{"title":"Primary precut techniques for biliary cannulation: a systematic review and meta-analysis.","authors":"Eugene Annor, Nneoma Ubah, Dhaval Save, Ishaan Vohra, Ritu Raj Singh, Dushyant Singh Dahiya, Bhanu Siva Mohan Pinnam, Harishankar Gopakumar","doi":"10.5946/ce.2025.110","DOIUrl":"https://doi.org/10.5946/ce.2025.110","url":null,"abstract":"<p><strong>Background/aims: </strong>Biliary cannulation is a critical component of endoscopic retrograde cholangiopancreatography (ERCP). When standard methods fail, needle-knife precut sphincterotomy (NKPS) is commonly employed. This systematic review and meta-analysis evaluated the safety and efficacy of using NKPS as a primary technique.</p><p><strong>Methods: </strong>Electronic databases were searched for studies published between January 2000 and November 2024 that assessed outcomes of primary precut techniques. \"Primary precut\" was defined as needle-knife sphincterotomy performed as the initial approach without any prior standard cannulation attempts. Pooled proportions were calculated using random-effects models, and heterogeneity was assessed using the Q-test and the I² statistic.</p><p><strong>Results: </strong>The mean patient age was 57.95 years (standard deviation [SD], 7.59), and 53.23% were female. The cannulation success rate was 96.50% (95% confidence interval [CI], 94.90-97.60) with no heterogeneity (Q, 7.10; df, 8; I²=0%; p=0.935). The rates of adverse events were as follows: post-ERCP pancreatitis, 1.90% (95% CI, 1.20-3.10; I²=0; p =0.942); bleeding, 2.60% (95% CI, 1.70-4.00, I²=0; p=0.725); cholangitis, 1.50% (95% CI, 0.60-3.60; I²=45.27; p=0.067); and perforation, 0.90% (95% CI, 0.40-1.90; I²=0; p=0.948). The overall adverse event rate was 9.70% (95% CI, 5.70-16.10; I²=83.39; p<0.001).</p><p><strong>Conclusions: </strong>Primary precut sphincterotomy appears to be an effective and safe technique for biliary cannulation in ERCP. These findings support its consideration as a viable first-line approach in appropriate clinical settings.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bisher Sawaf, Mohammed S Beshr, Rana H Shembesh, Mohammed Abu-Rumaileh, Wasef Sayeh, Azizullah Beran, Yusuf Hallak, Sami Ghazaleh, Muhammed Elhadi, Yaseen Alastal
{"title":"Spiral enteroscopy versus single-balloon enteroscopy for the evaluation and treatment of small bowel disorders: a systematic review and meta-analysis.","authors":"Bisher Sawaf, Mohammed S Beshr, Rana H Shembesh, Mohammed Abu-Rumaileh, Wasef Sayeh, Azizullah Beran, Yusuf Hallak, Sami Ghazaleh, Muhammed Elhadi, Yaseen Alastal","doi":"10.5946/ce.2025.184","DOIUrl":"https://doi.org/10.5946/ce.2025.184","url":null,"abstract":"<p><strong>Background/aims: </strong>Device-assisted enteroscopy has advanced small bowel disorder management. We conducted this meta-analysis to compare the clinical and procedural outcomes between spiral enteroscopy and single-balloon enteroscopy.</p><p><strong>Methods: </strong>A systematic search was performed on December 1, 2024, in the PubMed, Scopus, and Cochrane Library databases to identify studies that compared spiral enteroscopy and single-balloon enteroscopy. The outcomes included diagnostic and therapeutic yields, total procedure time, depth of maximum insertion, and adverse event rates.</p><p><strong>Results: </strong>Five studies (including 496 patients) met the inclusion criteria. The diagnostic yield was similar between spiral enteroscopy and single-balloon enteroscopy (risk ratio [RR], 1.07; 95% confidence interval [CI], 0.96-1.20; p=0.24). The therapeutic yield also showed no significant difference (RR, 1.10; 95% CI, 0.45-2.69; p=0.83). The total procedure time was comparable (mean difference, -22.85 minutes; 95% CI, -46.83 to 1.12; p=0.06), although motorized spiral enteroscopy reduced the procedure time (p<0.001). Spiral enteroscopy achieved greater depth of maximum insertion (standardized mean difference, 1.33; 95% CI, 0.65-2.01; p<0.001). Adverse event rates were comparable (RR, 1.72; 95% CI, 0.80-3.70; p=0.16).</p><p><strong>Conclusions: </strong>Spiral and single-balloon enteroscopies demonstrated similar diagnostic and therapeutic yields and safety. Spiral enteroscopy achieved a greater insertion depth, and motorized systems improved the efficiency in terms of procedure times.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Epidemiology of colonic adenoma and cancer.","authors":"Dong Hyun Kim","doi":"10.5946/ce.2025.189","DOIUrl":"https://doi.org/10.5946/ce.2025.189","url":null,"abstract":"<p><p>Colorectal cancer (CRC) remains a major global health concern, showing significant variation in incidence and trends across different populations and age groups. While overall rates in older adults have declined in many high-income countries due to effective screening, the incidence of early-onset CRC, diagnosed before age 50, has been rising worldwide, especially in East Asia. Both early- and late-onset CRC share many risk factors, broadly categorized as modifiable and non-modifiable. Non-modifiable factors include age, sex, family history, hereditary syndromes, and inflammatory bowel disease. Modifiable factors such as obesity, unhealthy diet, physical inactivity, smoking, and alcohol consumption play a substantial role in CRC development and offer important targets for prevention. Lifestyle modifications-including weight control, regular physical activity, smoking cessation, and a balanced diet rich in fiber and vegetables-are associated with reduced CRC risk. In selected individuals, chemoprevention with low-dose aspirin may also lower CRC incidence. Screening and early detection remain essential strategies to reduce the CRC incidence and mortality, while comprehensive prevention efforts are needed to address the growing burden of CRC across diverse populations.