Circulation最新文献

{"title":"Letter by Xu et al Regarding Article, \"Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial\".","authors":"Xiaoqun Xu, Houyong Zhu, Kan Xu","doi":"10.1161/CIRCULATIONAHA.124.069975","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.069975","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 20","pages":"e444"},"PeriodicalIF":35.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Yan et al to Letter Regarding Article, \"Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Myocardial Infarction: A Multicenter, Randomized, Double-Blind Trial\".","authors":"Yan Yan, Shaoping Nie, Gilles Montalescot","doi":"10.1161/CIRCULATIONAHA.124.071534","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071534","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 20","pages":"e445-e446"},"PeriodicalIF":35.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Resynchronization Therapy: New Perspectives.","authors":"Claude Daubert, Cecilia Linde","doi":"10.1161/CIRCULATIONAHA.124.070105","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.070105","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 20","pages":"1563-1566"},"PeriodicalIF":35.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Effects of <i>MTSS1</i> Downregulation on Dilated Cardiomyopathy.","authors":"Dongwook Choe, Megan Burke, Jeffrey A Brandimarto, Ingrid Marti-Pamies, Jaime Yob, Yifan Yang, Michael P Morley, Theodore G Drivas, Sharlene Day, Michael Levin, Scott Damrauer, Xiao Wang, Thomas P Cappola","doi":"10.1161/CIRCULATIONAHA.124.070418","DOIUrl":"10.1161/CIRCULATIONAHA.124.070418","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 20","pages":"1648-1651"},"PeriodicalIF":35.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11567047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Training in Patients With Hypertrophic Cardiomyopathy Without Left Ventricular Outflow Tract Obstruction: A Randomized Clinical Trial.","authors":"Helga Gudmundsdottir, Anna Axelsson Raja, Kasper Rossing, Hanne Rasmusen, Martin Snoer, Lars Juel Andersen, Rikke Gottlieb, Alex Hørby Christensen, Henning Bundgaard, Finn Gustafsson, Jens Jakob Thune","doi":"10.1161/CIRCULATIONAHA.124.070064","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.070064","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction commonly experience reduced exercise capacity. Physical training improves exercise capacity in these patients, but whether the underlying effects of exercise are a result of central hemodynamic or peripheral improvement is unclear. This study assessed whether exercise training reduces left ventricular filling pressure measured during exercise in patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between March 2019 and June 2022, patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction were randomly assigned (1:1) to a 12-week (3 h/wk) supervised, moderate-intensity exercise training program or continued usual activity. The primary outcome was the change in invasively measured pulmonary capillary wedge pressure during mild exercise (25 W) from baseline to week 12. Pressure tracings were analyzed offline by a blinded investigator. Secondary outcomes included changes in peak oxygen consumption, cardiac index, quality of life, echocardiographic indices of diastolic function, and natriuretic peptides.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 59 patients randomized (mean age, 58.1±12.2 years; 27% women), 51 (86%) completed all follow-up assessments. At week 12, the change in 25-W pulmonary capillary wedge pressure was -2.8±6.8 mm Hg in the exercise group, compared with +1.2±4.9 mm Hg in the usual-activity group (between-group difference, 4.0 mm Hg [95% CI, 0.7-7.3]; &lt;i&gt;P&lt;/i&gt;=0.018). Peak oxygen consumption improved by +1.8±2.0 mL/kg/min in the exercise group versus -0.3±3.1 mL/kg/min in the usual-activity group (&lt;i&gt;P&lt;/i&gt;=0.005). Exercise training improved the ventilatory efficiency (V&lt;sub&gt;E&lt;/sub&gt;/VCO&lt;sub&gt;2&lt;/sub&gt;) slope compared with usual activity (between-group difference, 2.0 [95% CI, 0.6-3.5]; &lt;i&gt;P&lt;/i&gt;=0.006). Peak cardiac index improved by +0.38±1.38 L/min/m&lt;sup&gt;2&lt;/sup&gt; in exercise versus -0.85±1.20 L/min/m&lt;sup&gt;2&lt;/sup&gt; in the usual-activity group (&lt;i&gt;P&lt;/i&gt;=0.002). Change in overall Kansas City Cardiomyopathy Questionnaire score was similar between groups. However, the change in physical limitation scores (+8.4±12.0 points in exercise versus +0.7±6.8 points in usual-activity group; &lt;i&gt;P&lt;/i&gt;=0.034) and quality-of-life scores (+8.7±18.0 points in exercise versus 0.7±4.0 points in usual-activity group; &lt;i&gt;P&lt;/i&gt;=0.01) differed significantly. There were no significant changes in diastolic function assessed by echocardiography or in natriuretic peptides.