Circulation最新文献

{"title":"Role of Cardiovascular Disease Journals in Reporting Sex and Gender in Research.","authors":"C Noel Bairey Merz, Robert O Bonow, Mercedes Carnethon, Filippo Crea, Joseph A Hill, Harlan M Krumholz, Roxana Mehran, Erica S Spatz","doi":"10.1161/CIRCULATIONAHA.125.074517","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.074517","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Heart Transplant Allocation Changes on Waitlist Mortality and Clinical Practice in Pediatric and Adult Patients With Congenital Heart Disease and Cardiomyopathy.","authors":"Luke Wooster, Matthew J O'Connor, Xuemei Zhang, Constantine D Mavroudis, Katsuhide Maeda, Humera Ahmed, Jonathan Edwards, Kimberly Y Lin, Carol Wittlieb-Weber, Joseph W Rossano, Jonathan B Edelson","doi":"10.1161/CIRCULATIONAHA.124.072335","DOIUrl":"10.1161/CIRCULATIONAHA.124.072335","url":null,"abstract":"<p><strong>Background: </strong>The United Network of Organ Sharing made changes to the priority for allocation of hearts for transplantation in 2016 for pediatric patients and 2018 for adult patients. Although recent work has evaluated the impact of the revised allocation systems on mechanical circulatory support practices and waitlist outcomes, there are limited data that focus more specifically on the impact of the allocation changes on patients with congenital heart disease (CHD) or cardiomyopathy and how these relationships might differ in pediatric and adult patients.</p><p><strong>Methods: </strong>The United Network of Organ Sharing database was queried for pediatric (<18 years of age) and adult (18-50 years of age) patients with a CHD or cardiomyopathy diagnosis listed for heart transplantation. Cohorts were grouped into preallocation and postallocation change eras: pediatric patients from January 1, 2011, to March 21, 2016, and January 1, 2017, to December 31, 2021; and adult patients from January 1, 2015, to October 17, 2018, and January 1, 2019, to December 31, 2021. Differences in era for survival or waitlist removal because of clinical deterioration from the time of heart transplantation listing were compared using competing risk models.</p><p><strong>Results: </strong>We identified 11 637 patients listed for heart transplantation during the study period, including 2882 pediatric patients with CHD, 594 adults with CHD, 2348 pediatric patients with cardiomyopathy, and 5813 adults with cardiomyopathy. In a competing risk model adjusting for demographic and clinical factors, allocation changes were significantly associated with lower death or waitlist removal within 1 year of heart transplantation listing in infants with CHD (hazard ratio, 0.75 [95% CI, 0.57-0.99]; <i>P</i>=0.04), children with CHD (hazard ratio, 0.61 [95% CI, 0.43-0.86]; <i>P</i>=0.005), and adults with cardiomyopathy (hazard ratio, 0.60 [95% CI, 0.44-0.81]; <i>P</i>=0.001), but not in infants with cardiomyopathy, children with cardiomyopathy, or adults with CHD.</p><p><strong>Conclusions: </strong>The recent allocation changes of the Organ Procurement and Transplantation Network associations with waitlist duration and outcome were not uniform across pediatric and adult cohorts with CHD or those with cardiomyopathy. Children with cardiomyopathy and adults with CHD did not experience the mortality benefits experienced by adults with cardiomyopathy and children with CHD. Future iterations of the allocation systems should consider differential access to mechanical circulatory support options for children and adults, patient sensitization status, and whether having separate systems for adults and children is the most appropriate method to allocate organs.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"814-824"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highlights From the <i>Circulation</i> Family of Journals.","authors":"","doi":"10.1161/CIRCULATIONAHA.125.074426","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.074426","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"878-883"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Atrial Fibrillation: A Frontier Review From the AF-SCREEN International Collaboration.","authors":"Teemu J Niiranen, Renate B Schnabel, Aletta E Schutte, Yitschak Biton, Giuseppe Boriani, Claire Buckley, Alan C Cameron, Albertino Damasceno, Søren Z Diederichsen, Wolfram Doehner, Yutao Guo, F D Richard Hobbs, Boyoung Joung, Graeme J Hankey, Gregory Y H Lip, Trudie Lobban, Maja-Lisa Løchen, Georges Mairesse, Amam Mbakwem, Peter A Noseworthy, George Ntaios, Steven Steinhubl, George