Clinical and Experimental Nephrology最新文献_第4页

Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease. 慢性肾脏病患者血清镁水平与肾脏预后的关系。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-08-01 Epub Date: 2024-03-20 DOI: 10.1007/s10157-024-02486-7

Seiji Kishi, Takaya Nakashima, Tadahiro Goto, Hajime Nagasu, Craig R Brooks, Hirokazu Okada, Kouichi Tamura, Toshiaki Nakano, Ichiei Narita, Shoichi Maruyama, Yuichiro Yano, Takashi Yokoo, Takashi Wada, Jun Wada, Masaomi Nangaku, Naoki Kashihara

{"title":"Association of serum magnesium levels with renal prognosis in patients with chronic kidney disease.","authors":"Seiji Kishi, Takaya Nakashima, Tadahiro Goto, Hajime Nagasu, Craig R Brooks, Hirokazu Okada, Kouichi Tamura, Toshiaki Nakano, Ichiei Narita, Shoichi Maruyama, Yuichiro Yano, Takashi Yokoo, Takashi Wada, Jun Wada, Masaomi Nangaku, Naoki Kashihara","doi":"10.1007/s10157-024-02486-7","DOIUrl":"10.1007/s10157-024-02486-7","url":null,"abstract":"Background: Magnesium deficiency is associated with various health conditions, but its impact on the progression of chronic kidney disease (CKD) remains unclear. This study aimed to investigate the association between serum magnesium levels and prognosis of renal function in CKD patients.Methods: This is an analysis of the Japan Chronic Kidney Disease Database Ex　(J-CKD-DB-Ex), which is a multicenter prospective cohort including CKD patients enrolled from January 1, 2014 to December 31, 2020. We included adult outpatients with CKD stage G3 and G4 at the time of initial magnesium measurement. Patients were classified by magnesium levels as low (<1.7 mg/dl), normal (1.7-2.6 mg/dl), or high (>2.6 mg/dl). The primary outcomes were the composite of an eGFR < 15 ml/min/1.73 m2 or a ≥30% reduction in eGFR from the initial measurement, which was defined as CKD progression. We applied the Kaplan-Meier analysis and Cox regression hazard model to examine the association between magnesium levels and CKD progression.Results: The analysis included 9868 outpatients during the follow-up period. The low magnesium group was significantly more likely to reach CKD progression. Cox regression, adjusting for covariates and using the normal magnesium group as the reference, showed that the hazard ratio for the low magnesium group was 1.20 (1.08-1.34). High magnesium was not significantly associated with poor renal outcomes compared with normal magnesium.Conclusion: Based on large real-world data, this study demonstrated that low magnesium levels are associated with poorer renal outcomes.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140173917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METTL14 derived from exosomes of M1 macrophages promotes high glucose-induced apoptosis, inflammation and oxidative stress in glomerular endothelial cells by mediating PAQR3 m6A modification. 源自 M1 巨噬细胞外泌体的 METTL14 通过介导 PAQR3 m6A 修饰，促进高血糖诱导的肾小球内皮细胞凋亡、炎症和氧化应激。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-30 DOI: 10.1007/s10157-024-02536-0

Yiqun Li, Jiarong Zhang, Yanli Zhu

{"title":"METTL14 derived from exosomes of M1 macrophages promotes high glucose-induced apoptosis, inflammation and oxidative stress in glomerular endothelial cells by mediating PAQR3 m6A modification.","authors":"Yiqun Li, Jiarong Zhang, Yanli Zhu","doi":"10.1007/s10157-024-02536-0","DOIUrl":"https://doi.org/10.1007/s10157-024-02536-0","url":null,"abstract":"Background: Methyltransferase 14 (METTL14) mediated N6-methyladenine (m6A) RNA methylation and progestin and AdipoQ receptor family member 3 (PAQR3) are reported to be involved in diabetic nephropathy (DN) progression. Here, we explored whether the effects of PAQR3 on DN was associated with METTL14-induced m6A and their relationship with macrophage-related exosomes in DN progression.Methods: Human glomerular endothelial cells (GECs) were incubated in high glucose (HG) condition to mimic DN condition in vitro. Exosomes were isolated from M1 macrophages and co-cultured with GECs. qRT-PCR and western blotting detected the levels of genes and proteins. Cell functions were determined using cell counting kit-8 assay and flow cytometry. ELISA analysis detected inflammatory factors, and oxidative stress was evaluated by measuring reactive oxygen species and malondialdehyde. The m6A modification profile was determined by methylated RNA immunoprecipitation assay and the interaction was verified by dual-luciferase reporter assay.Results: HG elevated PAQR3 expression levels in GECs. PAQR3 silencing reversed HG-induced viability arrest, apoptosis, inflammatory response, and oxidative stress. M1 macrophage co-culture could suppress HG-induced GEC injury. PAQR3 was packaged into M1 macrophage-derived exosomes, and M1 macrophages regulated HG-induced GEC injury by secreting PAQR3 into cells via exosomes. Mechanistically, METTL14 induced PAQR3 m6A modification. METTL14 was enriched in M1 macrophage-derived exosomes. METTL14 knockdown in M1 macrophage-derived exosomes protected GEC from HG-induced viability arrest, apoptosis, inflammation and oxidative stress by regulating PAQR3.Conclusion: Exosomal METTL14 derived from M1 macrophages promoted HG-induced apoptosis, inflammation and oxidative stress in GECs by mediating PAQR3 m6A modification.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of salt reduction education from a salt questionnaire on inter-dialysis weight gain in patients on hemodialysis 通过盐分问卷进行减盐教育对血液透析患者透析间体重增加的影响

