Circulation最新文献

{"title":"Targeting Calcium Regulation for Heart Failure and Arrhythmia Therapeutics: A Critical Review.","authors":"Gabriel Redel-Traub,Steven O Marx,Andrew R Marks","doi":"10.1161/circulationaha.125.075150","DOIUrl":"https://doi.org/10.1161/circulationaha.125.075150","url":null,"abstract":"Despite advances in pharmacologic and procedural therapies, heart failure (HF) and cardiac arrhythmias remain significant global health burdens, highlighting the urgent need for novel therapeutic strategies. Defective Ca2+ handling in cardiac myocytes is recognized as a central pathogenic mechanism underlying both heart failure and atrial and ventricular arrhythmias. In this review, we critically assess the current state of research on Ca2+-handling proteins and their role in causing heart failure and arrhythmias, highlighting therapeutic implications. Recent paradigm-shifting discoveries, clinical trial outcomes, and challenges of targeting Ca2+-handling proteins are examined. As outlined in this review, an improved understanding of the relevant proteins and their differential expression and function in human health and disease is crucial for developing Ca2+ handling-targeted therapeutics that can fundamentally alter the natural history of heart failure and arrhythmias.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"114 1","pages":"957-970"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subclinical Primary Aldosteronism: A Potential New Target in Cardiovascular Prevention?","authors":"Wanpen Vongpatanasin,Jesslin Abraham,John M Giacona","doi":"10.1161/circulationaha.125.076085","DOIUrl":"https://doi.org/10.1161/circulationaha.125.076085","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"16 1","pages":"924-926"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Bhatia and Tsimikas to Letter Regarding Article, \"Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol-Medicated Cardiovascular Risk: A Participant-Level Meta-Analysis\".","authors":"Harpreet S Bhatia,Sotirios Tsimikas","doi":"10.1161/circulationaha.125.075455","DOIUrl":"https://doi.org/10.1161/circulationaha.125.075455","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"30 1","pages":"e267-e268"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden Cardiac Arrest and Death Secondary to Congenital Coronary Artery Abnormalities in Young Competitive Athletes.","authors":"Bradley J Petek,Timothy W Churchill,Nathaniel Moulson,Aaron L Baggish,Stephanie A Kliethermes,Joseph J Maleszewski,Randi Delong,Kristen L Kucera,Kimberly G Harmon,Jonathan A Drezner","doi":"10.1161/circulationaha.125.074330","DOIUrl":"https://doi.org/10.1161/circulationaha.125.074330","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"4 1","pages":"971-973"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Jaber et al to Letter Regarding Article, \"Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial\".","authors":"Wissam A Jaber,Carin F Gonsalves,Stefan Stortecky,Jay Giri,C Michael Gibson","doi":"10.1161/circulationaha.125.075457","DOIUrl":"https://doi.org/10.1161/circulationaha.125.075457","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"199 1","pages":"e271-e272"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by White et al Regarding Article, \"Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial\".","authors":"R James White,Dominick Roto,Daniel Lachant","doi":"10.1161/circulationaha.124.073132","DOIUrl":"https://doi.org/10.1161/circulationaha.124.073132","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"199 1","pages":"e269-e270"},"PeriodicalIF":37.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guidance for Incorporating FDA Processes into the ACC/AHA Clinical Practice Guideline Methodology: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.","authors":"Hani Jneid,Abdul R Abdullah,Victor A Ferrari,Richard J Kovacs,Debabrata Mukherjee,Daichi Shimbo","doi":"10.1161/cir.0000000000001357","DOIUrl":"https://doi.org/10.1161/cir.0000000000001357","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"11 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults.","authors":"Yuichiro Mori,Mitsuaki Sawano,Shun Kohsaka,Yusuke Tsugawa,Motoko Yanagita,Shingo Fukuma","doi":"10.1161/circulationaha.125.074433","DOIUrl":"https://doi.org/10.1161/circulationaha.125.074433","url":null,"abstract":"BACKGROUNDEarly detection of atrial fibrillation (AF) is essential for preventing ischemic stroke and other cardiovascular complications. However, the incidence and prognosis of AF in the general middle-aged population remain unclear. In Japan, annual health screenings for employees include mandatory ECGs, offering a unique opportunity to fill this evidence gap.METHODSThis retrospective cohort study aimed to evaluate the incidence and subsequent cardiovascular outcomes of screening-detected AF in the general working population in Japan, using the Japan Health Insurance Association database, which covers