Clinical Microbiology Reviews最新文献_第4页

BCG therapy in bladder cancer and its tumor microenvironment interactions. 卡介苗治疗膀胱癌及其肿瘤微环境相互作用。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-06-12 Epub Date: 2025-03-20 DOI: 10.1128/cmr.00212-24

Ni Jian, Lei Yu, Lijuan Ma, Binbin Zheng, Weiren Huang

{"title":"BCG therapy in bladder cancer and its tumor microenvironment interactions.","authors":"Ni Jian, Lei Yu, Lijuan Ma, Binbin Zheng, Weiren Huang","doi":"10.1128/cmr.00212-24","DOIUrl":"10.1128/cmr.00212-24","url":null,"abstract":"SUMMARYBacillus Calmette-Guérin (BCG) has been the standard treatment for non-muscle-invasive bladder cancer for over 30 years. Despite its proven efficacy, challenges persist, including unclear mechanisms of action, resistance in 30%-50% of patients, and significant side effects. This review presents an updated and balanced discussion of the antitumor mechanisms of BCG, focusing on its direct effects on bladder cancer and its interactions with various cell types within the bladder tumor microenvironment. Notably, recent research on the interactions between BCG and the bladder microbiome is also incorporated. We further summarize and analyze the latest preclinical and clinical studies regarding both intrinsic and adaptive resistance to BCG in bladder cancer. Based on the current understanding of BCG's therapeutic principles and resistance mechanisms, we systematically explore strategies to improve BCG-based tumor immunotherapy. These include the development of recombinant BCG, combination therapy with different drugs, optimization of therapeutic regimens and management, and the exploration of new approaches by targeting changes in the bladder microbiota and its metabolites. These measures aim to effectively address the BCG resistance in bladder cancer, reduce its toxicity, and ultimately enhance the clinical anti-tumor efficacy. Bacterial therapy, represented by genetically engineered oncolytic bacteria, has gradually emerged in the field of cancer treatment in recent years. As the only bacterial drug successfully approved for oncology use, BCG has provided decades of clinical experience. By consolidating lessons from BCG's successes and limitations, we hope to provide valuable insights for the development and application of bacterial therapies in cancer treatment.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0021224"},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current perspectives in the epidemiology and control of lymphatic filariasis. 淋巴丝虫病流行病学和控制的最新进展。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-06-12 Epub Date: 2025-04-02 DOI: 10.1128/cmr.00126-23

Dziedzom K de Souza, Moses J Bockarie

{"title":"Current perspectives in the epidemiology and control of lymphatic filariasis.","authors":"Dziedzom K de Souza, Moses J Bockarie","doi":"10.1128/cmr.00126-23","DOIUrl":"10.1128/cmr.00126-23","url":null,"abstract":"SUMMARYLymphatic filariasis (LF), a debilitating tropical disease caused by parasitic filarial worms, Wuchereria bancrofti, Brugia malayi, and Brugia timori, remains a significant public health challenge in tropical and subtropical settings where the disease is endemic. The disease affects millions worldwide, leading to severe disability and social stigma. Following the World Health Assembly resolution WHA50.29 in 1997 encouraging Member States to eliminate LF as a public health problem, the Global Programme to Eliminate Lymphatic Filariasis (GPELF) was established in 2000. The establishment of the GPELF paced the way for global eradication efforts, with commitments from non-governmental organizations and Merck donating the drug ivermectin as long as it is needed to control the disease. The advances in the diagnosis and control of LF have shown promising results, including developing novel diagnostic tools, therapeutic agents, and integrated vector management and surveillance strategies. This review explores the latest advances in our understanding of LF epidemiology, transmission assessments, clinical manifestations, and immune response to infection. We further discuss the current state of diagnostic development, treatment approaches, and control measures, highlighting the importance of continued research in the fight against this disease.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0012623"},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral microbiota and respiratory diseases: advances and perspectives. 口腔微生物群与呼吸系统疾病：进展与展望。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-06-12 Epub Date: 2025-04-02 DOI: 10.1128/cmr.00150-24

Xiaohao Liu, Fengxiang Shi, Jiawei Zeng, Jiaming Bi, Chuzi Mo, Yan Chai, Buling Wu, Shuaimei Xu

引用次数: 0

Genital cutaneous candidiasis versus chronic recurrent vulvovaginal candidiasis: distinct diseases, different populations. 生殖器皮肤念珠菌病与慢性复发性外阴阴道念珠菌病：不同的疾病，不同的人群。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-06-12 Epub Date: 2025-05-28 DOI: 10.1128/cmr.00020-25

