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Clinical Lymphoma, Myeloma & Leukemia最新文献

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OA-22 Dysregulated RAS Signaling Modulates Apoptotic Dependencies and Therapeutic Response in Multiple Myeloma OA-22失调的RAS信号调节多发性骨髓瘤的凋亡依赖性和治疗反应
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03323-9
Rebecca W. Owens, Lucy Robbie, Shannon Matulis, Vikas A. Gupta, Marta Chesi, Leif Bergsagel, Francesco Maura, Linda Baughn, Benjamin G. Barwick, Ryan Young, Constantine S. Mitsiades, Lawrence Boise
{"title":"OA-22 Dysregulated RAS Signaling Modulates Apoptotic Dependencies and Therapeutic Response in Multiple Myeloma","authors":"Rebecca W. Owens, Lucy Robbie, Shannon Matulis, Vikas A. Gupta, Marta Chesi, Leif Bergsagel, Francesco Maura, Linda Baughn, Benjamin G. Barwick, Ryan Young, Constantine S. Mitsiades, Lawrence Boise","doi":"10.1016/S2152-2650(26)03323-9","DOIUrl":"10.1016/S2152-2650(26)03323-9","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S14-S15"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-50 Persistent Mucosal CAR-T Cells and Interferon-Driven Inflammation Drive BCMA-Targeted CAR-T Therapy–Associated Enterocolitis OA-50持续性粘膜CAR-T细胞和干扰素驱动的炎症驱动bcma靶向CAR-T治疗相关的小肠结肠炎
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03351-3
Adolfo Aleman, Nikhit Kethidi, Saumya Pothukuchi, Christina Kuhn, Daniel Charitonowicz, Zachary M. Avigan, Akankshaanil Acharya, Michael Tankelevich, Divya Jha, Matthias Ceulemans, Meenakshi Mehrotra, Shriya Desai, Sidorela Reci, Kedwin Ventura, Rachel Brody, Seunghee Kim-Schulze, Jane Houldsworth, Maximilian Merz, Shambavi Richard, Sundar Jagannath, Samir Parekh
{"title":"OA-50 Persistent Mucosal CAR-T Cells and Interferon-Driven Inflammation Drive BCMA-Targeted CAR-T Therapy–Associated Enterocolitis","authors":"Adolfo Aleman, Nikhit Kethidi, Saumya Pothukuchi, Christina Kuhn, Daniel Charitonowicz, Zachary M. Avigan, Akankshaanil Acharya, Michael Tankelevich, Divya Jha, Matthias Ceulemans, Meenakshi Mehrotra, Shriya Desai, Sidorela Reci, Kedwin Ventura, Rachel Brody, Seunghee Kim-Schulze, Jane Houldsworth, Maximilian Merz, Shambavi Richard, Sundar Jagannath, Samir Parekh","doi":"10.1016/S2152-2650(26)03351-3","DOIUrl":"10.1016/S2152-2650(26)03351-3","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S33"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-39 Low-Dose BCMA × CD3 Bispecific Antibody CM336 Induces Rapid and Universal Deep Hematologic Responses in Newly Diagnosed Systemic AL Amyloidosis: Primary Analysis of the Prospective Phase 2 AL-003 Trial OA-39低剂量BCMA × CD3双特异性抗体CM336在新诊断的全身性AL淀粉样变性中诱导快速和普遍的深度血液学反应：前瞻性2期AL-003试验的初步分析
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03340-9
Jieqiong Zhou, Qi Wang, Jian Cui, Yong Yu, Lugui Qiu, Gang An
{"title":"OA-39 Low-Dose BCMA × CD3 Bispecific Antibody CM336 Induces Rapid and Universal Deep Hematologic Responses in Newly Diagnosed Systemic AL Amyloidosis: Primary Analysis of the Prospective Phase 2 AL-003 Trial","authors":"Jieqiong Zhou, Qi Wang, Jian Cui, Yong Yu, Lugui Qiu, Gang An","doi":"10.1016/S2152-2650(26)03340-9","DOIUrl":"10.1016/S2152-2650(26)03340-9","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S26"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PA-003 A Model for Outpatient Cilta-cel Administration and Cytokine Release Syndrome (CRS) Management without a 24-hour Clinic: Clinical Protocol and Early Results PA-003：无24小时门诊的门诊cilta - cell给药和细胞因子释放综合征（CRS）管理模型：临床方案和早期结果
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03374-4
Christopher J. Ferreri, Chelsea Sprouse, Laura Horne, Leah Cupp, Marvin Knight, Jessica Jimenez, Caitlyn Barger, Alexandra S. Wolff, Nicole Pappaterra, Whitney Hollifield, Lynn Sanders, Reed Friend, Barry A. Paul, Shebli Atrash, Manisha Bhutani, Cindy Varga, Michael R. Grunwald, Peter M. Voorhees