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent technological advances in video capsule endoscopy: a comprehensive review.","authors":"Minjee Kim, Hyun Joo Jang","doi":"10.5946/ce.2025.135","DOIUrl":"https://doi.org/10.5946/ce.2025.135","url":null,"abstract":"<p><p>Video capsule endoscopy (VCE) originally revolutionized gastrointestinal imaging by providing a noninvasive method for evaluating small bowel diseases. Recent technological innovations, including enhanced imaging systems, artificial intelligence (AI), and improved localization, have significantly improved VCE's diagnostic accuracy, efficiency, and clinical utility. This review aims to summarize and evaluate recent technological advances in VCE, focusing on system comparisons, image enhancement, localization technologies, and AI-assisted lesion detection.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic full-thickness resection of upper gastrointestinal tract: a review on closure techniques.","authors":"Siew Fung Hau, Shannon Melissa Chan","doi":"10.5946/ce.2025.037","DOIUrl":"https://doi.org/10.5946/ce.2025.037","url":null,"abstract":"<p><p>Endoscopic full-thickness resection has become more and more popular. One of the most important parts of this procedure is the closure of these full-thickness defects. Apart from conventional through-the-scope (TTS) clips, several different methods and devices have emerged as safe and efficacious in recent years. New clips include the anchor pronged TTS clips, dual-action tissue clips, and over-the-scope-clips. There are also new line or loop-assisted closure methods such as clip loop method, reopenable clip over line method, loop 9 method, and the internal-traction-assisted suspended closure method. New devices include the helical tacking system and endoscopic suturing device. This review article will discuss in details the usage of these different methods and available literature on comparison between the different closure methods.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applying small bowel endoscopy in inflammatory bowel disease management.","authors":"Seong-Jung Kim, Sung Noh Hong","doi":"10.5946/ce.2025.144","DOIUrl":"https://doi.org/10.5946/ce.2025.144","url":null,"abstract":"<p><p>Inflammatory bowel disease is classified into Crohn's disease (CD) and ulcerative colitis. Ulcerative colitis involves only the colon, whereas CD is characterized by small bowel involvement, which is a hallmark feature. However, the small bowel is the final frontier of endoscopic evaluation; therefore, small bowel involvement is considered a significant medical challenge in the diagnosis and treatment of patients with CD. Endoscopic visualization and biopsy sampling of the small bowel are crucial for accurate diagnosis, effective monitoring, and management of complications of CD. Small bowel endoscopy enables the early detection of mucosal lesions, facilitates timely intervention for complications such as strictures or bleeding, and plays a critical role in reducing the need for surgical resection. Moreover, it enables targeted tissue acquisition and objective assessment of disease activity, both of which are crucial for optimal treatment planning and monitoring of therapeutic responses. Given these clinical advantages, small bowel endoscopy has become an indispensable tool in the comprehensive management of CD. This review summarizes the current role and evolving advances in small bowel endoscopy, with particular emphasis on its therapeutic applications-including enteroscopic balloon dilation, endoscopic hemostasis, and foreign body retrieval-and discusses future directions based on recent evidence and expert guidelines.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Radiofrequency ablation induced a stack of stones in the cystic cavity of a liver treated with endoscopic retrograde cholangiopancreatography using the SpyGlass Direct Visualization System.","authors":"Tae Hyeon Kim, Jin Hyun Maeng, Ji Ho Choi","doi":"10.5946/ce.2025.141","DOIUrl":"10.5946/ce.2025.141","url":null,"abstract":"","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2025-09-01Epub Date: 2025-04-08DOI: 10.5946/ce.2024.339
Mário Dinis-Ribeiro, Miguel Areia
