Clinical and Experimental Nephrology最新文献_第4页

Differences in employment and lifestyle situations between kidney transplant recipients and patients on hemodialysis: a nationwide questionnaire survey in Japan. 肾移植受者和血液透析患者的就业和生活方式差异：日本一项全国性问卷调查。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-23 DOI: 10.1007/s10157-025-02658-z

Tadashi Sofue, Shinichi Nakai, Naoki Nakagawa, Ken Sakai

{"title":"Differences in employment and lifestyle situations between kidney transplant recipients and patients on hemodialysis: a nationwide questionnaire survey in Japan.","authors":"Tadashi Sofue, Shinichi Nakai, Naoki Nakagawa, Ken Sakai","doi":"10.1007/s10157-025-02658-z","DOIUrl":"https://doi.org/10.1007/s10157-025-02658-z","url":null,"abstract":"Background: Kidney transplant recipients are reported to have more opportunities for employment compared with patients on hemodialysis. However, comparisons of employment and lifestyle situations between kidney transplant recipients and patients on hemodialysis in Japan are lacking.Methods: This cross-sectional study was conducted via a questionnaire survey in October and November 2023. The questionnaire covered patients' background, hospital visits, self-management, social assistance, and employment. Participants were members of the Japan Transplant Recipients Organization. We compared these participants with data from a survey of patients on hemodialysis conducted in September 2021 by the Japan Association of Dialysis Physicians.Results: Responses from 146 kidney transplant recipients were analyzed and compared with data for 7461 patients on hemodialysis. The overall employment rate for kidney transplant recipients was 41.0%, and was higher than that among patients on hemodialysis. Of the employed kidney transplant recipients, 67.8% worked at least 5 days per week, 45.8% had an annual income of more than 3 million yen, and 42.4% were in regular employment. The majority (78.7%) of kidney transplant recipients could visit hospital by themselves, with this proportion significantly higher than that among patients on hemodialysis. Substantially fewer kidney transplant recipients had been briefed by their hospital on disaster preparedness than patients on hemodialysis (20.4% vs. 53.2%).Conclusions: We evaluated current employment status among kidney transplant recipients in Japan through a questionnaire survey. Compatibility with work among kidney transplant recipients was relatively favorable compared with that among those on hemodialysis.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Comprehensive review of mitochondrial nephropathy-a renal phenotype in mitochondrial disease: causative genes, clinical and pathological features, diagnosis, prognosis, and treatment. 更正：线粒体肾病——线粒体疾病中的一种肾脏表型：致病基因、临床和病理特征、诊断、预后和治疗的综合综述。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-21 DOI: 10.1007/s10157-025-02665-0

Toshiyuki Imasawa, Kei Murayama, Daishi Hirano, Kandai Nozu

引用次数: 0

Need for life cycle assessment of pharmaceuticals for kidney healthcare. 肾脏保健药品生命周期评估的需求。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-19 DOI: 10.1007/s10157-025-02647-2

Kei Nagai, Keisuke Nansai

{"title":"Need for life cycle assessment of pharmaceuticals for kidney healthcare.","authors":"Kei Nagai, Keisuke Nansai","doi":"10.1007/s10157-025-02647-2","DOIUrl":"https://doi.org/10.1007/s10157-025-02647-2","url":null,"abstract":"Purpose: Global warming is a known risk factor for chronic kidney disease (CKD), and both progression of the disease and its treatment place a burden on the environment. Life cycle assessment (LCA) is an established method for evaluating the global impact of manufactured products, from materials' procurement to disposal. We aimed to examine available reports of its application to pharmaceuticals.Methods: A narrative review focused on LCA studies of any pharmaceuticals according to disease area.Results: We identified the drug types used for treatment of 13 disease areas described in 51 previous LCA studies, classified using the MIDAS database. Among the drug types, anesthetics, inhalants, and antibiotics have received the most attention. However, LCA studies are lacking for the wide range of pharmaceuticals used in kidney healthcare, in the fields of dialysis therapy, treatment of end-stage kidney disease, and associated cardiovascular, metabolic, and endocrine diseases.Discussion: As the proportion of the population affected by CKD increases, there is a particular urgency for LCA research into drugs administered for their kidney protective effects, such as renin--angiotensin system inhibitors and sodium-glucose cotransporter 2 inhibitors. As sustainable practices in drug production and the ability to identify and choose effective drugs with low environmental impact require comprehensive LCA data, clinical physicians and pharmacists involved in kidney healthcare should collaborate with pharmaceutical companies to develop an LCA research system . Incorporating rating of environmental burden of each drug into daily practice is desirable for achieving sustainable kidney healthcare and reducing its environmental impacts.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelsolin as a predictor of arteriovenous fistula maturation. Gelsolin作为动静脉瘘成熟的预测因子。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-19 DOI: 10.1007/s10157-025-02655-2

