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Clinical calcium最新文献

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[Association between osteoporosis and atherosclerosis in dyslipidemia.] [血脂异常患者骨质疏松与动脉粥样硬化的关系]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201902237
Nobuyuki Tai, Daisuke Inoue
{"title":"[Association between osteoporosis and atherosclerosis in dyslipidemia.]","authors":"Nobuyuki Tai, Daisuke Inoue","doi":"10.20837/4201902237","DOIUrl":"https://doi.org/10.20837/4201902237","url":null,"abstract":"Age-related osteoporosis and atherosclerosis is promoted by life style-related diseases such as dyslipidemia and diabetes mellitus. Common factors pathophysiologically involved in both osteoporosis and vascular calcification include senescent cells and osteoprotegerin(OPG). Dyslipidemia may impair both osteoclast and osteoblast function,thereby causing osteoporosis. Statins may have favorable effect on bone. Some anti-osteoporotic medications have also been suggested to show protective effect from atherosclerosis.","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 2","pages":"237-243"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Regulation of osteoblasts and chondrocytes by Wnt signaling.] [Wnt信号对成骨细胞和软骨细胞的调控]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903299
Riko Nishimura, Kenji Hata, Jumpei Kida
{"title":"[Regulation of osteoblasts and chondrocytes by Wnt signaling.]","authors":"Riko Nishimura,&nbsp;Kenji Hata,&nbsp;Jumpei Kida","doi":"10.20837/4201903299","DOIUrl":"https://doi.org/10.20837/4201903299","url":null,"abstract":"<p><p>Wnt plays important roles in regulation of differentiation of osteoblast and chondrocyte and their function. Wnt family members ingeniously utilize canonical Wnt signaling pathway through β-catenin and non-canonical Wnt signaling pathway independent of β-catenin, consequently regulating development, formation and homeostasis of bone and cartilage. Recent studies revealed that canonical Wnt signal activates transcriptional regulator, TAZ, in addition to transcription factors, LEF and TCF. Canonical Wnt signal crosstalks with BMP signal by stimulating complex formation of LEF1, TAZ and Runx2. Although molecular mechanism of non-canonical Wnt signal is getting clearer, the precise role of non-canonical Wnt signal in bone and cartilage seems still elusive.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"299-307"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
[Fracture management and current concepts related to pregnancy-associated osteoporosis.] [骨折管理和妊娠相关性骨质疏松症的最新概念]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19017884
Koji Ishikawa, Takashi Nagai, Takuma Kuroda, Yoshifumi Kudo, Tomoaki Toyone, Katsunori Inagaki
{"title":"[Fracture management and current concepts related to pregnancy-associated osteoporosis.]","authors":"Koji Ishikawa,&nbsp;Takashi Nagai,&nbsp;Takuma Kuroda,&nbsp;Yoshifumi Kudo,&nbsp;Tomoaki Toyone,&nbsp;Katsunori Inagaki","doi":"CliCa19017884","DOIUrl":"https://doi.org/CliCa19017884","url":null,"abstract":"<p><p>Pregnancy-associated osteoporosis is a rare condition characterized by a transient but significant reduction in bone mineral density. To date, the underlying pathophysiological mechanisms remain unclear. Related symptoms include severe back or hip pain secondary to vertebral fractures and/or transient osteoporosis of the hip, which typically occur during the third trimester or during lactation. Although most women are managed conservatively, a few women need surgery. Prompt diagnosis and appropriate treatment is important not only for pain control, but also to improve the woman's future quality of life.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"78-84"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Calcium Metabolism and Skeletal Changes during Pregnancy and Lactation.] [孕期和哺乳期钙代谢和骨骼变化]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19011926
Shun Yasuda, Hideki Mizunuma
{"title":"[Calcium Metabolism and Skeletal Changes during Pregnancy and Lactation.]","authors":"Shun Yasuda,&nbsp;Hideki Mizunuma","doi":"CliCa19011926","DOIUrl":"https://doi.org/CliCa19011926","url":null,"abstract":"<p><p>Calcium metabolism changes dramatically during pregnancy and lactation because offspring needs a supply of calcium. Approximately 30g of calcium, which passes through the placenta, is accumulated in a fetus during pregnancy mostly in the third trimester, and 220-340mg/day of calcium is supplied via breast milk during lactation. However, there are elaborate mechanisms to maintain maternal calcium homeostasis, which differs during pregnancy and lactation. Extra required calcium supply to the offspring in neither pregnancy nor breastfeeding normally do not cause any adverse consequences to the maternal skeleton even if any oral intake of calcium or vitamin D are increased. This article reviews the adaptation in calcium kinetics during pregnancy and lactation. Vitamin D, calciotropic hormones, and bone metabolism are also reviewed.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36818592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pathophysiology of bone and calcium metabolism in young women.] [年轻女性骨和钙代谢的病理生理学]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19012734
Nahoko Shirato
{"title":"[Pathophysiology of bone and calcium metabolism in young women.]","authors":"Nahoko Shirato","doi":"CliCa19012734","DOIUrl":"https://doi.org/CliCa19012734","url":null,"abstract":"<p><p>In young women, why bone and calcium become a problem, it is because it is possible to delay the reach of the fracture threshold, even if the bone density in the future is acquired high bone density(bone mineral density:BMD)in the young period. In addition, the acquisition of maximum bone mass(peak bone mass:PBM)is an effective intervention to prevent future osteoporosis for around 18 years old before the age of 18. Factors that affect bone density include nutrition, dietary habits, physical activity, load movement, UV irradiation, estrogen deficiency, aging, and lifestyle-related diseases. In this section, it explains the condition and the disease which causes estrogen deficiency by low weight at an important time for the metabolism of the bone and calcium of young woman.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36818593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pharmacological treatment for pregnancy and lactation associated osteoporosis.] [妊娠和哺乳期骨质疏松症的药物治疗]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19017076
