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[Pharmacological treatment for pregnancy and lactation associated osteoporosis.] [妊娠和哺乳期骨质疏松症的药物治疗]
Clinical calcium Pub Date : 2019-01-01
Maiko Kitajima, Osamu Chaki
{"title":"[Pharmacological treatment for pregnancy and lactation associated osteoporosis.]","authors":"Maiko Kitajima, Osamu Chaki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pregnancy and lactation associated osteoporosis(PLO)is a rare disorder for women during pregnancy, the post-partum period, or while breastfeeding. It still remains unknown factors in its pathogenesis. That makes it there is no evident strategy for PLO now. In most cases, bone mineral density(BMD)of PLO patients spontaneously recovers after giving lactation up. On the other hand, patients with severe cases sometimes need bone specific therapy. There are some reports that show bisphosphonate, teriparatide and/or denosumab are effective on PLO cases. When the patients have wishes for having babies, we have to pay attention if the prescription effect on next pregnancy.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ASBMR 2018 Topics.] [ASBMR 2018主题。]
Clinical calcium Pub Date : 2019-01-01
Seiji Fukumoto
{"title":"[ASBMR 2018 Topics.]","authors":"Seiji Fukumoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The annual meeting of ASBMR was held in Montr?al Convention Center between September 28th and October 1st, 2018. Many scientific papers concerning bone, mineral metabolism, muscle and so on were presented as usual. There were several new attempts such as discussion about clinically difficult cases and sessions for young scientists in this meeting. I will introduce several papers concerning cancer treatment-induced bone loss and treatment of patients with PTH-deficient hypoparathyroidism.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"121-124"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Regulations of osteoclast formation and function by Wnt signals.] [Wnt信号对破骨细胞形成和功能的调控]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903309
Yasuhiro Kobayashi, Shunsuke Uehara, Masanori Koide
{"title":"[Regulations of osteoclast formation and function by Wnt signals.]","authors":"Yasuhiro Kobayashi,&nbsp;Shunsuke Uehara,&nbsp;Masanori Koide","doi":"10.20837/4201903309","DOIUrl":"https://doi.org/10.20837/4201903309","url":null,"abstract":"<p><p>Wnt ligands activate β-catenin-dependent canonical and -independent non-canonical signaling pathways. Recent studies established importance of Wnt/β-catenin signaling in bone accrual. Antibodies against the Wnt inhibitor sclerostin and those against the Wnt inhibitor Dickkopf-1 have been shown to be effective for increasing bone mass. In addition to their effects on bone formation, roles of Wnt signals in bone resorption are gradually clarified. In this review, we would like to introduce recent advances in roles of Wnt signals in osteoclast formation and functions and regulation of sclerostin expression by osteoclasts.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"309-315"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Osteocytes and Wnt signaling.] [骨细胞和Wnt信号]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903317
Seiji Fukumoto
{"title":"[Osteocytes and Wnt signaling.]","authors":"Seiji Fukumoto","doi":"10.20837/4201903317","DOIUrl":"https://doi.org/10.20837/4201903317","url":null,"abstract":"<p><p>Osteocytes has many functions such as sensing mechanical stress to bone, regulating formation and activity of osteoclasts as well as modulation of bone metabolism and function of other organs through production of humoral factors such as sclerostin and FGF23. Sclerostin suppresses bone formation and stimulate bone resorption by inhibiting Wnt activity. FGF23 regulates phosphate metabolism mainly acting on kidney. In contrast, it is also reported that sclerostin works in kidney and FGF23 inhibits Wnt activity in osteoblasts. However, the physiological significance of these actions of sclerostin and FGF23 needs to be established by future investigations.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"317-321"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[ASBMR 2018 report on basic research.] [ASBMR 2018年基础研究报告]
Clinical calcium Pub Date : 2019-01-01
Yuuki Imai
{"title":"[ASBMR 2018 report on basic research.]","authors":"Yuuki Imai","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a brief report on ASBMR 2018 held at Montreal, Quebec, Canada, focusing on basic research. Topics of ASBMR 2018 were varied among wide research fields, however, this report focuses on several topics because of spatio-temporal restriction of attendees. Also, the selected topics were very limited according to the author's interests.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"99-103"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ASBMR topics from clinical research(osteoporosis and sarcopenia).] [来自临床研究的ASBMR主题（骨质疏松症和肌肉减少症）]