Rifat Ozmen, Cihan Uysal, Nevzat Herdem, Funda Ipekten, Inayet Gunturk, Aydin Tuncay, Okan Ozocak, Cevat Yazici, Ismail Kocyigit

{"title":"Gelsolin as a predictor of arteriovenous fistula maturation.","authors":"Rifat Ozmen, Cihan Uysal, Nevzat Herdem, Funda Ipekten, Inayet Gunturk, Aydin Tuncay, Okan Ozocak, Cevat Yazici, Ismail Kocyigit","doi":"10.1007/s10157-025-02655-2","DOIUrl":"https://doi.org/10.1007/s10157-025-02655-2","url":null,"abstract":"Background: Gelsolin is a key regulator of actin filament metabolism and plays a role in tissue remodeling. We evaluated plasma gelsolin (pGSN) in predicting arteriovenous fistula (AVF) maturation.Methods: Only patients with newly created radiocephalic AVF were included. pGSN and plasma F-actin levels were measured preoperatively. Maturation was defined as an access (cephalic) vein diameter > 5 mm and a fistula blood flow rate > 500 mL/min in ultrasound, 8 weeks after operation.Results: A total of 68 patients were analyzed with a mean age of 62.6 ± 11.1 years. AVF maturation was identified in 39 patients (57.3%). Mean pGSN level was 4726 (3836-6483) ng/mL in patients with mature AVF and 3237 (2895-4382) ng/mL in patients with immature AVF. pGSN levels were significantly higher (p < 0.001) in the mature AVF group. F-actin levels were not significantly different between two groups. pGSN levels positively correlated with fistula blood flows (r = 0.326, p = 0.007). Multivariate logistic regression analysis revealed that pGSN (p = 0.003) was determined to be an independent risk factor in predicting AVF maturation. Preoperative pGSN levels were significantly predictive of AVF maturation in the ROC analysis. Sensitivity and specificity of pGSN were 82.1% and 58.6%, respectively, with a cut-off value of > 3716 ng/mL and an area under the ROC curve of 0.75 (95% CI: 0.64-0.87, p < 0.001).Conclusion: Current results demonstrated that patients with mature AVFs had significantly higher preoperative pGSN levels compared to those with immature AVFs. Outcomes suggest that pGSN could serve as a predictive biomarker for AVF maturation.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of arginine vasopressin receptor 2-deficient rats by the rGONAD method. 用 rGONAD 方法构建精氨酸加压素受体 2 缺失大鼠。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-18 DOI: 10.1007/s10157-025-02652-5

Ayaka Kamada, Takuo Hirose, Shigemitsu Sato, Chika Takahashi, Takahito Kaburaki, Kaori Sato, Risa Ishikawa, Akari Endo, Hiroki Ito, Ikuko Oba-Yabana, Hannah Nakamura, Makoto Matsuyama, Takefumi Mori

{"title":"Construction of arginine vasopressin receptor 2-deficient rats by the rGONAD method.","authors":"Ayaka Kamada, Takuo Hirose, Shigemitsu Sato, Chika Takahashi, Takahito Kaburaki, Kaori Sato, Risa Ishikawa, Akari Endo, Hiroki Ito, Ikuko Oba-Yabana, Hannah Nakamura, Makoto Matsuyama, Takefumi Mori","doi":"10.1007/s10157-025-02652-5","DOIUrl":"https://doi.org/10.1007/s10157-025-02652-5","url":null,"abstract":"Background: Congenital nephrogenic diabetes insipidus (NDI) is a hereditary disease characterized by a reduced response to arginine vasopressin in the renal collecting duct. NDI is primarily caused by mutations in the arginine vasopressin receptor 2 (AVPR2). Several animal models have been developed for congenital NDI; however, the appropriate models are limited. Thus, we constructed a novel Avpr2-deficient rat model using gene-editing technology to study the pathophysiological mechanisms of NDI.Methods: Avpr2-deficient rats were generated via a novel genome editing approach termed the rat Genome-editing via Oviductal Nucleic Acid Delivery (rGONAD) method. The phenotypes were analyzed using biological, molecular, and histological examinations. The effects of hydrochlorothiazide (40 mg/kg/d) on 24-h water intake, urine volume, and urine osmolality were evaluated in a metabolic cage.Results: Avpr2-deficient rats were born and weaned under normal rearing conditions and exhibited symptoms similar to those of human congenital NDI, such as polydipsia, polyuria, and growth retardation. Although they exhibited hydronephrosis-like kidneys, no glomerular or tubular damage was observed. Aquaporin-2 was retained in the cytoplasm of collecting duct cells, and its phosphorylation was suppressed. Administration of hydrochlorothiazide decreased urine volume and improved urine osmolality in Avpr2-deficient rats.Conclusions: Avpr2-deficient rats are a reliable model of congenital NDI for elucidating the underlying mechanisms and identifying therapeutic targets.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of prepared vascular access on mortality and medical expenses in elderly and non-elderly Japanese patients with chronic kidney disease stage G5: a retrospective cohort study. 准备好的血管通路对日本老年和非老年慢性肾病 G5 期患者死亡率和医疗费用的影响：一项回顾性队列研究。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-18 DOI: 10.1007/s10157-025-02654-3