Tania Day, Jack D Sobel

{"title":"Genital cutaneous candidiasis versus chronic recurrent vulvovaginal candidiasis: distinct diseases, different populations.","authors":"Tania Day, Jack D Sobel","doi":"10.1128/cmr.00020-25","DOIUrl":"10.1128/cmr.00020-25","url":null,"abstract":"SUMMARYVulvovaginal candidiasis (VVC) affects over half of women during their lifetime. There are two categorization systems for VVC: uncomplicated versus complicated and acute versus recurrent. Most uncomplicated or acute cases occur in postpubertal premenopausal girls and women as sporadic vaginitis due to Candida albicans. Complicated VVC includes recurrent, chronic, or severe cases, presence of non-albicans species, and/or disease occurring in people with diabetes, immunosuppression, or pregnancy. These classification systems fail to distinguish the two distinct clinical categories of genital candidiasis: estrogen-dependent VVC and estrogen-independent cutaneous candidiasis. These entities are characterized by different pathogenesis, patient demographics, predisposing conditions, symptoms, signs, investigations, differential diagnosis, treatment, and ancillary measures. The current international and national guidelines on VVC are inadequate in their description of the clinical presentation, role and limitations of culture, biopsy findings, and management of cutaneous candidiasis. Progress toward improved patient outcomes will require the interdisciplinary collaboration of researchers and guideline authors to separate these two entities, unify terminology for each, explore the roles of medications and comorbid dermatoses, detail pragmatic and accessible diagnostic processes, define treatment goals, and discuss the long-term management strategies pertinent to each condition.","PeriodicalId":10378,"journal":{"name":"Clinical Microbiology Reviews","volume":" ","pages":"e0002025"},"PeriodicalIF":19.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12160500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call for the United States to continue investing in science. 呼吁美国继续对科学进行投资。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-06-12 Epub Date: 2025-02-27 DOI: 10.1128/cmr.00044-25

Ira Blader, Felicia Goodrum, Michael J Imperiale, Arturo Casadevall, Cesar A Arias, Andreas Baumler, Carey-Ann D Burnham, Christina A Cuomo, Corrella S Detweiler, Graeme N Forrest, Jack A Gilbert, Susan Lovett, Stanley Maloy, Alexander McAdam, Irene Newton, Gemma Reguera, George A O'Toole, Patrick D Schloss, Ashley Shade, Marvin Whiteley

引用次数: 0

Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections. 临床微生物实验室实用指南：二形真菌感染的抗体和抗原检测方法。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-21 DOI: 10.1128/cmr.00005-20

Elitza S Theel,Julianne V Kus,Thomas E Grys,Neil M Ampel,Ilan S Schwartz,Sean X Zhang

引用次数: 0

Correction for Moreland et al., "Rapid and accurate testing for urinary tract infection: new clothes for the emperor". 更正Moreland等人的“快速准确的尿路感染检测：皇帝的新衣”。

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-05-14 DOI: 10.1128/cmr.00103-25

Robert B Moreland,Linda Brubaker,Lana Tinawi,Alan J Wolfe

引用次数: 0

Recent advances in therapeutic probiotics: insights from human trials 治疗性益生菌的最新进展：来自人体试验的见解

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00240-24

Mu-Yeol ChoJe-Hyun EomEun-Mi ChoiSeung-Jo YangDahye LeeYoung Youn KimHye-Sung KimInseong Hwang1Apple Tree Institute of Biomedical Science, Apple Tree Medical Foundation, Goyang-si, South Korea2DOCSmedi, Co., Ltd., Goyang-si, South Korea3Department of Orthodontics, Apple Tree Dental Hospital, Goyang-si, South Korea4Department of Oral and Maxillofacial Surgery, Apple Tree Dental Hospital, Goyang-si, South KoreaChristopher Staley

引用次数: 0

Vaginal mycobiome characteristics and therapeutic strategies in vulvovaginal candidiasis (VVC): differentiating pathogenic species and microecological features for stratified treatment 外阴阴道念珠菌病（VVC）的阴道菌群特征和治疗策略：区分病原种类和微生态特征进行分层治疗

IF 36.8 1区医学

Clinical Microbiology Reviews Pub Date : 2025-04-22 DOI: 10.1128/cmr.00284-24

Zimo LiuHua YangRoujie HuangXiaochuan LiTianshu SunLan Zhu1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, China2State Key Laboratory of Complex, Severe, and Rare Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China3Clinical Biobank, Center for Biomedical Technology, Institute of Clinical Medicine, National Science and Technology Key Infrastructure on Translational Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical Collegehttps://ror.org/02drdmm93, Beijing, ChinaJorge CervantesLina Restrepo

引用次数: 0

Henipaviruses: epidemiology, ecology, disease, and the development of vaccines and therapeutics. 亨尼帕病毒：流行病学，生态学，疾病，以及疫苗和治疗方法的发展。

IF 19 1区医学

Clinical Microbiology Reviews Pub Date : 2025-03-13 Epub Date: 2024-12-23 DOI: 10.1128/cmr.00128-23

Jessica R Spengler, Michael K Lo, Stephen R Welch, Christina F Spiropoulou

引用次数: 0