Stergiou, Jesper Hastrup Svendsen, Robert G Tieleman, Jiguang Wang, Neil R Poulter, Jeff S Healey, Ben Freedman","doi":"10.1161/CIRCULATIONAHA.124.071047","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071047","url":null,"abstract":"<p><p>Hypertension is the leading modifiable risk factor for atrial fibrillation (AF) and is estimated to be present in >70% of AF patients. This Frontiers Review was prepared by 29 expert members of the AF-SCREEN International Collaboration to summarize existing evidence and knowledge gaps on links between hypertension, AF, and their cardiovascular sequelae; simultaneous screening for hypertension and AF; and the prevention of AF through antihypertensive therapy. Hypertension and AF are inextricably connected. Both are easily diagnosed, often silent, and frequently treated inadequately. Together, they additively increase the risk of ischemic stroke, heart failure, and many types of dementia, resulting in greater all-cause mortality, considerable disease burden, and increased health care expenditures. Automated upper arm cuff blood pressure devices with implemented technology can be used to simultaneously detect both hypertension and AF. However, positive screening for AF with an oscillometric blood pressure monitor still requires ECG confirmation. The current evidence suggests that high-risk individuals aged ≥65 years or with treatment-resistant hypertension could benefit from AF screening. Since antihypertensive therapy effectively lowers AF risk, particularly in individuals with left ventricular dysfunction, hypertension should be the key target for AF prediction and prevention rather than merely a comorbidity of AF. Nevertheless, several important gaps in knowledge need to be filled over the next years, including the ideal method and selection of patients for simultaneous screening of hypertension and AF and the optimal antihypertensive drug class and blood pressure targets for AF prevention.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"863-877"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease in Anabolic Androgenic Steroid Users.","authors":"Josefine Windfeld-Mathiasen, Ida M Heerfordt, Kim Peder Dalhoff, Jon Trærup Andersen, Michael Asger Andersen, Karl Sebastian Johansson, Tor Biering-Sørensen, Flemming Javier Olsen, Henrik Horwitz","doi":"10.1161/CIRCULATIONAHA.124.071117","DOIUrl":"10.1161/CIRCULATIONAHA.124.071117","url":null,"abstract":"<p><strong>Background: </strong>Use of anabolic androgenic steroids (AASs) is associated with increased mortality, and case reports have suggested that some of these deaths are due to cardiovascular disease. However, the epidemiology of cardiovascular disease in AAS users is still relatively unexplored. This study aimed to measure the incidence of cardiovascular disease in male AAS users and to compare these rates with those of a cohort from the general population matched by age and sex.</p><p><strong>Methods: </strong>Men sanctioned in an antidoping program for AAS use in Danish fitness centers between 2006 and 2018 were included and matched for age and sex with 50 times as many controls from the general Danish population. The cohort was followed until June 30, 2023. Using the nationwide registries, we obtained information on admissions, prescriptions, educational length, and occupational status for both the AAS users and controls. This study investigated the incidence of acute myocardial infarction, percutaneous coronary intervention, or coronary artery bypass graft, venous thromboembolism, ischemic stroke, arrhythmia, cardiomyopathy, heart failure, and cardiac arrest during the follow-up period.</p><p><strong>Results: </strong>During an average of 11 years of follow-up, AAS users (n=1189) demonstrated a significantly higher incidence of several cardiovascular events compared with controls (n=59 450). Correspondingly, AASs were associated with an increased risk of acute myocardial infarction (adjusted hazard ratio [aHR] 3.00 [95% CI, 1.67-5.39]), percutaneous coronary intervention or coronary artery bypass graft (aHR 2.95 [95% CI, 1.68-5.18]), venous thromboembolism (aHR 2.42 [95% CI, 1.54-3.80]), arrhythmias (aHR 2.26 [95% CI, 1.53-3.32]), cardiomyopathy (aHR 8.90 [95% CI, 4.99-15.88]), and heart failure (aHR 3.63 [95% CI, 2.01-6.55]). Due to the limited number of ischemic stroke and cardiac arrest cases among AAS users, these outcomes were not reportable.</p><p><strong>Conclusions: </strong>AAS use is associated with a substantially increased risk of cardiovascular disease in a large cohort with a long follow-up period.