Clinical and Experimental Nephrology最新文献

{"title":"Comparison of seroconversion rates after hepatitis B vaccination in patients with advanced chronic kidney disease and those receiving maintenance hemodialysis.","authors":"Tomoyuki Fujikura, Shinsuke Isobe, Shigeru Oikawa, Sayaka Ishigaki, Naoko Katahashi, Takamasa Iwakura, Naro Ohashi, Akihiko Kato, Hideo Yasuda","doi":"10.1007/s10157-025-02648-1","DOIUrl":"https://doi.org/10.1007/s10157-025-02648-1","url":null,"abstract":"<p><strong>Background: </strong>Patients receiving dialysis are at an increased risk of hepatitis B virus (HBV) infection due to a compromised immune system. While HBV vaccination is recommended, the response rate to the standard vaccination regimen (3 doses of 10 µg HBV vaccine) among patients with chronic kidney disease (CKD) or receiving hemodialysis in Japan is unclear. This study evaluated the seroconversion rate, optimal timing, and CKD stage in patients receiving HBV vaccination.</p><p><strong>Methods: </strong>In this prospective, observational study conducted from May 2021 to July 2024, patients with advanced CKD not on dialysis and those receiving maintenance hemodialysis at two centers in Japan received 3 doses of 10 µg HBV vaccine at 0, 1, and 6 months. The primary outcome was the seroconversion rate, defined as anti-HBs antibody levels of ≥10 IU/mL, measured 1-3 months after the third dose.</p><p><strong>Results: </strong>Overall, 113 participants (63 with non-dialysis CKD and 50 with hemodialysis CKD) were included. The seroconversion rates were 64.3% in non-dialysis patients and 54.2% in patients on hemodialysis, with no significant difference (OR = 0.62, 95% CI 0.28-1.38). Multivariate analysis adjusting for covariates showed no significant difference (OR = 0.74, 95% CI 0.29-1.91), and sensitivity analysis confirmed this finding.</p><p><strong>Conclusions: </strong>The seroconversion rate of the standard HBV vaccination (3×10 µg) was not significantly different from those in non-dialysis patients with CKD. More effective vaccination strategies such as higher doses, third-generation vaccines, or vaccination at an earlier CKD stage are required to improve HBV protection in this population.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term need and potential for withdrawal of enteral feeding in children with chronic kidney disease stage 5D or 5T.","authors":"Kei Osaka, Kentaro Nishi, Yuta Inoki, Satoshi Okada, Tomoya Kaneda, Misaki Akiyama, Masao Ogura, Koichi Kamei","doi":"10.1007/s10157-025-02650-7","DOIUrl":"https://doi.org/10.1007/s10157-025-02650-7","url":null,"abstract":"<p><strong>Background: </strong>Children with chronic kidney disease (CKD) stage 5 may require long-term enteral tube feeding. However, the factors associated with the need for tube feeding and the potential for its withdrawal are unclear.</p><p><strong>Methods: </strong>This single-center, retrospective cohort study included patients with CKD stage 5D or 5T aged <18 years between 2004 and 2021. We evaluated data on the initiation of enteral tube feeding and its associated factors, the potential and timing of the withdrawal of enteral tube feeding, and improvements in feeding difficulties before and after kidney transplantation.</p><p><strong>Results: </strong>Of the 58 study participants, 33 (57%) received enteral tube feeding for more than 1 month. After adjusting for males and major congenital complications, logistic regression analyses identified a younger age at the initiation of kidney replacement therapy as a factor associated with the need for enteral tube feeding (odds ratio: 1.82, 95% confidence interval: 1.28‒2.56, P < 0.001). During the study period, enteral tube feeding was withdrawn from 24 of the 33 (73%) children (withdrawal rates: 2 years, 26%; 3 years, 50%; and 5 years, 66%). Of the nine patients in whom enteral tube feeding was not withdrawn before kidney transplantation, six underwent withdrawal at 0.1, 0.1, 1.1, 1.6, 2.9, and 3.3 years after kidney transplantation, respectively. The remaining three patients continued enteral tube feeding after kidney transplantation.</p><p><strong>Conclusions: </strong>Although withdrawal from enteral nutrition is difficult in children with CKD stage 5D or 5T, it may be possible with kidney transplantation or over time.