IF 2.3 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-27 DOI: 10.1007/s10157-024-02541-3

Naro Ohashi, Yukitoshi Sakao, Yuri Uchiyama, Taro Aoki, Sayaka Ishigaki, Takamasa Iwakura, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda

{"title":"Effects of salt reduction education from a salt questionnaire on inter-dialysis weight gain in patients on hemodialysis","authors":"Naro Ohashi, Yukitoshi Sakao, Yuri Uchiyama, Taro Aoki, Sayaka Ishigaki, Takamasa Iwakura, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda","doi":"10.1007/s10157-024-02541-3","DOIUrl":"https://doi.org/10.1007/s10157-024-02541-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3>Heart failure is the leading cause of death in patients undergoing hemodialysis (HD), with fluid overload being the most common cause. Therefore, it is important for patients undergoing HD to reduce salt intake. We recently developed a highly accurate and simple self-administered salt questionnaire. Using this salt questionnaire, we aimed to determine whether salt intake and inter-HD weight gain decrease when patients with HD are instructed to reduce their salt intake.<h3 data-test=\"abstract-sub-heading\">Methods</h3>Seventy-eight outpatients at a maintenance HD facility were assessed for dietary salt intake using a salt questionnaire. After one month of dietary guidance, salt intake was assessed again using the salt questionnaire.<h3 data-test=\"abstract-sub-heading\">Results</h3>The mean age of the patients was 72.2 ± 11.9 years; 47 (60.3%) were men, 23 had diabetic nephropathy as the primary disease, and the median HD vintage was 74 months. Salt intake significantly decreased from 8.41 ± 2.43 g/day before the salt questionnaire intervention to 7.67 ± 2.60 g/day after the intervention (p = 0.010). Changes in salt intake before and after the intervention were significantly positively correlated with changes in weight gain before the start of HD sessions with an interval of 2 days (r = 0.24, p = 0.037). Furthermore, changes in salt intake significantly and positively correlated with changes in weight gain after adjusting for age, sex, and dry weight.<h3 data-test=\"abstract-sub-heading\">Conclusion</h3>The salt questionnaire may be an effective tool for reducing salt intake and controlling weight gain during HD.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141774815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic kidney disease: the kidney disease relevant to individuals with diabetes. 糖尿病肾病：与糖尿病患者相关的肾病。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-20 DOI: 10.1007/s10157-024-02537-z

Keizo Kanasaki, Kohjiro Ueki, Masaomi Nangaku

引用次数: 0

Prognostic role of nutritional and inflammatory indicators for patient survival and death with functional graft in living kidney transplant recipients. 营养和炎症指标对活体肾移植受者功能性移植物存活和死亡的预后作用。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-18 DOI: 10.1007/s10157-024-02524-4

Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Tatsuo Yoneda, Kenta Onishi, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Nobumichi Tanaka, Kiyohide Fujimoto

