Circulation最新文献

{"title":"The Role of Race in Cardiovascular Disease Risk Prediction.","authors":"Chiadi E Ndumele, Keith C Ferdinand, Sadiya S Khan","doi":"10.1161/CIRCULATIONAHA.124.071233","DOIUrl":"10.1161/CIRCULATIONAHA.124.071233","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"741-743"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Low Penetrance Sarcomere Variants Contribute to Additive Risk in Hypertrophic Cardiomyopathy.","authors":"Joshua K Meisner, Aaron Renberg, Eric D Smith, Yao-Chang Tsan, Brynn Elder, Abbey Bullard, Owen L Merritt, Sean L Zheng, Neal K Lakdawala, Anjali T Owens, Thomas D Ryan, Erin M Miller, Joseph W Rossano, Kimberly Y Lin, Brian L Claggett, Euan A Ashley, Michelle Michels, Rachel Lampert, John C Stendahl, Dominic Abrams, Christopher Semsarian, Victoria N Parikh, Matthew T Wheeler, Jodie Ingles, Iacopo Olivotto, Sharlene M Day, Sara Saberi, Mark W Russell, Michael Previs, Carolyn Y Ho, James S Ware, Adam S Helms","doi":"10.1161/CIR.0000000000001318","DOIUrl":"https://doi.org/10.1161/CIR.0000000000001318","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"e762"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Shang et al Regarding Article, \"Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest\".","authors":"Luxiang Shang, Baopeng Tang, Yinglong Hou","doi":"10.1161/CIRCULATIONAHA.124.071991","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071991","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"e712-e713"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Hidden Protein p-414aa Encoded by <i>circSETD2(14,15</i>) Inhibits Vascular Remodeling.","authors":"Si-Fan Wang, Li-Yun Yang, An-Qi Zhao, Zhao-Yi Wang, Sen Wang, Miao Gong, Ming-Qi Zheng, Gang Liu, Shu-Yan Yang, Jia-Jie Lin, Shao-Guang Sun","doi":"10.1161/CIRCULATIONAHA.124.070243","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.070243","url":null,"abstract":"<p><strong>Background: </strong>Phenotypic switching of vascular smooth muscle cells (VSMCs), leading to neointimal hyperplasia, is a fundamental cause of vascular remodeling diseases such as atherosclerosis and hypertension. Novel hidden proteins encoded by circular RNAs play crucial roles in disease progression, yet their involvement in vascular remodeling diseases has not been comprehensively studied. This study identifies a novel protein derived from a circular RNA in VSMCs and demonstrates its potential role in regulating vascular remodeling.</p><p><strong>Methods: </strong>Cell proliferation assays were performed to investigate the effects of <i>circSETD2(14,15</i>) on VSMC proliferation. Techniques such as vector construction, immunoprecipitation-mass spectrometry, and dual-luciferase reporter gene were used to confirm that <i>circSETD2(14,15</i>) encoded a novel protein, p-414aa. The interaction between p-414aa and HuR (human antigen R) was validated with techniques such as coimmunoprecipitation, mass spectrometry, and proximity ligation assay. Through experiments including RNA sequencing and RNA immunoprecipitation, the interaction between HuR and <i>C-FOS</i> (C-Fos proto-oncogene) mRNA was revealed. The role of p-414aa in neointimal hyperplasia was assessed with a carotid artery ligation model in male mice.</p><p><strong>Results: </strong>Overexpression of <i>circSETD2(14,15</i>) inhibits VSMC phenotypic switching. The novel protein p-414aa, encoded by <i>circSETD2(14,15</i>), interacts with HuR to reduce <i>C-FOS</i> mRNA stability, thereby suppressing VSMC proliferation and ultimately inhibiting neointimal hyperplasia in male mice.</p><p><strong>Conclusions: </strong>We uncover a novel hidden protein derived from <i>circSETD2(14,15</i>), called p-414aa, that inhibits vascular remodeling. <i>CircSETD2(14,15</i>) and p-414aa may serve as potential therapeutic targets for vascular remodeling diseases.