Takayuki Nimura, Makoto Harada, Daiki Aomura, Kosuke Yamaka, Koji Hashimoto, Yuji Kamijo

{"title":"Impact of prepared vascular access on mortality and medical expenses in elderly and non-elderly Japanese patients with chronic kidney disease stage G5: a retrospective cohort study.","authors":"Takayuki Nimura, Makoto Harada, Daiki Aomura, Kosuke Yamaka, Koji Hashimoto, Yuji Kamijo","doi":"10.1007/s10157-025-02654-3","DOIUrl":"https://doi.org/10.1007/s10157-025-02654-3","url":null,"abstract":"Background: Patients with chronic kidney disease (CKD) stage 5 (CKDG5) have greater dialysis requirements that increase the risk of cardiovascular disease and mortality. The elevated costs associated with CKDG5 are a serious concern. The impact of prepared vascular access (VA) through planned VA creation on mortality and medical expenses remains unclear in Japanese patients with CKDG5.Methods: We conducted a retrospective cohort study including 157 patients with CKD who started hemodialysis (HD) at Shinshu University Hospital from April 2016 to March 2021 and assessed the relationship between the presence of a prepared VA and mortality and hospitalization expenses in elderly and non-elderly patients with CKDG5.Results: The presence of a prepared VA was associated with lower mortality in non-elderly patients but not in elderly patients. Medical expenses, emergency HD, and hospitalization duration were significantly lower in patients with a prepared VA in both age groups. The contribution of a prepared VA to mortality and medical expenses remained consistent after adjusting for sex, performance status, comorbidities, and nutritional status.Conclusion: A prepared VA showed several benefits, including lower mortality rates and hospitalization costs; shorter hospital stays; and higher home discharge rates. Planned VA creation was significantly associated with lower hospitalization expenses, irrespective of age.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-transplant tacrolimus fluctuations predict BK virus infection risk in kidney transplants. 移植前他克莫司波动预测肾移植患者BK病毒感染风险

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-17 DOI: 10.1007/s10157-025-02649-0

Hisashi Sakurai, Teppei Okamoto, Anna Yonemaya, Fumiya Yonemaya, Tomoko Hamaya, Hirotake Kodama, Naoki Fujita, Hayato Yamamoto, Kazuyuki Mori, Takeshi Fujita, Atushi Imai, Reiichi Murakami, Hirofumi Tomita, Shingo Hatakeyama, Chikara Ohyama

{"title":"Pre-transplant tacrolimus fluctuations predict BK virus infection risk in kidney transplants.","authors":"Hisashi Sakurai, Teppei Okamoto, Anna Yonemaya, Fumiya Yonemaya, Tomoko Hamaya, Hirotake Kodama, Naoki Fujita, Hayato Yamamoto, Kazuyuki Mori, Takeshi Fujita, Atushi Imai, Reiichi Murakami, Hirofumi Tomita, Shingo Hatakeyama, Chikara Ohyama","doi":"10.1007/s10157-025-02649-0","DOIUrl":"https://doi.org/10.1007/s10157-025-02649-0","url":null,"abstract":"Background: BK virus (BKV) infection is a significant complication in kidney transplant recipients, potentially leading to graft loss. The relationship between pre-transplant tacrolimus (TAC) pharmacokinetics and BKV infection risk remains unclear. This study aimed to investigate whether pre-transplant TAC blood concentration fluctuations are associated with BKV infection risk.Methods: We conducted a retrospective study of 135 living donor kidney transplant recipients at Hirosaki University between 2006 and March 2024. Patients were divided into BKV-infected (BKV) and non-infected (non-BKV) groups. TAC blood concentrations were measured at 4 points, including 0 h (2 h before TAC administration), 4, 6, and 12 h on the day before transplantation. Changes in TAC concentration from baseline (0 h) were calculated for each time point. The concentration/dose (C0/D) ratio was used as an indicator of TAC metabolism rate.Results: During a median follow-up of 54 months, 29 recipients developed BKV infection. The BKV group had significantly older donors and showed a significantly larger decrease in TAC concentration at 12 h compared to the non-BKV group (-1.5 vs. 0 ng/mL, P = 0.008). There was no significant difference in pre-transplant C0/D ratios between the two groups. A decrease of ≥ 1.5 ng/mL at 12 h was identified as a significant risk factor for BKV infection (hazard ratio: 2.44, 95% confidence interval: 1.11-5.32, P = 0.026) in a propensity score-based inverse probability of treatment weighting multivariate Cox proportional hazards analysis.Conclusion: Pre-transplant TAC blood concentration fluctuations, particularly a large decrease at 12 h from baseline, may be associated with increased BKV infection risk.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic aspects of pediatric nephrotic syndrome and anti-nephrin antibodies. 小儿肾病综合征和抗肾素抗体的遗传学问题。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-14 DOI: 10.1007/s10157-025-02645-4