{"title":"Prognostic role of nutritional and inflammatory indicators for patient survival and death with functional graft in living kidney transplant recipients.","authors":"Shunta Hori, Mitsuru Tomizawa, Kuniaki Inoue, Tatsuo Yoneda, Kenta Onishi, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Kazumasa Torimoto, Nobumichi Tanaka, Kiyohide Fujimoto","doi":"10.1007/s10157-024-02524-4","DOIUrl":"https://doi.org/10.1007/s10157-024-02524-4","url":null,"abstract":"Background: The clinical importance of nutrition and inflammation in patients with end-stage renal disease is well established. In this study, we investigated the role of nutritional and inflammatory indicators in the patient outcomes of living donor kidney transplant recipients.Methods: We included 204 consecutive patients who underwent kidney transplantation at our institute between 2003 and 2022. We retrospectively reviewed medical charts to obtain clinical information. Six nutritional indicators and two inflammatory indicators were assessed. Patient outcomes were investigated, and predictive factors were explored.Results: The median patient age and follow-up period were 48 years and 99 months, respectively. The cohort included patients with preoperative malnutrition and microinflammation. No significant differences in graft survival were identified according to nutritional and inflammatory indicators, whereas the survival index, controlled nutritional status, and C-reactive protein levels were associated with patient survival. The survival index was an independent indicator of survival and death in patients with functioning grafts (P = 0.047 and P = 0.013, respectively). Furthermore, the C-reactive protein level could distinguish between low and high mortality risks in patients with good nutrition (P = 0.019).Conclusions: Our findings suggest that nutrition and inflammation indicators play important roles in predicting outcomes in living donor kidney transplantation recipients. Further research is warranted to establish optimal management strategies.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the genetic background in complicated WT1-related disorders. 复杂 WT1 相关疾病的遗传背景综述。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-13 DOI: 10.1007/s10157-024-02539-x

China Nagano, Kandai Nozu

{"title":"A review of the genetic background in complicated WT1-related disorders.","authors":"China Nagano, Kandai Nozu","doi":"10.1007/s10157-024-02539-x","DOIUrl":"https://doi.org/10.1007/s10157-024-02539-x","url":null,"abstract":"The Wilms tumor 1 (WT1) gene was first identified in 1990 as a strong candidate for conferring a predisposition to Wilms tumor. The WT1 protein has four zinc finger structures (DNA binding domain) at the C-terminus, which bind to transcriptional regulatory sequences on DNA, and acts as a transcription factor. WT1 is expressed during kidney development and regulates differentiation, and is also expressed in glomerular epithelial cells after birth to maintain the structure of podocytes. WT1-related disorders are a group of conditions associated with an aberrant or absent copy of the WT1 gene. This group of conditions encompasses a wide phenotypic spectrum that includes Denys-Drash syndrome (DDS), Frasier syndrome (FS), Wilms-aniridia-genitourinary-mental retardation syndrome, and isolated manifestations of nephropathy or Wilms tumor. The genotype-phenotype correlation is becoming clearer: patients with missense variants in DNA binding sites including C2H2 sites manifest DDS and develop early-onset and rapidly developing end-stage kidney disease. A deeper understanding of the genotype-phenotype correlation has also been obtained in DDS, but no such correlation has been observed in FS. The incidence of Wilms tumor is higher in patients with DDS and exon-truncating variants than in those with non-truncating variants. Here, we briefly describe the genetic background of this highly complicated WT1-related disorders.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of anti-SARS-CoV-2 vaccination in living kidney transplant recipients prior to transplantation. 活体肾移植受者在移植前接种抗 SARS-CoV-2 疫苗的效果。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-06 DOI: 10.1007/s10157-024-02535-1

Yusuke Tomita, Saeko Uehara, Mari Terada, Norio Yamamoto, Michio Nakamura

引用次数: 0

Correction to: Adolescence‑onset atypical hemolytic uremic syndrome: is it different from infant‑onset? 更正为青春期发病的非典型溶血性尿毒症综合征：它与婴儿发病的非典型溶血性尿毒症综合征不同吗？

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-06 DOI: 10.1007/s10157-024-02520-8

Kubra Celegen, Bora Gulhan, Kibriya Fidan, Selcuk Yuksel, Neslihan Yilmaz, Aysun Caltik Yılmaz, Beltinge Demircioğlu Kılıç, Ibrahim Gokce, Aslı Kavaz Tufan, Mukaddes Kalyoncu, Hulya Nalcacıoglu, Sare Gulfem Ozlu, Eda Didem Kurt Sukur, Nur Canpolat, Aysun K Bayazit, Elif Çomak, Yılmaz Tabel, Sebahat Tulpar, Mehtap Celakil, Kenan Bek, Cengiz Zeybek, Ali Duzova, Zeynep Birsin Özçakar, Rezan Topaloglu, Oguz Soylemezoglu, Fatih Ozaltin

引用次数: 0

Favorable changes in the eGFR slope after dapagliflozin treatment and its association with the initial dip. 达帕格列净治疗后 eGFR 斜率的有利变化及其与初始骤降的关系。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-06 DOI: 10.1007/s10157-024-02532-4

Rina Kawano, Tatsuya Haze, Akira Fujiwara, Aiko Haruna, Moe Ozawa, Yusuke Kobayashi, Sanae Saka, Nobuhito Hirawa, Kouichi Tamura