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covered Stent Treatment for Sinus Venosus Atrial Septal Defects: Early Promise and Potential Limitations.","authors":"Glen Van Arsdell, Doff B McElhinney","doi":"10.1161/CIRCULATIONAHA.124.072394","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.072394","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"757-759"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Relevance of Type 4a Myocardial Infarction and Periprocedural Myocardial Injury in Patients With Non-ST-Segment-Elevation Myocardial Infarction.","authors":"Matteo Armillotta, Luca Bergamaschi, Pasquale Paolisso, Marta Belmonte, Francesco Angeli, Angelo Sansonetti, Andrea Stefanizzi, Davide Bertolini, Francesca Bodega, Sara Amicone, Lisa Canton, Damiano Fedele, Nicole Suma, Andrea Impellizzeri, Francesco Pio Tattilo, Daniele Cavallo, Ornella Di Iuorio, Khrystyna Ryabenko, Andrea Rinaldi, Gabriele Ghetti, Francesco Saia, Cinzia Marrozzini, Gianni Casella, Paola Rucci, Alberto Foà, Carmine Pizzi","doi":"10.1161/CIRCULATIONAHA.124.070729","DOIUrl":"10.1161/CIRCULATIONAHA.124.070729","url":null,"abstract":"<p><strong>Background: </strong>Periprocedural myocardial injury (PMI) with or without type 4a myocardial infarction (MI) might occur in patients with non-ST-segment-elevation MI (NSTEMI) after percutaneous coronary intervention (PCI). This study investigated the incidence and prognostic relevance of these events, according to current definitions, in patients with NSTEMI undergoing PCI. The best cardiac troponin I (cTnI) threshold of PMI for prognostic stratification is also suggested.</p><p><strong>Methods: </strong>Consecutive patients with NSTEMI from January 2017 to April 2022 undergoing PCI with stable or falling pre-PCI cTnI levels were enrolled. According to the Fourth Universal Definition of Myocardial Infarction, the study population was stratified into those experiencing (1) PMI with type 4a MI, (2) PMI without type 4a MI, or (3) no PMI. Post-PCI cTnI increase >20% with an absolute postprocedural value of ≥5 times the 99th percentile upper reference limit within 48 hours after PCI was used to define PMI. The primary end point was 1-year all-cause mortality, and the secondary end point consisted of major adverse cardiovascular events at 1 year, including all-cause mortality, nonfatal reinfarction, urgent revascularization, nonfatal ischemic stroke, and hospitalization for heart failure. Internal validation was performed in patients enrolled between May 2022 and April 2023.</p><p><strong>Results: </strong>Among 1412 patients with NSTEMI undergoing PCI with stable or falling cTnI levels at baseline, 240 (17%) experienced PMI with type 4a MI, 288 (20.4%) experienced PMI without type 4a MI, and 884 (62.6%) experienced no PMI. PMI was associated with an increased risk of adverse clinical outcomes, with patients with type 4a MI demonstrating the highest rates of 1-year all-cause mortality and major adverse cardiovascular events. A post-PCI ΔcTnI >20% but ≤40% showed similar outcomes to patients without PMI, whereas >40% was identified as the optimal threshold for prognostically relevant PMI, confirmed in an internal validation cohort of 305 patients.</p><p><strong>Conclusions: </strong>Periprocedural ischemic events were frequent in patients with NSTEMI undergoing PCI with prognostic implications. A post-PCI ΔcTnI >40%, combined with an absolute postprocedural value of ≥5 times the 99th percentile upper reference limit, was identified as the optimal threshold for diagnosing prognostically relevant PMI. Recognizing these events may improve risk stratification and management of patients with NSTEMI.