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;In patients with hypertrophic cardiomyopathy without left ventricular outflow tract obstruction, a 12-week moderate-intensity exercise training program resulted in reduced left ventricular filling pressures at mild exertion and improved exercise performance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Registration: &lt;/strong&gt;URL: https://www.clinicaltrials.gov; Unique identi","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Rounds: Advancing Cardiovascular Health in China.","authors":"Changsheng Ma, Junbo Ge, Yaling Han","doi":"10.1161/CIRCULATIONAHA.124.071544","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071544","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device-Measured 24-Hour Movement Behaviors and Blood Pressure: A 6-Part Compositional Individual Participant Data Analysis in the ProPASS Consortium.","authors":"Joanna M Blodgett, Matthew N Ahmadi, Andrew J Atkin, Richard M Pulsford, Vegar Rangul, Sebastien Chastin, Hsiu-Wen Chan, Kristin Suorsa, Esmée A Bakker, Nidhi Gupta, Pasan Hettiarachchi, Peter J Johansson, Lauren B Sherar, Borja Del Pozo Cruz, Nicholas Koemel, Gita D Mishra, Thijs M H Eijsvogels, Sari Stenholm, Alun D Hughes, Armando Teixeira-Pinto, Ulf Ekelund, I-Min Lee, Andreas Holtermann, Annemarie Koster, Emmanuel Stamatakis, Mark Hamer","doi":"10.1161/CIRCULATIONAHA.124.069820","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.069820","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP)-lowering effects of structured exercise are well-established. Effects of 24-hour movement behaviors captured in free-living settings have received less attention. This cross-sectional study investigated associations between a 24-hour behavior composition comprising 6 parts (sleeping, sedentary behavior, standing, slow walking, fast walking, and combined exercise-like activity [eg, running and cycling]) and systolic BP (SBP) and diastolic BP (DBP).</p><p><strong>Methods: </strong>Data from thigh-worn accelerometers and BP measurements were collected from 6 cohorts in the Prospective Physical Activity, Sitting and Sleep consortium (ProPASS) (n=14 761; mean±SD, 54.2±9.6 years). Individual participant analysis using compositional data analysis was conducted with adjustments for relevant harmonized covariates. Based on the average sample composition, reallocation plots examined estimated BP reductions through behavioral replacement; the theoretical benefits of optimal (ie, clinically meaningful improvement in SBP [2 mm Hg] or DBP [1 mm Hg]) and minimal (ie, 5-minute reallocation) behavioral replacements were identified.</p><p><strong>Results: </strong>The average 24-hour composition consisted of sleeping (7.13±1.19 hours), sedentary behavior (10.7±1.9 hours), standing (3.2±1.1 hours), slow walking (1.6±0.6 hours), fast walking (1.1±0.5 hours), and exercise-like activity (16.0±16.3 minutes). More time spent exercising or sleeping, relative to other behaviors, was associated with lower BP. An additional 5 minutes of exercise-like activity was associated with estimated reductions of -0.68 mm Hg (95% CI, -0.15, -1.21) SBP and -0.54 mm Hg (95% CI, -0.19, 0.89) DBP. Clinically meaningful improvements in SBP and DBP were estimated after 20 to 27 minutes and 10 to 15 minutes of reallocation of time in other behaviors into additional exercise. Although more time spent being sedentary was adversely associated with SBP and DBP, there was minimal impact of standing or walking.</p><p><strong>Conclusions: </strong>Study findings reiterate the importance of exercise for BP control, suggesting that small additional amounts of exercise are associated with lower BP in a free-living setting.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response by Caller et al to Letter Regarding Article, \"Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth\".","authors":"Tal Caller, Crislyn D'Souza-Schorey, Nili Naftali-Shani, Jonathan Leor","doi":"10.1161/CIRCULATIONAHA.124.071538","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071538","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 19","pages":"e350"},"PeriodicalIF":35.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Care in Canada: Strengths, Challenges, and Opportunities For Improvement.","authors":"Tauben Averbuch, Krista Stelkia, Harriette G C Van Spall","doi":"10.1161/CIRCULATIONAHA.124.070628","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.070628","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 19","pages":"1490-1492"},"PeriodicalIF":35.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transseptal Transcatheter Valve-in-Valve Mitral Valve Implantation: Ready for Prime Time.","authors":"Marina Urena","doi":"10.1161/CIRCULATIONAHA.124.071666","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071666","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"150 19","pages":"1505-1507"},"PeriodicalIF":35.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142575422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}