[细胞代谢物控制氧化应激抵抗。]

Clinical calcium Pub Date : 2018-01-01 DOI:CliCa18013944

Tadahiro Shimazu

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引用次数: 0

摘要

细胞代谢物如乙酰辅酶A和烟酰胺腺嘌呤二核苷酸通过调节组蛋白修饰中的读取器或擦除蛋白来控制基因转录。作为酮体，D-β-羟基丁酸酯是一种内源性代谢物，已被报道为一类Ⅰ组蛋白去乙酰化酶(HDACs)。本章对酮体在氧化应激转录控制和保护中的分子基础进行了综述和讨论。

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[Cellular metabolite controls oxidative stress resistance.]

Cellular metabolites such as acetylcoenzyme A and nicotinamide adenine dinucleotide control gene transcription via modulating the reader or eraser protein in histone modification. A ketone body, D-β-hydroxybutyrate is an endogenous metabolite which has been reported as a class Ⅰ histone deacetylases(HDACs). In this chapter, a molecular basis of the ketone body in transcriptional control and protection against oxidative stress is reviewed and discussed.

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Clinical calcium

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