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of monoclonal gammopathy in the progression of acute kidney injury and chronic kidney disease: a retrospective observational study.","authors":"Keita Mitani, Taro Horino, Yoshio Terada, Yoshiyasu Okuhara, Yutaka Hatakeyama","doi":"10.1007/s10157-024-02571-x","DOIUrl":"10.1007/s10157-024-02571-x","url":null,"abstract":"<p><strong>Background: </strong>The involvement of monoclonal immunoglobulin (MIg) in renal damage in patients with haematological disorders and renal biopsy-proven monoclonal gammopathy of renal significance is well established. However, no epidemiological studies have been conducted on the effects of MIg on renal function in other patients. We aimed to evaluate the renal prognosis of MIg-positive patients and the effects of MIg on renal function.</p><p><strong>Methods: </strong>This retrospective observational study was performed using clinical data from all outpatients and inpatients who underwent MIg measurements at the time of enrolment at Kochi Medical School Hospital between 1 January 2017 and 31 December 2021. The primary outcomes were the occurrence of acute kidney injury (AKI) and a decline of > 30% in the estimated glomerular filtration rate (eGFR).</p><p><strong>Results: </strong>Among the 1362 patients, 750 were included in our cohort. The number of MIg-positive and MIg-negative patients was 119 (15.9%) and 631 (84.1%), respectively. In addition, the MIg-positive patients were significantly older than the MIg-negative patients. The survival probability of the MIg-positive group was significantly lower than that of the MIg-negative group during the 2 year observation period. The risk factors for the primary endpoint were positive MIg, female sex, lower eGFR, and lower albumin level.</p><p><strong>Conclusions: </strong>Our study showed that the presence of MIg was an independent risk factor for renal damage. Therefore, we suggest that MIg-positive patients require careful follow-up of their renal function, even in the absence of a clear underlying disease, such as multiple myeloma.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"283-291"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the prevalence of chronic kidney disease in the older population using health screening data in Japan.","authors":"Arisa Kobayashi, Keita Hirano, Tadahisa Okuda, Tatsuyoshi Ikenoue, Takashi Yokoo, Shingo Fukuma","doi":"10.1007/s10157-024-02570-y","DOIUrl":"10.1007/s10157-024-02570-y","url":null,"abstract":"<p><strong>Background: </strong>In aging societies, the prevalence of chronic kidney disease (CKD) is expected to increase but may be underestimated because many asymptomatic patients remain undiagnosed. This study aimed to estimate the CKD prevalence among the general older population in Japan.</p><p><strong>Methods: </strong>This cross-sectional study used health screening data from the Japan Health Insurance Association collected between April 2014 and March 2023. Data from older people aged 65-90 years who underwent renal function screening for estimated glomerular filtration rate (eGFR) and urine protein tests were analyzed. CKD was defined as eGFR < 60 mL/min/1.73 m² or proteinuria ≥ 1 + . Inverse probability weighting was used to account for the selection bias. The variables used for weighting were age, sex, insurance status, and the number of previous screenings.</p><p><strong>Results: </strong>Among 2.98 million older individuals, 588,809 (19.7%) had undergone screening (median [IQR] age, 69.9 [67.9-76.2] years, 337,862 women [57.4%]). Regarding the weighted CKD prevalence, 25.3% of the individuals aged 65-90 years had CKD; 11.8% of those aged 65-75 years and 34.6% of those aged 75 years and over showed an increase in prevalence with age. Among the patients with CKD, over half exhibited mild renal dysfunction without proteinuria. Hypertension and diabetes were common comorbidities in older patients with CKD.</p><p><strong>Conclusions: </strong>This cross-sectional study revealed that the weighted prevalence of CKD in the older population aged 65-90 years was high (one in four individuals), indicating that it increases with age. Further studies are required to examine the clinical significance of these findings.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"276-282"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893708/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney lesions and risk of cardiovascular events in biopsy-proven diabetic kidney disease with type 2 diabetes.","authors":"Miho Shimizu, Kengo Furuichi, Tadashi Toyama, Masayuki Yamanouchi, Daiki Hayashi, Akihiko Koshino, Keisuke Sako, Keisuke Horikoshi, Takahiro Yuasa, Akira Tamai, Taichiro Minami, Megumi Oshima, Shiori Nakagawa, Shinji Kitajima, Ichiro Mizushima, Akinori Hara, Norihiko Sakai, Kiyoki Kitagawa, Mitsuhiro Yoshimura, Junichi Hoshino, Yoshifumi Ubara, Yasunori Iwata, Takashi Wada","doi":"10.1007/s10157-024-02576-6","DOIUrl":"10.1007/s10157-024-02576-6","url":null,"abstract":"<p><strong>Background: </strong>This study assessed the association of pathological kidney lesions with cardiovascular events in biopsy-proven diabetic kidney disease (DKD) with type 2 diabetes.