Clinical calcium最新文献_第10页

[Bone and calcium metabolism associated with malignancy. Bone management of prostate cancer in the novel anti-androgen era.] 与恶性肿瘤相关的骨和钙代谢。新抗雄激素时代前列腺癌的骨管理。

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa181115351544

Hisashi Matsushima

{"title":"[Bone and calcium metabolism associated with malignancy. Bone management of prostate cancer in the novel anti-androgen era.]","authors":"Hisashi Matsushima","doi":"CliCa181115351544","DOIUrl":"https://doi.org/CliCa181115351544","url":null,"abstract":"Androgen deprivation therapy(ADT)is a standard systemic therapy for prostate cancer. ADT induces bone loss(ADTIBL)and muscle loss(sarcopenia)leading to falls and farctures. There are 2 aims in bone management of prostate cancer:one is to prevent fragility fractures in patients without bone metastasis and the other is to prevent symptomatic skeletal events(SSE)which are pathologic fractures, spinal compression, radiation to bones and surgery to bones. Bone fractures and SSE are both correlated with worse overall survival(OS). Concomitant use of novel anti-androgens further increases the risk of falls and fractures. The earlier and appropiriate intervention with vitamin D and bone modifying agents(BMA)is necessary to prevent treatment related bone fractures and SSE. Bone management algorithm aids to decide the timing and doses of BMA. As for sarcopenia physical exercise and life style advices are important. Because abiraterone with glucocorticoid therapy induces stronger bone resorption, it is recommended to start denosumab simultaneously. Ra-223, bone seeking radiopharmaceuticals should not be used with abiraterone and predonisone because of high incidence of fracture and death.","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"28 11","pages":"1535-1544"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36629954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Inter-Organ Metabolic Communication via the Unfolded Stress Response.] [通过未展开应激反应的器官间代谢通讯。]

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa181115481553

Masato Miyake, Seiichi Oyadomari

引用次数: 0

[Diagnosis and treatment of rheumatoid arthritis:toward the best practice. The Pathophysiology in Rheumatoid Arthritis.] 类风湿关节炎的诊断与治疗:走向最佳实践。类风湿关节炎的病理生理学[j]。

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa1805595600

Kosaku Murakami, Tsuneyo Mimori

引用次数: 0

[Bone and calcium metabolism associated with malignancy. Clinical Characteristics and Treatment of Cancer Treatment Induced Bone Loss(CTIBL)in Breast Cancer.] 与恶性肿瘤相关的骨和钙代谢。乳腺癌治疗性骨质流失(CTIBL)的临床特点及治疗[j]。

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa181115151517

Tetsuya Taguchi

{"title":"[Bone and calcium metabolism associated with malignancy. Clinical Characteristics and Treatment of Cancer Treatment Induced Bone Loss(CTIBL)in Breast Cancer.]","authors":"Tetsuya Taguchi","doi":"CliCa181115151517","DOIUrl":"https://doi.org/CliCa181115151517","url":null,"abstract":"Breast cancer is a typical hormone-dependent tumor and at the time of diagnosis more than 60% of breast cancers are positive for estrogen receptors and estrogen(E)is required for proliferation. Since breast cancer is a tumor easily to cause micrometastasis, adjuvant hormonal therapy(HT)for 5 to 10 years after surgery that suppresses the action of estrogen actively prevents recurrence is very popular. However, HT with aromatase inhibitor(AI)for postoperative postmenopausal breast cancer markedly reduces the E concentration in the body, leading to significant bone loss and fracture as known as aromatase inhibitor-induced bone loss(AIBL), a typical example of CTIBL. Under these circumstances, the usefulness of bone modifying agents as a supportive therapy to increase bone density and decrease fracture rate without interrupting the treatment of breast cancer became clear, mainly in Europe and the United States. And recently, our study revealed even in Japanese breast cancer patients denosumab injection every 6 months showed significant increase in bone density. The number of women suffering from breast cancer in Japan reaches approximately 90,000 per year, a considerable number is estimated as a preliminary group of CTIBL, so early appropriate measures are desired.","PeriodicalId":10389,"journal":{"name":"Clinical calcium","volume":"28 11","pages":"1515-1517"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36629956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Mechanisms of systemic energy metabolism control through gene regulation in skeletal muscle.] [骨骼肌中通过基因调控控制全身能量代谢的机制]

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa18012329

Jun Tanihata, Shin'ichi Takeda

引用次数: 0

[Homeostasis and Disorder of Musculoskeletal System.Influence of steroid therapy on muscuoskeletal system.] 肌肉骨骼系统的内稳态和紊乱。类固醇治疗对肌肉骨骼系统的影响。

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa1803402409

Hirotoshi Tanaka

引用次数: 0

[Cartilage/chondrocyte research and osteoarthritis. Epidemiological studies on osteoarthritis:design and findings.] 软骨/软骨细胞研究和骨关节炎。骨关节炎的流行病学研究:设计和结果。

Clinical calcium Pub Date : 2018-01-01 DOI: CliCa1806767774

Tomoko Fujii