Nanette S van Roermund, Veerle M H Coupé, Manon C W Spaander, Monique E van Leerdam, Evelien Dekker, Joep E G IJspeert
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引用次数: 0
Abstract
Background and aims: Current post-polypectomy guidelines set intervals based solely on features of resected polyps. Despite the well-known inverse relationship between both adenoma detection rate (ADR) and proximal serrated polyp detection rate (PSPDR) with post-colonoscopy colorectal cancers (PCCRCs), both quality indicators are not considered when determining surveillance intervals.
Methods: We used colonoscopy data from 2014 to 2020 performed for a positive fecal immunochemical test in the Dutch colorectal cancer screening program. Individuals were categorized into having high-risk polyps or no/low-risk polyps resected. The association between 3-year PCCRC-risk and presence of high-risk polyps and either ADR or PSPDR was studied with Cox proportional hazard regression. Secondly, endoscopists were categorized into low/medium/high ADR and PSPDR to enable stratified analysis.
Results: A total of 239,217 individuals were included; 74,289 had high-risk polyps resected at baseline and 202 had PCCRC within the subsequent 3 years. Presence of high-risk polyps was not associated with PCCRC-risk (hazard ratio [HR], 1.00; 95% confidence interval [CI], 0.75-1.35), whereas ADR and PSPDR showed a strong association with PCCRC (per point increase HR, 0.94; 95% CI, 0.92-0.96; HR, 0.92; 95% CI, 0.89-0.95, respectively). For individuals with no/low-risk polyps but examined by endoscopists with low ADR, the HR of PCCRC was 2.11 (95% CI, 1.21-3.65), as compared with individuals with high-risk polyps but examined by endoscopists with high ADR.
Conclusions: An individual's PCCRC risk in the initial years is primarily influenced by endoscopist performance, rather than the presence of high-risk polyps. To reduce PCCRCs, besides ensuring appropriate surveillance intervals, it is crucial to monitor and audit endoscopist quality indicators.
期刊介绍：
Clinical Gastroenterology and Hepatology (CGH) is dedicated to offering readers a comprehensive exploration of themes in clinical gastroenterology and hepatology. Encompassing diagnostic, endoscopic, interventional, and therapeutic advances, the journal covers areas such as cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, absorption, and secretion.
As a peer-reviewed publication, CGH features original articles and scholarly reviews, ensuring immediate relevance to the practice of gastroenterology and hepatology. Beyond peer-reviewed content, the journal includes invited key reviews and articles on endoscopy/practice-based technology, health-care policy, and practice management. Multimedia elements, including images, video abstracts, and podcasts, enhance the reader's experience. CGH remains actively engaged with its audience through updates and commentary shared via platforms such as Facebook and Twitter.
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