</p><p><strong>Methods: </strong>This multicenter, retrospective study involved 244 patients with no previous cardiovascular events before biopsy, estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m² at biopsy (baseline), and ≥ 1 year of observation after biopsy. The outcomes were the first occurrence of cardiovascular events (cardiovascular death, non-fatal myocardial infarction, coronary intervention, or non-fatal stroke), and non-cardiovascular deaths before cardiovascular events were considered competing events. The association between the severity of each pathological lesion and cardiovascular events was investigated.</p><p><strong>Results: </strong>During follow-up (median: 6.4 years), 43 patients experienced cardiovascular events. The baseline clinical characteristics did not differ according to cardiovascular events. The cumulative incidence of cardiovascular events was higher in patients with mesangiolysis, global glomerulosclerosis ≥ 50%, moderate/severe interstitial inflammation, and moderate/severe arteriolar hyalinosis than in those having less advanced each lesion. Fine-Gray regression models revealed that global glomerulosclerosis ≥ 50% (subdistribution hazard ratio [SHR]: 3.85; 95% confidence interval [95% CI] 1.28-11.52), moderate/severe interstitial inflammation (SHR: 2.49; 95% CI 1.18-5.29), and moderate/severe arteriolar hyalinosis (SHR: 3.51; 95% CI 1.15-10.69) were linked to increased risk of cardiovascular events, after adjusting for clinical variables including RAAS inhibitors use at baseline. Adding the severity of these lesions to clinical variables improved the predictive value for cardiovascular events.</p><p><strong>Conclusions: </strong>In DKD with type 2 diabetes, advanced glomerulosclerosis, interstitial inflammation, and arteriolar hyalinosis were associated with cardiovascular events, adding predictive value to clinical features.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"376-386"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of monoclonal immunoglobulin-associated renal disease: a retrospective cohort study.","authors":"Toshiyuki Narimiya, Hiroki Hayashi, Soshiro Ogata, Shigeo Hara, Akinao Okamoto, Kazuo Takahashi, Shigehisa Koide, Daijo Inaguma, Midori Hasegawa, Akihiro Tomita, Yukio Yuzawa, Naotake Tsuboi","doi":"10.1007/s10157-024-02552-0","DOIUrl":"10.1007/s10157-024-02552-0","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical epidemiological data on monoclonal gammopathy of renal significance (MGRS) are lacking. In this retrospective observational study, MGRS was compared with B-cell or plasma cell malignancies (BCM/PCM) with renal involvement to clarify differences in their clinical features.</p><p><strong>Methods: </strong>Among the 1408 renal biopsies performed at our hospital, 25 MGRS and 18 BCM/PCM patients were identified. We investigated baseline characteristics and hematologic parameters of MGRS in reference to BCM/PCM using multivariable analysis. Cox proportional hazards analysis was performed for end-stage kidney disease (ESKD) and all-cause mortality.</p><p><strong>Results: </strong>Comparing the MGRS with the BCM/PCM, mean differences in creatinine level, estimated glomerular filtration rate, and clonal bone marrow plasma cell percentage were - 2.76 mg/dL, 27.72 mL/min/1.73 m², and - 18.86%, respectively (all P < 0.001). MGRS group had a predominance of glomerular lesions such as immunoglobulin-associated amyloidosis, cryoglobulinemic GN, and MIDD, and a lower risk of acute kidney injury/acute renal disease compared to BCM/PCM. During a median observation period of 23.7 months, clone-directed therapy was performed in 32.0% of patients in the MGRS group, compared to 83.3% of patients in the BCM/PCM group. Compared with BCM/PCM, MGRS had a hazard ratio of 0.66 (95% confidence interval (CI) 0.23-1.92, P = 0.45) for ESKD and 0.33 (95% CI 0.11-1.03, P = 0.06) for death in multivariate logistic regression analysis.</p><p><strong>Conclusions: </strong>The clinical characteristics of MGRS and BCM/PCM with monoclonal immunoglobulin-associated renal disease are disparate. Understanding these differences is crucial for developing tailored clinical approaches and therapeutic strategies to improve patient outcome.