Maiko Kitajima, Osamu Chaki
{"title":"[Pharmacological treatment for pregnancy and lactation associated osteoporosis.]","authors":"Maiko Kitajima,&nbsp;Osamu Chaki","doi":"CliCa19017076","DOIUrl":"https://doi.org/CliCa19017076","url":null,"abstract":"<p><p>Pregnancy and lactation associated osteoporosis(PLO)is a rare disorder for women during pregnancy, the post-partum period, or while breastfeeding. It still remains unknown factors in its pathogenesis. That makes it there is no evident strategy for PLO now. In most cases, bone mineral density(BMD)of PLO patients spontaneously recovers after giving lactation up. On the other hand, patients with severe cases sometimes need bone specific therapy. There are some reports that show bisphosphonate, teriparatide and/or denosumab are effective on PLO cases. When the patients have wishes for having babies, we have to pay attention if the prescription effect on next pregnancy.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"70-76"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ASBMR 2018 Topics.] [ASBMR 2018主题。]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa1901121124
Seiji Fukumoto
{"title":"[ASBMR 2018 Topics.]","authors":"Seiji Fukumoto","doi":"CliCa1901121124","DOIUrl":"https://doi.org/CliCa1901121124","url":null,"abstract":"<p><p>The annual meeting of ASBMR was held in Montr?al Convention Center between September 28th and October 1st, 2018. Many scientific papers concerning bone, mineral metabolism, muscle and so on were presented as usual. There were several new attempts such as discussion about clinically difficult cases and sessions for young scientists in this meeting. I will introduce several papers concerning cancer treatment-induced bone loss and treatment of patients with PTH-deficient hypoparathyroidism.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"121-124"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The prevention and treatment of vascular calcification.] 【血管钙化的预防与治疗】
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201902231
Kazuki Kawakami, Masaki Ohya, Takashi Shigematsu
{"title":"[The prevention and treatment of vascular calcification.]","authors":"Kazuki Kawakami,&nbsp;Masaki Ohya,&nbsp;Takashi Shigematsu","doi":"10.20837/4201902231","DOIUrl":"https://doi.org/10.20837/4201902231","url":null,"abstract":"<p><p>We had called the various bone disorder in chronic kidney disease(CKD)as a \"ROD:renal osteodystrophy\" until last decade. However the concept of ROD have changed into the chronic kidney disease-mineral and bone disease(CKD-MBD)within this decade. This concept is containing systemic disorder affected mortality. Vascular calcification is an independent risk factor for the development of cardiovascular disease and mortality. The best strategy to prevent and treat vascular calcification would consist of the CKD-MBD management. It is expected that the treatment of preventing directly vascular calcification to appear by finding the detailed mechanism in the future.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 2","pages":"231-236"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Wnt Signaling and Skeletal Dysplasias.] [Wnt信号与骨骼发育不良。]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903323
Toshimi Michigami
{"title":"[Wnt Signaling and Skeletal Dysplasias.]","authors":"Toshimi Michigami","doi":"10.20837/4201903323","DOIUrl":"https://doi.org/10.20837/4201903323","url":null,"abstract":"<p><p>Identification of responsible genes for skeletal dysplasias evidences their critical roles in the skeletal development and maintenance. Mutations in the genes encoding the components of Wnt canonical pathway, which include <i>WNT1</i>, <i>LRP5</i>, <i>LRP4</i>, <i>SOST</i> and <i>WTX</i>, cause the disorders characterized by abnormal in bone mass. On the other hand, mutations in the genes for the components of Wnt non-canonical pathway such as <i>WNT5A</i>, <i>ROR2</i>, <i>DVL1</i> and <i>DVL3</i> are associated with dysmorphic skeletal disorders which manifest short limbs and facial anomalies. Thus, both canonical and non-canonical pathways of Wnt signaling play substantial roles in the human skeletons, and it is suggested that the former mainly controls bone mass while the latter regulates skeletal morphogenesis.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"323-328"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Control of inflammatory bone destruction by targeting the Wnt signaling pathway.] [通过靶向Wnt信号通路控制炎性骨破坏]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903337
Satoshi Soen
{"title":"[Control of inflammatory bone destruction by targeting the Wnt signaling pathway.]","authors":"Satoshi Soen","doi":"10.20837/4201903337","DOIUrl":"https://doi.org/10.20837/4201903337","url":null,"abstract":"<p><p>Bone erosions develop early in the course of rheumatoid arthritis(RA)and are predictive of a worse prognosis. They deteriorate gradually and cause joint damage, resulting in impaired functional capacity and disability. Lately, a considerable number of studies have increased our understanding of the pathogenic mechanisms participating in the development of bone erosions in RA. Osteoclasts are responsible cells and multiple factors have been identified to stimulate their differentiation and function. RANKL(receptor activator of NF-κB ligand)and other cytokines have been known for a long time to enhance osteoclastogenesis, but the role of other pathways has also been revealed recently. Besides to excessive ostaoclastogenesis, impair osteoblast differentiation and function also plays part in bone erosion formation in RA. Inflamed synovial membrane products increased levels of cytokines and antagonists of the canonical Wnt signaling pathway, which inhibit osteoblast differentiation and function. It seems that downregulation of this pathway leads to impaired osteoblast differentiation and activity and consequently, to reduced capacity of bone erosion to repair. Preclinical studies show that these findings could have implications in RA treatment, although more studies are required in this direction.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"337-341"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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