Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2026-08-20DOI: 10.5946/ce.2025.471
Jaehee Han, Sang-Il Oh, Piljoo Kim, Kyung-Nam Kim
{"title":"Impact of expert-curated video training data on computer-aided detection of sessile serrated lesions: a retrospective study in Korea.","authors":"Jaehee Han, Sang-Il Oh, Piljoo Kim, Kyung-Nam Kim","doi":"10.5946/ce.2025.471","DOIUrl":"10.5946/ce.2025.471","url":null,"abstract":"<p><strong>Background: </strong>Computer-aided detection (CADe) improves adenoma detection; however, its performance for sessile serrated lesion (SSL) detection remains inconsistent. We hypothesized that models trained on expert-curated, histopathologically-confirmed datasets would improve SSL detection compared to models trained on public datasets without verified labels.</p><p><strong>Methods: </strong>Two CADe models with identical Visual Geometry Group 16 architectures were trained using different datasets: Model A on public datasets (~54,000 frames) and model B on a histopathologically-confirmed private dataset (~120,000 frames) derived from examinations performed by endoscopists with adenoma detection rates of >35%. Validation was conducted using 31 independent colonoscopy videos obtained from another endoscopist. Diagnostic performance was evaluated using event- and frame-based analyses.</p><p><strong>Results: </strong>Model B demonstrated a significantly higher event-based sensitivity than model A (99.7% vs. 39.9%, p<0.001). The detection of SSLs was markedly improved with model B. Frame-based sensitivity and F1-score were also higher for model B. Although model B generated more false positives per video (2.55 vs. 0.16, p<0.001), these alerts were brief and unlikely to meaningfully interfere with the endoscopic workflow.</p><p><strong>Conclusions: </strong>CADe models trained on expert-curated, histopathologically-confirmed datasets showed improved detection of neoplastic colorectal lesions, including SSLs, compared to models trained on public datasets. These findings highlight the importance of clinically curated datasets for optimizing the CADe performance for subtle colorectal lesions.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"821-832"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2026-09-18DOI: 10.5946/ce.2026.020
Juyoung Lee, Mina Kim, Gwang Hyo Yim, Hyeong Ho Jo, Joong Goo Kwon, Eun Young Kim, June Hwa Bae
{"title":"Effectiveness and safety of screening colonoscopy in adults aged 75 years and older: a retrospective cohort study from Korea.","authors":"Juyoung Lee, Mina Kim, Gwang Hyo Yim, Hyeong Ho Jo, Joong Goo Kwon, Eun Young Kim, June Hwa Bae","doi":"10.5946/ce.2026.020","DOIUrl":"10.5946/ce.2026.020","url":null,"abstract":"<p><strong>Background: </strong>The role of screening colonoscopy in older adults remains controversial because of procedural risks and limited life expectancy. We evaluated the diagnostic yield, procedural success, and safety of screening colonoscopy in patients aged ≥75 years.</p><p><strong>Methods: </strong>We retrospectively reviewed 602 patients aged ≥75 years who underwent screening colonoscopy between January 2013 and December 2024. Patients were stratified into two age groups: 75-79 years (n=486) and ≥80 years (n=116). Baseline characteristics, procedural outcomes, and safety were compared.</p><p><strong>Results: </strong>Baseline characteristics were comparable between groups. The detection rates were 10.5%, 6.8%, and 0.9% for non-advanced adenoma, advanced adenoma, and colorectal cancer, respectively. Cecal intubation success was high in both groups (98.1% vs. 99.1%, p=0.454), and adequate bowel preparation rates were similar (71.2% vs. 72.4%, p=0.880). Sedation was used less frequently in patients aged ≥80 years (65.5% vs. 76.7%, p=0.013). Complications were rare (1.5%) and comparable between groups, with only mild events.</p><p><strong>Conclusions: </strong>Screening colonoscopy in adults aged ≥75 years demonstrated high procedural success, substantial neoplasia detection rates, and low adverse event rates, with comparable outcomes in patients aged ≥80 years. However, overall clinical benefit should be interpreted cautiously, particularly in those aged ≥80 years, supporting an individualized approach.