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"259-268"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective randomized trial of antibiotic prophylaxis for percutaneous renal biopsy.","authors":"Kensei Yahata, Kenichi Koga, Daisuke Hirai, Koichi Seta, Keita P Mori, Yoshiaki Higashi, Tatsuo Tsukamoto, Akira Ishii, Keiichi Kaneko, Motoko Yanagita, Chiharu Kinoshita, Keisuke Osaki, Akihiro Yoshimoto, Hiroaki Hata, Naoki Sakane","doi":"10.1007/s10157-024-02553-z","DOIUrl":"10.1007/s10157-024-02553-z","url":null,"abstract":"<p><strong>Background: </strong>Infection is a rare complication of percutaneous renal biopsy (RB). However, the questionnaire included in the Kidney Biopsy Guidebook 2020 in Japan revealed that antibiotic prophylaxis (AP) was administered at about 60% of hospitals. The objective of this study was to evaluate whether it is possible to omit AP for RB.</p><p><strong>Methods: </strong>Patients aged ≥ 15 years were eligible. Three hundred and sixty-four patients were recruited at 6 hospitals. The patients were randomly assigned to receive either a single dose of intravenous cefazolin or no antibiotic prophylaxis. The primary outcome was the percentage of patients that exhibited positive urine cultures 3 or 4 days after the RB. The secondary outcomes were the percentage of patients who were diagnosed with pyelonephritis, puncture site infections (PSI), or an infection other than pyelonephritis or PSI within 30 days, and cefazolin-induced side effects.</p><p><strong>Results: </strong>With regard to the primary outcome, there was no statistically significant difference between the cefazolin group and the no AP group (2.9% versus 5.1%, p = 0.416). With regard to the secondary outcomes, only one patient (who belonged to no AP group) developed pyelonephritis. This patient underwent urinary catheterization. No PSI occurred. There were no significant intergroup differences in any secondary outcomes.</p><p><strong>Conclusion: </strong>This study revealed the incidence of post-percutaneous RB infections was minimal. Although the outcomes of this study did not lead to the conclusion that it is unnecessary to use AP for RB, the obtained data suggest that the effects of such AP may not be clinically significant.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"269-275"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of valganciclovir prophylaxis in kidney transplant recipients following low-dose rituximab induction therapy: a multicenter retrospective study.","authors":"Tomohiro Takehara, Hayato Nishida, Kazunobu Ichikawa, Takaaki Nawano, Satoshi Takai, Hiroki Fukuhara, Tomohiko Matsuura, Shinya Maita, Mitsuru Saito, Reiichi Murakami, Shingo Hatakeyama, Wataru Obara, Hisao Saitoh, Chikara Ohyama, Tomonori Habuchi, Masafumi Watanabe, Norihiko Tsuchiya","doi":"10.1007/s10157-024-02578-4","DOIUrl":"10.1007/s10157-024-02578-4","url":null,"abstract":"<p><strong>Background: </strong>Rituximab (RIT) induction therapy is widely used for desensitization against ABO-incompatible living-donor kidney transplants (KT). However, the efficacy of valganciclovir (VGCV) prophylaxis against cytomegalovirus (CMV) disease and infection in KT recipients (KTRs) following RIT induction remains unclear.</p><p><strong>Methods: </strong>The current multicenter retrospective study included 213 KTRs who received low-dose RIT induction between 1998 and 2021, across 6 facilities included in the Michinoku Renal Transplant Network (MRTN). VGCV dosage varied from 450 mg/day (twice weekly) to 900 mg/day (daily), with treatment durations of 3-12 months. The primary and secondary endpoints were the incidence of CMV disease and infection, respectively.</p><p><strong>Results: </strong>The incidence of CMV disease was significantly higher in the VGCV group (23.5%; 16 patients) than in the non-VGCV group (5.5%; 8 patients) (p < 0.01). The incidence of CMV infection was 54.5% (79 patients) in the non-VGCV group and 48.5% (33 patients) in the VGCV group, with no significant difference (p = 0.42). In the subgroup of CMV-seronegative KTRs receiving allografts from CMV-seropositive donors (CMV IgG (D + /R-)), 18 out of 24 KTRs received VGCV prophylaxis, of whom 10 (55.6%) developed CMV disease. Within this subgroup, only 4 KTRs received VGCV with the standard protocol (900 mg daily for 6 months), and none developed CMV disease.</p><p><strong>Conclusion: </strong>Insufficient VGCV prophylaxis does not reduce the incidence of CMV disease in KTRs following low-dose RIT induction. Despite concerns about leukopenia due to RIT and VGCV, in KTRs with CMV IgG (D + /R-) serostatus, VGCV prophylaxis with a standard protocol may be advisable.