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OA-09 Mezigdomide Enhances Activity of BCMA-Targeted Cellular and T-Cell Engager Therapies and Mitigates Immune Toxicity in Preclinical Models of Multiple Myeloma OA-09 麦吉多米德能增强多发性骨髓瘤临床前模型中 BCMA 靶向细胞疗法和 T 细胞诱导疗法的活性并减轻免疫毒性
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01850-0
Marta Larrayoz, Chad Chad Bjorklund, Maddalen Jimenez, Teresa Lozano, Sonia Sanz, Elena Arriazu, Rebecca Zon, Juan Roberto Rodríguez-Madoz, Bruno Paiva, Paula Rodríguez-Otero, Jesús San-Miguel, Felipe Prósper, Juan Jose Lasarte, Benjamin Ebert, Patrick Hagner, Jose Angel Martinez-Climent
{"title":"OA-09 Mezigdomide Enhances Activity of BCMA-Targeted Cellular and T-Cell Engager Therapies and Mitigates Immune Toxicity in Preclinical Models of Multiple Myeloma","authors":"Marta Larrayoz, Chad Chad Bjorklund, Maddalen Jimenez, Teresa Lozano, Sonia Sanz, Elena Arriazu, Rebecca Zon, Juan Roberto Rodríguez-Madoz, Bruno Paiva, Paula Rodríguez-Otero, Jesús San-Miguel, Felipe Prósper, Juan Jose Lasarte, Benjamin Ebert, Patrick Hagner, Jose Angel Martinez-Climent","doi":"10.1016/S2152-2650(24)01850-0","DOIUrl":"10.1016/S2152-2650(24)01850-0","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Pages S6-S7"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-10 Impaired Membrane Trafficking of GPRC5D Mediates Resistance to Anti-GPRC5D TCE OA-10 GPRC5D 的膜运输受损介导了对抗肿瘤药物 GPRC5D TCE 的耐药性
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01851-2
Holly Lee, Sungwoo Ahn, Noemie Leblay, Bachisio Ziccheddu, Marietta Truger, Michael Durante, Elie Barakat, Mansour Poorebrahim, David Jung, Ola Landgren, Hermann Einsele, K. Martin Kortüm, Jean Baptiste Alberge, Leo Rasche, Francesco Maura, Paola Neri, Nizar J. Bahlis
{"title":"OA-10 Impaired Membrane Trafficking of GPRC5D Mediates Resistance to Anti-GPRC5D TCE","authors":"Holly Lee, Sungwoo Ahn, Noemie Leblay, Bachisio Ziccheddu, Marietta Truger, Michael Durante, Elie Barakat, Mansour Poorebrahim, David Jung, Ola Landgren, Hermann Einsele, K. Martin Kortüm, Jean Baptiste Alberge, Leo Rasche, Francesco Maura, Paola Neri, Nizar J. Bahlis","doi":"10.1016/S2152-2650(24)01851-2","DOIUrl":"10.1016/S2152-2650(24)01851-2","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Page S7"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-22 A Single-Cell Atlas of Bone Marrow Immune Microenvironment Characterizes Dysregulation Associated With Multiple Myeloma Outcomes OA-22 骨髓免疫微环境单细胞图谱描述了与多发性骨髓瘤结局相关的失调特征
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01863-9
Chaitanya Acharya, William Pilcher, Lijun Yao, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Dimitra Karagkouni, Marina Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia Wang, Sarthak Sathpathy, Yuling Ma, Jessica Schulman, Immune Network, Sagar Lonial, David Avigan, Swati Bhasin, Hearn Cho, Taxiarchis Kourelis, George Mulligan
{"title":"OA-22 A Single-Cell Atlas of Bone Marrow Immune Microenvironment Characterizes Dysregulation Associated With Multiple Myeloma Outcomes","authors":"Chaitanya Acharya, William Pilcher, Lijun Yao, Edgar Gonzalez-Kozlova, Yered Pita-Juarez, Dimitra Karagkouni, Marina Michaud, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia Wang, Sarthak Sathpathy, Yuling Ma, Jessica Schulman, Immune Network, Sagar Lonial, David Avigan, Swati Bhasin, Hearn Cho, Taxiarchis Kourelis, George Mulligan","doi":"10.1016/S2152-2650(24)01863-9","DOIUrl":"10.1016/S2152-2650(24)01863-9","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Page S15"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-017 Impact of Genetic Ancestry on Outcomes and Toxicity of Ide-cel in Patients with Relapsed/Refractory Multiple Myeloma (RRMM) P-017 遗传血统对复发性/难治性多发性骨髓瘤（RRMM）患者服用伊达凯（Ide-cel）治疗效果和毒性的影响