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"843-850"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-world management and in-hospital outcomes of foreign body-associated esophageal perforations in the United States: a national retrospective cohort study.","authors":"Stephanie Rodriguez, Spencer R Goble, Gaurav Suryawanshi, Khalid Ahmed, Nabeel Azeem","doi":"10.5946/ce.2025.411","DOIUrl":"10.5946/ce.2025.411","url":null,"abstract":"<p><strong>Background: </strong>Esophageal perforations can be managed conservatively, endoscopically, or surgically. We aimed to characterize the outcomes of these approaches and assess the impact of intervention timing.</p><p><strong>Methods: </strong>We retrospectively analyzed hospitalizations in the National Inpatient Sample from 2016 to 2022 for foreign body-associated esophageal perforations. Patients were grouped into endoscopic, surgical, or conservative management. Outcomes included mortality, respiratory failure, sepsis, hemorrhage, parenteral nutrition, and gastrostomy.</p><p><strong>Results: </strong>Among the 2,045 patients, 145 (7.1%) underwent endoscopic management, 190 (9.3%) underwent surgical management, and 1,710 (83.6%) received conservative treatment. Food impaction accounted for 76% of foreign bodies. The mortality rates were 0%, 5.3%, and 2.9%, respectively. Respiratory failure occurred in 17.2% of endoscopically managed patients and 42.1% of surgically managed patients. Surgical cases had higher use of parenteral nutrition (15.8%) and gastrostomy (31.6%), whereas conservative management had the highest hemorrhage rate (18.1%). Intervention timing was not significantly associated with outcomes.</p><p><strong>Conclusions: </strong>Most foreign body-associated esophageal perforations are managed conservatively. Among patients selected for intervention, endoscopic management was associated with lower rates of mortality, selected complications, and healthcare utilization than surgery. These findings reflect clinical triage pathways and should be interpreted cautiously, given potential selection bias, confounding by indication, and administrative data limitations.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"797-805"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2026-09-30DOI: 10.5946/ce.2026.315
Jun Heo, Min Kyu Jung, Yoo Na Kang
{"title":"A duodenal mass with biliary obstruction in a 60-year-old man.","authors":"Jun Heo, Min Kyu Jung, Yoo Na Kang","doi":"10.5946/ce.2026.315","DOIUrl":"10.5946/ce.2026.315","url":null,"abstract":"","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":"59 5","pages":"864-867"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2026-09-28DOI: 10.5946/ce.2025.251
Zahid Ijaz Tarar, Mustafa Gandhi, Umer Farooq, Gopala K Konduri, Ahmad Zain, Zohaib Ahmed, Baltej Singh, Ryan J Law, Nirav Thosani
{"title":"Safety and effectiveness of endoscopic ultrasound-guided coil plus glue vs. direct endoscopic glue injection for the treatment of gastric varices: a systematic review and meta-analysis.","authors":"Zahid Ijaz Tarar, Mustafa Gandhi, Umer Farooq, Gopala K Konduri, Ahmad Zain, Zohaib Ahmed, Baltej Singh, Ryan J Law, Nirav Thosani","doi":"10.5946/ce.2025.251","DOIUrl":"10.5946/ce.2025.251","url":null,"abstract":"<p><strong>Background: </strong>Although endoscopic glue injection is the conventional first-line treatment for gastric variceal (GV) bleeding, a large body of evidence supports the safety and effectiveness of endoscopic ultrasound (EUS)-guided coil and glue injections. We compared the safety and efficacy of these two modalities.</p><p><strong>Methods: </strong>A random-effects model was used for the pooled estimates. The outcomes of interest were the odds of technical success, GV obliteration, adverse events, rebleeding, reintervention, and pulmonary embolization (PE).</p><p><strong>Results: </strong>Eight studies involving 659 patients (EUS-guided coil+glue, n=200; endoscopic glue, n=459) were included in the meta-analysis. The rebleeding (odds ratio [OR], 0.28, 95% confidence interval [CI], 0.16-0.51; I2=0%) and reintervention (OR, 0.28; 95% CI, 0.15-0.52; I2=0%) rates were significantly lower in the EUS-guided coil+glue. EUS-guided coil+glue group had higher rates (OR, 4.56; 95% CI, 2.04 -10.19; I2=30%) of GV obliteration after the first session. No difference in the odds of technical success (OR, 2.03; 95% CI, 0.50-8.22; I2=0%), adverse events (OR, 1.19; 95% CI, 0.44-3.20; I2=45%), abdominal pain (OR, 1.17; 95% CI, 0.36-3.82; I2=44%) fever (OR, 1.09; 95% CI, 0.41-2.92; I2=0%), PE (OR, 0.52; 95% CI, 0.19-1.47; I2=0%) and all-cause mortality (OR, 0.67; 95% CI, 0.32-1.40; I2=0%) was identified.</p><p><strong>Conclusions: </strong>EUS-guided coil and glue injections are safe and effective for the treatment of gastric varices.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":"59 5","pages":"741-753"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2025-12-03DOI: 10.5946/ce.2025.246
