{"title":"Salvage underwater endoscopic mucosal resection for early gastric cancer following incomplete endoscopic submucosal dissection in a patient with gastric adenocarcinoma and proximal polyposis syndrome.","authors":"Yoshiaki Ando, Minoru Kato, Takeshi Nakajima, Tomoki Michida, Ryu Ishihara","doi":"10.5946/ce.2025.360","DOIUrl":"https://doi.org/10.5946/ce.2025.360","url":null,"abstract":"","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic treatment in anastomotic leakage after upper gastrointestinal surgery: endoscopic self-expandable metallic stent or endoluminal vacuum therapy?","authors":"Chul-Hyun Lim, Chan Gyoo Kim","doi":"10.5946/ce.2025.229","DOIUrl":"https://doi.org/10.5946/ce.2025.229","url":null,"abstract":"<p><p>Anastomotic leakage is a serious complication following upper gastrointestinal (UGI) surgery, associated with high morbidity and mortality rates. Effective management strategies aim to close or cover the defect, contain the leak, and adequately drain the affected area. In recent years, endoscopic techniques have emerged as viable alternatives or adjuncts to surgical interventions. This review discusses two major endoscopic modalities using self-expandable metal stents (SEMS), and endoscopic vacuum therapy (EVT) in anastomotic leaks after gastric and esophageal cancer surgery. By evaluating the efficacy, indications, and limitations of SEMS and EVT technique, this article provides a comprehensive overview to assist clinicians in optimizing patient outcomes in UGI postoperative anastomotic leaks.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Palliative endoscopic biliary drainage for malignant hilar biliary obstruction.","authors":"Shuji Mitsuhashi, Manik Aggarwal, Vinay Chandrasekhara","doi":"10.5946/ce.2025.395","DOIUrl":"https://doi.org/10.5946/ce.2025.395","url":null,"abstract":"<p><p>Malignant hilar biliary obstruction (MHBO) is most commonly caused by cholangiocarcinoma or gallbladder cancer and frequently presents with obstructive jaundice, pruritus, and/or cholangitis. These symptoms impair performance status and delay the initiation of chemotherapy, making biliary drainage essential for both palliation and oncologic treatment. Endoscopic transpapillary biliary stenting via endoscopic retrograde cholangiopancreatography is the standard approach for biliary decompression. In patients with unresectable disease, either plastic or self-expandable metal stents may be used. Optimal outcomes are achieved when drainage encompasses more than 50% of functional liver volume, while atrophic segments should be avoided. When transpapillary access is not feasible or unsuccessful, alternative approaches such as percutaneous transhepatic biliary drainage or endoscopic ultrasound-guided biliary drainage may be considered. Adjunctive therapies, including photodynamic therapy and radiofrequency ablation, are being investigated to enhance local tumor control and prolong stent patency. With continued advances in stent technology, imaging modalities, and endoscopic techniques, the management of MHBO is expected to become increasingly individualized and effective.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemostatic powder for gastrointestinal malignant tumor bleeding.","authors":"Thanrada Vimonsuntirungsri, Rapat Pittayanon","doi":"10.5946/ce.2025.387","DOIUrl":"https://doi.org/10.5946/ce.2025.387","url":null,"abstract":"<p><p>Gastrointestinal (GI) tumor bleeding remains a major clinical challenge worldwide, particularly for endoscopists. GI malignant tumor bleeding is uniquely characterized by diffuse oozing and friable tissue, which is vulnerable to further injury. This poses inherent limitations to conventional endoscopic treatments, resulting in low immediate hemostasis rates and a high risk of rebleeding. Traditional salvage surgery or embolization is the rescue treatment; however, they carry a higher mortality risk in the absence of stabilization. Importantly, survival in these patients depends on definitive oncological therapy, and endoscopic hemostasis is an essential frontline approach as a critical bridge to subsequent tumor treatment. Over the past decade, hemostatic powder has evolved into a promising treatment for malignant GI bleeding, distinguished by its ability to provide broad mucosal coverage through non-contact application. To date, adequately powered randomized controlled trials and meta-analyses have demonstrated superior immediate hemostasis and lower rebleeding rates with only a hemostatic powder agent (TC-325) over conventional endoscopic therapy. Thus, the efficacy of other hemostatic powder agents needs to be explored. To date, no luminal or systemic adverse events have been reported in studies on malignant bleeding, reassuring the safety of hemostatic powder in this setting.