CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.126.079054
Alec Stepanian,Iris Z Jaffe
{"title":"Response by Stepanian and Jaffe to Letters Regarding Article, \"Ponatinib, but Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke\".","authors":"Alec Stepanian,Iris Z Jaffe","doi":"10.1161/circulationaha.126.079054","DOIUrl":"https://doi.org/10.1161/circulationaha.126.079054","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"247 1","pages":"e1113-e1114"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.125.077193
Taotao Zheng,Xiao Yuan,Huawen Liu
{"title":"Letter by Zheng et al Regarding Article, \"Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke\".","authors":"Taotao Zheng,Xiao Yuan,Huawen Liu","doi":"10.1161/circulationaha.125.077193","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077193","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"2 1","pages":"e1109-e1110"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.126.079462
Thijs J Schrama,Vincent L Aengevaeren
{"title":"Disentangling the Relationship Between Exercise and Coronary Atherosclerosis: Wearable Training Data Are the Way Forward.","authors":"Thijs J Schrama,Vincent L Aengevaeren","doi":"10.1161/circulationaha.126.079462","DOIUrl":"https://doi.org/10.1161/circulationaha.126.079462","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"4 1","pages":"1023-1025"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.125.078078
Xin Xu,Shuyan Zhang,Lingling Bao
{"title":"Letter by Xu et al Regarding Article, \"Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke\".","authors":"Xin Xu,Shuyan Zhang,Lingling Bao","doi":"10.1161/circulationaha.125.078078","DOIUrl":"https://doi.org/10.1161/circulationaha.125.078078","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"18 1","pages":"e1111-e1112"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.125.077133
Chao Liu,Ximing Li
{"title":"Letter by Liu and Li Regarding Article, \"Ponatinib, But Not the New Abl-Kinase Inhibitor Asciminib, Activates Platelets, Leukocytes, and Endothelial Cell TNF Signaling to Induce Atherosclerotic Plaque Inflammation, Myocardial Infarction, and Stroke\".","authors":"Chao Liu,Ximing Li","doi":"10.1161/circulationaha.125.077133","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077133","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"63 1","pages":"e1107-e1108"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/cir.0000000000001428
Antonio G Cabrera,Jack F Price,Borah J Hong,Aamir Jeewa,Christine Tabulov,Sally S Wong,Leigh Reardon,Nadine A Kasparian,Shahnawaz Amdani,
{"title":"Evaluation and Management of the Child With Acute Decompensated Heart Failure: A Scientific Statement From the American Heart Association.","authors":"Antonio G Cabrera,Jack F Price,Borah J Hong,Aamir Jeewa,Christine Tabulov,Sally S Wong,Leigh Reardon,Nadine A Kasparian,Shahnawaz Amdani, ","doi":"10.1161/cir.0000000000001428","DOIUrl":"https://doi.org/10.1161/cir.0000000000001428","url":null,"abstract":"Nationally, there has been a rise in the number of children and adolescents with congenital and acquired heart disease presenting with acute decompensated heart failure. Compared with adults, these children have increased morbidity and mortality and use significantly more health care resources once admitted. Currently, there is little guidance on how to assess, manage, and create successful discharge plans for children presenting with acute decompensated heart failure. Given that this population represents an intersection among emergency medicine, cardiology, surgery, critical care, and psychology, a guidance document for the comprehensive management of this high-risk population is needed. This scientific statement reflects the state of current evidence and highlights important knowledge gaps in this domain.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"122 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147619421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-06DOI: 10.1161/circulationaha.125.077277
Brendon L Neuen,John W Ostrominski,Muthiah Vaduganathan
{"title":"Is Placebo Still Ethical in Trials of Incretin Therapies?","authors":"Brendon L Neuen,John W Ostrominski,Muthiah Vaduganathan","doi":"10.1161/circulationaha.125.077277","DOIUrl":"https://doi.org/10.1161/circulationaha.125.077277","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"117 1","pages":"1005-1008"},"PeriodicalIF":37.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CirculationPub Date : 2026-04-02DOI: 10.1161/cir.0000000000001422
Soni Savai Pullamsetti,Rebecca R Vanderpool,Frances de Man,Vinicio A de Jesus Perez,Anna R Hemnes,Monica Mukherjee,Laura Mercer-Rosa,Edda Spiekerkoetter,Khodr Tello,Sebastien Bonnet,
{"title":"Advanced Molecular, Metabolic, and Imaging Approaches to Characterizing Right Ventricular Failure: A Scientific Statement From the American Heart Association.","authors":"Soni Savai Pullamsetti,Rebecca R Vanderpool,Frances de Man,Vinicio A de Jesus Perez,Anna R Hemnes,Monica Mukherjee,Laura Mercer-Rosa,Edda Spiekerkoetter,Khodr Tello,Sebastien Bonnet, ","doi":"10.1161/cir.0000000000001422","DOIUrl":"https://doi.org/10.1161/cir.0000000000001422","url":null,"abstract":"Right ventricular (RV) dysfunction is a key predictor of outcomes in pulmonary hypertension (PH), substantially contributing to illness and death. As PH progresses, increased pulmonary vascular resistance places chronic pressure overload on the right ventricle. Initially, the right ventricle adapts through hypertrophic remodeling, thickening the heart wall to maintain cardiac output. Over time, this adaptive phase shifts to maladaptive remodeling, marked by RV dilation, fibrosis, stiffness, and decoupling from the pulmonary artery, known as RV-pulmonary arterial uncoupling. This uncoupling reflects the inability of the right ventricle to sustain contractility against elevated afterload, ultimately leading to right heart failure, the primary cause of death in late-stage PH. Awareness of RV dysfunction has grown, extending beyond PH and pulmonary arterial hypertension to systemic conditions, such as heart failure with preserved ejection fraction, congenital heart disease, COVID-19, and complications of left ventricular assist device implantation. Research is increasingly focused on understanding the molecular and hemodynamic drivers of RV failure, including inflammation and altered cellular signaling. Innovations in imaging and biomarker discovery are improving the detection of maladaptive RV remodeling. Promising treatments, such as the activin signaling inhibitor sotatercept, may reduce pulmonary vascular resistance and support RV recovery. Further work is needed to enhance RV function and prevent failure. This review summarizes current knowledge on RV dysfunction in PH, emphasizing its mechanisms, clinical relevance, and therapeutic potential. Recognizing the right ventricle as a central therapeutic target may lead to more personalized, effective interventions and improved patient outcomes in PH and related conditions.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"9 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}