{"title":"How to improve the quality of upper gastrointestinal diagnostic endoscopy?","authors":"Mário Dinis-Ribeiro, Miguel Areia","doi":"10.5946/ce.2024.339","DOIUrl":"10.5946/ce.2024.339","url":null,"abstract":"<p><p>Upper gastrointestinal endoscopy is commonly performed worldwide and is the gold standard for most upper gastrointestinal tract diseases, particularly cancer. This review will use gastric cancer as an example to tackle how providers can improve the quality of endoscopy being delivered to reduce the missing rate, which may reach up to 10% of cases. In brief, endoscopists must consider pre-, intra-, and post-procedural attitudes to achieve this purpose. \"Preparing or planning endoscopy,\" cancer as a possible diagnosis in all procedures should be thought. Fasting of patients and the use of mucosal cleaning solutions help ensure mucosal cleansing, while planned sedation increases comfort. During endoscopy, taking time for complete inspection and photodocumentation to assure completeness. Importantly, training and knowledge of cancer (superficial) endoscopic features, particularly using advanced imaging technologies, are of paramount importance, as they are regular post-endoscopy audits of practice that positively impact quality. Finally, human-machine interaction through artificial intelligence has been shown to improve photodocumentation, detection, and auditing, and it may well assure a more homogenous service, particularly among low-performing deliverers.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"633-637"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical significance of computer-aided quality assessment systems in colonoscopy: a comprehensive review.","authors":"Wai Phyo Lwin, Katsuro Ichimasa, Shin-Ei Kudo, Yuta Kouyama, Taishi Okumura, Yasuharu Maeda, Yutaro Ide, Khay Guan Yeoh, Masashi Misawa","doi":"10.5946/ce.2025.022","DOIUrl":"10.5946/ce.2025.022","url":null,"abstract":"<p><p>Colonoscopy is the primary tool for colorectal cancer screening. High-quality colonoscopy is crucial for the detection of precancerous adenomas; however, the adenoma detection rate varies depending on the skill and experience of the endoscopist. Computer-aided quality assessment (CAQ) uses artificial intelligence (AI) technology to evaluate the quality of colonoscopy examinations. It plays an important role in reducing variations in examination quality and obtaining high-quality colonoscopic images. In this review, we focus specifically on the speedometer, effective withdrawal time, fold examination quality, bowel preparation quality assessment, and cecal intubation with CAQ systems and discuss the role and effectiveness of these systems. CAQ systems are expected to contribute to increase in adenoma detection rates, improvement in endoscopist skills, and standardization of examination quality. However, challenges such as variability in AI performance across different clinical settings and potential overreliance on automated prompts remain key limitations.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"638-645"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical EndoscopyPub Date : 2025-09-01Epub Date: 2025-07-17DOI: 10.5946/ce.2025.018
Krzysztof Dąbkowski, Maciej Tryba, Ernest Biesiada, Kamila Konczanin, Małgorzata Michalak, Magdalena Szczygłowska, Krzysztof Safranow, Teresa Starzyńska
{"title":"Endoscopic assessment of terminal ileum in screening colonoscopy: is it worth the effort?","authors":"Krzysztof Dąbkowski, Maciej Tryba, Ernest Biesiada, Kamila Konczanin, Małgorzata Michalak, Magdalena Szczygłowska, Krzysztof Safranow, Teresa Starzyńska","doi":"10.5946/ce.2025.018","DOIUrl":"10.5946/ce.2025.018","url":null,"abstract":"<p><strong>Background: </strong>Screening colonoscopies often do not include terminal ileum assessment. In this study, we examined how often endoscopists assessed the terminal ileum during screening colonoscopy, how it influenced the procedure time and patient comfort, and whether it revealed pathological findings.</p><p><strong>Methods: </strong>We retrospectively analyzed the screening colonoscopy examinations performed in our department between 2017 and 2021. We retrieved the procedure duration (minutes), patient age and sex, pain scale, and screening colonoscopy results.</p><p><strong>Results: </strong>A total of 2,449 screening colonoscopy examinations were performed between 2017 and 2021. The patients were classified into one of two groups: the cecum reached or the terminal ileum intubated. These two groups did not significantly differ in sex or reported pain score, while the patients were significantly younger (55.2±6.5 vs. 56.2±6 years, p=0.015) and the colonoscopy duration was longer (22.8±9.8 vs. 18±10.5 min, p<0.001) in the terminal ileum group. Pathological conditions (nonspecific inflammatory lesions) in the small intestine were reported in 5/297 patients.</p><p><strong>Conclusions: </strong>Small intestine intubation was associated with a significantly longer colonoscopy duration and revealed pathological conditions of no apparent clinical significance.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":"731-737"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}