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01920-7
Christen Dillard, Michelle Hildebrandt, Hans Lee, Nilesh Kalariya, Naveen Subramanian, Oren Pasvolsky, Christopher Ferreri, Mahmoud Gaballa, Sheeba Thomas, Donna Weber, Melody Becnel, Gregory Kaufman, Jessica Chen, Misha Hawkins, Michelly Abreu, Muzaffar Qazilbash, Robert Orlowski, Krina Patel
{"title":"P-017 Impact of Genetic Ancestry on Outcomes and Toxicity of Ide-cel in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)","authors":"Christen Dillard, Michelle Hildebrandt, Hans Lee, Nilesh Kalariya, Naveen Subramanian, Oren Pasvolsky, Christopher Ferreri, Mahmoud Gaballa, Sheeba Thomas, Donna Weber, Melody Becnel, Gregory Kaufman, Jessica Chen, Misha Hawkins, Michelly Abreu, Muzaffar Qazilbash, Robert Orlowski, Krina Patel","doi":"10.1016/S2152-2650(24)01920-7","DOIUrl":"10.1016/S2152-2650(24)01920-7","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Pages S49-S50"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-47 Daratumumab (DARA) + Bortezomib/Thalidomide/Dexamethasone (D-VTd) and DARA Maintenance in Transplant-eligible Newly Diagnosed Multiple Myeloma (NDMM): CASSIOPEIA Minimal Residual Disease (MRD) Update OA-47达拉单抗（DARA）+硼替佐米/他利度胺/地塞米松（D-VTd）和DARA维持治疗符合移植条件的新诊断多发性骨髓瘤（NDMM）：CASSIOPEIA最小残留病灶（MRD）最新进展
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01888-3
Jill Corre, Laure Vincent, Philippe Moreau, Benjamin Hébraud, Cyrille Hulin, Marie Bene, Annemiek Broijl, Denis Caillot, Michel Delforge, Thomas Dejoie, Thierry Facon, Jérôme Lambert, Xavier Leleu, Margaret Macro, Aurore Perrot, Sonja Zweegman, Winnie Hua, Maria Krevvata, Veronique Vanquickelberghe, Alba Tuozzo, Pieter Sonneveld
{"title":"OA-47 Daratumumab (DARA) + Bortezomib/Thalidomide/Dexamethasone (D-VTd) and DARA Maintenance in Transplant-eligible Newly Diagnosed Multiple Myeloma (NDMM): CASSIOPEIA Minimal Residual Disease (MRD) Update","authors":"Jill Corre, Laure Vincent, Philippe Moreau, Benjamin Hébraud, Cyrille Hulin, Marie Bene, Annemiek Broijl, Denis Caillot, Michel Delforge, Thomas Dejoie, Thierry Facon, Jérôme Lambert, Xavier Leleu, Margaret Macro, Aurore Perrot, Sonja Zweegman, Winnie Hua, Maria Krevvata, Veronique Vanquickelberghe, Alba Tuozzo, Pieter Sonneveld","doi":"10.1016/S2152-2650(24)01888-3","DOIUrl":"10.1016/S2152-2650(24)01888-3","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Pages S29-S30"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-43 Interim Results of a Phase 2 Trial of Isatuximab-Lenalidomide for Patients with High-Risk Smoldering Multiple Myeloma 伊沙妥昔单抗-来那度胺治疗高危烟雾型多发性骨髓瘤患者2期试验的OA-43中期结果
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01884-6
Sheeba Thomas, Elisabet Manasanch, Neha Korde, Hans Lee, Sundar Jagannath, Melody Becnel, Gregory Kaufman, Krina Patel, Swaminathan Iyer, Sham Mailankody, Donna Weber, Zuzana Lutter-Berka, Shawnee Carpenter, David Berrios Nolasco, Michelle Hildebrandt, Lei Feng, Behrang Amini, Sattva Neelapu, Robert Orlowski, Ola Landgren
{"title":"OA-43 Interim Results of a Phase 2 Trial of Isatuximab-Lenalidomide for Patients with High-Risk Smoldering Multiple Myeloma","authors":"Sheeba Thomas, Elisabet Manasanch, Neha Korde, Hans Lee, Sundar Jagannath, Melody Becnel, Gregory Kaufman, Krina Patel, Swaminathan Iyer, Sham Mailankody, Donna Weber, Zuzana Lutter-Berka, Shawnee Carpenter, David Berrios Nolasco, Michelle Hildebrandt, Lei Feng, Behrang Amini, Sattva Neelapu, Robert Orlowski, Ola Landgren","doi":"10.1016/S2152-2650(24)01884-6","DOIUrl":"10.1016/S2152-2650(24)01884-6","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Page S27"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-44 Frontline Systemic Treatment Outcomes in POEMS Syndrome – Analysis from the UCLH POEMS Centre Registry Spanning 25 Years OA-44 POEMS 综合征的前线系统治疗结果--来自 UCLH POEMS 中心长达 25 年的登记分析