{"title":"Favorable changes in the eGFR slope after dapagliflozin treatment and its association with the initial dip.","authors":"Rina Kawano, Tatsuya Haze, Akira Fujiwara, Aiko Haruna, Moe Ozawa, Yusuke Kobayashi, Sanae Saka, Nobuhito Hirawa, Kouichi Tamura","doi":"10.1007/s10157-024-02532-4","DOIUrl":"https://doi.org/10.1007/s10157-024-02532-4","url":null,"abstract":"Background: Renoprotective effects of sodium glucose transporter 2 (SGLT2) inhibitors, including dapagliflozin, were observed in randomized controlled trials (RCTs). The suspected underlying mechanism is a correction of hyperfiltration, observed as an \"initial dip\". Whether SGLT2 inhibitors can attenuate the rate of decline in the estimated glomerular filtration rate (eGFR) in clinical settings, even when considering the pre-treatment decline rate, is unknown. Although several RCTs identified an association between the initial dip and long-term renal prognoses, a conclusion has not been reached.Methods: We collected the eGFR data of patients for whom dapagliflozin was initiated in our hospital and then calculated their eGFR slopes before and after the start of the treatment. We investigated the changes in the eGFR slopes (ΔeGFR slope) and the association between the ΔeGFR slope and the initial dip. Risks for rapid eGFR decliners (eGFR slope < - 3 mL/min/1.73 m2/year) were also examined.Results: The eGFR slope was significantly milder after dapagliflozin treatment (p < 0.01). A deeper initial dip was associated with a milder rate of eGFR decline (adjusted beta: - 0.29, p < 0.001). Dapagliflozin treatment reduced the proportion of rapid eGFR decliners from 52.9 to 14.7%, and a smaller initial dip was identified as a significant risk for post-treatment rapid eGFR decline (adjusted odds ratio: 1.73, p < 0.05).Conclusions: Compared to before the administration of dapagliflozin, the rate of eGFR decline was significantly milder after its administration. The initial dip was significantly associated with long-term renoprotective effects and may be a useful predictor of treatment response.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum magnesium levels and cognitive function in patients undergoing hemodialysis. 血液透析患者血清镁水平与认知功能之间的关系。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2024-07-02 DOI: 10.1007/s10157-024-02528-0

Kazuhiko Kato, Akio Nakashima, Shunichiro Shinagawa, Arisa Kobayashi, Ichiro Ohkido, Mitsuyoshi Urashima, Takashi Yokoo

{"title":"Association between serum magnesium levels and cognitive function in patients undergoing hemodialysis.","authors":"Kazuhiko Kato, Akio Nakashima, Shunichiro Shinagawa, Arisa Kobayashi, Ichiro Ohkido, Mitsuyoshi Urashima, Takashi Yokoo","doi":"10.1007/s10157-024-02528-0","DOIUrl":"https://doi.org/10.1007/s10157-024-02528-0","url":null,"abstract":"Background: The relationship between chronic kidney disease-mineral and bone disorder (CKD-MBD) and cognitive function remains largely unknown. This cross-sectional study aimed to explore the association between CKD-MBD and cognitive function in patients on hemodialysis.Methods: Hemodialysis patients aged ≥ 65 years without diagnosed dementia were included. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE). CKD-MBD markers, serum magnesium, intact parathyroid hormone (PTH), 25-hydroxyvitamin D (25-OHD), fibroblast growth factor (FGF)-23, and soluble α-klotho were measured.Results: Overall, 390 patients with a median age of 74 (interquartile range, 70-80) years, mean serum magnesium level of 2.4 ± 0.3 mg/dL, and median MoCA and MMSE scores of 25 (22-26) and 28 (26-29), respectively, were analyzed. MoCA and MMSE scores were significantly higher (preserved cognitive function) in the high-magnesium group than in the low-magnesium group according to the unadjusted linear regression analysis (β coefficient [95% confidence interval (CI)] 1.05 [0.19, 1.92], P = 0.017 for MoCA; 1.2 [0.46, 1.94], P = 0.002 for MMSE) and adjusted multivariate analysis with risk factors for dementia (β coefficient [95% CI] 1.12 [0.22, 2.02], P = 0.015 for MoCA; 0.92 [0.19, 1.65], P = 0.014 for MMSE).Conclusions: Higher serum magnesium levels might be associated with preserved cognitive function in hemodialysis patients. Conversely, significant associations were not observed between cognitive function and intact PTH, 25-OHD, FGF-23, or soluble α-klotho levels.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141491133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0