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"760-772"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Young Man With Syncope: What Is the Diagnosis?","authors":"Pongprueth Rujirachun, Svita Taveeamornrat, Arjbordin Winijkul","doi":"10.1161/CIRCULATIONAHA.124.072433","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.072433","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"804-806"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mysterious Masks of Hypercholesterolemia: A Unique Clinical Case.","authors":"Uliana Chubykina, Petr Vasiluev, Olga Ivanova, Marat Ezhov","doi":"10.1161/CIRCULATIONAHA.124.071638","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071638","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"799-803"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Cancer in Newborns With Congenital Heart Disease and Their Mothers: A Nationwide Cohort Study.","authors":"Danbee Kang, Gwang-Jun Choi, Jihye Heo, Seung Woo Park, Juyoung Sung, Insung Kim, Taegyun Park, Juhee Cho, June Huh","doi":"10.1161/CIRCULATIONAHA.124.071811","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071811","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 11","pages":"807-809"},"PeriodicalIF":35.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress.","authors":"Lauriane Y M Michel, Hrag Esfahani, Delphine De Mulder, Roxane Verdoy, Jérôme Ambroise, Véronique Roelants, Bertrand Bouchard, Nathalie Fabian, Jérôme Savary, Joseph P Dewulf, Thomas Doumont, Caroline Bouzin, Vincent Haufroid, Joost J F P Luiken, Miranda Nabben, Michael L Singleton, Luc Bertrand, Matthieu Ruiz, Christine Des Rosiers, Jean-Luc Balligand","doi":"10.1161/CIRCULATIONAHA.124.067876","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.067876","url":null,"abstract":"<p><strong>Background: </strong>Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.</p><p><strong>Methods: </strong>To dissect functional, transcriptional, and metabolic effects, hearts and isolated ventricular myocytes from mice harboring a moderate, cardiac-specific expression of a human <i>ADRB3</i> transgene (β3AR-Tg) and subjected to transverse aortic constriction were assessed with echocardiography, RNA sequencing, positron emission tomography scan, metabolomics, and metabolic flux analysis. Subsequently, signaling and metabolic pathways were further investigated in vivo in β3AR-Tg and ex vivo in neonatal rat ventricular myocytes adenovirally infected to express β3AR and subjected to neurohormonal stress. These results were complemented with an analysis of single-nucleus RNA-sequencing data from human cardiac myocytes from patients with heart failure.</p><p><strong>Results: </strong>Compared with wild-type littermates, β3AR-Tg mice were protected from hypertrophy after transaortic constriction, and systolic function was preserved. β3AR-expressing hearts displayed enhanced myocardial glucose uptake under stress in the absence of increased lactate levels. Instead, metabolomic and metabolic flux analyses in stressed hearts revealed an increase in intermediates of the pentose-phosphate pathway in β3AR-Tg, an alternative route of glucose utilization, paralleled with increased transcript levels of NADPH-producing and rate-limiting enzymes of the pentose-phosphate pathway, without fueling the hexosamine metabolism. The ensuing increased content of NADPH and of reduced glutathione decreased myocyte oxidant stress, whereas downstream oxidative metabolism assessed by oxygen consumption was preserved with higher glucose oxidation in β3AR-Tg mice after transaortic constriction compared with wild type, together with increased mitochondrial biogenesis. Unbiased transcriptomics and pathway analysis identified NRF2 (NFE2L2) as an upstream transcription factor that was functionally verified in vivo and in β3AR-expressing cardiac myocytes, where its translocation and nuclear activity were dependent on β3AR activation of nitric oxide synthase and nitric oxide production through S-nitrosation of the NRF2-negative regulator Keap1.</p><p><strong>Conclusions: </strong>Moderate expression of cardiac β3AR, at levels observed in human cardiac myocardium, exerts metabolic and antioxidant effects through activation of the pentose-phosphate pathway and NRF2 pathway through S-nitrosation of Keap1, thereby preserving myocardial oxidative metabolism, function, and integrity under pathophysiological stress.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}