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01885-8
Oliver Tomkins, Jahanzaib Khwaja, Michael Lunn, Ryan Keh, Stephen Keddie, Shirley D'Sa, Jonathan Sive
{"title":"OA-44 Frontline Systemic Treatment Outcomes in POEMS Syndrome – Analysis from the UCLH POEMS Centre Registry Spanning 25 Years","authors":"Oliver Tomkins, Jahanzaib Khwaja, Michael Lunn, Ryan Keh, Stephen Keddie, Shirley D'Sa, Jonathan Sive","doi":"10.1016/S2152-2650(24)01885-8","DOIUrl":"10.1016/S2152-2650(24)01885-8","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Pages S27-S28"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
P-021 A German Multicenter Real-World Analysis of Talquetamab in 102 Patients With Relapsed/Refractory Multiple Myeloma P-021 Talquetamab 在 102 例复发性/难治性多发性骨髓瘤患者中的德国多中心实际应用分析
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01924-4
Jan Frenking, Christine Riedhammer, Britta Besemer, Jan Braune, Annamaria Brioli, Franziska Brunner, Maria Dampmann, Deniz Gezer, Sarah Goldman-Mazur, Mathias Hänel, Christine Hanoun, Marion Högner, Katja Kolditz, Igor Kos, Miriam Kull, Theo Leitner, Maximilan Merz, Ivana von Metzler, Christian S. Michel, Raphael Teipel, Marc-Steffen Raab
{"title":"P-021 A German Multicenter Real-World Analysis of Talquetamab in 102 Patients With Relapsed/Refractory Multiple Myeloma","authors":"Jan Frenking, Christine Riedhammer, Britta Besemer, Jan Braune, Annamaria Brioli, Franziska Brunner, Maria Dampmann, Deniz Gezer, Sarah Goldman-Mazur, Mathias Hänel, Christine Hanoun, Marion Högner, Katja Kolditz, Igor Kos, Miriam Kull, Theo Leitner, Maximilan Merz, Ivana von Metzler, Christian S. Michel, Raphael Teipel, Marc-Steffen Raab","doi":"10.1016/S2152-2650(24)01924-4","DOIUrl":"10.1016/S2152-2650(24)01924-4","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Pages S52-S53"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142310418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-34 HBI0101, an Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) for Relapsed/Refractory Multiple Myeloma 治疗复发性/难治性多发性骨髓瘤的抗 BCMA 嵌合抗原受体 T 细胞 (CART) OA-34 HBI0101
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01875-5
Eyal Lebel, Nathalie Asherie, Shlomit kfir-Erenfeld, Sigal Grisariu, Batia Avni, Shlomo Elias, Miri Assayag, Tali Dubnikov-Sharon, Eran Zimran, Adir Shaulov, marjorie Pick, Cyrille Cohen, Polina Stepensky, Moshe Gatt
{"title":"OA-34 HBI0101, an Anti-BCMA Chimeric Antigen Receptor T-Cell (CART) for Relapsed/Refractory Multiple Myeloma","authors":"Eyal Lebel, Nathalie Asherie, Shlomit kfir-Erenfeld, Sigal Grisariu, Batia Avni, Shlomo Elias, Miri Assayag, Tali Dubnikov-Sharon, Eran Zimran, Adir Shaulov, marjorie Pick, Cyrille Cohen, Polina Stepensky, Moshe Gatt","doi":"10.1016/S2152-2650(24)01875-5","DOIUrl":"10.1016/S2152-2650(24)01875-5","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Page S22"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-36 METTL14 Enhances Multiple Myeloma Progression via m6A RNA Methylation-Mediated Regulation of TRAF6 Translation OA-36 METTL14通过m6A RNA甲基化介导的TRAF6翻译调控促进多发性骨髓瘤进展
IF 2.7 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2024-09-01 DOI: 10.1016/S2152-2650(24)01877-9
Liping Zuo, Zhixin Li, Linyu Cai, Aoshuang Xu, Qun Li, Chunyan Sun
{"title":"OA-36 METTL14 Enhances Multiple Myeloma Progression via m6A RNA Methylation-Mediated Regulation of TRAF6 Translation","authors":"Liping Zuo, Zhixin Li, Linyu Cai, Aoshuang Xu, Qun Li, Chunyan Sun","doi":"10.1016/S2152-2650(24)01877-9","DOIUrl":"10.1016/S2152-2650(24)01877-9","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"24 ","pages":"Page S23"},"PeriodicalIF":2.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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