Clinics in dermatology最新文献

{"title":"Genetic and molecular drivers of scleroderma pathogenesis.","authors":"Ian D Odell","doi":"10.1016/j.clindermatol.2024.12.007","DOIUrl":"10.1016/j.clindermatol.2024.12.007","url":null,"abstract":"<p><p>Scleroderma is a heterogeneous disease with various clinical findings involving immune dysregulation, vasculopathy, and fibrosis. Biological and genetic studies over recent decades have elucidated molecular mechanisms of scleroderma pathogenesis. Genetic association studies have identified interferon and other immune regulatory genes as strongly linked to scleroderma risk, highlighting the immune system as a fundamental determinant of disease. Human and murine biological studies have identified growth factor signaling as a central feature linking tissue damage to the clinical phenotype. Growth factors activated in vascular endothelial cells overlap with those of other diseases having vascular abnormalities, such as hereditary hemorrhagic telangiectasia. Activated growth factor receptors in fibroblasts drive excessive collagen expression in the skin and lungs. Because growth factor signaling is overactivated in multiple malignancies, biological insights and therapeutic approaches may be translated from oncology to understand scleroderma better. Enhanced understanding of the molecular drivers of scleroderma pathogenesis has given greater insight into patient phenotypes and new therapeutic approaches, including those that target immune and growth factor signaling.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constant Joseph Desbordes' painting of Jean-Louis Alibert administering the smallpox vaccine (\"La Vaccine\"): An historic vaccination or artistic imagination?","authors":"Leonard J Hoenig, Uwe Wollina, Gerard Tilles, Daniel Wallach, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2024.12.003","DOIUrl":"10.1016/j.clindermatol.2024.12.003","url":null,"abstract":"<p><p>In 1822, France's Ministry of the Interior, concerned about dropping vaccination rates among the population, commissioned the French artist Constant Joseph Desbordes (1761-1828) to create an artwork that would educate the public about the benefits of the smallpox vaccine. The painting that resulted is entitled: \"La Vaccine\" (\"The Cowpox Inoculation\") and a copy of it is entitled \"La Vaccine au Chateau de Liancourt\" (\"Performing the Vaccination against Smallpox in the Chateau of Liancourt\").The highlight of the painting is its central figure, one of France's most distinguished physicians, Jean-Louis Alibert (1768-1837) performing, in dramatic fashion, the arm to arm method of smallpox vaccination that was common at that time. The painting was highly praised for bringing together, on opposite sides of the painting, persons from lower and upper socioeconomic classes, with Alibert serving as a bridge between them. The setting for the painting is a chateau and there is no evidence that a smallpox vaccination ever took place there. Thus, this painting is not a record of a specific, real-life vaccination but a celebration of vaccination itself, in an idealized artistic representation. The painting honors Alibert, a strong advocate of vaccination and demonstrates how art can impact patient education.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatology office visit out-of-pocket costs and copays: A Medicare Physician Office Visit Costs database study, 2020-2024.","authors":"Kaushik P Venkatesh, Gabriel Brito, Vinod E Nambudiri","doi":"10.1016/j.clindermatol.2024.12.002","DOIUrl":"10.1016/j.clindermatol.2024.12.002","url":null,"abstract":"","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impersonating expertise: The ethics of misleading dermatology advertising.","authors":"Akash Rau, Andrew Z Li, Julia Giordano, Jane M Grant-Kels, Zelma C Chiesa Fuxench","doi":"10.1016/j.clindermatol.2024.11.005","DOIUrl":"10.1016/j.clindermatol.2024.11.005","url":null,"abstract":"<p><p>The proliferation of medical spas has led to an increase in misleading advertising practices, particularly relating to the qualifications of practitioners and the risks of cosmetic procedures. Estheticians manage many spas without having the extensive and rigorous training that board-certified dermatologists undergo. By advertising physician oversight when there is none and promoting procedures as minimally invasive, these facilities create a false sense of security for patients. Procedures such as laser therapies and injectables require specialized expertise to avoid and, if necessary, treat potentially dangerous complications. The ethics of misleading advertising in dermatology must be considered due to its impact on patient decision-making (autonomy), safety (beneficence), and confidence regarding the medical profession.