{"title":"PA-003 A Model for Outpatient Cilta-cel Administration and Cytokine Release Syndrome (CRS) Management without a 24-hour Clinic: Clinical Protocol and Early Results","authors":"Christopher J. Ferreri, Chelsea Sprouse, Laura Horne, Leah Cupp, Marvin Knight, Jessica Jimenez, Caitlyn Barger, Alexandra S. Wolff, Nicole Pappaterra, Whitney Hollifield, Lynn Sanders, Reed Friend, Barry A. Paul, Shebli Atrash, Manisha Bhutani, Cindy Varga, Michael R. Grunwald, Peter M. Voorhees","doi":"10.1016/S2152-2650(26)03374-4","DOIUrl":"10.1016/S2152-2650(26)03374-4","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S48"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-18 Distinct Immune and Genomic Signatures Predict Resistance to Ibrutinib Therapy in Waldenström Macroglobulinemia OA-18独特的免疫和基因组特征预测Waldenström巨球蛋白血症患者对伊鲁替尼治疗的耐药性
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03319-7
Tina Bagratuni, Christos Vlachos, Maria Sakkou, Ioannis Kollias, Ourania Theologi, Nefeli Mavrianou Koutsoukou, Christine Liacos, Konstantina Taouxi, Alexandra Papadimou, Katerina Chrisostomidou, Agisilaos Papadopoulos, Eleni Kalafati, Foteini Theodorakakou, Maria Gavriatopoulou, Evangelos Terpos, Zachary Hunter, Steven P. Treon, Meletios A. Dimopoulos, Efstathios Kastritis
{"title":"OA-18 Distinct Immune and Genomic Signatures Predict Resistance to Ibrutinib Therapy in Waldenström Macroglobulinemia","authors":"Tina Bagratuni, Christos Vlachos, Maria Sakkou, Ioannis Kollias, Ourania Theologi, Nefeli Mavrianou Koutsoukou, Christine Liacos, Konstantina Taouxi, Alexandra Papadimou, Katerina Chrisostomidou, Agisilaos Papadopoulos, Eleni Kalafati, Foteini Theodorakakou, Maria Gavriatopoulou, Evangelos Terpos, Zachary Hunter, Steven P. Treon, Meletios A. Dimopoulos, Efstathios Kastritis","doi":"10.1016/S2152-2650(26)03319-7","DOIUrl":"10.1016/S2152-2650(26)03319-7","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S12"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-42 MRD Depth by NGS and Distinct Clonotypic Patterns Below the Limit of Detection Predict Divergent Relapse Risk After Sustained Remission NGS的OA-42 MRD深度和低于检测极限的不同克隆型模式预测持续缓解后的不同复发风险
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03343-4
Zachary M. Avigan, Hana Andrlova, Alison S. Park, Lucia Y. Chen, Abigail Chutnik, Tianxiang Sheng, Marcio Diniz, Hearn Jay Cho, Gurbakhash Kaur, Shambavi Richard, Joshua Richter, Cesar Rodriguez, Adriana Rossi, Larysa Sanchez, Santiago Thibaud, Alessandro Lagana, Samir Parekh, Sundar Jagannath
{"title":"OA-42 MRD Depth by NGS and Distinct Clonotypic Patterns Below the Limit of Detection Predict Divergent Relapse Risk After Sustained Remission","authors":"Zachary M. Avigan, Hana Andrlova, Alison S. Park, Lucia Y. Chen, Abigail Chutnik, Tianxiang Sheng, Marcio Diniz, Hearn Jay Cho, Gurbakhash Kaur, Shambavi Richard, Joshua Richter, Cesar Rodriguez, Adriana Rossi, Larysa Sanchez, Santiago Thibaud, Alessandro Lagana, Samir Parekh, Sundar Jagannath","doi":"10.1016/S2152-2650(26)03343-4","DOIUrl":"10.1016/S2152-2650(26)03343-4","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S27-S28"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-46 NKp30 is Expressed on Natural Killer (NK) Cells of Multiple Myeloma Patients and Can be Potently Activated by [GPRC5DxNKp30] and [CD38xNKp30] Bispecific NK Cell Engagers OA-46 NKp30在多发性骨髓瘤患者的自然杀伤（NK）细胞上表达，可被[GPRC5DxNKp30]和[CD38xNKp30]双特异性NK细胞接合物有效激活
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03347-1
Dorothee Winterberg, Josefine Krueger, Jing Fu, Svenja Andreas, Carina Lynn Gehlert, Steffen Krohn, Matthias Peipp, Suzanne Lentzsch, Katja Klausz
{"title":"OA-46 NKp30 is Expressed on Natural Killer (NK) Cells of Multiple Myeloma Patients and Can be Potently Activated by [GPRC5DxNKp30] and [CD38xNKp30] Bispecific NK Cell Engagers","authors":"Dorothee Winterberg, Josefine Krueger, Jing Fu, Svenja Andreas, Carina Lynn Gehlert, Steffen Krohn, Matthias Peipp, Suzanne Lentzsch, Katja Klausz","doi":"10.1016/S2152-2650(26)03347-1","DOIUrl":"10.1016/S2152-2650(26)03347-1","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S30-S31"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-15 Dara-VRD Plus Tandem Autologous Stem Cell Transplantation Followed by Prolonged Consolidation for Primary Plasma Cell Leukemia: A French Phase II Prospective Trial OA-15 Dara-VRD +串联自体干细胞移植后延长巩固治疗原发性浆细胞白血病：一项法国II期前瞻性试验