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Underwater endoscopic submucosal dissection in the gastrointestinal tract: technical review and dual-approach endoscopic submucosal dissection.","authors":"Mitsuru Nagata","doi":"10.5946/ce.2025.330","DOIUrl":"https://doi.org/10.5946/ce.2025.330","url":null,"abstract":"<p><p>Endoscopic submucosal dissection (ESD) has become an established technique for en bloc resection of superficial gastrointestinal neoplasms. However, conventional ESD (CESD) under gas insufflation remains technically demanding, particularly in gravity-side lesions or in cases with submucosal fibrosis. Underwater ESD (UESD) was developed to overcome these challenges. Complete submergence mitigates gravity-related difficulties, enhances visualization through the natural zoom effect, and facilitates submucosal dissection via buoyancy and water pressure. Retrospective data further suggest that UESD may reduce the risk of post-ESD coagulation syndrome, which is likely attributable to the heat sink effect. UESD can also be integrated with device-assisted traction and pocket creation methods. However, limitations, such as visual field impairment caused by bleeding or bubble formation, remain concerns, and their optimal management requires further investigation. Nevertheless, UESD allows procedural flexibility by switching between UESD and CESD within the same procedure, herein referred to as dual-approach ESD. Despite its routine use in clinical practice, dual-approach ESD has not been clearly distinguished from UESD in most clinical studies, complicating comparisons with CESD. To advance both clinical practice and research, future investigations should clearly differentiate UESD from dual-approach ESD for a more accurate evaluation. Furthermore, appropriate procedural selection requires careful consideration of multiple factors.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tae In Kim, Jonghyun Lee, Ho Seung Lee, Sung Yong Han, Jae Min Lee
{"title":"Current role of endoscopic ablation in the management of pancreatic cancer.","authors":"Tae In Kim, Jonghyun Lee, Ho Seung Lee, Sung Yong Han, Jae Min Lee","doi":"10.5946/ce.2025.216","DOIUrl":"https://doi.org/10.5946/ce.2025.216","url":null,"abstract":"<p><p>Pancreatic cancer remains one of the most challenging malignancies to treat, with its incidence steadily rising owing to factors such as aging populations, lifestyle changes, and improved diagnostic capabilities. Surgery is an essential treatment; however, most patients are diagnosed at advanced stages. Conventional therapies offer limited survival benefits, underscoring the need for innovative approaches. Local treatments have emerged as critical strategies for improving tumor control and patient outcomes, particularly in unresectable or metastatic cases. Recent advancements include refinements in radiofrequency ablation (RFA), stereotactic body radiotherapy, irreversible electroporation, cryotherapy, and brachytherapy. RFA is a well-known modality that has been used effectively for the treatment of solid tumors such as hepatocellular cancer and cholangiocarcinoma. Cryotherapy offers targeted ablation with extreme cold, minimizing damage to surrounding tissues, whereas brachytherapy delivers localized radiation with precision, enhancing efficacy and reducing systemic toxicity. Nanoparticle-based drug delivery systems are an emerging trend in immunotherapy and advanced imaging techniques. This review evaluates advancements and declines in local treatments for unresectable pancreatic cancer. It underscores the importance of addressing rising pancreatic cancer rates through personalized approaches, robust clinical trials, and multidisciplinary collaboration to optimize therapeutic outcomes.</p>","PeriodicalId":10351,"journal":{"name":"Clinical Endoscopy","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147644315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}