Clinical Gastroenterology and Hepatology最新文献_第7页

Antibiotic Exposure and Risk of New-Onset Inflammatory Bowel Disease: A Systematic Review and Dose-Response Meta-Analysis. 抗生素暴露与新发炎症性肠病的风险：系统回顾与剂量反应荟萃分析。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-02-28 DOI: 10.1016/j.cgh.2024.02.010

Ruqiao Duan, Cunzheng Zhang, Gaonan Li, Jun Li, Liping Duan

{"title":"Antibiotic Exposure and Risk of New-Onset Inflammatory Bowel Disease: A Systematic Review and Dose-Response Meta-Analysis.","authors":"Ruqiao Duan, Cunzheng Zhang, Gaonan Li, Jun Li, Liping Duan","doi":"10.1016/j.cgh.2024.02.010","DOIUrl":"10.1016/j.cgh.2024.02.010","url":null,"abstract":"Background & aims: The association between antibiotic exposure and inflammatory bowel disease (IBD) remains controversial, especially whether there is a dose-response relationship. We aimed to conduct a systematic review and meta-analysis to thoroughly evaluate the risk of new-onset IBD associated with antibiotic exposure.Methods: Four databases were searched from their inception to September 30, 2023 for all relevant studies. The risk estimates were pooled together using random-effects models, and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated, stratified by IBD subtype, age, exposure period, study type, and antibiotic classes. Dose-response relationship between the number of antibiotic prescriptions and IBD risk was assessed using generalized least squares regression analysis.Results: Twenty-eight studies involving 153,027 patients with IBD were included. Antibiotic exposure was significantly associated with an increased risk of new-onset IBD for prescription-based studies (pooled OR, 1.41; 95% CI, 1.29-1.53) and for questionnaire-based studies (pooled OR, 1.35; 95% CI, 1.08-1.68). This association existed for both Crohn's disease and ulcerative colitis, as well as in children and adults for prescription-based studies. The majority of antibiotic classes were associated with an increased IBD risk, with metronidazole (OR, 1.70; 95% CI, 1.38-2.10) and quinolones (OR, 1.56; 95% CI, 1.37-1.77) having relatively higher risk estimates. A positive nonlinear dose-response association was observed between the number of antibiotic prescriptions and IBD risk.Conclusions: Antibiotic exposure was significantly associated with an increased risk of new-onset IBD, and a positive nonlinear dose-response relationship was observed. Antibiotic stewardship may be important for reducing IBD risk.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":"45-58.e15"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of De Novo Barrett's Esophagus Post Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Studies With Long-Term Follow-Up. 袖带胃切除术后新发巴雷特食管病的风险：对长期随访研究的系统回顾和荟萃分析。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1016/j.cgh.2024.06.041

Saurabh Chandan, Shahab R Khan, Smit S Deliwala, Dushyant S Dahiya, Babu P Mohan, Daryl Ramai, Syed M Saghir, Banreet S Dhindsa, Lena L Kassab, Antonio Facciorusso, Kalyana Nandipati, Dennis Yang, Douglas G Adler

{"title":"Risk of De Novo Barrett's Esophagus Post Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Studies With Long-Term Follow-Up.","authors":"Saurabh Chandan, Shahab R Khan, Smit S Deliwala, Dushyant S Dahiya, Babu P Mohan, Daryl Ramai, Syed M Saghir, Banreet S Dhindsa, Lena L Kassab, Antonio Facciorusso, Kalyana Nandipati, Dennis Yang, Douglas G Adler","doi":"10.1016/j.cgh.2024.06.041","DOIUrl":"10.1016/j.cgh.2024.06.041","url":null,"abstract":"Background & aims: Sleeve gastrectomy (SG) is one of the most commonly performed bariatric procedures worldwide. Gastroesophageal reflux disease (GERD) is a major concern in patients undergoing SG and is a risk factor for Barrett's esophagus (BE). We conducted a systematic review and meta-analysis to assess the incidence of and analyze predictive factors for post-SG BE.Methods: A comprehensive literature search was conducted in April 2024, for studies reporting on incidence of BE, erosive esophagitis (EE), and hiatal hernia (HH) post-SG. Primary outcomes were post-SG pooled rates of de novo BE, EE, GERD symptoms, proton pump inhibitor use, and HH. Meta-regression analysis was performed to assess if patient and post-SG factors influenced the rates of post-SG BE.Results: Nineteen studies with 2046 patients (79% females) were included. Mean age was 42.2 years (standard deviation, 11.1) and follow-up ranged from 2 to 11.4 years. The pooled rate of de novo BE post-SG was 5.6% (confidence interval, 3.5-8.8). Significantly higher pooled rates of EE (risk ratio [RR], 3.37], HH (RR, 2.09), GER/GERD symptoms (RR, 3.32), and proton pump inhibitor use (RR, 3.65) were found among patients post-SG. GER/GERD symptoms post-SG positively influenced the pooled BE rates, whereas age, sex, body mass index, post-SG EE, and HH did not.Conclusions: Our analysis shows that SG results in a significantly increased risk of de novo BE and higher rates of EE, proton pump inhibitor use, and HH. Our findings suggest that clinicians should routinely screen patients with SG for BE and future surveillance intervals should be followed as per societal guidelines.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":"33-44.e10"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Re-evaluating the Proposed Association Between Vonoprazan and Gastric Cancer Following Eradication of H. pylori Infection. 重新评估根除幽门螺杆菌感染后vonoprazan与胃癌之间的关联。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-05-08 DOI: 10.1016/j.cgh.2024.04.015

