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Clinical calcium最新文献

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[Mineral metabolism and aging.] 矿物质代谢和衰老。
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201902165
Makoto Kuro-O
{"title":"[Mineral metabolism and aging.]","authors":"Makoto Kuro-O","doi":"10.20837/4201902165","DOIUrl":"https://doi.org/10.20837/4201902165","url":null,"abstract":"<p><p>Analysis of a mutant mouse exhibiting accelerated aging identified phosphorus as a pro-aging factor in mammals. In the blood, phosphorus exists in the form of phosphate ions and colloidal particles composed of solid-phase calcium-phosphate and serum protein fetuin-A, which are termed calciprotein particles(CPP). Blood CPP levels increase with age and decline of renal function. Because CPP have the ability to induce inflammation and vascular smooth muscle cell calcification in vitro, we hypothesize that CPP may serve as a pathogen that accelerates aging. Therapeutic interventions in phosphate and/or CPP may open a new avenue for practical anti-aging medicine.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 2","pages":"165-170"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Non-canonical Wnt signaling and cellular responses.] [非典型Wnt信号和细胞反应。]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903291
Michiru Nishita, Takeshi Saji, Yasuhiro Minami
{"title":"[Non-canonical Wnt signaling and cellular responses.]","authors":"Michiru Nishita,&nbsp;Takeshi Saji,&nbsp;Yasuhiro Minami","doi":"10.20837/4201903291","DOIUrl":"https://doi.org/10.20837/4201903291","url":null,"abstract":"<p><p>Non-canonical Wnt signaling, including planar cell polarity and Ca<sup>2+</sup> pathways, plays crucial roles in developmental processes, including morphogenesis and tissue-/organo-genesis, in animals. Ror2 receptor tyrosine kinase mediates non-canonical Wnt signaling by acting as a receptor for Wnt5a, which also inhibits canonical Wnt signaling. Dysregulation of Wnt5a-Ror2 signaling causes a wide range of developmental defects and cancer progression. Recently, Ror2-mediated non-canonical Wnt signaling has also been shown to induce formation of filopodia that facilitates transport of Wnt to neighboring cells, thereby activating canonical Wnt signaling there.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"291-297"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37007571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
[The sequential therapy of romosozumab followed by denosumab for osteoporosis.] [罗莫索单抗加地诺单抗序贯治疗骨质疏松症。]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903357
Kumiko Ono, Sakae Tanaka
{"title":"[The sequential therapy of romosozumab followed by denosumab for osteoporosis.]","authors":"Kumiko Ono,&nbsp;Sakae Tanaka","doi":"10.20837/4201903357","DOIUrl":"https://doi.org/10.20837/4201903357","url":null,"abstract":"<p><p>Romosozumab is a bone-forming agent with a dual effect of increasing bone formation and decreasing bone resorption by inhibiting sclerostin. In the pivotal Fracture study in postmenopausal women with osteroposis(FRAME)and the extension trial, 12 months of romosozumab led to persistent fracture, especially new vertebral fracture, reduction benefit and ongoing BMD(bone mineral density)gains when follow 24 months of denosumab. The sequence therapy of romosozumab followed by denosumab may be a promising regimen for the treatment of osteoporosis.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"357-362"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37168089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[ASBMR topics from basic research.] [来自基础研究的ASBMR主题]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa1901104107
Yoshifumi Takahata, Riko Nishimura
{"title":"[ASBMR topics from basic research.]","authors":"Yoshifumi Takahata,&nbsp;Riko Nishimura","doi":"CliCa1901104107","DOIUrl":"https://doi.org/CliCa1901104107","url":null,"abstract":"<p><p>One of the major topics of ASBMR in this year was progress in research on \"Bone and muscle crosstalk\". It has been practically and clinically known that appropriate exercise has good effects on bones strength, however the mechanism is still elusive. In this ASBMR meeting, there were many reports that muscle-derived hormones, e.g. Irisin, β-aminoisobutyric acid(BAIBA)or Myostatin interact with skeletal cells. Especially, the report regarding Irisin was impressive. Moreover, several reports regarding new aspects of osteoblasts and bone formation were also interesting. In this report, we would like to introduce these interesting abstracts.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"104-107"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Metabolism of bone and calcium period in perinatal patients treated with glucocorticoids.] 糖皮质激素对围生期患者骨钙代谢的影响
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19015761
Ikuko Tanaka
{"title":"[Metabolism of bone and calcium period in perinatal patients treated with glucocorticoids.]","authors":"Ikuko Tanaka","doi":"CliCa19015761","DOIUrl":"https://doi.org/CliCa19015761","url":null,"abstract":"<p><p>Pregnancy and child birth are possible even in young females with diseases to be treated with glucocorticoid by controlling disease activity and careful follow-up. There is no description about expectant and nursing mothers in the guide lines for glucocorticoid-induced osteoporosis published in many countries. Obtaining informed consent is more important for understanding the benefit and risk of the pregnancy and child birth during the glucocorticoid treatment in the female patients, to whom getting a child is very meaningful.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36818598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Osteoporosis as a risk factor for cardiovascular disease.] [骨质疏松是心血管疾病的危险因素。]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201902171
