Circulation最新文献

{"title":"Role of Technology in Promoting Heart Healthy Behavior Change to Increase Equity in Optimal Cardiovascular Health: A Scientific Statement From the American Heart Association.","authors":"Tiffany M Powell-Wiley, LaPrincess C Brewer, Lora E Burke, Rosalba Hernandez, Jill Landsbaugh Kaar, Maura Kepper, Christopher E Kline, Keila N Lopez, Shamarial Roberson, Colleen K Spees, Gerald J Jerome","doi":"10.1161/CIR.0000000000001314","DOIUrl":"10.1161/CIR.0000000000001314","url":null,"abstract":"<p><p>Populations most affected by cardiovascular health disparities, including underrepresented populations with lower socioeconomic status, people with disabilities, and those living in underserved rural communities, are disproportionately exposed to adverse social determinants of health. Specifically, economic instability and suboptimal living conditions within the neighborhood and built environment directly determine access to resources and opportunities for healthful behaviors. In this scientific statement, we examined the technology-enabled interventions that address cardiovascular health behaviors from adolescence to adulthood in populations most affected by health disparities. We used a broad definition of technology, including wearables, applications, and telehealth, for behavior tracking. Aligning with Life's Essential 8, we focused on interventions targeting behavior change related to physical activity, sedentary time, dietary intake, tobacco cessation, and sleep health to improve cardiovascular health. The digital determinants of health are important adjuncts to the social determinants and operate at the individual, interpersonal, community, and societal levels. The digital determinants of health include the impact of digital technologies (eg, wearables, telemedicine) across health outcomes. Evidence of effective interventions using technology to improve cardiovascular health through positive behavior change is critical for preventing cardiovascular disease events. Stronger evidence is needed to inform and implement effective approaches that are scalable and cost-effective across communities and health care institutions to advance digital equity in cardiovascular health. Dissemination of digital solutions to improve cardiovascular health in communities or across health care systems must ensure effective, feasible, available, and affordable solutions for populations most in need.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"e972-e985"},"PeriodicalIF":35.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MYSTERY-HF: Myeloperoxidase Inhibition in Patients With Heart Failure and Reduced Ejection Fraction: A Phase II Randomized Controlled Trial.","authors":"Simon Braumann, Sascha Macherey-Meyer, Amin Polzin, Angelika Costard-Jäckle, Caroline Morbach, Bernhard Haring, Harald Lapp, Vincent Ten Cate, Alexander Gieswinkel, Jithmi Weliwitage, Martin Hellmich, Erik Michaëlsson, Karin Nelander, Nelli Ens-Jäger, Stephan Rosenkranz, Simon Geißen, Norbert Frey, P Christian Schulze, Malin Aurell, Michael Böhm, Stefan Frantz, Malte Kelm, Volker Rudolph, Sanjiv J Shah, Philipp S Wild, Stephan Baldus","doi":"10.1161/CIRCULATIONAHA.125.074085","DOIUrl":"10.1161/CIRCULATIONAHA.125.074085","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"1372-1374"},"PeriodicalIF":35.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the Literature.","authors":"Tracy Hampton","doi":"10.1161/CIRCULATIONAHA.125.074787","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.074787","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 18","pages":"1369-1371"},"PeriodicalIF":35.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Salt Diet <i>and</i> Thiazide Diuretics.","authors":"Franz H Messerli, C Venkata S Ram, Michel Burnier","doi":"10.1161/CIRCULATIONAHA.125.074388","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.074388","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 18","pages":"1297-1298"},"PeriodicalIF":35.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence Generation and Implementation of Transcatheter Interventions for Atrioventricular Valvular Heart Disease in Heart Failure: Current Status and Future Directions.","authors":"Marco Metra,Daniela Tomasoni,Marianna Adamo,Stefan D Anker,Antoni Bayes-Genis,Ralph Stephan von Bardeleben,Michael Böhm,Erwan Donal,Gerasimos S Filippatos,Francesco Maisano,Piotr Ponikowski,Gianluigi Savarese,Fabien Praz,Javed Butler","doi":"10.1161/circulationaha.124.070411","DOIUrl":"https://doi.org/10.1161/circulationaha.124.070411","url":null,"abstract":"Mitral regurgitation and tricuspid regurgitation are the most common valvular heart diseases in patients with heart failure and have independent prognostic value. Transcatheter interventions are now available for the treatment of valvular heart disease, and their efficacy and safety have been tested in randomized controlled trials. However, evidence is still limited and sometimes inconclusive because several aspects of these trials limit their interpretation or consistency. These include heterogeneity in the pathogenesis and clinical characteristics of patients, the dynamic nature of secondary atrioventricular valve disease severity, the role of heart failure medications and devices, dependency on procedural results and operators' skills, smaller number of patients enrolled and the power to detect differences in trials, and limitations to use patients' reported outcomes with unblinded study protocols. These specific aspects of trials in patients with atrioventricular valve disease are reviewed in this article with a focus on possible solutions to generate further evidence for the efficacy and safety for transcatheter treatments of atrioventricular valve disease in patients with heart failure.