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive bibliometric analysis of prurigo nodularis literature (1951-2024): Key contributors, trends, and thematic evolution.","authors":"Siddig Ibrahim Abdelwahab, Abdullah Farasani, Hassan Ahmad Alfaifi, Ahmed S Alamer, Tawfeeq Altherwi, Saeed Alshahrani, Ahmad Assiri, Waseem Hassan","doi":"10.1016/j.clindermatol.2024.11.004","DOIUrl":"10.1016/j.clindermatol.2024.11.004","url":null,"abstract":"<p><p>This study provides a comprehensive bibliometric analysis of prurigo nodularis (PN) literature, identifying influential studies, key contributors, and emerging trends to understand the evolution of research and guide future investigations. A total of 499 contributions published between 1951 and October 2024, containing the term \"prurigo nodularis\" in their abstracts, were analyzed. Keyword analysis was conducted to determine the main themes across these publications. Additionally, the top 100 most cited articles on PN from 1979 to 2023 were examined, involving 51 journals. Metrics such as mean total citations per contribution (MeanTCperArt) and mean total citations per year (MeanTCperYear) were calculated for these top 100 articles. The analysis of the top 100 most cited articles revealed contributions from 453 authors. The number of publications, citations, h-index, g-index, m-index, hg composite, and Q2 index were calculated for each author. We have illustrated the dynamics of top authors, universities, and countries, as well as their respective collaboration networks. The thematic evolution of PN research was assessed using coword analysis, followed by a systematic discussion of the findings. This bibliometric analysis provides a comprehensive overview of the key contributors and research trends in PN literature, offering valuable insights for guiding future investigations.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The church spire sign.","authors":"Uwe Wollina, Leonard J Hoenig, Sophie Walter, Lawrence Charles Parish","doi":"10.1016/j.clindermatol.2024.11.003","DOIUrl":"10.1016/j.clindermatol.2024.11.003","url":null,"abstract":"<p><p>We are pleased to introduce in this issue of Clinics in Dermatology a new section entitled \"Art in Dermatology,\" which explores the interface between the visual arts and dermatology. This contribution focuses on the architectural structure known as a church spire that sits atop a church tower and has lent its name to a dermatologic sign. Key phrases play an important role in clinical dermatology and dermatopathology. The \"church spire sign\" is a descriptive term used to describe epidermal changes of hyperkeratosis, acanthosis, and elongated projections (papillomatosis) in various cutaneous disorders. Zvonimir Zambal (1922-1993) coined the term \"church spire sign\" in a contribution he published in 1965 with Hans Gotz (1915-1997). The term was adopted promptly by the dermatology community and was applied in 1966 by Emery Kocsard (1912-2005) and his colleague Franjo Ofner (1913-1973) in stucco keratosis. We describe the beautiful church spires of the Bamberg Cathedral located in Bamberg, Germany and compare its architectural appearance with the dermatopathology features seen in the church spire sign.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of calcium alginate-based dressings in wound healing: A comprehensive bibliometric review of the top 100 cited studies.","authors":"Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Abdullah Farasani, Ahmed Ali Jerah, Saleh M Abdullah, Bassem Oraibi, Yasir Babiker, Hassan Ahmad Alfaifi, Amal Hamdan Alzahrani, Ahmed S Alamer, Tawfeeq Altherwi, Ibrahim Abdel Aziz Ibrahim, Waseem Hassan","doi":"10.1016/j.clindermatol.2024.11.002","DOIUrl":"10.1016/j.clindermatol.2024.11.002","url":null,"abstract":"<p><p>Calcium alginate, a naturally derived polysaccharide from brown seaweed, has gained significant prominence in advanced wound care technologies. Despite its widespread application, there is a need for a bibliometric analysis to map the scientific advancements and thematic evolution in the field. To conduct a bibliometric analysis of the top 100 most cited papers on calcium alginate wound dressings to identify key contributors, collaborative networks, prominent themes, and trends in citation impact. The Scopus database was utilized for its broad multidisciplinary coverage. A search string \"(wound dressing) AND (calcium alginate)\" was applied to the Title, Abstract, and Keywords fields without time restrictions. Only articles and reviews were included. The analysis involved two phases: (1) a general examination of all retrieved publications for productive authors, institutions, countries, sponsors, and sources; and (2) an in-depth analysis of the top 100 most cited papers using VOSviewer and the bibliometrix package in R Studio. Co-authorship, citation networks, keyword co-occurrences, and citation metrics were visualized