Shinsuke Yamada, Masaaki Inaba
{"title":"[Osteoporosis as a risk factor for cardiovascular disease.]","authors":"Shinsuke Yamada,&nbsp;Masaaki Inaba","doi":"10.20837/4201902171","DOIUrl":"https://doi.org/10.20837/4201902171","url":null,"abstract":"<p><p>Osteoporosis(OP)is associated with high risk for cardiovascular disease(CVD). Concomitant occurrence of both OP and CVD seems to result from common pathological mechanisms between bone system and vascular system. It is expected that therapeutic agent for OP may be effective not only in normalization of bone metabolism but also in reducing vascular calcification. I give an outline with the relationship between bone metabolism and vascular calcification including epidemiology, outbreak mechanism, and effect on vascular calcification of OP treatment.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 2","pages":"171-177"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[In vivo detection of coronary artery calcification by optical coherence tomography.] 光学相干断层成像在体内检测冠状动脉钙化
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201902199
Yosuke Katayama, Takashi Kubo, Takashi Akasaka
{"title":"[In vivo detection of coronary artery calcification by optical coherence tomography.]","authors":"Yosuke Katayama,&nbsp;Takashi Kubo,&nbsp;Takashi Akasaka","doi":"10.20837/4201902199","DOIUrl":"https://doi.org/10.20837/4201902199","url":null,"abstract":"<p><p>Acute coronary syndromes are caused by sudden luminal thrombosis due to plaque rupture, plaque erosion, or calcified nodule in coronary atherosclerotic lesions. Coronary calcification is a well-known marker of atherosclerotic plaque burden. Accurate evaluation of coronary calcification is critical for percutaneous coronary intervention(PCI)strategy. Optical coherence tomography(OCT)is a high-resolution(10~20 μm)intravascular imaging technique that uses near infrared light to create images. OCT allows us to identify the details of coronary calcification and assess the effect of cutting balloon angioplasty and rotational atherectomy. Then, OCT is a useful technique to guide PCI in the severe calcified lesions.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 2","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36895572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Fate decision of hematopoietic stem cells by Wnt signaling.] [Wnt信号对造血干细胞命运的决定]
Clinical calcium Pub Date : 2019-01-01 DOI: 10.20837/4201903343
Yoshio Katayama
{"title":"[Fate decision of hematopoietic stem cells by Wnt signaling.]","authors":"Yoshio Katayama","doi":"10.20837/4201903343","DOIUrl":"https://doi.org/10.20837/4201903343","url":null,"abstract":"<p><p>Over the past 15 years, many studies have revealed that Wnt signaling has a strong impact on hematopoietic stem cell fate. After a controversy over the interpretation of some results, the current understanding is that an appropriate degree of canonical Wnt signaling induces hematopoietic stem cell self-renewal and that noncanonical Wnt signaling keeps the quiescence. It is also likely that the balance between canonical and noncanonical Wnt pathways regulates the stress response and aging of hematopoietic stem cells.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 3","pages":"343-347"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37168087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[A meeting Report on the 2018 annual meeting of ASBMR-Clinical practice of the osteoporosis-.] [asbmr 2018年年会会议报告-骨质疏松症临床实践-]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa1901108111
Reiko Watanabe, Daisuke Inoue
{"title":"[A meeting Report on the 2018 annual meeting of ASBMR-Clinical practice of the osteoporosis-.]","authors":"Reiko Watanabe,&nbsp;Daisuke Inoue","doi":"CliCa1901108111","DOIUrl":"https://doi.org/CliCa1901108111","url":null,"abstract":"<p><p>In the 2018 ASBMR annual meeting, many important results were reported, showing the effects of anti-osteoporotic drugs already focusing on bone quality and the concept of \"treat-to-target\", although there were few big topics on novel drugs. However, some reports on new drugs, such as probiotics and SARM(selective androgen receptor modulator), did draw attention.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"108-111"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36808018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical features and diagnosis of lumbar fractures caused by pregnancy- and lactation-associated osteoporosis.] [妊娠及哺乳期骨质疏松所致腰椎骨折的临床特点及诊断]
Clinical calcium Pub Date : 2019-01-01 DOI: CliCa19014650
Takuma Kuroda, Takashi Nagai, Koji Ishikawa, Katsunori Inagaki
{"title":"[Clinical features and diagnosis of lumbar fractures caused by pregnancy- and lactation-associated osteoporosis.]","authors":"Takuma Kuroda,&nbsp;Takashi Nagai,&nbsp;Koji Ishikawa,&nbsp;Katsunori Inagaki","doi":"CliCa19014650","DOIUrl":"https://doi.org/CliCa19014650","url":null,"abstract":"<p><p>Pregnancy- and lactation-associated osteoporosis is a rare disease. Although researchers have reported a few cases, there are no established diagnostic criteria for pregnancy- and lactation-associated osteoporosis. However, a diagnosis can be easily obtained by an accurate medical interview, physical examination, imaging studies, and laboratory data, including bone mineral density measurement. This disease should be suspected when a woman presents with severe back pain in the late stages of pregnancy or the early postpartum period. An accurate and prompt diagnosis helps with appropriate treatment and prevents the progression of the disease.</p>","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"29 1","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36818596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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