one-quarter of the working-age population of that country. From individuals 35 to 59 years of age who underwent annual health screenings between April 2015 and March 2020, excluding those with a history of cardiovascular disease, those with initial AF detection upon screening ECGs were identified. The primary outcome was hospitalization for ischemic stroke. The secondary outcomes were all-cause death and hospitalization for heart failure. The association between screening-detected AF and outcomes was evaluated using adjusted subdistribution hazard models compared with matched controls.RESULTSAmong 9.5 million individuals included in our study, 11 790 initial AF cases (42.4 of 100 000 person-years [95% CI, 41.6-43.1]) were detected. Individuals with AF were older (mean age, 50.9 versus 46.3 years) and more likely to be male (91.6% versus 63.6%) compared with non-AF cases. Among these individuals with screening-detected AF, the 3-year incidences of ischemic stroke, all-cause death, and heart failure were 1.83% (95% CI, 1.57-2.09), 0.78% (95% CI, 0.61-0.95), and 3.87% (95% CI, 3.50-4.24), respectively. Compared with age- and sex-matched controls, individuals with AF had a higher risk of incident ischemic stroke (hazard ratio, 5.38 [95% CI, 4.51-6.42]), all-cause death (hazard ratio, 1.98 [95% CI, 1.66-2.36]), and heart failure (hazard ratio, 18.35 [95% CI, 15.10-22.31]).CONCLUSIONSAF was detected in one out of 2400 screening ECGs among the middle-aged population in Japan, with higher relative risks of ischemic stroke and heart failure, compared with those without AF. These findings highlight the association of screening-detected AF with stroke and heart failure, warranting further study into AF as an early sign of heart failure and optimal cardiovascular risk reduction strategies after AF detection in the general middle-aged population.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"17 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 ACC/AHA Clinical Practice Guidelines Core Principles and Development Process: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.","authors":"Catherine M Otto,Abdul R Abdullah,Leslie L Davis,Victor A Ferrari,Stephen Fremes,Debabrata Mukherjee,Lauren Prestera,Boback Ziaeian","doi":"10.1161/cir.0000000000001383","DOIUrl":"https://doi.org/10.1161/cir.0000000000001383","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"41 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults.","authors":"Francesco Gentile,Eliana Carapellucci,Vincenzo Uggenti,Valentina Lorenzoni,Francesco Arsì,Giulia Fulceri,Michele Coceani,Angelo Monteleone,Dante Chiappino,Claudio Passino,Alberto Giannoni,Sergio Berti,Michele Emdin,Alberto Clemente","doi":"10.1161/circulationaha.125.074198","DOIUrl":"https://doi.org/10.1161/circulationaha.125.074198","url":null,"abstract":"BACKGROUNDThe clinical significance and outcome predictors of anomalous aortic origin of a coronary artery (AAOCA) in adults remains unclear. Therefore, the aim of this study was to analyze the clinical and prognostic implications of AAOCA in a large cohort of patients undergoing coronary computed tomography angiography (CCTA) in an Italian tertiary referral center.METHODSConsecutive adults with AAOCA identified through CCTA from September 2004 to September 2024 were included. Data on clinical indications of CCTA, AAOCA subtypes, evidence of inducible myocardial ischemia, and concomitant coronary atherosclerotic disease were collected. Patients were followed up for the end points of all-cause mortality and major adverse cardiac events (nonfatal acute coronary syndromes, revascularization procedures, and heart failure hospitalization). Outcomes were compared with matched controls with normal coronary artery anatomy.RESULTSAmong 17 454 CCTAs performed over a span of 20 years, AAOCA was detected in 173 patients (62±15 years of age, n=58 women [34%]). Chest pain (34%) was the most common indication of CCTA. Obstructive coronary atherosclerotic disease was present in 36 patients (21%), and myocardial ischemia was detected in 60% of those (n=62) who underwent functional imaging testing. AAOCA repair was performed in 10 patients (6%), whereas the majority of patients were treated conservatively. After a median 37-month follow-up (17 to 69 months), mortality (P=0.321) and major adverse cardiac events (P=0.392) were similar between patients with AAOCA and controls. Only obstructive coronary atherosclerotic disease was associated with a higher event rate during follow-up, whereas AAOCA subtype and ischemia were not.CONCLUSIONSIn adults with AAOCA, concomitant obstructive coronary atherosclerotic disease is the primary determinant of adverse events. Given the low prevalence of AAOCA and event rates, multicenter registries are needed to refine risk stratification and management of these patients.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"57 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}