Clinical calcium Pub Date : 2019-01-01
Ken-Ichiro Tanaka
{"title":"[ASBMR topics from clinical research(osteoporosis and sarcopenia).]","authors":"Ken-Ichiro Tanaka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There are a lot of progressive topics about osteoporosis and sarcopenia in 2018 ASBMR Annual Meeting, involving an association between diabetes and bone microarchitecture, associations between atypical femoral fractures and bisphosphonate drug holidays as well as pre-treatment bone mineral density, an effect of combined denosumab and high-dose teriparatide on bone parameters, and relationships between muscle and deuterated creatine, a selective androgen receptor modulator, and high-dose vitamin D supplementation.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"112-115"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ASBMR Topics from clinical research concerning bone and mineral metabolism other than osteoporosis.] [ASBMR除骨质疏松症外有关骨和矿物质代谢的临床研究主题]
Clinical calcium Pub Date : 2019-01-01
Yuichi Takashi
{"title":"[ASBMR Topics from clinical research concerning bone and mineral metabolism other than osteoporosis.]","authors":"Yuichi Takashi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This is a brief report summarizing topics in ASBMR 2018 held at Montreal, Canada in September 28th to October 1st, 2018. In this report, I would like to introduce several topics from clinical research concerning bone and mineral metabolism other than osteoporosis. One of the topics in this area is the progress of research and development of drugs for rare skeletal diseases, which have been considered to be difficult to treat. Especially, there were many abstracts concerning burosumab, which is a new therapeutic medicine for FGF23-related hypophosphatemic rickets/osteomalacia. In addition, I will focus on the papers concerning muscle, osteocalcin, vitamin D and microbiota.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"116-120"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cellular metabolite controls oxidative stress resistance.] [细胞代谢物控制氧化应激抵抗。]
Clinical calcium Pub Date : 2018-01-01
Tadahiro Shimazu
{"title":"[Cellular metabolite controls oxidative stress resistance.]","authors":"Tadahiro Shimazu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cellular metabolites such as acetylcoenzyme A and nicotinamide adenine dinucleotide control gene transcription via modulating the reader or eraser protein in histone modification. A ketone body, D-β-hydroxybutyrate is an endogenous metabolite which has been reported as a class Ⅰ histone deacetylases(HDACs). In this chapter, a molecular basis of the ketone body in transcriptional control and protection against oxidative stress is reviewed and discussed.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"28 1","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35689711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Drugs for osteoporosis.] [治疗骨质疏松的药物。]
Clinical calcium Pub Date : 2018-01-01
Seiji Fukumoto
{"title":"[Drugs for osteoporosis.]","authors":"Seiji Fukumoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many important results concerning several drugs for osteoporosis have been presented in ASBMR 2017 meeting. Longer use of denosumab for up to 10 years was shown to induce lower risk of fractures. In addition, antiresorptives were shown to be useful after abaloparatide or romosozumab. Now that several important drugs have been already developed for osteoporosis, research and drug development for other musculoskeletal organs than bone are necessary.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"28 1","pages":"114-116"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35689607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intravital bone imaging:osteoclast.] [活体骨成像：破骨细胞。]
Clinical calcium Pub Date : 2018-01-01
Junichi Kikuta, Masaru Ishii
{"title":"[Intravital bone imaging:osteoclast.]","authors":"Junichi Kikuta, Masaru Ishii","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursors. We have originally established an advanced imaging system for visualizing the in vivo behavior of mature osteoclasts in living bone tissues with intravital multiphoton microscopy. By means of this system, we could grasp the real time-course of osteoclastic bone resorption, and identified two distinct functional states of differentiated osteoclasts, 'bone-resorptive' and 'non-resorptive'. Intravital imaging also revealed that various biologic drugs acted directly on mature osteoclasts during inflammatory bone destruction. In this review, we show the latest data of intravital imaging of osteoclast dynamics.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"28 2","pages":"211-216"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35767321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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