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"828-834"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-Label ARIVA Trial.","authors":"Stefano Barco, Houman Jalaie, Tim Sebastian, Simon Wolf, Riccardo M Fumagalli, Michael Lichtenberg, Thomas Zeller, Christian Erbel, Oliver Schlager, Nils Kucher","doi":"10.1161/CIRCULATIONAHA.124.073050","DOIUrl":"10.1161/CIRCULATIONAHA.124.073050","url":null,"abstract":"<p><strong>Background: </strong>In patients with post-thrombotic syndrome, stent recanalization of iliofemoral veins or the inferior vena cava can restore venous patency and improve functional outcomes. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. The ARIVA trial (Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS) tested whether 100 mg of daily aspirin plus 20 mg of rivaroxaban is superior to 20 mg of rivaroxaban alone to prevent stent thrombosis within 6 months after stent placement for post-thrombotic syndrome.</p><p><strong>Methods: </strong>In this multinational, academic, open-label, independently adjudicated trial, patients with a Villalta score >4 points and a stenosis or occlusion of the inferior vena cava, iliac veins, or common femoral vein successfully treated with venous stent placement were randomized in a 1:1 fashion to the study groups. Key exclusion criteria included <18 or >75 years of age, contraindications to anticoagulant use, or acute venous thrombosis <3 months. The primary efficacy outcome was the composite of no occlusion in the treated segment assessed at serial duplex ultrasound examinations or no reintervention needed to maintain patency within 6 months. Secondary outcomes, including Villalta score, quality of life, and safety outcomes, were also assessed. The study was registered at ClinicalTrials.gov (NCT04128956).</p><p><strong>Results: </strong>From 2020 through 2022, 172 patients were screened, 169 were randomized, and 162 were included in the full analysis set, receiving either aspirin plus rivaroxaban (n=80) or rivaroxaban alone (n=82) for 6 months. Mean±SD age was 42.8±14.7 years; 103 patients (60.9%) were women; 154 patients (97.5%) were White; and leg ulcers were present in 7% of patients. The primary patency rate at 6 months was 94.8% versus 92.4% (absolute risk difference, 2.4% [95% CI, -13.6 to 18.0]), respectively. The mean±SD decrease in the Villalta score for the affected leg (without ulcer) from baseline to 6 months was -6.7±4.4 and -7.0±5.2 points (<i>P</i>=0.36), respectively. There were no differences in other outcomes or quality of life at 6 months. No major bleeding occurred.</p><p><strong>Conclusions: </strong>The overall primary patency rate during the first 6 months after endovascular intervention for post-thrombotic syndrome was higher than expected and comparable between patients receiving aspirin combined with rivaroxaban and those receiving rivaroxaban alone.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04128956.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"835-846"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Wei and Yu Regarding Article, \"Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)\".","authors":"Shouxin Wei, Sijia Yu","doi":"10.1161/CIRCULATIONAHA.124.071784","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.071784","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"e764"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Xu et al Regarding Article, \"Intracranial Atherosclerotic Disease and Incident Dementia: The ARIC Study (Atherosclerosis Risk in Communities)\".","authors":"Lingyu Xu, Yanfei Wang, Yan Xu","doi":"10.1161/CIRCULATIONAHA.124.072061","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.072061","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"e765"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Interpretation of Statistical Interaction.","authors":"Andrea Bellavia, Sabina A Murphy","doi":"10.1161/CIRCULATIONAHA.125.073644","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.125.073644","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"811-813"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coupling Interval Counts in Ventricular Premature Depolarizations During Acute Ischemia.","authors":"Yusuke Yamazaki, Hideo Mitamura, Toru Egashira","doi":"10.1161/CIRCULATIONAHA.124.073654","DOIUrl":"https://doi.org/10.1161/CIRCULATIONAHA.124.073654","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"151 12","pages":"884-886"},"PeriodicalIF":35.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}