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"359-367"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescents and parents' knowledge of chronic kidney disease: the potential of school-based education.","authors":"Junko Nakamura, Ryohei Kaseda, Mizuki Takeuchi, Kou Kitabayashi, Ichiei Narita","doi":"10.1007/s10157-024-02574-8","DOIUrl":"10.1007/s10157-024-02574-8","url":null,"abstract":"<p><strong>Background: </strong>Preventing the progression of chronic kidney disease (CKD), reducing the incidence of new dialysis patients, and increasing public awareness about CKD are pivotal in mitigating renal impairment. This study aimed to assess the relevance of kidney disease and CKD knowledge among junior high school students and their parents.</p><p><strong>Methods: </strong>A questionnaire survey on kidney function and CKD was conducted among students aged 14-15 years and their parents (851 pairs). Parents were also asked about their age, sex, and participation in health checkups.</p><p><strong>Results: </strong>The study achieved a collection rate of 49.1%, with a valid response rate of 79.7%. Both junior high school students and their parents exhibited limited knowledge about kidney functions, primarily understanding these functions only in terms of waste product excretion and lacking awareness of other functions. A significant positive correlation was observed in awareness of kidney functions between students and their parents. Regarding CKD awareness, only 2.4% of students and 16.5% of parents were knowledgeable about CKD itself, while 18.9% of students and 45.3% of parents were aware of its name only. Importantly, CKD knowledge among both students and parents was associated, with those aware of CKD also demonstrating better understanding of kidney functions.</p><p><strong>Conclusion: </strong>This study highlights inadequate knowledge among junior high school students and their parents regarding renal function and CKD. A significant correlation was observed in CKD awareness between students and their parents. These findings underscore the need for targeted strategies to enhance public education and awareness about kidney health.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"292-300"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of communication environment and health literacy of patients on chronic hemodialysis: a multicenter observational study (SMEL-HD study).","authors":"Chieko Hamada, Junko Kuwamura, Mitsumine Fukui, Isao Ohsawa, Yuuya Nakamura, Shigenobu Suzuki, Fukuji Takeda, Reo Kanda, Atsuko Urita, Yasuhiko Tomino","doi":"10.1007/s10157-024-02572-w","DOIUrl":"10.1007/s10157-024-02572-w","url":null,"abstract":"<p><strong>Background: </strong>The ability to access health and medical information have implications for prognosis and quality of life. This study investigated the current communication environment and health literacy in chronic hemodialysis (HD) patients and their associations with patients' physical condition and clinical findings.</p><p><strong>Methods: </strong>This was a cross-sectional, single-arm, multicenter exploratory study. Data were collected from 211 patients (64 males) undergoing chronic HD at five facilities. This included a survey of communication environments, health literacy, dialysis management information, and clinical findings.</p><p><strong>Results: </strong>Among the participants, 145 (68.7%) reported using the Internet. They primarily collected health-related as well as everyday life information through the Internet. Health literacy fell within the problematic range. In terms of e-Health literacy, \"understanding\" and \"easy\" showed a positive trend, while \"accessing,\" \"appraising,\" and \"applying\" were perceived as \"difficult.\" Three groups were identified based on Internet usage: good communication environment (CE) group (134 participants), poor-CE group (56 participants), and a group that did not respond (21 participants). Grip strength, serum albumin level, and \"information acquisition\" were significantly lower in the poor-CE group. Health literacy increases as the duration of dialysis extends, and decreases with advancing age.</p><p><strong>Conclusions: </strong>Patients who used the Internet gained a wide range of information, including health-related information, for their daily lives. The use of ICT is lower among patients with decreased physical activity, and further investigation is desired into how actively encouraging these patients to collect health information via the Internet can enhance their health literacy.</p>","PeriodicalId":10349,"journal":{"name":"Clinical and Experimental Nephrology","volume":" ","pages":"322-331"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}