Hyoung Il Choi, Jae Myung Cha
{"title":"Non-invasive colorectal cancer screening: emerging tools and clinical evidence.","authors":"Hyoung Il Choi, Jae Myung Cha","doi":"10.5946/ce.2025.246","DOIUrl":"10.5946/ce.2025.246","url":null,"abstract":"<p><p>The fecal immunochemical test (FIT) is a widely used non-invasive screening method for colorectal cancer (CRC) in many countries, valued for its simplicity, affordability, and reasonable sensitivity. Typically recommended on an annual or biennial basis, the FIT is effective in reducing CRC incidence and mortality by facilitating early detection. Stool DNA tests, including multitarget DNA tests and DNA methylation assays, demonstrate higher sensitivity than FIT for CRC and advanced adenomas, although they have slightly lower specificity and higher cost. These tests are generally performed at longer intervals, such as every 3 years, and are useful alternatives for individuals who are unwilling or unable to undergo a colonoscopy. Emerging non-invasive CRC screening tools, such as liquid biopsy, microRNA, microbiome tests, and urine-based tests, are being developed to improve patient compliance and test convenience. In particular, liquid biopsy offers a minimally invasive option that may be more acceptable to populations hesitant to undergo stool-based tests. Furthermore, the integration of machine learning with metagenomic sequencing data has shown promise in distinguishing patients with CRC from healthy individuals. As CRC screening evolves, these novel approaches may enable the development of more personalized, accessible, and effective screening strategies, ultimately improving adherence and reducing CRC-related mortality.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"732-740"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145660756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2026-09-01Epub Date: 2026-09-30DOI: 10.5946/ce.2026.481
Yuna Kim, Young Hoon Youn
{"title":"Anterior or posterior peroral endoscopic myotomy: anatomy may matter more than orientation.","authors":"Yuna Kim, Young Hoon Youn","doi":"10.5946/ce.2026.481","DOIUrl":"10.5946/ce.2026.481","url":null,"abstract":"","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":"59 5","pages":"765-767"},"PeriodicalIF":3.4,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linear endoscopic ultrasound of the liver: a practical, landmark-based approach to segmental orientation.","authors":"Hyung Ku Chon, Jung Hyun Yang, Tae Hyeon Kim","doi":"10.5946/ce.2026.013","DOIUrl":"https://doi.org/10.5946/ce.2026.013","url":null,"abstract":"<p><p>Linear endoscopic ultrasound (EUS) has emerged as an essential tool in endohepatology, enabling high-resolution evaluation of the hepatic parenchyma, vascular structures, and segmental anatomy of the liver via transgastric and transduodenal imaging. As the role of linear EUS has expanded to include tissue acquisition, biliary drainage, portal pressure measurement, and targeted hepatic interventions, a thorough understanding of the liver anatomy has become indispensable to ensure procedural safety and efficacy. However, EUS-based liver evaluation remains technically challenging because of its use of dynamic imaging planes and the absence of fixed anatomical reference points. This review proposes a structured, station-based approach that integrates Couinaud's segmental anatomy with reproducible vascular and ligamentous landmarks. By correlating the transgastric and transduodenal imaging views with the corresponding portal venous, hepatic venous, and ligamentous axes, this framework provides a systematic method for accurate segmental identification. Adoption of this approach may enhance diagnostic accuracy, facilitate safe therapeutic interventions, and promote more structured and reproducible training frameworks.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rin Van Bui, Jin Woong Cho, Seol Bong Yoo, Jin Sol Choi, Kyu Sung Jung
{"title":"Successful endoscopic subserosal dissection for subepithelial tumor in gastric antrum.","authors":"Rin Van Bui, Jin Woong Cho, Seol Bong Yoo, Jin Sol Choi, Kyu Sung Jung","doi":"10.5946/ce.2026.093","DOIUrl":"https://doi.org/10.5946/ce.2026.093","url":null,"abstract":"","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}