Colin W Howden, William D Chey, Shailja C Shah

引用次数: 0

Can Endoscopic Ultrasound-guided Ablation Prolong Disease-specific Survival In Pancreatic Cysts? 内镜超声引导下消融术能否延长胰腺囊肿患者的疾病特异性生存期？

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-05-08 DOI: 10.1016/j.cgh.2024.04.012

Yousuke Nakai, Tsuyoshi Hamada, Hiroki Oyama

引用次数: 0

Prevalence of Liver Steatosis and Fibrosis in Adults With Primary Hypobetaliproteinemia: Results From the HYPOCHOL Study. 原发性低脂血症成人肝脏脂肪变性和纤维化的发病率：HYPOCHOL 研究的结果。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-07-05 DOI: 10.1016/j.cgh.2024.06.031

Sarra Smati, Matthieu Wargny, Jerome Boursier, Philippe Moulin, Mathilde Di Filippo, Bertrand Cariou

引用次数: 0

Clinical Presentation and Outcomes of Alpha-Gal Syndrome. 阿尔法-醛综合征的临床表现和预后

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-07-26 DOI: 10.1016/j.cgh.2024.06.044

Elvira Lesmana, Sameer Rao, Ashley Keehn, Adam L Edwinson, Ashima Makol, Madhusudan Grover

{"title":"Clinical Presentation and Outcomes of Alpha-Gal Syndrome.","authors":"Elvira Lesmana, Sameer Rao, Ashley Keehn, Adam L Edwinson, Ashima Makol, Madhusudan Grover","doi":"10.1016/j.cgh.2024.06.044","DOIUrl":"10.1016/j.cgh.2024.06.044","url":null,"abstract":"Background and aims: Alpha-gal syndrome (AGS) is an IgE-mediated allergic reaction to galactose-α-1,3-galactose, primarily linked with Lone Star tick bites in the United States. It presents with symptoms ranging from urticaria and gastrointestinal (GI) manifestations to delayed anaphylaxis following red meat consumption. We aimed to study AGS patients' clinical manifestations, diagnosis, and outcomes.Methods: A retrospective chart review of patients who underwent serological testing for suspected AGS between 2014 and 2023 at Mayo Clinic was performed. Patients with positive serology were age and sex matched with those who tested negative. Clinical characteristics of seropositive cohort with and without GI symptoms were compared, and outcomes assessed.Results: Of 1260 patients who underwent testing, 124 tested positive for AGS. They were matched with 380 seronegative control subjects. AGS patients reported a higher frequency of tick bites (odds ratio [OR], 26.0; 95% confidence interval [CI], 9.8-68.3), reported a higher prevalence of urticaria (56% vs 37%; P = .0008), and were less likely to have asthma (OR, 0.4; 95% CI, 0.3-0.7). They had a lower prevalence of heartburn (6% vs 12%; P = .03) and bloating (6% vs 13%; P = .03). A total of 47% had GI symptoms, and a higher proportion were female than those without GI symptoms (69% vs 35%; P = .002). During a mean follow-up of 27 months, 22 of 40 patients reported symptom resolution after avoiding red meat, and 7 were able to transition to regular diet.Conclusions: A diagnosis of AGS should be strongly considered in patients with a history of tick bites and clinical presentation of allergic or GI manifestations. Dietary intervention is effective in most but not all patients.","PeriodicalId":10347,"journal":{"name":"Clinical Gastroenterology and Hepatology","volume":" ","pages":"69-78"},"PeriodicalIF":11.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Impact of Immigration Status on Gastric Cancer Risk in a Community Hospital in New York City. 移民身份对纽约市一家社区医院胃癌风险的影响。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-10-04 DOI: 10.1016/j.cgh.2024.08.038

Meredith E Pittman, Avleen Kaur, Thin Phyu Phyu Aung, Linda A Lee, Yasutoshi Shiratori

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Reply. 回应。

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-06-08 DOI: 10.1016/j.cgh.2024.05.033

Junya Arai, Yoku Hayakawa, Mitsuhiro Fujishiro

引用次数: 0

Reply. 对 "感染后肠道与大脑互动失调：一个头脑风暴的故事

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-06-21 DOI: 10.1016/j.cgh.2024.06.009

Olafur S Palsson, B Joseph Elmunzer

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Reply. 对 Kamarajah 等人的答复

IF 11.6 1区医学

Clinical Gastroenterology and Hepatology Pub Date : 2025-01-01 Epub Date: 2024-06-18 DOI: 10.1016/j.cgh.2024.06.011

Jayanta Samanta, Jahnvi Dhar, Antonio Facciorusso

引用次数: 0