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"68 1","pages":"1342-1363"},"PeriodicalIF":37.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Gu et al Regarding Article, \"Antisense Oligonucleotide Therapy for Calmodulinopathy\".","authors":"Siyuan Gu,Ye Chen,Xiaojian Shi","doi":"10.1161/circulationaha.124.073198","DOIUrl":"https://doi.org/10.1161/circulationaha.124.073198","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"15 1","pages":"e968-e969"},"PeriodicalIF":37.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Coronary Calcium Mean the Same in Active and Sedentary Individuals?","authors":"Paul D Thompson","doi":"10.1161/circulationaha.125.074396","DOIUrl":"https://doi.org/10.1161/circulationaha.125.074396","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"38 1","pages":"1309-1311"},"PeriodicalIF":37.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Bortolin and Pu to Letter Regarding Article, \"Antisense Oligonucleotide Therapy for Calmodulinopathy\".","authors":"Raul H Bortolin,William T Pu","doi":"10.1161/circulationaha.125.073965","DOIUrl":"https://doi.org/10.1161/circulationaha.125.073965","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"115 1","pages":"e970-e971"},"PeriodicalIF":37.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD206⁺IL-4Rα⁺ Macrophages Are Drivers of Adverse Cardiac Remodeling in Ischemic Cardiomyopathy.","authors":"Qiongxin Wang, Mohamed Ameen Ismahil, Yujie Zhu, Gregg Rokosh, Tariq Hamid, Guihua Zhou, Steven M Pogwizd, Sumanth D Prabhu","doi":"10.1161/CIRCULATIONAHA.124.072411","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.072411","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The role of cardiac CD (cluster of differentiation) 206&lt;sup&gt;+&lt;/sup&gt; macrophages in chronic heart failure (HF) is unknown. We examined whether CD206&lt;sup&gt;+&lt;/sup&gt; macrophages expressing IL (interleukin)-4Rα are key drivers of adverse left ventricular (LV) remodeling in HF.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Adult C57BL/6 mice underwent nonreperfused myocardial infarction to induce HF. Macrophages in murine and human hearts were profiled using flow cytometry and immunostaining. In vivo myeloid-specific IL-4Rα deletion and intramyocardial macrophage adoptive transfer defined the functional effects of M[IL-4] macrophages. Antisense oligonucleotides were used for in vivo IL-4Rα gene silencing in mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;CD206&lt;sup&gt;+&lt;/sup&gt; macrophages steadily expanded in hearts after myocardial infarction, such that at 8 weeks after myocardial infarction, they comprised ≈85% of all macrophages. These macrophages were proliferative, predominantly CCR2&lt;sup&gt;-&lt;/sup&gt; (C-C motif chemokine receptor) and MHC (major histocompatibility complex) II&lt;sup&gt;hi&lt;/sup&gt;, and correlated with LV dysfunction and fibrosis. Nearly half of CD206&lt;sup&gt;+&lt;/sup&gt; macrophages expressed IL-4Rα, and the majority of CD206&lt;sup&gt;+&lt;/sup&gt;IL-4Rα&lt;sup&gt;+&lt;/sup&gt; macrophages coexpressed profibrotic FIZZ (found in inflammatory zone) 1. IL-4-polarized bone marrow-derived CD206&lt;sup&gt;+&lt;/sup&gt; macrophages also exhibited marked upregulation of FIZZ1 and induced FIZZ1-dependent myofibroblast differentiation of both cardiac mesenchymal stem cells and cardiac fibroblasts, in part related to DLL-4/Jagged1-Notch1 signaling in cardiac mesenchymal stem cells. Intramyocardial adoptive transfer of M[IL-4], but not M[IL-10], CD206&lt;sup&gt;+&lt;/sup&gt; macrophages to naïve mice induced progressive LV remodeling over 4 weeks, increasing fibrosis, cardiomyocyte hypertrophy, and apoptosis. Myeloid-specific IL-4Rα gene deletion in HF (initiated 4 weeks after myocardial infarction) in IL-4Rα&lt;sup&gt;f/f&lt;/sup&gt;LysM-Cre&lt;sup&gt;ERT2&lt;/sup&gt; mice significantly reduced CD206&lt;sup&gt;+&lt;/sup&gt; macrophage proliferation and effectively depleted CD206&lt;sup&gt;+&lt;/sup&gt;IL-4Rα&lt;sup&gt;+&lt;/sup&gt; cardiac macrophages. This was associated with abrogation of LV remodeling progression, reduction of cardiac fibrosis, and improved neovascularization. In vivo IL-4Rα gene silencing in mice with established HF effectively depleted cardiac CD206&lt;sup&gt;+&lt;/sup&gt;IL-4Rα&lt;sup&gt;+&lt;/sup&gt; macrophages and reversed LV remodeling, improving fibrosis, neovascularization, and dysfunction, and suppressed both local and systemic inflammation. Last, alternatively activated CD206&lt;sup&gt;+&lt;/sup&gt; and CD163&lt;sup&gt;+&lt;/sup&gt; macrophages were significantly expanded in human failing hearts and correlated with fibrosis. The majority of CD163&lt;sup&gt;+&lt;/sup&gt; macrophages expressed IL-4Rα and FIZZ3, the human homolog of FIZZ1.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Cardiac CD206&lt;sup&gt;+&lt;/sup&gt;IL-4Rα&lt;sup&gt;+&lt;/sup&gt; macrophages proliferate and expand in HF and are key mediators of pathological rem","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palpitations After Leadless Pacemaker Implantation.","authors":"Khush M Kharidia, Mason D Marcus, Nimesh S Patel","doi":"10.1161/CIRCULATIONAHA.125.074657","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.074657","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 17","pages":"1291-1293"},"PeriodicalIF":35.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}