and statistically analyzed. From a total of 330 publications identified, the United States (57 publications), the United Kingdom (54), and China (46) emerged as leading contributors. Key institutions included Donghua University (9 publications) and Chulalongkorn University (5 publications). Prominent funding sources were the National Natural Science Foundation of China (20 publications) and the Ministry of Science and Technology of China (6 publications). The International Journal of Biological Macromolecules, the International Wound Journal, and the British Journal of Plastic Surgery were frequently cited sources. The top 100 cited papers, spanning 1983-2023, demonstrated peaks in citation impact in 2014 and 2015, with mean citations per article exceeding 270. Co-word analysis revealed evolving research themes over decades, highlighting foundational and innovative contributions. This comprehensive analysis may provide valuable insights into the thematic evolution and emerging trends, serving as a foundation for future research in wound care technologies.</p>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A call for action: Formalin exposure and broader occupational hazards and assessing the risk of glioblastoma in clinician scientists","authors":"Hossein Akbarialiabad MD, MSc ,&nbsp;Jane M. Grant-Kels MD ,&nbsp;Dedee F. Murrell BMBCh, DSc","doi":"10.1016/j.clindermatol.2024.05.008","DOIUrl":"10.1016/j.clindermatol.2024.05.008","url":null,"abstract":"<div><div>Physicians and surgeons have a threefold increased risk of glioblastoma<span><span> compared with population controls. We discuss the potential role of dermatology </span>neurotoxin and carcinogenic occupational exposure, particularly to formalin/formaldehyde; how to reduce those exposures; and the ethical imperative for dermatologists to protect themselves, their staff, and their patients.</span></div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 723-726"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141199562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More than just dermatitis: The multifaceted nature of chronic itch through the historical perspective of Napoleon Bonaparte","authors":"Zachary Leibovit-Reiben BS ,&nbsp;Hannah Godfrey BS ,&nbsp;Alissa Stanley BS ,&nbsp;Rebecca Thiede MD","doi":"10.1016/j.clindermatol.2024.06.025","DOIUrl":"10.1016/j.clindermatol.2024.06.025","url":null,"abstract":"<div><div>Derived from the survival advantage needed to eradicate harmful irritants from the skin's surface, itch, also known as pruritus, is an intriguing phenomenon and a key feature of many dermatologic diseases. The pathologic form, chronic itch, is a condition that precedes itself by its complex pathophysiology, numerous etiologies, and interplay of mechanisms that often make it difficult to diagnose and treat. One particular sufferer of this condition, the 18th-century French emperor Napoleon Bonaparte, makes for a compelling case study of the complexity of chronic itch. We delve into the many etiologies and mechanisms of chronic itch, using Napoleon's lifelong struggle with this condition as our model, identifying potential environmental, neurologic, psychiatric, and immunologic origins of his condition.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 709-714"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics of dynamic and differential pricing for cosmetic procedures","authors":"Albert E. Zhou MD, PhD ,&nbsp;Alyssa Swearingen BA ,&nbsp;Christian Gronbeck MD ,&nbsp;Neelesh P. Jain MD ,&nbsp;Brett Sloan MD ,&nbsp;Jane M. Grant-Kels MD ,&nbsp;Hao Feng MD, MHS","doi":"10.1016/j.clindermatol.2024.08.008","DOIUrl":"10.1016/j.clindermatol.2024.08.008","url":null,"abstract":"<div><div>Patient demand for procedures has increased in the evolving landscape of cosmetic dermatology. This has been fueled, in part, by social media and the growing normalization of cosmetic enhancements, developments that have led some patients to have potentially unrealistic expectations and place undue pressure on dermatologists to meet these often unrealistic demands. This pressure is exacerbated further by patients who are seen as difficult, demanding, and time-consuming and who may require extensive counseling. Physicians may adopt dynamic or differential pricing strategies to offset the additional time and effort that these patients require. We discuss the ethical concerns surrounding these pricing strategies in the cosmetic sphere, highlight the importance of transparency in pricing, and offer suggestions to promote clarity and fairness in cosmetic dermatology practices.</div></div>","PeriodicalId":10358,"journal":{"name":"Clinics in dermatology","volume":"42 6","pages":"Pages 739-741"},"PeriodicalIF":2.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142105015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}