Tomoko Horinouchi, Kandai Nozu, Kazumoto Iijima

引用次数: 0

Booster effect of the fourth dose of the SARS-CoV-2 mRNA vaccine in kidney transplant recipients. 肾移植受者接种第四剂 SARS-CoV-2 mRNA 疫苗的增效作用。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-11 DOI: 10.1007/s10157-025-02651-6

Ayaka Hayashi, Mayuko Kawabe, Izumi Yamamoto, Yutaro Ohki, Akimitsu Kobayashi, Fumihiko Urabe, Jun Miki, Hiroki Yamada, Nanae Matsuo, Yudo Tanno, Tetsuya Horino, Ichiro Ohkido, Takahiro Kimura, Hiroyasu Yamamoto, Takashi Yokoo

{"title":"Booster effect of the fourth dose of the SARS-CoV-2 mRNA vaccine in kidney transplant recipients.","authors":"Ayaka Hayashi, Mayuko Kawabe, Izumi Yamamoto, Yutaro Ohki, Akimitsu Kobayashi, Fumihiko Urabe, Jun Miki, Hiroki Yamada, Nanae Matsuo, Yudo Tanno, Tetsuya Horino, Ichiro Ohkido, Takahiro Kimura, Hiroyasu Yamamoto, Takashi Yokoo","doi":"10.1007/s10157-025-02651-6","DOIUrl":"https://doi.org/10.1007/s10157-025-02651-6","url":null,"abstract":"Background: Solid organ transplant recipients taking immunosuppressive drugs are at greater risk of severe COVID-19 than the general population. In particular, kidney transplant recipients (KTRs) are known to have lower seropositivity after basal doses of SARS-CoV-2 vaccines, and the strategy of administering booster doses in these immunocompromised individuals has been promoted worldwide.Methods: This study evaluated the effect of a fourth dose (D4) of SARS-CoV-2 vaccine in Japanese KTRs. Anti-spike (anti-S) IgG antibody titers at 1 and 3 months after D4 of SARS-CoV-2 vaccine were evaluated in 75 KTRs.Results: The median anti-S IgG antibody titers at 1 and 3 months after D4 were 4728.1 (interquartile range [IQR]: 643.2-13,953.1) AU/mL and 3778 (IQR: 642-9436.6) AU/mL, respectively. The seropositivity rate after D4 was 85.1% at 1 month and 83.1% at 3 months, and the seroconversion rate was 28.6% (4 of 14 KTRs seronegative after the third dose). Factors associated with poor humoral responses were shorter time post-transplant to infection, a higher mycophenolate mofetil dose, a lower lymphocyte count, and a lower estimated glomerular filtration rate.Conclusion: This study demonstrates some efficacy of D4 of SARS-CoV-2 vaccine in KTRs who are seronegative after three doses and encourages consideration of further booster doses of the SARS-CoV-2 vaccine.","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A digest of the clinical practice guideline for pediatric idiopathic nephrotic syndrome 2020 updated: medical therapy. 儿科特发性肾病综合征临床实践指南摘要2020更新：药物治疗。

IF 2.2 4区医学

Clinical and Experimental Nephrology Pub Date : 2025-03-10 DOI: 10.1007/s10157-025-02636-5

Riku Hamada, Yoshitsugu Kaku, Aya Inaba, Hiroshi Kaito, Takahisa Kimata, Shuji Kondo, Mayumi Sako, Mai Sato, Keisuke Sugimoto, Seiji Tanaka, Yoshinobu Nagaoka, Kandai Nozu, Junya Hashimoto, Kenichiro Miura, Masaki Yamamoto, Fujimi Kawai, Shoichi Maruyama, Kenji Ishikura

引用次数: 0