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03316-1
Bruno Royer, Jérôme Lambert, Karim Belhadj, Cécile Fohrer-Sonntag, Salomon Manier, Denis Caillot, Valentin Vinnat, Jean-Noël Bastié, Xavier Leleu, Cyrille Touzeau, Margaret Macro, Caroline Jacquet, Aurore Perrot, Jill Corre, Alexis Talbot
{"title":"OA-15 Dara-VRD Plus Tandem Autologous Stem Cell Transplantation Followed by Prolonged Consolidation for Primary Plasma Cell Leukemia: A French Phase II Prospective Trial","authors":"Bruno Royer, Jérôme Lambert, Karim Belhadj, Cécile Fohrer-Sonntag, Salomon Manier, Denis Caillot, Valentin Vinnat, Jean-Noël Bastié, Xavier Leleu, Cyrille Touzeau, Margaret Macro, Caroline Jacquet, Aurore Perrot, Jill Corre, Alexis Talbot","doi":"10.1016/S2152-2650(26)03316-1","DOIUrl":"10.1016/S2152-2650(26)03316-1","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S10"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-16 Diffuse Bone Marrow Activity in Patients With Smouldering Multiple Myeloma: A WB-MRI Analysis 阴燃型多发性骨髓瘤患者的OA-16弥漫性骨髓活性：WB-MRI分析
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03317-3
Gianluca Maiorana, Marta Zerunian, Giusy Antolino, Damiano Caruso, Federica Lubrano Lobianco, Chiara Valenti, Gjergji Nika, Diletta Tripi, Giulia Pileggi, Valentina De Santis, Eugenio Santacroce, Chiara Togni, Marco Francone, Giacinto La Verde
{"title":"OA-16 Diffuse Bone Marrow Activity in Patients With Smouldering Multiple Myeloma: A WB-MRI Analysis","authors":"Gianluca Maiorana, Marta Zerunian, Giusy Antolino, Damiano Caruso, Federica Lubrano Lobianco, Chiara Valenti, Gjergji Nika, Diletta Tripi, Giulia Pileggi, Valentina De Santis, Eugenio Santacroce, Chiara Togni, Marco Francone, Giacinto La Verde","doi":"10.1016/S2152-2650(26)03317-3","DOIUrl":"10.1016/S2152-2650(26)03317-3","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Pages S10-S11"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OA-70 Updated Safety and Efficacy of Ramantamig (Ram; JNJ-5322) at the Recommended Phase 2 Dose (RP2D), Demonstrating Feasibility of Outpatient Dosing (OPD) in Relapsed/Refractory Multiple Myeloma (RRMM) Ramantamig （Ram; JNJ-5322）推荐2期剂量（RP2D）的安全性和有效性更新，证明门诊给药（OPD）治疗复发/难治性多发性骨髓瘤（RRMM）的可行性
IF 4.1 4区 医学
Clinical Lymphoma, Myeloma & Leukemia Pub Date : 2026-09-01 Epub Date: 2026-09-22 DOI: 10.1016/S2152-2650(26)03371-9
Jeffrey V. Matous, Cindy Varga, Amrita Y. Krishnan, Monique C. Minnema, Niels W.C.J. van de Donk, Hans Lee, Saad Z. Usmani, Gala Vega, Nicolas Kint, Darren Pan, Jing Christine Ye, Laura Rosiñol, Sébastien Anguille, Cyrille Touzeau, Albert Oriol, Paula Rodríguez-Otero, María-Victoria Mateos, Caroline Hodin, Daniel Jonathan, Sangmin Lee, Alfred Garfall
{"title":"OA-70 Updated Safety and Efficacy of Ramantamig (Ram; JNJ-5322) at the Recommended Phase 2 Dose (RP2D), Demonstrating Feasibility of Outpatient Dosing (OPD) in Relapsed/Refractory Multiple Myeloma (RRMM)","authors":"Jeffrey V. Matous, Cindy Varga, Amrita Y. Krishnan, Monique C. Minnema, Niels W.C.J. van de Donk, Hans Lee, Saad Z. Usmani, Gala Vega, Nicolas Kint, Darren Pan, Jing Christine Ye, Laura Rosiñol, Sébastien Anguille, Cyrille Touzeau, Albert Oriol, Paula Rodríguez-Otero, María-Victoria Mateos, Caroline Hodin, Daniel Jonathan, Sangmin Lee, Alfred Garfall","doi":"10.1016/S2152-2650(26)03371-9","DOIUrl":"10.1016/S2152-2650(26)03371-9","url":null,"abstract":"","PeriodicalId":10348,"journal":{"name":"Clinical Lymphoma, Myeloma & Leukemia","volume":"26 ","pages":"Page S46"},"PeriodicalIF":4.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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