRA Vs. TOF-MRA After Flow Diverter Stent Placement.","authors":"Yosuke Ishii, Toshihiko Hayashi, Haruna Furuya, So Akutsu, Aya Namba, Shigeru Nemoto","doi":"10.1007/s00062-025-01607-3","DOIUrl":"10.1007/s00062-025-01607-3","url":null,"abstract":"<p><strong>Purpose: </strong>Digital subtraction angiography (DSA) is the gold standard for evaluating outcomes after flow diverter (FD) stent placement, though its invasive nature presents limitations. Time-of-flight magnetic resonance angiography (TOF-MRA) is commonly used as a non-invasive alternative; however, it is susceptible to artifacts related to magnetic susceptibility and phase dispersion. Recently, Pointwise Encoding Time Reduction with Radial Acquisition (PETRA)-MRA, which employs an ultra-short echo time technique, has emerged as a promising option for post-endovascular imaging. This study aimed to quantitatively assess and compare the signal properties of PETRA-MRA and TOF-MRA in patients following FD treatment, in order to minimize observer-dependent variability.</p><p><strong>Methods: </strong>A retrospective review was conducted on patients treated with a Pipeline Flex with Shield Technology stent for internal carotid artery aneurysms between April 2021 and March 2024. All patients underwent both TOF-MRA and PETRA-MRA scans on the day after treatment, using a 3‑T MRI system. Signal intensities were evaluated in the FD, contralateral internal carotid artery (ICA), aneurysm, and background across three slices for each patient. For aneurysm analysis, the slice with the largest visible aneurysm diameter was selected. Contrast-to-noise ratios (CNR) were computed in relation to the background signal, and signal intensity ratios (SIR) were calculated with reference to the contralateral ICA. These metrics were then compared between TOF-MRA and PETRA-MRA.</p><p><strong>Results: </strong>The analysis included 21 patients (mean age 60.2 years; 14 female), with 7 (33%) receiving additional coiling. The average aneurysm diameter was 9.2 ± 5.6 mm. PETRA-MRA yielded significantly higher CNR values for both the FD (3.80 ± 1.21) and aneurysm (8.04 ± 5.79) compared with TOF-MRA (FD 2.51 ± 0.95, p < 0.001; aneurysm 3.92 ± 2.41, p = 0.001). Similarly, SIR values were notably greater with PETRA-MRA for the FD (0.44 ± 0.07 vs. 0.35 ± 0.08, p < 0.001) and the aneurysm (0.95 ± 0.19 vs. 0.62 ± 0.23, p < 0.001).</p><p><strong>Conclusions: </strong>Compared to TOF-MRA, PETRA-MRA provided higher CNR and SIR in the evaluation of both FD and aneurysm visualization. These findings indicate that PETRA-MRA is a promising noninvasive technique for early postprocedural assessment after FD treatment.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"535-543"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RCBVmax from DSC Perfusion MRI as a Supportive Imaging Biomarker for Differentiating IDH-Mutant Astrocytomas and Oligodendroglioma.","authors":"Manoj Mannil, Christian Rubbert, Manfred Musigmann, Mathias Prokop, Paola Feraco, Frederick J A Meijer, Marion Smits, Anja G Van der Kolk, Dylan Henssen","doi":"10.1007/s00062-026-01624-w","DOIUrl":"10.1007/s00062-026-01624-w","url":null,"abstract":"<p><strong>Background: </strong>Gliomas, particularly astrocytomas (IDH-mutated, 1p/19q intact) and oligodendrogliomas (IDH-mutated, 1p/19q co-deleted), differ significantly in their clinical behavior and prognosis. Accurate differentiation between these subtypes is crucial for guiding therapeutic decisions. Non-invasive imaging biomarkers, such as T2-Flair mismatch sign and relative cerebral blood volume (rCBV), have shown promise in glioma classification.</p><p><strong>Methods: </strong>This retrospective multicenter study analyzed 42 patients with astrocytoma and 21 with oligodendroglioma. Demographic, histopathological, and imaging data were collected, with a focus on rCBV parameters derived from dynamic susceptibility contrast perfusion MRI. Statistical analyses were conducted to assess differences between the groups and evaluate the discriminatory power of rCBV metrics. After correction for multiple corrections, level of significance was set at p < 0.01.</p><p><strong>Results: </strong>Patients with astrocytoma and oligodendroglioma were similar in age and gender distribution (mean age and male-female-ratio; p = 0.01 respectively p = 0.04). The rCBVmax value was significantly higher in oligodendrogliomas (11.64 vs. 7.69, p < 0.001) and demonstrated a good discriminatory power (AUC = 0.764). Median and mean rCBV values showed non-significant differences between oligodendroglioma and astrocytoma (p = 0.02 respectively p = 0.03).</p><p><strong>Conclusion: </strong>rCBVmax emerges as a potential imaging marker for differentiating oligodendrogliomas from astrocytomas. These findings can be explained by biological properties of oligodendrogliomas and thereby underscore the potential of advanced imaging techniques in non-invasive glioma classification. However, larger prospective studies are required to validate these results and standardize imaging protocols.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"673-679"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunistic Assessment of Dental Pathologies in Cervical Computed Tomography Angiography: A Proof of Concept Study.","authors":"Tim Halstenbach, Maximilian F Russe, Sabrina Zimmermann, Fabian Cieplik, Rainer Schmelzeisen, Horst Urbach, Wiebke Semper-Hogg, Alexander Rau","doi":"10.1007/s00062-026-01630-y","DOIUrl":"10.1007/s00062-026-01630-y","url":null,"abstract":"<p><strong>Objective: </strong>Computed tomography angiography (CTA) of the head and neck routinely encompasses dentoalveolar structures within the field of view, yet dental findings are rarely reported. Opportunistic detection of dental pathologies could provide valuable information for patient management. This feasability study evaluated the diagnostic potential of CTA for identifying common dental pathologies compared with panoramic radiography (orthopantomogram, OPG).</p><p><strong>Materials and methods: </strong>Fifty-seven patients (39% female, mean age: 63 years), who underwent both OPG and head-and-neck CTA within 100 days were retrospectively included. Three experienced dental radiological examiners independently assessed each tooth for periapical radiolucencies, periodontal bone lesions, carious lesions, root residues, retained teeth, and dental implants in cervical CTA and vascular kernel. Cohen's κ and Fleiss' κ were calculated to determine intra- and inter-rater-intramodality agreement between OPG and CTA findings.</p><p><strong>Results: </strong>CTA demonstrated good intermodality agreement with OPG regarding the detection of periapical lesions and periodontal bone defects, root canal-filled, retained teeth, and root residues (κ = 0.60-0.98). Carious lesions demonstrated moderate concordance. OPG identified more periodontal bone defects (mean number of detections per rater: CTA: 141.3; OPG: 173) and carious lesions (CTA: 48; OPG: 77; both p < 0.001).</p><p><strong>Conclusions: </strong>This systematic comparison of CTA and OPG demonstrated the feasability of CTA for opportunistic screening of dental status. While CTA can not replace dedicated dental imaging and clinical assessment, integrating dental evaluation into CTA interpretation may support early detection of oral infection sources and streamline interdisciplinary patient management in neurovascular imaging workflows.</p>","PeriodicalId":10391,"journal":{"name":"Clinical Neuroradiology","volume":" ","pages":"701-709"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13319318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}